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MTEPWIAFPPEVHSAMLNYGAGVGPMLISATQNGELSAQYAEAASEVEELLGVVASEGWQGQAAEAFVAA YMPFLAWLIQASADCVEMAAQQHAVIEAYTAAVELMPTQVELAANQIKLAVLVATNFFGINTIPIAINEA EYVEMWVRAATTMATYSTVSRSALSAMPHTSPPPLILKSDELLPDTGEDSDEDGHNHGGHSHGGHARMID NFFAEILRGVSAGRIVWDPVNGTLNGLDYDDYVYPGHAIWWLARGLEFFQDGEQFGELLFTNPTGAFQFL LYVVVVDLPTHIAQIATWLGQYPQLLSAALTGVIAHLGAITGLAGLSGLSAIPSAAIPAVVPELTPVAAA PPMLAVAGVGPAVAAPGMLPASAPAPAAAAGATAAGPTPPATGFGGFPPYLVGGGGPGIGFGSGQSAHAK AAASDSAAAESAAQASARAQARAARRGRSAAKARGHRDEFVTMDMGFDAAAPAPEHQPGARASDCGAGPI GFAGTVRKEAVVKAAGLTTLAGDDFGGGPTMPMMPGTWTHDQGVFDEHR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1422 | PPE20 | - | 100% (539) | PPE family protein |
| M. bovis AF2122 / 97 | Mb0461 | PPE11 | e-140 | 50.56% (534) | PPE family protein |
| M. bovis AF2122 / 97 | Mb0288 | PPE3 | e-139 | 51.67% (540) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0325 | - | 4e-75 | 37.07% (553) | PPE protein |
| M. tuberculosis H37Rv | Rv1387 | PPE20 | 0.0 | 99.81% (539) | PPE family protein |
| M. leprae Br4923 | MLBr_00539 | PPE | 0.0 | 69.30% (544) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 4e-85 | 40.52% (538) | PPE family protein |
| M. marinum M | MMAR_0538 | - | 1e-134 | 49.62% (530) | PPE family protein, PPE3 |
| M. avium 104 | MAV_4879 | - | 1e-119 | 46.44% (547) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-77 | 39.27% (545) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 4e-57 | 33.27% (559) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1202 | - | 1e-134 | 50.00% (530) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-79 | 37.59% (556) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
Mb1422|M.bovis_AF2122/97 -----------MTEPWIAFPPEVHSAMLNYGAGVGPMLISATQNGELSAQ
Rv1387|M.tuberculosis_H37Rv -----------MTEPWIAFPPEVHSAMLNYGAGVGPMLISATQNGELSAQ
MLBr_00539|M.leprae_Br4923 -----------MTNPWMAFPPEVQSAMLNFGAGVGPMLNSASYNLWLSAE
MMAR_0538|M.marinum_M ----------MVAPVWFASPPEVHSALLSSGPGPASLLSGAAAWAGLSTE
MUL_1202|M.ulcerans_Agy99 --------------MWFTSPPEVHSALLSSGPGPASLLSGAAAWAGLSTE
MAV_4879|M.avium_104 ----------MTAPIFMASPPELHSALLSSGPGPASLLAAAGAWSQLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
:: ***::*::* *.* ..: .. *. .
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
Mb1422|M.bovis_AF2122/97 YAEAASEVEELLGVVASEGWQGQAAEAFVAAYMPFLAWLIQASADCVEMA
Rv1387|M.tuberculosis_H37Rv YAEAASEVEELLGVVASEGWQGQAAEAFVAAYMPFLAWLIQASADCVEMA
MLBr_00539|M.leprae_Br4923 YRWVASEVEALLREVRSGGWQGQAVEMFVGSCMPFLAWLMKAAADYMDVA
MMAR_0538|M.marinum_M YASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQAA
MUL_1202|M.ulcerans_Agy99 YASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQAA
MAV_4879|M.avium_104 YASAAEQLSTLLTGVAAGAWQGVSGESYVGAHAPYLAWLTKASADSAAVA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
* .* :: :: . . .*.* . : :..: *:* ** : .
