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SQPPENPGNQADPQDGDQSTPGYPPPPNYGTPPPPPPPGYGAPPAGPPGYGAPPPPPGYGTPPPPPPPGY GQAPGGYAPPGYNPPPPPPPGYGPPPAGYSTQPGFGGPAKPPFSVGEAISWAWNRFTQNAMALVVPIVIY GLILSAVGGVMVGLFFAFSDRTSTTYTDAYGNTSETVNMTMSPLASIVMFIGYLAVFAVVLFMHAGITTG CLDIADGKPVTIGSFFKPRNLGMVILTGLLVIVLTAIGSVLCIVPGLIFGFLAQFAIIAAVDRSLSPIDS IKSSCATVRAELGNTALSWLVQYAVVLAGELLCFVGMLVGVPVASLIQTYTWRKLSGGQVVELSQPGPPA GLPPGPPPGAPPGPQFG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1750 | - | - | 100% (368) | proline and glycine rich transmembrane protein |
| M. ulcerans Agy99 | MUL_4272 | - | 5e-26 | 30.27% (337) | hypothetical protein MUL_4272 |
| M. ulcerans Agy99 | MUL_0202 | pra | 2e-19 | 51.52% (99) | proline-rich antigen Pra-like protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2590 | - | 1e-121 | 58.89% (360) | hypothetical protein Mb2590 |
| M. gilvum PYR-GCK | Mflv_2044 | - | 5e-76 | 44.41% (331) | integral membrane protein-like protein |
| M. tuberculosis H37Rv | Rv2560 | - | 1e-121 | 58.61% (360) | hypothetical protein Rv2560 |
| M. leprae Br4923 | MLBr_02395 | Ag36 | 9e-14 | 43.48% (92) | proline rich antigenic protein |
| M. abscessus ATCC 19977 | MAB_0651c | - | 5e-52 | 37.94% (340) | hypothetical protein MAB_0651c |
| M. marinum M | MMAR_2166 | - | 0.0 | 96.55% (377) | proline and glycine rich transmembrane protein |
| M. avium 104 | MAV_3436 | - | 1e-95 | 52.79% (341) | hypothetical protein MAV_3436 |
| M. smegmatis MC2 155 | MSMEG_5268 | - | 3e-66 | 37.08% (391) | hypothetical protein MSMEG_5268 |
| M. thermoresistible (build 8) | TH_4441 | - | 5e-39 | 34.78% (253) | PUTATIVE putative conserved hypothetical protein |
| M. vanbaalenii PYR-1 | Mvan_4673 | - | 6e-73 | 45.37% (324) | hypothetical protein Mvan_4673 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_1750|M.ulcerans_Agy99 -MSQ------------PPENPGNQADPQDG--DQSTPGYPPPPN--YGTP
MMAR_2166|M.marinum_M -MSQ------------PPENPGNQADPQGG--DQSTPGYPPPPN--YGTP
Mb2590|M.bovis_AF2122/97 -MSQ------------PPEHPGNPADPQGG--NQGAGSYP----------
Rv2560|M.tuberculosis_H37Rv -MSQ------------PPEHPGNPADPQGG--NQGAGSYP----------
MAV_3436|M.avium_104 -MSQ------------PPEYPGTPPEPPPG--YGPPPGYGP---------
MAB_0651c|M.abscessus_ATCC_199 -MTY------------PPQEPPTSGDPSAYDPNQPPPGYPNQP-------
MSMEG_5268|M.smegmatis_MC2_155 -MTDQPPGN------NPPPPDGGYPPPPPPDGGYPPPPPPDGGYPPAQPG
Mvan_4673|M.vanbaalenii_PYR-1 -MTE-----------NPPP--GGYPPPPP--GGYPPPPPP---------G
Mflv_2044|M.gilvum_PYR-GCK -MTE-----------NPPP--GGYPPPPQ--GGYPPPPPSE--------G
TH_4441|M.thermoresistible__bu MLSAVFIGRGVDAVRSPKPAADAARPTIEGLTKLPEPVGPR--------V
MLBr_02395|M.leprae_Br4923 -MTD------------QPPPSGSNPTPAP-----PPPGSSG---------
:: .
