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TAPIFMASPPELHSALLSSGPGPASLLAAAGAWSQLSAEYASAAEQLSTLLTGVAAGAWQGVSGESYVGA HAPYLAWLTKASADSAAVAAQHEVAATAYTTALATMPTLPELAANHAVHATLVATNFFGVNTVPIAVNEA DYARMWTQAATTMSTYHAVSTAAVASTPQAEPAPQIVKSDASQDDSGNEDHDPKIDNPFNDFIANILRNL GIDWDPAKGTVNGLDYDAYTNAGEPIFWVVRALELLEDFEQFGYYLVHNPALAFQYLVQLMLFDWPTHIL EIFMSQPELLAPALLLAAAPFAAVGGFAGLAGLAALPQPVAVPAAVAAPPAPPGLPPAIAIAPTPVAAAA PVATAPAPAPAATATTVAGAPPAAPAPVAPAAGFFPPYVIGPPGMGTGSGMSASASSSAKRKAPEPDSAA AAAAAAARAAARSRRRRRATRHGHGEEFMDMNVDVDPDWGGPAGPESSASDRGAGALGFAGTARKDAAGA AAGLTTLPGAELGGPTMPMMPGSWEPGDDAGAEHDS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4879 | - | - | 100% (527) | PPE family protein |
| M. avium 104 | MAV_4349 | - | e-177 | 62.00% (529) | PPE family protein |
| M. avium 104 | MAV_4872 | - | e-120 | 50.19% (540) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0288 | PPE3 | 1e-170 | 59.74% (529) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-96 | 42.75% (552) | PPE protein |
| M. tuberculosis H37Rv | Rv0280 | PPE3 | 1e-169 | 59.55% (529) | PPE family protein |
| M. leprae Br4923 | MLBr_00539 | PPE | 1e-110 | 43.57% (544) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 1e-101 | 43.81% (525) | PPE family protein |
| M. marinum M | MMAR_0538 | - | 1e-166 | 58.35% (533) | PPE family protein, PPE3 |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 6e-96 | 43.12% (552) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 3e-74 | 38.28% (546) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1202 | - | 1e-164 | 58.03% (529) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-100 | 41.77% (553) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
Mb0288|M.bovis_AF2122/97 ------------MTLWMASPPEVHSALLSSGPGPGSVLSAAGVWSSLSAE
Rv0280|M.tuberculosis_H37Rv ------------MTLWMASPPEVHSALLSSGPGPGSVLSAAGVWSSLSAE
MMAR_0538|M.marinum_M ----------MVAPVWFASPPEVHSALLSSGPGPASLLSGAAAWAGLSTE
MUL_1202|M.ulcerans_Agy99 --------------MWFTSPPEVHSALLSSGPGPASLLSGAAAWAGLSTE
MAV_4879|M.avium_104 ----------MTAPIFMASPPELHSALLSSGPGPASLLAAAGAWSQLSAE
MLBr_00539|M.leprae_Br4923 -----------MTNPWMAFPPEVQSAMLNFGAGVGPMLNSASYNLWLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
:: ***::*::* *.* ..: .. *. .
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
Mb0288|M.bovis_AF2122/97 YAAVADELIGLLGAVQTGAWQGPSAAAYVAAHAPYLAWLMRASETSAEAA
Rv0280|M.tuberculosis_H37Rv YAAVADELIGLLGAVQTGAWQGPSAAAYVAAHAPYLAWLMRASETSAEAA
MMAR_0538|M.marinum_M YASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQAA
MUL_1202|M.ulcerans_Agy99 YASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQAA
MAV_4879|M.avium_104 YASAAEQLSTLLTGVAAGAWQGVSGESYVGAHAPYLAWLTKASADSAAVA
MLBr_00539|M.leprae_Br4923 YRWVASEVEALLREVRSGGWQGQAVEMFVGSCMPFLAWLMKAAADYMDVA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
* .* :: :: . .*.* . :..: *:* ** : .
