For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTMKSLAALDRPSWLSSSAWPWQPYLLSHHQGGIAVTDIGDGPAVLFVHVGSWSFVWRDVLLRLANDFRC VAIDAPGCGLSDRLSTPPTLAQAADAITSVIDALQLRDLTLVAHDLGGPAGFLAAARRGDRVAALAAVNC FAWRPTGPLFRGMLAAMGSAPVRELDAAINALARATSTRFGAGRHWSRADRAAFRAGIDAPARRAWHAYF RDARRAHALYTDVDAALRGGLADRPLLTIFGQFNDPLRFQPRWKELFPTARQLQVRRGNHFPMCDDPDLV AGALTSFVQRST
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1190 | - | - | 100% (292) | hypothetical protein Rv1190 |
| M. tuberculosis H37Rv | Rv1833c | - | 1e-18 | 28.41% (271) | haloalkane dehalogenase |
| M. tuberculosis H37Rv | Rv0134 | ephF | 3e-11 | 37.72% (114) | epoxide hydrolase EphF |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1222 | - | 1e-172 | 100.00% (292) | hypothetical protein Mb1222 |
| M. gilvum PYR-GCK | Mflv_3236 | - | 2e-10 | 28.47% (281) | alpha/beta hydrolase fold |
| M. leprae Br4923 | MLBr_00862 | ephD | 5e-06 | 35.24% (105) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2289 | - | 2e-13 | 28.57% (238) | putative hydrolase, alpha/beta hydrolase fold |
| M. marinum M | MMAR_2710 | - | 5e-15 | 24.63% (272) | haloalkane dehalogenase |
| M. avium 104 | MAV_1840 | - | 2e-18 | 32.35% (272) | hydrolase, alpha/beta fold family protein, putative |
| M. smegmatis MC2 155 | MSMEG_6837 | - | 2e-11 | 29.75% (279) | haloalkane dehalogenase |
| M. thermoresistible (build 8) | TH_3479 | - | 4e-13 | 29.04% (272) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_3052 | - | 8e-14 | 23.90% (272) | haloalkane dehalogenase |
| M. vanbaalenii PYR-1 | Mvan_5882 | - | 9e-11 | 28.52% (277) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1840|M.avium_104 ---------------------------MASIAVGDVEIDYVDAGS--GPV
TH_3479|M.thermoresistible__bu -------------------------MSATTITVDDAAIEYTDVGG--GPP
Mflv_3236|M.gilvum_PYR-GCK ---------------------------MSTVGVPSGTIAYEDTGGD-GPV
Rv1190|M.tuberculosis_H37Rv ----MTMKSLAALDRPSWLSSSAWPWQPYLLSHHQGGIAVTDIGD--GPA
Mb1222|M.bovis_AF2122/97 ----MTMKSLAALDRPSWLSSSAWPWQPYLLSHHQGGIAVTDIGD--GPA
MMAR_2710|M.marinum_M ----MGRQFTPDFTP----DPKLYPFASRWFDSSRGRLHYIDEGD--GPP
MUL_3052|M.ulcerans_Agy99 ----MGRQFTPDFTP----DPKLYPFASRWFDSSRGRLHYIDESD--GPP
MAB_2289|M.abscessus_ATCC_1997 MGVAAHQQIYRPVSGHGGAMSLGLEKHRRSVDIERGRISYLDIGA--GSP
MSMEG_6837|M.smegmatis_MC2_155 ------------------MPGSEPYGRLQYREINGKRMAYIDEAR--GDA
Mvan_5882|M.vanbaalenii_PYR-1 ---------------------------MPLVPTRAGTLAYHVRGS--GPT
MLBr_00862|M.leprae_Br4923 ---------------MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPA
: . *
MAV_1840|M.avium_104 VVFVHGAYVTGLLWQDVVDRLSD-SHRCIAPTLPFGAQAAPVGAHVD-LS
TH_3479|M.thermoresistible__bu IVFVHGAYVTGALWDDVVTRLSR-GHRCIAPTWPFGAQRTPVGDSVD-LD
Mflv_3236|M.gilvum_PYR-GCK MVFGHGLLMDGRQWRKVLPQLP--EYRCITPTLPMGAHTSPMRHDAD-LT
Rv1190|M.tuberculosis_H37Rv VLFVHVG-SWSFVWRDVLLRLAN-DFRCVAIDA-PGCGLSDRLSTP--PT
Mb1222|M.bovis_AF2122/97 VLFVHVG-SWSFVWRDVLLRLAN-DFRCVAIDA-PGCGLSDRLSTP--PT
MMAR_2710|M.marinum_M ILLCHGNPTWSFLYRHIIVALRD-HFRCIAPDY-LGFGLSEHPGTFG-YK
MUL_3052|M.ulcerans_Agy99 ILLCHGNPTWSFLYRHIIVALRD-HFRCIAPDY-LGFGLSEHPGTFG-YK