MUL_1750|M.ulcerans_Agy99 PPPPPPGYGAPPAGPPGYGAPPPPPGYGTPPPPP---------PPGYGQA
MMAR_2166|M.marinum_M PPPPPPGYGAPPAGPPGYGAPPPPPGYGTPPPPPGYGTPPPPPPPGYGQA
Mb2590|M.bovis_AF2122/97 --------------PPGYGAPPPPPGYGPP--------------------
Rv2560|M.tuberculosis_H37Rv --------------PPGYGAPPPPPGYGPP--------------------
MAV_3436|M.avium_104 --------------PPGYG---PPPGYGTPPPPP----------------
MAB_0651c|M.abscessus_ATCC_199 --------------PPGYQ--PPPPGYQPG-------------------Y
MSMEG_5268|M.smegmatis_MC2_155 GFGPPPQ-GGYPPPPPPGGYP-PPPQGGFPPPP-----------------
Mvan_4673|M.vanbaalenii_PYR-1 GYQPPP------PPPSGGGYP-PPPSGGFPPPQ-----------------
Mflv_2044|M.gilvum_PYR-GCK GYPPPPPEGGYPPPPPAGGYQQPPPGGAYPPPPG----------------
TH_4441|M.thermoresistible__bu PTDAETVARINGMVQIAGGAL--LATGKLPRVAS----------------
MLBr_02395|M.leprae_Br4923 ----------------GYEPSFAPSELGSAYP------------------
.
MUL_1750|M.ulcerans_Agy99 PGGYAP--PGYNPPPPPPP-----GYGPP----PAGYSTQPG------FG
MMAR_2166|M.marinum_M PGGYAP--PGYNPPPPPPP-----GYGPP----PAGYPAQPG------FG
Mb2590|M.bovis_AF2122/97 PGTYLP--PGYN-APPPPP-----GYGPP----PG--PPPPG------YP
Rv2560|M.tuberculosis_H37Rv PGTYLP--PGYN-APPPPP-----GYGPP----PG--PPPPG------YP
MAV_3436|M.avium_104 PGYGPP--PGYG---APPP-----GYGPP----PG-YGPPPG------FG
MAB_0651c|M.abscessus_ATCC_199 QAGPPPGGPQYQGAQFPPP-----GY--P----PAGYGYPQQ------RP
MSMEG_5268|M.smegmatis_MC2_155 PGGYPPPPPPQGGSYPPPPPPGAAGYPPPGYPGGPGAGYPPAGGFGQPGG
Mvan_4673|M.vanbaalenii_PYR-1 EGGYPPPQGP--GGYPPP-----AGYGPP------QGGFPPP-----AQG
Mflv_2044|M.gilvum_PYR-GCK PGGYPPPPGQ--GGYPPPP----GGYGMP--PAGFGGGYPPP-----GQG
TH_4441|M.thermoresistible__bu AVLALSVVPGSLGGHMFWTESDPQRKAXX-----XTGGYPPA-------G
MLBr_02395|M.leprae_Br4923 ----PPTAPPVGGSYPPPP--------PP------GGSYPPP--------
.
MUL_1750|M.ulcerans_Agy99 GPAKPP------FSVGEAISWAWNRFTQNAMALVVPIVIYGLILSAVGGV
MMAR_2166|M.marinum_M GPAKPP------FSVGEAISWAWNRFTQNAMALVVPIVIYGLILSAVGGV
Mb2590|M.bovis_AF2122/97 THLQSSG-----FSVGDAISWSWNRFTQNAVTLVVPVLAYAVALAAVIGA
Rv2560|M.tuberculosis_H37Rv THLQSSG-----FSVGDAISWSWNRFTQNAVTLVVPVLAYAVALAAVIGA
MAV_3436|M.avium_104 GPPKPA------FSVGEAFGWAWNAFTKNPVALIVPTLVYLVVLGGAS--
MAB_0651c|M.abscessus_ATCC_199 WPPQGP------FSAGESWSWSWAQVSKRFGTFIPPYLVWFLAIGLPVGI
MSMEG_5268|M.smegmatis_MC2_155 YAPVGAPGFGGAYSVGDAFSWAWNKFSKHAVEMIVPALVFGLVYAILQGI
Mvan_4673|M.vanbaalenii_PYR-1 YPPVGGP---PAYSVGDAFNWAWNKFSKNAMPLIVATLVFGIVVIALQAI
Mflv_2044|M.gilvum_PYR-GCK YPPVGGP---PSLDIGAAFSWSFNKFSKNAVPLIVPTLVYALVIGVLGAV
TH_4441|M.thermoresistible__bu FPPPGGFG--ASYRFGDAFNWAWSAFTRHAAPLMLAALAYVAIIFALSFL
MLBr_02395|M.leprae_Br4923 -PPPGGS-----YPPPPPSTGAYAPPPPGPAIRSLPKEAYTFWVTRVLAY
. :: . . :