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
Mb1422|M.bovis_AF2122/97 AQQHAVIEAYTAAVELMPTQVELAANQIKLAVLVATNFFGINTIPIAINE
Rv1387|M.tuberculosis_H37Rv AQQHVVIEAYTAAVELMPTQVELAANQIKLAVLVATNFFGINTIPIAINE
MLBr_00539|M.leprae_Br4923 TQQEVVAAAYAAAVEAMPTQFELAANRVVRGVLMATNFFGVNTIPIALNE
MMAR_0538|M.marinum_M AQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAANE
MUL_1202|M.ulcerans_Agy99 AQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAANE
MAV_4879|M.avium_104 AQHEVAATAYTTALATMPTLPELAANHAVHATLVATNFFGVNTVPIAVNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
.* .. *:::*: *** **: *: ..*:.***:*:**:** .*
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPG---------
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPG---------
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPG---------
Mb1422|M.bovis_AF2122/97 AEYVEMWVRAATTMATYSTVSRSALSAMPHTSPPPLILKSDELLPDTGED
Rv1387|M.tuberculosis_H37Rv AEYVEMWVRAATTMATYSTVSRSALSAMPHTSPPPLILKSDELLPDTGED
MLBr_00539|M.leprae_Br4923 EEYVQMWVRAATTMATYSAISQSALAATPQATPPPLILKSNVLVDDVEKD
MMAR_0538|M.marinum_M ADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAAPAAAHD----
MUL_1202|M.ulcerans_Agy99 ADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAAPAAAHD----
MAV_4879|M.avium_104 ADYARMWTQAATTMSTYHAVSTAAVASTPQAEPAPQIVKSDASQDDS---
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHDHDHGHDD---
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
:*..** :*****:** : : *::: * : ..* ::
Mflv_0325|M.gilvum_PYR-GCK ---------VGEAGRAAADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYG
Mvan_0415|M.vanbaalenii_PYR-1 ---------VGEAGRAAADVTAFAAQAQAAEAGSALDLSNIIADLIRAYG
MSMEG_0619|M.smegmatis_MC2_155 ---------VGEAGSASASVQQMSAQATAAESGSSLDLSSIISDLLNQYL
Mb1422|M.bovis_AF2122/97 SDEDGHNHGGHSHGGHARMIDNFFAEILRGVSAGRIVWDPVNGTLNGLDY
Rv1387|M.tuberculosis_H37Rv SDEDGHNHGGHSHGGHARMIDNFFAEILRGVSAGRIVWDPVNGTLNGLDY
MLBr_00539|M.leprae_Br4923 S-----RHDGHSHGGHASAMDRVFADILRNVSGGRLVWDPLNGTLNGLDY
MMAR_0538|M.marinum_M --------HDHDHGGDPTPIDYFVAEVLRIISGGRIIWDPAEGTVNGIPY
MUL_1202|M.ulcerans_Agy99 --------HDHDHGGDPTPIDYFVAEVLRIISGGRIIWDPAEGTVNGIPY
MAV_4879|M.avium_104 ------GNEDHDPKID-NPFNDFIANILRNLG---IDWDPAKGTVNGLDY
MAB_0809c|M.abscessus_ATCC_199 --------HDHEHGHD---------------------DDHGHGDLD----
TH_3113|M.thermoresistible__bu TG-------AHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPD
.
Mflv_0325|M.gilvum_PYR-GCK EVLRFLFEPIFNFLR---DPIGNTFALITDFLTNPVQALITWGPFLLAVV
Mvan_0415|M.vanbaalenii_PYR-1 ELLRFLFEPIFDFLR---DPLGNTIKLITDFLTNPAQALITWGPFLAAVA
MSMEG_0619|M.smegmatis_MC2_155 QGVPGG-QAILDFLK---DPLGNLGRLLTDFMTNPAGALATWWPFLFGVA
Mb1422|M.bovis_AF2122/97 DDYVYPGHAIWWLARG-LEFFQDGEQFGELLFTNPTGAFQFLLYVVVVDL
Rv1387|M.tuberculosis_H37Rv DDYVYPGHAIWWLARG-LEFFQDGEQFGELLFTNPTGAFQFLLYVVVVDL
MLBr_00539|M.leprae_Br4923 DDYVYPGQPIWWLARG-LEFFQDGEQFWELLFINPTAAFQFLLYIVVLDL
MMAR_0538|M.marinum_M DDYVNAAQPIWWLVRA-LEFGQDFQTFIKELFTNPIGAIEFMVELVLFDW
MUL_1202|M.ulcerans_Agy99 DDYVNAAQPIWWLVRA-LEFGQDFQTFIKELFTNPIGAIEFMVELVLFDW
