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TAPSGSSGESAHDAAGGPPPVGERPPEQPIADAPWAPPASSPMANHPPPAYPPSGYPPAYQPGYPTGYPP PMPPGGYAPPGYPPPGTSSAGYGDIPYPPMPPPYGGSPGGYYPEPGYLDGYGPSQPGMNTMALVSLISAL VGVLCCIGSIVGIVFGAIAINQIKQTREEGYGLAVAGIVIGIATLLVYMIAGIFAIP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1233c | - | - | 100% (198) | hypothetical protein Rv1233c |
| M. tuberculosis H37Rv | Rv3689 | - | 8e-13 | 35.44% (158) | transmembrane protein |
| M. tuberculosis H37Rv | Rv1078 | pra | 1e-12 | 45.98% (87) | proline-rich antigen |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1265c | - | 1e-120 | 98.99% (198) | hypothetical protein Mb1265c |
| M. gilvum PYR-GCK | Mflv_2210 | - | 5e-31 | 40.27% (226) | hypothetical protein Mflv_2210 |
| M. leprae Br4923 | MLBr_02395 | Ag36 | 1e-11 | 42.11% (95) | proline rich antigenic protein |
| M. abscessus ATCC 19977 | MAB_1370c | - | 3e-26 | 37.38% (214) | hypothetical protein MAB_1370c |
| M. marinum M | MMAR_4208 | - | 3e-70 | 58.93% (224) | proline and glycine rich transmembrane protein |
| M. avium 104 | MAV_1372 | - | 2e-47 | 50.00% (210) | hypothetical protein MAV_1372 |
| M. smegmatis MC2 155 | MSMEG_5063 | - | 1e-23 | 37.74% (159) | integral membrane protein |
| M. thermoresistible (build 8) | TH_3105 | - | 2e-24 | 38.12% (202) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_1750 | - | 2e-17 | 33.49% (209) | proline and glycine rich transmembrane protein |
| M. vanbaalenii PYR-1 | Mvan_4486 | - | 4e-44 | 49.28% (209) | hypothetical protein Mvan_4486 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1233c|M.tuberculosis_H37Rv ----MTAPSGSSGE--SAHDAAGGPPPVGERPPEQPIA---DAPWAPP-A
Mb1265c|M.bovis_AF2122/97 ----MTAPSGSSGE--SAHDAAGGPPPVGERPPEQPIA---DAPWAPP-A
MMAR_4208|M.marinum_M ----MTAPGGSFDE--GAHDGAASPPP-GEQPSEQPFSPPPDAPWAAPEA
MAV_1372|M.avium_104 -MNTMTAPGAGFGE--SAQHDHHGDQAHGDKPNDDATS----APHAQPAP
MSMEG_5063|M.smegmatis_MC2_155 ----MTNP---DG------PAGGTP-------------PSGSGEPPAYQ-
TH_3105|M.thermoresistible__bu ----MTNPGNADGT----PPAEGQPGPSETGADDLAREPTGGADPTASEH
Mflv_2210|M.gilvum_PYR-GCK ----MTSSDNDADRVESSESAADGSEPTPAGYEAPSIEHTPSAPDTSSDD
Mvan_4486|M.vanbaalenii_PYR-1 ----MTSSDNDAGRGESSDSTASGSEPSSAGYEPPPIEQTQSAPPPAQDY
MAB_1370c|M.abscessus_ATCC_199 ----MTTPGHEP---------SGSSPDASSGYEYPSLEKSAPPADPAVAA
MUL_1750|M.ulcerans_Agy99 MSQPPENPGNQADPQDGDQSTPGYPPPPNYGTPPPPPPPGYGAPPAGPPG
MLBr_02395|M.leprae_Br4923 ----MTDQPPPSGS----NPTPAPPPPGSSGGYEPSFAPSELGSAYPPPT
Rv1233c|M.tuberculosis_H37Rv SSPMANHPPPAYPPSGYPP------------AYQPGYPTGYPPPMPPGGY
Mb1265c|M.bovis_AF2122/97 SSPMADHPPPAYPPSGYPP------------AYQPGYPTDYPPPMPPGGY
MMAR_4208|M.marinum_M ASPADDYPAPSYPPPAYPPE------PVGPGGYPPDYATGYPP--PPG-Y
MAV_1372|M.avium_104 WEPPAGSVPPPYPPPGYPA------------DYPPGYPPPYPPP-APSPV