MUL_1750|M.ulcerans_Agy99 MVGLFFAFSDRTSTTYTDAYGNTSETVNMT---MSPLASIVMFIGYLAVF
MMAR_2166|M.marinum_M MVGLFFAFSDRTSTTYTDAYGNTSETVNMT---MSPLASIVMFIGYLAVF
Mb2590|M.bovis_AF2122/97 TAGLVVALSDRATTAYTNTSGVSSESVDIT---MTPAAGIVMFLGYIALF
Rv2560|M.tuberculosis_H37Rv TAGLVVALSDRATTAYTNTSGVSSESVDIT---MTPAAGIVMFLGYIALF
MAV_3436|M.avium_104 ---TLIGLSQDVGTS-GGGSGDDYFTFTAN---LNGGGMALLVLGYLVAY
MAB_0651c|M.abscessus_ATCC_199 VYAILMASLPQTSTSGYGGNSRSSYSYSYEGPELSGGAIAIMILLYAVVF
MSMEG_5268|M.smegmatis_MC2_155 VNGISGAFTS------TSSADGFELSMATG-------GGVVSIIGAIITL
Mvan_4673|M.vanbaalenii_PYR-1 IN-IVQALVSPGDTSYIADDSGFSFSYATTG----VAGTIVAIVGWFLSL
Mflv_2044|M.gilvum_PYR-GCK IFGLASLFPADYTSYSGADGAGMSLDMGPA-------ATIILFLGLIMLF
TH_4441|M.thermoresistible__bu FSLVLTAFTPGG--ATTVDPDSFFDMFGVG-------GTLTMVVGVILLL
MLBr_02395|M.leprae_Br4923 VIDNIPATVLLG----------------------------------IGML
MUL_1750|M.ulcerans_Agy99 AVVLFMHAGITTGCLDIADGKPVTIGSFFKPRNLGMVILTGLLVIVLTAI
MMAR_2166|M.marinum_M AVVLFMHAGITTGCLDIADGKPVTIGSFFKPRNLGMVILTGLLVIVLTAI
Mb2590|M.bovis_AF2122/97 ALVLYMHAGILTGCLDIADGKPVTIATFFRPRNLGLVLVTGLLIVALTFI
Rv2560|M.tuberculosis_H37Rv ALVLYMHAGILTGCLDIADGKPVTIATFFRPRNLGLVLVTGLLIVAVTFI
MAV_3436|M.avium_104 LVGAFAQSAYLSGCLDLADGRPVTIGSFFKPRNFGMVFLAALLVGILTSI
MAB_0651c|M.abscessus_ATCC_199 AVSLYVGACLISANLDVADGKPVSFGTFFRARGFGLYVGAALLVGVGVLI
MSMEG_5268|M.smegmatis_MC2_155 IVTAVIQAAYISGVLEIANGQPVTIGSFFKPRNVGDVIIATVIVGVINFV
Mvan_4673|M.vanbaalenii_PYR-1 IVTAAIQSAFLGGIFDIANGQQVAVGSFFRPRNVGNVIIAGLIVGVITTV
Mflv_2044|M.gilvum_PYR-GCK VVGGAISAAYMAGVLDIANGQQVEFGSFFKPRNIGAVVIASLIVGIATSI
TH_4441|M.thermoresistible__bu FVSGVITSAFLNGLLAIADGQQIELASFFRPRNVGSVVIATVIVGVLSYI
MLBr_02395|M.leprae_Br4923 IQTLTKQEACVTDITQYN----VNQYCATQPTGIGMLAFWFAWLMATAYL
: :. ..* : :
MUL_1750|M.ulcerans_Agy99 GSVLCIVPG------------------LIFGFLAQFAIIAAVDRSLSPID
MMAR_2166|M.marinum_M GSVLCIVPG------------------LIFGFLAQFAIIAAVDRSLSPID
Mb2590|M.bovis_AF2122/97 GGLLCVIPG------------------LIFGFVAQFAVAFAVDRSTSPID
Rv2560|M.tuberculosis_H37Rv GGLLCVIPG------------------LIFGFVAQFAVAFAVDRSTSPID
MAV_3436|M.avium_104 ASALCFLPG------------------LILGLFAQFTIAYAIDRSESAVK
MAB_0651c|M.abscessus_ATCC_199 G-SLLIIGG------------------VIFGFFAQYAVFFAIDRGLGPVD
MSMEG_5268|M.smegmatis_MC2_155 VAAILLFPGFFVPGYLFVGVPVLLIASAIIAVLFLFTTVAVLDRNLSGVD
Mvan_4673|M.vanbaalenii_PYR-1 GLFLCIVPG------------------VIASFLLMFTTIAVLDRNLAPMD
Mflv_2044|M.gilvum_PYR-GCK GYVLCIVPG------------------LIVSIFALFTTVFIVDRNLSAID
TH_4441|M.thermoresistible__bu GTALCVVPG------------------LIVSLFAMFTTVAVVDRNLSPID
MLBr_02395|M.leprae_Br4923 VWNYGYRQG---------------------------ATGSSIGKTVMKFK
* : :.: ..