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
Mb0288|M.bovis_AF2122/97 ARHETVAAAYTTAVAAMPTLVELAANHTLHGVLVATNFFGINTIPIALNE
Rv0280|M.tuberculosis_H37Rv ARHETVAAAYTTAVAAMPTLVELAANHTLHGVLVATNFFGINTIPIALNE
MMAR_0538|M.marinum_M AQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAANE
MUL_1202|M.ulcerans_Agy99 AQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAANE
MAV_4879|M.avium_104 AQHEVAATAYTTALATMPTLPELAANHAVHATLVATNFFGVNTVPIAVNE
MLBr_00539|M.leprae_Br4923 TQQEVVAAAYAAAVEAMPTQFELAANRVVRGVLMATNFFGVNTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
.: ..* *:::*: .*** **: *:. :..*:.***:*:**:** .*
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLP----------
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAP----------
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKP----------
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGA----------
Mb0288|M.bovis_AF2122/97 ADYARMWTQAASTMATYQAVAEAAVASAPQTTPAPPILAA-----EAADD
Rv0280|M.tuberculosis_H37Rv ADYARMWTQAASTMATYQAVAEAAVASAPQTTPAPPILAA-----EAADD
MMAR_0538|M.marinum_M ADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAA-----PAAA-
MUL_1202|M.ulcerans_Agy99 ADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAA-----PAAA-
MAV_4879|M.avium_104 ADYARMWTQAATTMSTYHAVSTAAVASTPQAEPAPQIVKS-----DASQD
MLBr_00539|M.leprae_Br4923 EEYVQMWVRAATTMATYSAISQSALAATPQATPPPLILKSNVLVDDVEKD
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
:*.:** :**:**:** : : *::::* : ..* ::
Mflv_0325|M.gilvum_PYR-GCK ---GVGEAGRAAADMSAFAAQPMAAQAG--AAFDVSNIIADIIRLYGEVL
Mvan_0415|M.vanbaalenii_PYR-1 ---GVGEAGRAAADVTAFAAQAQAAEAG--SALDLSNIIADLIRAYGELL
MSMEG_0619|M.smegmatis_MC2_155 ---GVGEAGSASASVQQMSAQATAAESG--SSLDLSSIISDLLNQYLQGV
TH_3113|M.thermoresistible__bu ---GTGESATAAITGAHVTAELRAAESR--TLLDEINELIDRLFAP----
Mb0288|M.bovis_AF2122/97 DHDHDHDHGGEPTPLDYLVAEILRIISGGRLIWDPAEGTMNGIPFEDYTD
Rv0280|M.tuberculosis_H37Rv DHDHDHDHGGEPTPLDYLVAEILRIISGGRLIWDPAEGTMNGIPFEDYTD
MMAR_0538|M.marinum_M -HDHDHDHGGDPTPIDYFVAEVLRIISGGRIIWDPAEGTVNGIPYDDYVN
MUL_1202|M.ulcerans_Agy99 -HDHDHDHGGDPTPIDYFVAEVLRIISGGRIIWDPAEGTVNGIPYDDYVN
MAV_4879|M.avium_104 DSGNEDHDPKIDNPFNDFIANILRNLG---IDWDPAKGTVNGLDYDAYTN
MLBr_00539|M.leprae_Br4923 SRHDGHSHGGHASAMDRVFADILRNVSGGRLVWDPLNGTLNGLDYDDYVY
MAB_0809c|M.abscessus_ATCC_199 -HDHGHDDHDHEHGHDD----------------DHGHGDLD---------
* :
Mflv_0325|M.gilvum_PYR-GCK RFLFEPIFNFLRDPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA---
Mvan_0415|M.vanbaalenii_PYR-1 RFLFEPIFDFLRDPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA---
MSMEG_0619|M.smegmatis_MC2_155 PGG-QAILDFLKDPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFN
TH_3113|M.thermoresistible__bu LFPPGFADALPDGLLGTLLAPLLPGATGDGPPMATIMSFLLMGLSNP---
Mb0288|M.bovis_AF2122/97 AAQPIWWVVRAIEFSKDFETFVQELFVNPVEAFQFYFELLLFDYPTH--I
Rv0280|M.tuberculosis_H37Rv AAQPIWWVVRAIEFSKDFETFVQELFVNPVEAFQFYFELLLFDYPTH--I
MMAR_0538|M.marinum_M AAQPIWWLVRALEFGQDFQTFIKELFTNPIGAIEFMVELVLFDWPTH--I
