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MTAPIWMASPPEVHSALLSSGPGPGPLLSAAAAWSQLSNEYASAANELTAMLGAVQAGPWEGSSAEQYVA AHLPYVAWLMQASVDTTQAAAQLETAAAAYTTALAAMPTLPELATNHTIHAALTATNFFGINTIPITLNE ADYVRMWIQAATTMSTYQAVSGTALASTPQTAPAPYILKSNAQTEDSQPPVEGSDPLDSLVADILRAITD GRVNWDPVSRTVNGIEYEEYTDAGDPVWWVVRALEFSQDFRTFARLLPTDPQAALQFYGELFLFDYPVHI PQLLTWLSQSPQLLAVALGQAVSGLGAVTGFAGLAGLAAQPIGTVASALGPVAAPADMLPVTSMAPTVTT PVAAPVSATAPAPATALTAGGPPPVPPAAGGAGFSYPYLIGGGPSIGFGSGMSTSASASAKKKTPEPDTA AAAAARERARARRRRRATLRGYGDEFMDIEVDPDWGAPPGEGPGASTVASDHGAGPVGIAGTVHTGSVTP AAGLTTLGGDDFDGEPRMPMLPGTWDPDGARDAGKGS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1418 | - | - | 100% (527) | PPE family protein |
| M. marinum M | MMAR_0538 | - | 0.0 | 61.69% (522) | PPE family protein, PPE3 |
| M. marinum M | MMAR_0545 | - | e-103 | 43.78% (539) | PPE family protein, PPE4 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0288 | PPE3 | 0.0 | 63.02% (530) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-104 | 44.14% (546) | PPE protein |
| M. tuberculosis H37Rv | Rv0280 | PPE3 | 0.0 | 63.02% (530) | PPE family protein |
| M. leprae Br4923 | MLBr_00539 | PPE | 1e-126 | 47.38% (534) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 1e-107 | 45.27% (539) | PPE family protein |
| M. avium 104 | MAV_4879 | - | 1e-155 | 56.93% (541) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 5e-98 | 42.40% (566) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 3e-71 | 38.68% (517) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1202 | - | 1e-180 | 61.00% (518) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-102 | 44.01% (559) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
Mb0288|M.bovis_AF2122/97 ------------MTLWMASPPEVHSALLSSGPGPGSVLSAAGVWSSLSAE
Rv0280|M.tuberculosis_H37Rv ------------MTLWMASPPEVHSALLSSGPGPGSVLSAAGVWSSLSAE
MUL_1202|M.ulcerans_Agy99 --------------MWFTSPPEVHSALLSSGPGPASLLSGAAAWAGLSTE
MMAR_1418|M.marinum_M ----------MTAPIWMASPPEVHSALLSSGPGPGPLLSAAAAWSQLSNE
MAV_4879|M.avium_104 ----------MTAPIFMASPPELHSALLSSGPGPASLLAAAGAWSQLSAE
MLBr_00539|M.leprae_Br4923 -----------MTNPWMAFPPEVQSAMLNFGAGVGPMLNSASYNLWLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
:: ***::*::* *.* ..: .. *. .
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
Mb0288|M.bovis_AF2122/97 YAAVADELIGLLGAVQTGAWQGPSAAAYVAAHAPYLAWLMRASETSAEAA
Rv0280|M.tuberculosis_H37Rv YAAVADELIGLLGAVQTGAWQGPSAAAYVAAHAPYLAWLMRASETSAEAA
MUL_1202|M.ulcerans_Agy99 YASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQAA
MMAR_1418|M.marinum_M YASAANELTAMLGAVQAGPWEGSSAEQYVAAHLPYVAWLMQASVDTTQAA
MAV_4879|M.avium_104 YASAAEQLSTLLTGVAAGAWQGVSGESYVGAHAPYLAWLTKASADSAAVA
MLBr_00539|M.leprae_Br4923 YRWVASEVEALLREVRSGGWQGQAVEMFVGSCMPFLAWLMKAAADYMDVA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
* .* :: :: . *.* . :..: *:: ** : .