MAV_4879|M.avium_104 DAYTNAGEPIFWVVRA-LELLEDFEQFGYYLVHNPALAFQYLVQLMLFDW
MAB_0809c|M.abscessus_ATCC_199 -----PTDPEWWVHVA-GEMVEHFELLLNNLLTDPAALLTNLP-MVLADV
TH_3113|M.thermoresistible__bu GLLGTLLAPLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGV
. : . :* : .:
Mflv_0325|M.gilvum_PYR-GCK YQA----VSWVGA-SILYPSLFLLPLLATT--LAIVAGVGQHLLSLLNTP
Mvan_0415|M.vanbaalenii_PYR-1 YQA----VSWVGA-SILYPSLLLLPLVATT--LAIVLGVGAYLLENLPAP
MSMEG_0619|M.smegmatis_MC2_155 YQVFFNLVGWPTW-GMIFASPFLIPALAALGITGLVLLIDHVLNNPVDVP
Mb1422|M.bovis_AF2122/97 PTHIAQIATWLGQ-YPQLLSAALTGVIAHLGAITGLAGLS-GLSAIPS-A
Rv1387|M.tuberculosis_H37Rv PTHIAQIATWLGQ-YPQLLSAALTGVIAHLGAITGLAGLS-GLSAIPS-A
MLBr_00539|M.leprae_Br4923 PTHIVQLGTWLAE-YPQLLLVALGGTIANLGAVTGLAGLSSGLSAGPS-A
MMAR_0538|M.marinum_M PTHIAQIIQALAQ-SPQLLAVALGGVVANLGAISGLAGLS-GLAGLHS-A
MUL_1202|M.ulcerans_Agy99 PTHIAQIIQALAQ-SPQLLAVALGGVVANLGAISGLAGLS-GLAGLHS-A
MAV_4879|M.avium_104 PTHILEIFMS----QPELLAPALLLAAAPFAAVGGFAGLA-GLAALPQPV
MAB_0809c|M.abscessus_ATCC_199 AFHAAQLASTIGQFAPALIQPALALAIANLGWAAGFAGLA-GIQPSPEIL
TH_3113|M.thermoresistible__bu VHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLS-GLAGLAGLT
* : :
Mflv_0325|M.gilvum_PYR-GCK PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPP
Mvan_0415|M.vanbaalenii_PYR-1 AEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAP
MSMEG_0619|M.smegmatis_MC2_155 AEDEAPQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGT
Mb1422|M.bovis_AF2122/97 AIPAVVPELTPVAAAPPMLAVAGVGPAVAAPGMLPASAPAPAAAAGATAA
Rv1387|M.tuberculosis_H37Rv AIPAVVPELTPVAAAPPMLAVAGVGPAVAAPGMLPASAPAPAAAAGATAA
MLBr_00539|M.leprae_Br4923 AIPTVVPESAPIATVPAMLAGAGVAPAVVAPGASPSSAAPPASAASAAAA
MMAR_0538|M.marinum_M ALPAAIAP-IAPP-MPPGVALAPT-VATSVAAPTPPSAPPSATSTVANAA
MUL_1202|M.ulcerans_Agy99 ALPAAIAP-IAPP-MPPGVALAPT-VAASVAAPTPPSAPPSAASTVANAA
MAV_4879|M.avium_104 AVPAAVAAPPAPPGLPPAIAIAPTPVAAAAPVATAPAPAPAATATTVAGA
MAB_0809c|M.abscessus_ATCC_199 AVEPGSVEDAPMA-ASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAP
TH_3113|M.thermoresistible__bu AVPAADGGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPP
. . . .. . .
Mflv_0325|M.gilvum_PYR-GCK AP---GAPAAAAATFVPYVVAGRDPYEGFSPTVRDSTG--AKAPAGTIPA
Mvan_0415|M.vanbaalenii_PYR-1 AP---GAPAAATASFVPYAVAGRDPGTGFSPTVRDSTS--AKAPASGIPA
MSMEG_0619|M.smegmatis_MC2_155 TV---AAPAPAAATFVPYAVANRDPGEGFTPTLGNKSQ--VAAPASGVPA
Mb1422|M.bovis_AF2122/97 GP---TPPATGFGGFPPYLVGGGGPGIGFGSG-QSAHA---KAAASDSAA
Rv1387|M.tuberculosis_H37Rv GP---TPPATGFGGFPPYLVGGGGPGIGFGSG-QSAHA---KAAASDSAA
MLBr_00539|M.leprae_Br4923 AP---APPGTGFGGFSPYLVDGRGPGVGFGSGRQSAYANKVSESVSDSAV
MMAR_0538|M.marinum_M PPPPPAPAAAGFG-FPFVVGGG--PGIGYGEGMSASAAASARRKAPEPDS
MUL_1202|M.ulcerans_Agy99 PPPPPAPAAAGFG-FPFVVGGG--PGIGYGEGMSASAAASARRKAPEPDS
MAV_4879|M.avium_104 PPAAPAPVAPAAGFFPPYVIGP--PGMGTGSGMSASASSSAKRKAPEPDS
MAB_0809c|M.abscessus_ATCC_199 PS---PPPVGDPGFSFPYAVGG---GPRLGTGLALAAQVRRGTSAAARSS
TH_3113|M.thermoresistible__bu PAGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPA
. .