MSMEG_5063|M.smegmatis_MC2_155 --------------------------------------PGYPPA-QPDPF
TH_3105|M.thermoresistible__bu TPDQPTAADQAADQAGDRP---DEQAFDGSWAAAGETAPAYGES-PPAGF
Mflv_2210|M.gilvum_PYR-GCK TPPHGYTPPPAYNPPPSSTPPMYGTPPNTGYPAPGDFTSPPYPP-PPAGY
Mvan_4486|M.vanbaalenii_PYR-1 LPPPAYDAPPAYPPSPG-----YEQQP--GYPPSGGFAAPDYPP-PPAGY
MAB_1370c|M.abscessus_ATCC_199 NPTP--SPPPAWEAPGQ---------PTASYPAYPASAYPTAPP-AYPTA
MUL_1750|M.ulcerans_Agy99 YGAPPPPPGYGTPPPPPPP---------GYGQAPGGYAPPGYNPPPPPPP
MLBr_02395|M.leprae_Br4923 APPVGGSYPPPPPPGGSYP--------------PPPPPGGSYPP-PPPST
Rv1233c|M.tuberculosis_H37Rv APPGYPPPGTSSAGYGDIPYPPMPPP-------YGGSP---------GGY
Mb1265c|M.bovis_AF2122/97 APPGYPPPGTSSAGYGDIPYPPMPPP-------YGGSP---------GGY
MMAR_4208|M.marinum_M PPPGYPPYGAAAGEYGGTPYPPPPPPPAPMAAPYGAPPPNYPPPSYPGGY
MAV_1372|M.avium_104 PPP--PP------GYG----PPPPPG-------YGPPG-------YPGGY
MSMEG_5063|M.smegmatis_MC2_155 APVDYP-------------YSPPP-------AAFPPPYPP--PQPG-FSY
TH_3105|M.thermoresistible__bu APLDYPGAGAGTEPYQPSGYPAPPPG-----AQYPPPYPPGPQQPG-YGY
Mflv_2210|M.gilvum_PYR-GCK GAQNYPPPGYGAQGYGAQGYGPQGYG-----AQSYGAQG-YPSPYG--AY
Mvan_4486|M.vanbaalenii_PYR-1 PPP-YPDAGPPPP---HPGYGAPGYG-----APSYPPPPPYGTMPG--GY
MAB_1370c|M.abscessus_ATCC_199 PPP-YPTASQAAYPQYGQSYPSYQPG-----QPGTYPPPGYPVAGGYPGY
MUL_1750|M.ulcerans_Agy99 GYGPPPAGYSTQPGFGGPAKPPFSVGEAISWAWNRFTQNAMALVVPIVIY
MLBr_02395|M.leprae_Br4923 GAYAPPPPGPAIRSLPKEAYTFWVTRVLAYVIDNIPATVLLGIGMLIQTL
* .
Rv1233c|M.tuberculosis_H37Rv YP--------------------EPGYLDGYGP------------------
Mb1265c|M.bovis_AF2122/97 YP--------------------EPGYLDGYGP------------------
MMAR_4208|M.marinum_M YP--------------------PPDPMAGYGP------------------
MAV_1372|M.avium_104 YP--------------------GPD-YGGYPPQPPL--------------
MSMEG_5063|M.smegmatis_MC2_155 ---------------------------APFDP------------------
TH_3105|M.thermoresistible__bu PAPPPYD--------------APRYPTPPYDPAQPPQFGAGQFGAAGYPD
Mflv_2210|M.gilvum_PYR-GCK P---------------------GGYPGADYGYGTP---------------
Mvan_4486|M.vanbaalenii_PYR-1 PPA-------------------GGYPDAGYGYGAP---------------
MAB_1370c|M.abscessus_ATCC_199 PP--------------------PGYADP-YGYGAY---------------
MUL_1750|M.ulcerans_Agy99 GLILSAVGGVMVGLFFAFSDRTSTTYTDAYGNTSETVNMTMSPLASIVMF
MLBr_02395|M.leprae_Br4923 TKQ-----------------EACVTDITQYNVNQY---------------
:
Rv1233c|M.tuberculosis_H37Rv ------------------------------------SQPGMNTMALVSLI
Mb1265c|M.bovis_AF2122/97 ------------------------------------SQPGMNTMALVSLI
MMAR_4208|M.marinum_M ------------------------------------ALPGMNTMAIVALV
MAV_1372|M.avium_104 ----------------------------------LGGQPGTNGLAIASLI
MSMEG_5063|M.smegmatis_MC2_155 ----------------------------------YGRPPGTNGLAIASLV
TH_3105|M.thermoresistible__bu PNQPGYPGYYGYPQG---------------YSQGYTQPPSTNTLSIWSLV