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
Mb0288|M.bovis_AF2122/97 ARHETVAAAYTTAVAAMPTLVELAANHTLHGVLVATNFFGINTIPIALNE
Rv0280|M.tuberculosis_H37Rv ARHETVAAAYTTAVAAMPTLVELAANHTLHGVLVATNFFGINTIPIALNE
MUL_1202|M.ulcerans_Agy99 AQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAANE
MMAR_1418|M.marinum_M AQLETAAAAYTTALAAMPTLPELATNHTIHAALTATNFFGINTIPITLNE
MAV_4879|M.avium_104 AQHEVAATAYTTALATMPTLPELAANHAVHATLVATNFFGVNTVPIAVNE
MLBr_00539|M.leprae_Br4923 TQQEVVAAAYAAAVEAMPTQFELAANRVVRGVLMATNFFGVNTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
.: ..* *:::*: .*** **: *:. :..* .***:*:**:** .*
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVG-------
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVG-------
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVG-------
Mb0288|M.bovis_AF2122/97 ADYARMWTQAASTMATYQAVAEAAVASAPQTTPAPPILAAEAADDDHDHD
Rv0280|M.tuberculosis_H37Rv ADYARMWTQAASTMATYQAVAEAAVASAPQTTPAPPILAAEAADDDHDHD
MUL_1202|M.ulcerans_Agy99 ADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAAPAAA--HDHD
MMAR_1418|M.marinum_M ADYVRMWIQAATTMSTYQAVSGTALASTPQTAPAPYILKSNAQT--EDSQ
MAV_4879|M.avium_104 ADYARMWTQAATTMSTYHAVSTAAVASTPQAEPAPQIVKSDASQDDSGNE
MLBr_00539|M.leprae_Br4923 EEYVQMWVRAATTMATYSAISQSALAATPQATPPPLILKSNVLVDDVEKD
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILH--------DHD
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
:*.:** :**:**:** : : *::::* : ..* ::
Mflv_0325|M.gilvum_PYR-GCK ------EAGRAAADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRF
Mvan_0415|M.vanbaalenii_PYR-1 ------EAGRAAADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRF
MSMEG_0619|M.smegmatis_MC2_155 ------EAGSASASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPG
Mb0288|M.bovis_AF2122/97 H-----DHGGEPTPLDYLVAEILRIISGGRLIWDPAEGTMNGIPFEDYTD
Rv0280|M.tuberculosis_H37Rv H-----DHGGEPTPLDYLVAEILRIISGGRLIWDPAEGTMNGIPFEDYTD
MUL_1202|M.ulcerans_Agy99 H-----DHGGDPTPIDYFVAEVLRIISGGRIIWDPAEGTVNGIPYDDYVN
MMAR_1418|M.marinum_M P-----PVEG-SDPLDSLVADILRAITDGRVNWDPVSRTVNGIEYEEYTD
MAV_4879|M.avium_104 D-----HDPKIDNPFNDFIANILRNLG---IDWDPAKGTVNGLDYDAYTN
MLBr_00539|M.leprae_Br4923 SRHDGHSHGGHASAMDRVFADILRNVSGGRLVWDPLNGTLNGLDYDDYVY
MAB_0809c|M.abscessus_ATCC_199 H--------GHDD-------------------HDHEHGHDDDHGHGD-LD
TH_3113|M.thermoresistible__bu TG--AHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGT
Mflv_0325|M.gilvum_PYR-GCK LFEPIFNFLR---DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA--
Mvan_0415|M.vanbaalenii_PYR-1 LFEPIFDFLR---DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA--
MSMEG_0619|M.smegmatis_MC2_155 G-QAILDFLK---DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFF
Mb0288|M.bovis_AF2122/97 AAQPIWWVVRA-IEFSKDFETFVQELFVNPVEAFQFYFELLLFDYPTHIV
Rv0280|M.tuberculosis_H37Rv AAQPIWWVVRA-IEFSKDFETFVQELFVNPVEAFQFYFELLLFDYPTHIV
MUL_1202|M.ulcerans_Agy99 AAQPIWWLVRA-LEFGQDFQTFIKELFTNPIGAIEFMVELVLFDWPTHIA
MMAR_1418|M.marinum_M AGDPVWWVVRA-LEFSQDFRTFARLLPTDPQAALQFYGELFLFDYPVHIP
MAV_4879|M.avium_104 AGEPIFWVVRA-LELLEDFEQFGYYLVHNPALAFQYLVQLMLFDWPTHIL
MLBr_00539|M.leprae_Br4923 PGQPIWWLARG-LEFFQDGEQFWELLFINPTAAFQFLLYIVVLDLPTHIV
MAB_0809c|M.abscessus_ATCC_199 PTDPEWWVHVA-GEMVEHFELLLNNLLTDP-AALLTNLPMVLADVAFHAA
TH_3113|M.thermoresistible__bu LLAPLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTV
. : :* : :.