Mflv_0325|M.gilvum_PYR-GCK AASGIAASAAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPR
Mvan_0415|M.vanbaalenii_PYR-1 AASGVAASAAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPR
MSMEG_0619|M.smegmatis_MC2_155 AASGVAASLASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPR
Mb1422|M.bovis_AF2122/97 AESAAQASARAQARAARRGRSAAKARGHRDEFVTMDMGFDAAAPAPEHQP
Rv1387|M.tuberculosis_H37Rv AESAAQASARAQARAARRGRSAAKARGHRDEFVTMDMGFDAAAPAPEHQP
MLBr_00539|M.leprae_Br4923 AEAAAQASAREQARAWRR-RSAAKERGYREEVITMNTGFDAAIPSPVDQT
MMAR_0538|M.marinum_M AALAAAAAAREEARRRRRKRKTER--GYGEEFMD--VEVDPDWGGPRDDE
MUL_1202|M.ulcerans_Agy99 AALAAAAAVREEARRRRRKRKTER--GYGEEFMD--VEVDPDWGGPLDDE
MAV_4879|M.avium_104 AAAAAAAAARAAARSRRRRRATRH--GHGEEFMDMNVDVDPDWGGPAGPE
MAB_0809c|M.abscessus_ATCC_199 AREQAAAAETAAARQARRRRDKGKQQGRGIEYMDMNATARCEEPAP----
TH_3113|M.thermoresistible__bu GSAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPASMSAAT--------
. *: *: .
Mflv_0325|M.gilvum_PYR-GCK -VTASTRGAGPMGFAGTVSRGD-EQAGGLTTLAG-DSFGGGPREPMLPGT
Mvan_0415|M.vanbaalenii_PYR-1 -IAATERGAGPMGFAGTVSRDA-AQAGGLTTLPG-DPFGGGPKAPMLPGT
MSMEG_0619|M.smegmatis_MC2_155 -VRASERGSDAMGFTGTVTRHD-VTAAGLTTLTG-DTFDDRPVTPMLPGT
Mb1422|M.bovis_AF2122/97 GARASDCGAGPIGFAGTVRKEAVVKAAGLTTLAG-DDFGGGPTMPMMPGT
Rv1387|M.tuberculosis_H37Rv GARASDCGAGPIGFAGTVRKEAVVKAAGLTTLAG-DDFGGGPTMPMMPGT
MLBr_00539|M.leprae_Br4923 GSRVSDCGAGSFGFAGTVSKEAVVEVAGLTTLAG-DDFGGGPTMPMVPGT
MMAR_0538|M.marinum_M -PVASTQGAGRLGFAGTVHSESAATAAGLTTLVA-DEFGGGPKMPMLPGT
MUL_1202|M.ulcerans_Agy99 -PVASTQGAGRLGFAGTVHSESAATAAGLTTLVA-DEFGGGPKMPMLPGT
MAV_4879|M.avium_104 -SSASDRGAGALGFAGTARKDAAGAAAGLTTLPG-AELGG-PTMPMMPGS
MAB_0809c|M.abscessus_ATCC_199 DTTASHRGAGTMGFAGTVIKTG-ATASGLAMLSRDDDLFEGVRAPMVPNT
TH_3113|M.thermoresistible__bu --APSAAGIRVLGGAGRISRTRGSVPHAEITPGD-------PTEPSSPTD
: * :* :* . * *
Mflv_0325|M.gilvum_PYR-GCK WDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 WDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 WDGDENPAP------SPDDPEGGPRR
Mb1422|M.bovis_AF2122/97 WTHD------------QGVFDEHR--
Rv1387|M.tuberculosis_H37Rv WTHD------------QGVFDEHR--
MLBr_00539|M.leprae_Br4923 WAPA------------RESSDEGR--
MMAR_0538|M.marinum_M WDTD------------SDAPSD----
MUL_1202|M.ulcerans_Agy99 WDTD------------SDAPSD----
MAV_4879|M.avium_104 WEPG------------DDAGAEHDS-
MAB_0809c|M.abscessus_ATCC_199 WDPE------------HGRQD-----
TH_3113|M.thermoresistible__bu RAHR------------PAEPN-----