Mflv_2210|M.gilvum_PYR-GCK -----------------------------------AQQG-SNGMAIGSLV
Mvan_4486|M.vanbaalenii_PYR-1 -----------------------------------APQG-TNSLAIASLV
MAB_1370c|M.abscessus_ATCC_199 -----------------------------------GQTGGTNGLAIASLI
MUL_1750|M.ulcerans_Agy99 IGYLAVFAVVLFMHAGITTGCLDIADGKPVTIGSFFKPRNLGMVILTGLL
MLBr_02395|M.leprae_Br4923 ---------------------------------CATQPTGIGMLAFWFAW
. : :
Rv1233c|M.tuberculosis_H37Rv SALVG------------VLCCIG---SIVGIVFGAIAINQIKQTRE----
Mb1265c|M.bovis_AF2122/97 SALVG------------VLCCIG---SIVGIVFGAIAINQIKQTRE----
MMAR_4208|M.marinum_M SSLVG------------VFCCIG---SVVAIVVGTIAINQIKQTRE----
MAV_1372|M.avium_104 ASFTG------------LLCGIG---SVVAIVLGAIALDQIKRTRQ----
MSMEG_5063|M.smegmatis_MC2_155 CSLA------------GMLCCLP---GLAGLVLGILGMRETRRTGQ----
TH_3105|M.thermoresistible__bu ISLISIP-----LLCSGLLSFLAPPAAIAGIVLGSLGLNQIKNTGE----
Mflv_2210|M.gilvum_PYR-GCK TSLLALP-----L---NIACFSGTIASIVAVVLGVVALNQIKTSGQ----
Mvan_4486|M.vanbaalenii_PYR-1 ASCVGL-----------FCCIG----SIAGIAMGVIALSQIKQTRA----
MAB_1370c|M.abscessus_ATCC_199 TSIAAI-----------VTCYLGIILGIVGVILGVVALNQLKTRQQ----
MUL_1750|M.ulcerans_Agy99 VIVLTAIGSVLCIVPGLIFGFLAQFAIIAAVDRSLSPIDSIKSSCATVRA
MLBr_02395|M.leprae_Br4923 LMATAY-----------LVWNYGYRQGATGSSIGKTVMKFKVISEATG--
. .. . :
Rv1233c|M.tuberculosis_H37Rv -----------------EGYGLAVAGIVIGIATLLVYMIAGIFAIP----
Mb1265c|M.bovis_AF2122/97 -----------------EGYGLAVAGIVIGIATLLVYMIAGIFAIP----
MMAR_4208|M.marinum_M -----------------DGYGLAVAGIVIAVATLLIYLVVGIFSIPSH--
MAV_1372|M.avium_104 -----------------DGFGLAVAGIVIGIATLVVTLVVVLFALHTH--
MSMEG_5063|M.smegmatis_MC2_155 -----------------DGYGIAVAGTVIGAFVTVGIALYFVLLLIGAAV
TH_3105|M.thermoresistible__bu -----------------NGRALAIGGIVAGAAVLVMVVVIILMIMLAAAA
Mflv_2210|M.gilvum_PYR-GCK -----------------SGKEMAIAGIAIGVLGLIGAFVLMAVVFAGSG-
Mvan_4486|M.vanbaalenii_PYR-1 -----------------EGQGLAVAGIIVGVITLLISGIATVAVMAS---
MAB_1370c|M.abscessus_ATCC_199 -----------------DGKGIAIAGIILGAVIPVLWILVLIVIAAGSSS
MUL_1750|M.ulcerans_Agy99 ELGNTALSWLVQYAVVLAGELLCFVGMLVGVPVASLIQTYTWRKLSGGQV
MLBr_02395|M.leprae_Br4923 ---------------QPIGFGMSVVRQLAHFVDAVICCIGFLFPLWDSKR
* :..
Rv1233c|M.tuberculosis_H37Rv ---------------------------
Mb1265c|M.bovis_AF2122/97 ---------------------------
MMAR_4208|M.marinum_M ---------------------------
MAV_1372|M.avium_104 ---------------------------
MSMEG_5063|M.smegmatis_MC2_155 APN------------------------
TH_3105|M.thermoresistible__bu GA-------------------------
Mflv_2210|M.gilvum_PYR-GCK ---------------------------
Mvan_4486|M.vanbaalenii_PYR-1 ---------------------------
MAB_1370c|M.abscessus_ATCC_199 TSGSF----------------------
MUL_1750|M.ulcerans_Agy99 VELSQPGPPAGLPPGPPPGAPPGPQFG
MLBr_02395|M.leprae_Br4923 QTLADKIMTTVCLPI------------