Mflv_0325|M.gilvum_PYR-GCK --VSWVGA-SILYPSLFLLPLLATT--LAIVAGVGQHLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 --VSWVGA-SILYPSLLLLPLVATT--LAIVLGVGAYLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 NLVGWPTW-GMIFASPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEA
Mb0288|M.bovis_AF2122/97 QIVEALSQ-SPQLLAVALGSVISNLGAVTGFAGLS-GLAGMQP-AAIPAL
Rv0280|M.tuberculosis_H37Rv QIVEALSQ-SPQLLAVALGSVISNLGAVTGFAGLS-GLAGMQP-AAIPAL
MUL_1202|M.ulcerans_Agy99 QIIQALAQ-SPQLLAVALGGVVANLGAISGLAGLS-GLAGLHS-AALPA-
MMAR_1418|M.marinum_M QLLTWLSQ-SPQLLAVALGQAVSGLGAVTGFAGLA-GLAAQPIGTVASAL
MAV_4879|M.avium_104 EIFMSQ----PELLAPALLLAAAPFAAVGGFAGLA-GLAALPQPVAVPAA
MLBr_00539|M.leprae_Br4923 QLGTWLAE-YPQLLLVALGGTIANLGAVTGLAGLSSGLSAGPS-AAIPTV
MAB_0809c|M.abscessus_ATCC_199 QLASTIGQFAPALIQPALALAIANLGWAAGFAGLA-GIQPSPEILAVEPG
TH_3113|M.thermoresistible__bu AVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLS-GLAGLAGLTAVPAA
: : :
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQS-----APSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPP
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSP-----APTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAP
MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP---------RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGT
Mb0288|M.bovis_AF2122/97 APVAAAPP------TLPAVAMAPTMAAPGAAVASAAAPASAPAASTVASA
Rv0280|M.tuberculosis_H37Rv APVAAAPS------TLPAVAMAPTMAAPGAAVASAAAPASAPAASTVASA
MUL_1202|M.ulcerans_Agy99 AIAPIAPP------MPPGVALAPTVAASVAAPTPPSAPPSA--ASTVANA
MMAR_1418|M.marinum_M GPVAAPAD------MLPVTSMAPTVTTPVAAPVSATAPAPA--TALTAGG
MAV_4879|M.avium_104 VAAPPAPPG-----LPPAIAIAPTPVAAAAPVATAPAPAPAATATTVAGA
MLBr_00539|M.leprae_Br4923 VPESAPIAT-----VPAMLAGAGVAPAVVAPGASPSSAAPPASAASAAAA
MAB_0809c|M.abscessus_ATCC_199 SVEDAPMA------ASAGTALAPSPPASAAAPAAP-ASAPAPTASGTAPA
TH_3113|M.thermoresistible__bu DGGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHS
. .. . :. .
Mflv_0325|M.gilvum_PYR-GCK APGAP--AAAAATFVPYVVAGRDPYEGFSPTVRDS--TGAKAPAGTIPAA
Mvan_0415|M.vanbaalenii_PYR-1 APGAP--AAATASFVPYAVAGRDPGTGFSPTVRDS--TSAKAPASGIPAA
MSMEG_0619|M.smegmatis_MC2_155 TVAAP--APAAATFVPYAVANRDPGEGFTPTLGNK--SQVAAPASGVPAA
Mb0288|M.bovis_AF2122/97 TPAPP-PAPGAAGFGYPYAIAP-PGIGFGSGMSAS--ASAQRKAPQPDSA
Rv0280|M.tuberculosis_H37Rv TPAPP-PAPGAAGFGYPYAIAP-PGIGFGSGMSAS--ASAQRKAPQPDSA
MUL_1202|M.ulcerans_Agy99 APPPP-PAPAAAGFGFPFVVGGGPGIGYGEGMSASAAASARRKAPEPD-S
MMAR_1418|M.marinum_M PPPVP-PAAGGAGFSYPYLIGGGPSIGFGSGMSTSASASAKKKTPEPD--
MAV_4879|M.avium_104 PPAAPAPVAPAAGFFPPYVIGP-PGMGTGSGMSASASSSAKRKAPEPD-S
MLBr_00539|M.leprae_Br4923 APAPP--GTGFGGFSPYLVDGRGPGVGFGSGRQSAYANKVSESVSDSA-V
MAB_0809c|M.abscessus_ATCC_199 PPSPP--PVGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSARE
TH_3113|M.thermoresistible__bu VPPAPHSAPPVGTSGPPYLIAAQPAPGVARR-----SAGARRAASIVEPA
* * * . .