MUL_1750|M.ulcerans_Agy99 SIKSSCATVRAELGNTALSWLVQYAVVLAG----ELLCFVGMLVGVPVA-
MMAR_2166|M.marinum_M SIKSSFATVRAELGNTALSWLVQYAVVLAG----ELLCFVGMLVGVPVA-
Mb2590|M.bovis_AF2122/97 SVKASIETVGSNIGGSVLSWLAQLTAVLVG----ELLCFVGMLIGIPVA-
Rv2560|M.tuberculosis_H37Rv SVKASIETVGSNIGGSVLSWLAQLTAVLVG----ELLCFVGMLIGIPVA-
MAV_3436|M.avium_104 ALSSSFSTVTANLANALLVWLAEFALVVVG----ALACGVGLLLAAPVA-
MAB_0651c|M.abscessus_ATCC_199 ALKASFQLVKDNLGQALVVFLITLGVAFGGFALTFITCGLGGIIAYPAAG
MSMEG_5268|M.smegmatis_MC2_155 AVKTSFELSKANFGTVFITAVVIFLLLLAG----AIACGIGLLVAYPLV-
Mvan_4673|M.vanbaalenii_PYR-1 AIKSSFETSKNNVGPVLLTWLASVAVVFVG----ALLCGVGLLVAAPLA-
Mflv_2044|M.gilvum_PYR-GCK GIKASIAVAKANFLQVFLTWLIFNVLISVG----SFVCYIGLIVTVPLA-
TH_4441|M.thermoresistible__bu GILASVDVVKKNFGPAILVWLASGVLIFLG----SLLCGVGLLITGPLA-
MLBr_02395|M.leprae_Br4923 VISEATGQPIG-FGMSVVRQLAHFVD--------AVICCIGFLFPLWDS-
: : . : : . * :* :.
MUL_1750|M.ulcerans_Agy99 ---SLIQTYTWRKLSGGQVVELS--QPGPPAGLPPGPPPGAPPGPQFG
MMAR_2166|M.marinum_M ---SLIQTYTWRKLSGGQVVELS--QPGPPAGLPPGPPPGAPPGPQFG
Mb2590|M.bovis_AF2122/97 ---ALIHVYTYRKLSGGQVVEAV--RPAPPVGWPPGP--------QLA
Rv2560|M.tuberculosis_H37Rv ---ALIHVYTYRKLSGGQVVEAV--RPAPPVGWPPGP--------QLA
MAV_3436|M.avium_104 ---ALVGIYAYRKLSGGQVAPPPGYQPGPPPGYQPGPPPGAPPA----
MAB_0651c|M.abscessus_ATCC_199 ALTGLIHVYTYRRLTGGTIAPAPV------------------------
MSMEG_5268|M.smegmatis_MC2_155 ---ALIEVYAFRRLTGAPIAPPTQ------------------------
Mvan_4673|M.vanbaalenii_PYR-1 ---ALILVYAYRTLNGGFVAPAVP------------------------
Mflv_2044|M.gilvum_PYR-GCK ---VLYMVYAYRTLTGGYVAPATP------------------------
TH_4441|M.thermoresistible__bu ---GLLVVCTFRRLTGAPVAPQAV------------------------
MLBr_02395|M.leprae_Br4923 ----KRQTLADKIMTTVCLPI---------------------------
: : :. :