MUL_1202|M.ulcerans_Agy99 AAQPIWWLVRALEFGQDFQTFIKELFTNPIGAIEFMVELVLFDWPTH--I
MAV_4879|M.avium_104 AGEPIFWVVRALELLEDFEQFGYYLVHNPALAFQYLVQLMLFDWPTH--I
MLBr_00539|M.leprae_Br4923 PGQPIWWLARGLEFFQDGEQFWELLFINPTAAFQFLLYIVVLDLPTH--I
MAB_0809c|M.abscessus_ATCC_199 PTDPEWWVHVAGEMVEHFELLLNNLLTDPAALLTN-LPMVLADVAFH--A
. : ::
Mflv_0325|M.gilvum_PYR-GCK -VSWVGASILYPSLFLLPLLATT--LAIVAGVGQHLLSLLNTPPAEEAAE
Mvan_0415|M.vanbaalenii_PYR-1 -VSWVGASILYPSLLLLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAE
MSMEG_0619|M.smegmatis_MC2_155 LVGWPTWGMIFASPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQ
TH_3113|M.thermoresistible__bu -------AYLFPVLVYLLFTGVVHTTVAVSGMLAQLVPLMPALLPVAVAA
Mb0288|M.bovis_AF2122/97 VQIVEALSQS-PQLLAVALGSVISNLGAVTGFAG-LSGLAGM-QPAAIPA
Rv0280|M.tuberculosis_H37Rv VQIVEALSQS-PQLLAVALGSVISNLGAVTGFAG-LSGLAGM-QPAAIPA
MMAR_0538|M.marinum_M AQIIQALAQS-PQLLAVALGGVVANLGAISGLAG-LSGLAGL-HSAALPA
MUL_1202|M.ulcerans_Agy99 AQIIQALAQS-PQLLAVALGGVVANLGAISGLAG-LSGLAGL-HSAALPA
MAV_4879|M.avium_104 LEIFMSQ----PELLAPALLLAAAPFAAVGGFAG-LAGLAALPQPVAVPA
MLBr_00539|M.leprae_Br4923 VQLGTWLAEY-PQLLLVALGGTIANLGAVTGLAG-LSSGLSAGPSAAIPT
MAB_0809c|M.abscessus_ATCC_199 AQLASTIGQFAPALIQPALALAIANLGWAAGFAG-LAGIQPSPEILAVEP
. . . . *
Mflv_0325|M.gilvum_PYR-GCK EPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAA
Mvan_0415|M.vanbaalenii_PYR-1 EPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAA
MSMEG_0619|M.smegmatis_MC2_155 EVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAP
TH_3113|M.thermoresistible__bu LGGLAGVWAGLSGLAGLAGLTAVPAADGGASAAPVPAGGPSLPS-GSSAP
Mb0288|M.bovis_AF2122/97 LAPVAAAPP-TLPAVAMAPTMAAPGAAVASAAAPASAPAASTVASATPAP
Rv0280|M.tuberculosis_H37Rv LAPVAAAPS-TLPAVAMAPTMAAPGAAVASAAAPASAPAASTVASATPAP
MMAR_0538|M.marinum_M -AIAPIAPP-MPPGVALAPTVATSVAAPTPPSAPPSA--TSTVANAAPPP
MUL_1202|M.ulcerans_Agy99 -AIAPIAPP-MPPGVALAPTVAASVAAPTPPSAPPSA--ASTVANAAPPP
MAV_4879|M.avium_104 AVAAPPAPPGLPPAIAIAPTPVAAAAPVATAPAPAPAATATTVAGAPPAA
MLBr_00539|M.leprae_Br4923 VVPESAPIATVPAMLAGAGVAPAVVAPGASPSSAAPPASAASAAAAAPAP
MAB_0809c|M.abscessus_ATCC_199 GSVEDAPMA-ASAGTALAPSPPASAAAPAAP-ASAPAPTASGTAPAPPSP
. .. : . : : .....
Mflv_0325|M.gilvum_PYR-GCK A-----AATFVPYVVAGRDPYEGFSPTVRDSTGAKAPAGTIPAAASG---
Mvan_0415|M.vanbaalenii_PYR-1 A-----TASFVPYAVAGRDPGTGFSPTVRDSTSAKAPASGIPAAASG---
MSMEG_0619|M.smegmatis_MC2_155 A-----AATFVPYAVANRDPGEGFTPTLGNKSQVAAPASGVPAAASG---
TH_3113|M.thermoresistible__bu P-----APTGSAAPTTGTAPGGAGSPPPAGHSVPPAPHSAPPVGTSGPPY
Mb0288|M.bovis_AF2122/97 P-PAPGAAGFGYPYAIAP-PGIGFGSGMSAS--ASAQRKAPQPDSAAAAA
Rv0280|M.tuberculosis_H37Rv P-PAPGAAGFGYPYAIAP-PGIGFGSGMSAS--ASAQRKAPQPDSAAAAA
MMAR_0538|M.marinum_M P-PAPAAAGFGFPFVVGGGPGIGYGEGMSASAAASARRKAPEPD-SAALA
MUL_1202|M.ulcerans_Agy99 P-PAPAAAGFGFPFVVGGGPGIGYGEGMSASAAASARRKAPEPD-SAALA
MAV_4879|M.avium_104 PAPVAPAAGFFPPYVIGP-PGMGTGSGMSASASSSAKRKAPEPD-SAAAA
MLBr_00539|M.leprae_Br4923 P--GTGFGGFSPYLVDGRGPGVGFGSGRQSAYANKVSESVSDSA-VAEAA
MAB_0809c|M.abscessus_ATCC_199 P--PVGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAA
. . * . .