MAB_2289|M.abscessus_ATCC_1997 TVFVHGVLTNSLLWRDVVTAVAATGRRCIALDLPGHGHSPVPADGID-VT
MSMEG_6837|M.smegmatis_MC2_155 IVFQHGNPSSSYLWRNVLPHTEGLGRLVACDLIGMGASDKLDGSGPDSYH
Mvan_5882|M.vanbaalenii_PYR-1 VVLLPAALHDHHDFDAVSADLAR-HHRVVAVDW-PGCGDSPPAPDPHAVT
MLBr_00862|M.leprae_Br4923 IVLVHGFPDSHVLWDGVVPLLAK-RFRIVRYDN-RGVGQSSVPKPVSAYT
:: : :
MAV_1840|M.avium_104 VAASGRLIAGLLDALDLSD-VTLVANDTGGGIVLAALGNASLKWDRVSKL
TH_3479|M.thermoresistible__bu VVACGRRIIGLLEQLDLRD-VTLVANDSGGGITLSALGILGLDWSRVSRL
Mflv_3236|M.gilvum_PYR-GCK ETGMANILADFLDALDLDD-VTLVLNDWGGGQFMISEGRD----KRIGRM
Rv1190|M.tuberculosis_H37Rv LAQAADAITSVIDALQLRD-LTLVAHDLGGPAGFLAAARRG---DRVAAL
Mb1222|M.bovis_AF2122/97 LAQAADAITSVIDALQLRD-LTLVAHDLGGPAGFLAAARRG---DRVAAL
MMAR_2710|M.marinum_M VDEHAQVVGEFVDHLGLDN-YLTMGQDWGGPISMAVAVERA---ERVRGI
MUL_3052|M.ulcerans_Agy99 VDEHAQVVGEFVDHLGLDN-YLTMGQDWGGPISMAVAVERA---ERVRGI
MAB_2289|M.abscessus_ATCC_1997 LSGLAQLIAEFLDSIGIDE-FDLVANDTGGAVAQIMVARQP---DRIRTL
MSMEG_6837|M.smegmatis_MC2_155 YHENRDYLFALWDALDLGDRVTLVLHDWGGALGFDWANRHR---DRVAGI
Mvan_5882|M.vanbaalenii_PYR-1 APVLADGLEDLVAGLGEEP-VVLIGNSVGGFAAARLAIRRP---HRVAGL
MLBr_00862|M.leprae_Br4923 MTRFADDFAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSG-ASDRVASF
. . : : :. *. *: :
MAV_1840|M.avium_104 VFTN---------------------CDSFEHFPPKSFAPIVRLCALSQSL
TH_3479|M.thermoresistible__bu VFTN---------------------CDTFEHFPPKQFAPLVKLCRVAPPL
Mflv_3236|M.gilvum_PYR-GCK VLAS---------------------VTAFDNYPPEPARPAALLCRMPG--
Rv1190|M.tuberculosis_H37Rv AAVN---------------------CFAWRPTGPLFRGMLAAMGSAPVRE
Mb1222|M.bovis_AF2122/97 AAVN---------------------CFAWRPTGPLFRGMLAAMGSAPVRE
MMAR_2710|M.marinum_M VLGN---------------------TWFWPADTLTMKAFSTVMSSLPMQY
MUL_3052|M.ulcerans_Agy99 VLGN---------------------TWFWPADTLTMKAFSTVMSSLPMQY
MAB_2289|M.abscessus_ATCC_1997 ALTN---------------------CDTEGHVPPKLFKPVVALARPPL-M
MSMEG_6837|M.smegmatis_MC2_155 VHMETVSV-----------------PMEWDDFPDEVAQMFRGLRSPQGEE
Mvan_5882|M.vanbaalenii_PYR-1 VLVN---------------------TGGFLPINPIMRLFCRTLGTPQVAR
MLBr_00862|M.leprae_Br4923 TSVSGPSQDQLVDYILSGLRRPWRPRTFARAVSQLFRLTYMVLFSIPVLV
. . :
MAV_1840|M.avium_104 GAIALKGLTTAPGLKVFTS---AVTLNGVDAARRRAVFGGFLTSPAVRRE
TH_3479|M.thermoresistible__bu GGAVLRLLATGPGLAFFKR---AVTRNGITGDRDDAIFGGFLSSAAVRRE
Mflv_3236|M.gilvum_PYR-GCK GGWVLSRMLGTRFFRHSRRAYGAMAKSGLPDELFDAWFAPAVENPAIRRD
Rv1190|M.tuberculosis_H37Rv LDAAINALARATSTRFGAG------RHWSRADRAAFRAGIDAPARRAWHA
Mb1222|M.bovis_AF2122/97 LDAAINALARATSTRFGAG------RHWSRADRAAFRAGIDAPARRAWHA
MMAR_2710|M.marinum_M AILHHNFFVERLIPAGTTH------RPSSAVMEHYRGVQPTASARVGVAE
MUL_3052|M.ulcerans_Agy99 AILHHNFFVERLIPAGTTH------RPSSAVMEHYRGVQPTASARVGVAE
MAB_2289|M.abscessus_ATCC_1997 ALIGPRLFARRKVLRALLG--AGYRKPGRLPDSIVESYGQPVFGTAESSR
MSMEG_6837|M.smegmatis_MC2_155 MVLENNAFIEGVLPSIVMR--TLSEEEMIHYRRPFLNAGEDRRPTLSWPR
Mvan_5882|M.vanbaalenii_PYR-1 RILPAFIRLYMQADNDLAR------AARDRAVTRAKTTSGVAMTAALWRS
MLBr_00862|M.leprae_Br4923 PMVLWIALSSATIRRTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRA
MAV_1840|M.avium_104 AARFTADLKP-SHTLAAVDALKRWDR--------------PVLMAWGTSD