Mflv_0325|M.gilvum_PYR-GCK ASGIAASAAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRV
Mvan_0415|M.vanbaalenii_PYR-1 ASGVAASAAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRI
MSMEG_0619|M.smegmatis_MC2_155 ASGVAASLASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRV
Mb0288|M.bovis_AF2122/97 AAAAAAAAVRDQARARRRR-RVTRRGYGDEFMDMNIDVDPDWGPPPGEDP
Rv0280|M.tuberculosis_H37Rv AAAAAAAAVRDQARARRRR-RVTRRGYGDEFMDMNIDVDPDWGPPPGEDP
MUL_1202|M.ulcerans_Agy99 AALAAAAAVREEARRRRRK-RKTERGYGEEFMDV--EVDPDWGGPLDDEP
MMAR_1418|M.marinum_M --TAAAAAARERARARRRR-RATLRGYGDEFMDI--EVDPDWGAPPGEGP
MAV_4879|M.avium_104 AAAAAAAAARAAARSRRRR-RATRHGHGEEFMDMNVDVDPDWGGPAGPES
MLBr_00539|M.leprae_Br4923 AEAAAQASAREQARAWRRRSAAKERGYREEVITMNTGFDAAIPSPVDQTG
MAB_0809c|M.abscessus_ATCC_199 QAAAAETAAARQARRRRDK--GKQQGRGIEYMDMN--ATARCEEPAPDTT
TH_3113|M.thermoresistible__bu GSAAAAAAARESAPIRRRR------GQKDGLHGHRHEHQQPASMSAATAP
* : . : .
Mflv_0325|M.gilvum_PYR-GCK T----ASTRGAGPMGFAGTVSRGD-EQAGGLTTLA-GDSFGGGPREPMLP
Mvan_0415|M.vanbaalenii_PYR-1 A----ATERGAGPMGFAGTVSRDA-AQAGGLTTLP-GDPFGGGPKAPMLP
MSMEG_0619|M.smegmatis_MC2_155 R----ASERGSDAMGFTGTVTRHD-VTAAGLTTLT-GDTFDDRPVTPMLP
Mb0288|M.bovis_AF2122/97 VTSTVASDRGAGHLGFAGTARREAVADAAGMTTLA-GDDFGDGPTTPMVP
Rv0280|M.tuberculosis_H37Rv VTSTVASDRGAGHLGFAGTARREAVADAAGMTTLA-GDDFGDGPTTPMVP
MUL_1202|M.ulcerans_Agy99 ----VASTQGAGRLGFAGTVHSESAATAAGLTTLV-ADEFGGGPKMPMLP
MMAR_1418|M.marinum_M GASTVASDHGAGPVGIAGTVHTGSVTPAAGLTTLG-GDDFDGEPRMPMLP
MAV_4879|M.avium_104 ----SASDRGAGALGFAGTARKDAAGAAAGLTTLP-GAELGG-PTMPMMP
MLBr_00539|M.leprae_Br4923 ---SRVSDCGAGSFGFAGTVSKEAVVEVAGLTTLA-GDDFGGGPTMPMVP
MAB_0809c|M.abscessus_ATCC_199 -----ASHRGAGTMGFAGTVIKTG-ATASGLAMLSRDDDLFEGVRAPMVP
TH_3113|M.thermoresistible__bu ------SAAGIRVLGGAGRISRTRGSVPHAEITPG-------DPTEPSSP
: * .* :* . * *
Mflv_0325|M.gilvum_PYR-GCK GTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 GTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 GTWDGDENPAP------SPDDPEGGPRR
Mb0288|M.bovis_AF2122/97 GSWDPD--RDAPGSAEPGDRG-------
Rv0280|M.tuberculosis_H37Rv GSWDPD--RDAPGSAEPGDRG-------
MUL_1202|M.ulcerans_Agy99 GTWDTD--SDAPSD--------------
MMAR_1418|M.marinum_M GTWDPDGARDAGKGS-------------
MAV_4879|M.avium_104 GSWEPG--DDAGAEHDS-----------
MLBr_00539|M.leprae_Br4923 GTWAPA--RESSDEGR------------
MAB_0809c|M.abscessus_ATCC_199 NTWDPEHGRQD-----------------
TH_3113|M.thermoresistible__bu TDRAHRPAEPN-----------------