Mflv_0325|M.gilvum_PYR-GCK -IAASAAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAP--RV
Mvan_0415|M.vanbaalenii_PYR-1 -VAASAAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEP--RI
MSMEG_0619|M.smegmatis_MC2_155 -VAASLASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEP--RV
TH_3113|M.thermoresistible__bu LIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAAARESAPIRRRR--GQ
Mb0288|M.bovis_AF2122/97 AAAAVRDQARARRRR-RVTRRGYGDEFMDMNIDVDPDWGPPPGEDPVTST
Rv0280|M.tuberculosis_H37Rv AAAAVRDQARARRRR-RVTRRGYGDEFMDMNIDVDPDWGPPPGEDPVTST
MMAR_0538|M.marinum_M AAAAAREEARRRRRK-RKTERGYGEEFMDV--EVDPDWGGPRDDEP----
MUL_1202|M.ulcerans_Agy99 AAAAVREEARRRRRK-RKTERGYGEEFMDV--EVDPDWGGPLDDEP----
MAV_4879|M.avium_104 AAAAARAAARSRRRR-RATRHGHGEEFMDMNVDVDPDWGGPAGPES----
MLBr_00539|M.leprae_Br4923 AQASAREQARAWRRRSAAKERGYREEVITMNTGFDAAIPSPVDQTG---S
MAB_0809c|M.abscessus_ATCC_199 AETAAARQARRRRDK--GKQQGRGIEYMDMN--ATARCEEPAPDTT----
:: * . .
Mflv_0325|M.gilvum_PYR-GCK TASTRGA--GPMGFAGTVSRGD-EQAGGLTTLAG-DSFGGGPREPMLPGT
Mvan_0415|M.vanbaalenii_PYR-1 AATERGA--GPMGFAGTVSRDA-AQAGGLTTLPG-DPFGGGPKAPMLPGT
MSMEG_0619|M.smegmatis_MC2_155 RASERGS--DAMGFTGTVTRHD-VTAAGLTTLTG-DTFDDRPVTPMLPGT
TH_3113|M.thermoresistible__bu KDGLHGHRHEHQQPASMSAATA-PSAAGIRVLGG-AGRISRTRGSVPHAE
Mb0288|M.bovis_AF2122/97 VASDRGAG--HLGFAGTARREAVADAAGMTTLAG-DDFGDGPTTPMVPGS
Rv0280|M.tuberculosis_H37Rv VASDRGAG--HLGFAGTARREAVADAAGMTTLAG-DDFGDGPTTPMVPGS
MMAR_0538|M.marinum_M VASTQGAG--RLGFAGTVHSESAATAAGLTTLVA-DEFGGGPKMPMLPGT
MUL_1202|M.ulcerans_Agy99 VASTQGAG--RLGFAGTVHSESAATAAGLTTLVA-DEFGGGPKMPMLPGT
MAV_4879|M.avium_104 SASDRGAG--ALGFAGTARKDAAGAAAGLTTLPG-AELG-GPTMPMMPGS
MLBr_00539|M.leprae_Br4923 RVSDCGAG--SFGFAGTVSKEAVVEVAGLTTLAG-DDFGGGPTMPMVPGT
MAB_0809c|M.abscessus_ATCC_199 -ASHRGAG--TMGFAGTVIKTG-ATASGLAMLSRDDDLFEGVRAPMVPNT
* :. ..*: * .:
Mflv_0325|M.gilvum_PYR-GCK WDPDATDDRHTDGRDGHDGHDGKEKP--
Mvan_0415|M.vanbaalenii_PYR-1 WDPDTEPD------ERHNHHDGKDSQ--
MSMEG_0619|M.smegmatis_MC2_155 WDGDENPAP------SPDDPEGGPRR--
TH_3113|M.thermoresistible__bu ITPGDPTEP-----SSPTDRAHRPAEPN
Mb0288|M.bovis_AF2122/97 WDPDRDAPG-----------SAEPGDRG
Rv0280|M.tuberculosis_H37Rv WDPDRDAPG-----------SAEPGDRG
MMAR_0538|M.marinum_M WDTDSDAPS-----------D-------
MUL_1202|M.ulcerans_Agy99 WDTDSDAPS-----------D-------
MAV_4879|M.avium_104 WEPGDDAGA-----------EHDS----
MLBr_00539|M.leprae_Br4923 WAPARESSD-----------EGR-----
MAB_0809c|M.abscessus_ATCC_199 WDPEHGRQD-------------------