TH_3479|M.thermoresistible__bu AVRFSAGLHP-QHTAAAAQAIGKWTK--------------PVLVLWGTAD
Mflv_3236|M.gilvum_PYR-GCK LVKFATGAPPRARLLEMSEQMRTFDR--------------PVLVIWARED
Rv1190|M.tuberculosis_H37Rv YFRDARRAHALYTDVDAALRGGLADR--------------PLLTIFGQFN
Mb1222|M.bovis_AF2122/97 YFRDARRAHALYTDVDAALRGGLADR--------------PLLTIFGQFN
MMAR_2710|M.marinum_M MPKQILAARPLLARLASEVPAQLGTK--------------PALLVWGMKD
MUL_3052|M.ulcerans_Agy99 MPKQILAARPLLARLASEVPAQLGTK--------------PALLVWGMKD
MAB_2289|M.abscessus_ATCC_1997 FLSKMLRAMHTRDLEAARAGLVTFTK--------------PTLIAWGLGD
MSMEG_6837|M.smegmatis_MC2_155 DVPLAGEPAEVVAVIEDFGEWLATSD--------------IPKLFIRADP
Mvan_5882|M.vanbaalenii_PYR-1 FATDAHDLRR---------DADKLTA--------------PALIVWGSRD
MLBr_00862|M.leprae_Br4923 FSGRRRGKGVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIKA
MAV_1840|M.avium_104 KMFP-LSHAERLAETFP-NAVVRAIDNSSTYVMLDRPDETAQAIRAFVDP
TH_3479|M.thermoresistible__bu DLFP-VSHAQRLAEAFP-NSRLRLIEGSSTYVMLDHPSETADAIGTFIAG
Mflv_3236|M.gilvum_PYR-GCK RMMP-LEHADRLVELYP-DATKIVVDDSWTLIPEDQPAAMAQALRDFVSL
Rv1190|M.tuberculosis_H37Rv DPLR---FQPRWKELFP-TARQLQVRRGNHFPMCDDPDLVAGALTSFVQR
Mb1222|M.bovis_AF2122/97 DPLR---FQPRWKELFP-TARQLQVRRGNHFPMCDDPDLVAGALTSFVQR
MMAR_2710|M.marinum_M FAFRPEPMLARMRAVFA-DHVLVELPEAKHFIQEDAPDEIAAAIIARFG-
MUL_3052|M.ulcerans_Agy99 FAFRPEPMLARMRAVFA-DHILVELPEAKHLIQEDAPDEIAAAIIARFG-
MAB_2289|M.abscessus_ATCC_1997 YFFP-LKYGQRLAELFGGPVTFETVPDGRLYFPDEDADRLLPLLYRHWHS
MSMEG_6837|M.smegmatis_MC2_155 GVIQGKQRILDIVRSWP-NQTEITVP-GTHFLQEDSADQIGEAIASFVRE
Mvan_5882|M.vanbaalenii_PYR-1 TAIP-LPIGRATHTALP-RARFETLPTGHVPFAS-APQDFLAILRPFLTR
MLBr_00862|M.leprae_Br4923 GHFSPMSHPQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDTFGDTLVS
: :
MAV_1840|M.avium_104 MKDVTR--------------------------------------------
TH_3479|M.thermoresistible__bu RS------------------------------------------------
Mflv_3236|M.gilvum_PYR-GCK SPRES---------------------------------------------
Rv1190|M.tuberculosis_H37Rv ST------------------------------------------------
Mb1222|M.bovis_AF2122/97 ST------------------------------------------------
MMAR_2710|M.marinum_M --------------------------------------------------
MUL_3052|M.ulcerans_Agy99 --------------------------------------------------
MAB_2289|M.abscessus_ATCC_1997 AGRQESSTEVGS--------------------------------------
MSMEG_6837|M.smegmatis_MC2_155 IRAGDNLHREAAPEMNSAS-------------------------------
Mvan_5882|M.vanbaalenii_PYR-1 TLGTTAGSPHQ---------------------------------------
MLBr_00862|M.leprae_Br4923 VTGAGSGIGRETALALARRGAEVVVSDIDEAAAKNTAAQIVASGGVAYAY
MAV_1840|M.avium_104 --------------------------------------------------
TH_3479|M.thermoresistible__bu --------------------------------------------------
Mflv_3236|M.gilvum_PYR-GCK --------------------------------------------------
Rv1190|M.tuberculosis_H37Rv --------------------------------------------------
Mb1222|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2710|M.marinum_M --------------------------------------------------
MUL_3052|M.ulcerans_Agy99 --------------------------------------------------
MAB_2289|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_6837|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5882|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 ALDVSDAAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRV
MAV_1840|M.avium_104 --------------------------------------------------
TH_3479|M.thermoresistible__bu --------------------------------------------------
Mflv_3236|M.gilvum_PYR-GCK --------------------------------------------------
Rv1190|M.tuberculosis_H37Rv --------------------------------------------------
Mb1222|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2710|M.marinum_M --------------------------------------------------
MUL_3052|M.ulcerans_Agy99 --------------------------------------------------
MAB_2289|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_6837|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5882|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LAVNLGGVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSK
MAV_1840|M.avium_104 --------------------------------------------------
TH_3479|M.thermoresistible__bu --------------------------------------------------
Mflv_3236|M.gilvum_PYR-GCK --------------------------------------------------
Rv1190|M.tuberculosis_H37Rv --------------------------------------------------
Mb1222|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2710|M.marinum_M --------------------------------------------------
MUL_3052|M.ulcerans_Agy99 --------------------------------------------------
MAB_2289|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_6837|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5882|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 AATYMFSDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVR
MAV_1840|M.avium_104 --------------------------------------------------
TH_3479|M.thermoresistible__bu --------------------------------------------------
Mflv_3236|M.gilvum_PYR-GCK --------------------------------------------------
Rv1190|M.tuberculosis_H37Rv --------------------------------------------------
Mb1222|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2710|M.marinum_M --------------------------------------------------
MUL_3052|M.ulcerans_Agy99 --------------------------------------------------
MAB_2289|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_6837|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5882|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRRGQLDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRV
MAV_1840|M.avium_104 --------------
TH_3479|M.thermoresistible__bu --------------
Mflv_3236|M.gilvum_PYR-GCK --------------
Rv1190|M.tuberculosis_H37Rv --------------
Mb1222|M.bovis_AF2122/97 --------------
MMAR_2710|M.marinum_M --------------
MUL_3052|M.ulcerans_Agy99 --------------
MAB_2289|M.abscessus_ATCC_1997 --------------
MSMEG_6837|M.smegmatis_MC2_155 --------------
Mvan_5882|M.vanbaalenii_PYR-1 --------------
MLBr_00862|M.leprae_Br4923 LPQVLRSTARIRVI