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PGSEPYGRLQYREINGKRMAYIDEARGDAIVFQHGNPSSSYLWRNVLPHTEGLGRLVACDLIGMGASDKL DGSGPDSYHYHENRDYLFALWDALDLGDRVTLVLHDWGGALGFDWANRHRDRVAGIVHMETVSVPMEWDD FPDEVAQMFRGLRSPQGEEMVLENNAFIEGVLPSIVMRTLSEEEMIHYRRPFLNAGEDRRPTLSWPRDVP LAGEPAEVVAVIEDFGEWLATSDIPKLFIRADPGVIQGKQRILDIVRSWPNQTEITVPGTHFLQEDSADQ IGEAIASFVREIRAGDNLHREAAPEMNSAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6837 | - | - | 100% (311) | haloalkane dehalogenase |
| M. smegmatis MC2 155 | MSMEG_6314 | - | 2e-15 | 26.99% (289) | haloalkane dehalogenase |
| M. smegmatis MC2 155 | MSMEG_6106 | - | 1e-09 | 25.31% (324) | epoxide hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2610 | dhaA | 1e-123 | 69.39% (294) | haloalkane dehalogenase |
| M. gilvum PYR-GCK | Mflv_4004 | - | 1e-11 | 42.42% (99) | haloalkane dehalogenase |
| M. tuberculosis H37Rv | Rv2579 | dhaA | 1e-123 | 69.73% (294) | haloalkane dehalogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 3e-06 | 28.83% (163) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0528c | - | 5e-09 | 23.32% (313) | epoxide hydrolase EphA |
| M. marinum M | MMAR_0112 | dhaA_1 | 6e-90 | 53.57% (280) | haloalkane dehalogenase DhaA_1 |
| M. avium 104 | MAV_0357 | - | 3e-18 | 31.58% (285) | haloalkane dehalogenase |
| M. thermoresistible (build 8) | TH_1615 | linB | 1e-122 | 67.35% (294) | POSSIBLE HALOALKANE DEHALOGENASE DHAA (1-CHLOROHEXANE |
| M. ulcerans Agy99 | MUL_3979 | dhaA | 7e-71 | 49.28% (278) | haloalkane dehalogenase |
| M. vanbaalenii PYR-1 | Mvan_2384 | - | 4e-21 | 31.38% (290) | haloalkane dehalogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4004|M.gilvum_PYR-GCK --MDVLRTPYERFTDLP----------------------GFPFDPHYVEV
Mvan_2384|M.vanbaalenii_PYR-1 --MDILRTPDERFADLP----------------------DFPFAPHYVEV
MAV_0357|M.avium_104 --MHTLRTPDDRFHTVP----------------------DFPYPPRYCEV
Mb2610|M.bovis_AF2122/97 MTAFGVEP-----YGQP----------------------------KYLEI
Rv2579|M.tuberculosis_H37Rv MTAFGVEP-----YGQP----------------------------KYLEI
TH_1615|M.thermoresistible__bu --MPGSKP-----YGEP----------------------------RFREI
MSMEG_6837|M.smegmatis_MC2_155 --MPGSEP-----YGRL----------------------------QYREI
MMAR_0112|M.marinum_M --MPAGAPPIDCRYGLPGHYARVQAFSPTHLEAPMTEIDPTPLTKRRLAV
MUL_3979|M.ulcerans_Agy99 --------------------------------------------MKRVDV
MAB_0528c|M.abscessus_ATCC_199 --MTDAAVDIR---------------------------------ERDIAT
MLBr_00862|M.leprae_Br4923 --MPATQS----IHKVP---------------------------HQFVES
:
Mflv_4004|M.gilvum_PYR-GCK GG-----LRMHYLDEGPAGGDVVLLLHGEPSWSYLYRTMIPVLVDAGLRA
Mvan_2384|M.vanbaalenii_PYR-1 DG-----LRMHYLDEGPADGPVVLLLHGEPSWSYLYRRMIPVLVDAGLRA
MAV_0357|M.avium_104 SDDDGGALRVAWVEDGPAGADPVLMLHGEPSWSYLYRKMIPVLAGAGHRV
Mb2610|M.bovis_AF2122/97 AG-----KRMAYIDEG--KGDAIVFQHGNPTSSYLWRNIMPHLEGLG-RL
Rv2579|M.tuberculosis_H37Rv AG-----KRMAYIDEG--KGDAIVFQHGNPTSSYLWRNIMPHLEGLG-RL
TH_1615|M.thermoresistible__bu KN-----KRMAYIDEG--EGDAIVFQHGNPTSSYLWRNVLPHLEGLG-RL
MSMEG_6837|M.smegmatis_MC2_155 NG-----KRMAYIDEA--RGDAIVFQHGNPSSSYLWRNVLPHTEGLG-RL
MMAR_0112|M.marinum_M DG-----KQMAYHESG--EGRSVVFLHGNPTSSYLWRNIIPHVSDRA-RC
MUL_3979|M.ulcerans_Agy99 LD-----SAMSYIDVG--QGDPIVFLHGNPTSSYLWRNVIPHLSDVG-RC
MAB_0528c|M.abscessus_ATCC_199 NG-----VHLRIVEAGEPGQPAVILSHGFPELAYSWRHQIPALAAAGYHV
MLBr_00862|M.leprae_Br4923 PD----GVRLAIYQSGQPEGPAIVLVHGFPDSHVLWDGVVPLLAKRF-RI
. : : . ::: ** * : :* :
Mflv_4004|M.gilvum_PYR-GCK VAIDLVGFGRSDK--PADRADYTYQAHVDWTWG-AVAALGLADITLVCQD
Mvan_2384|M.vanbaalenii_PYR-1 VAIDLVGFGRSDK--PTRREDYTYQAHVDWTWA-AIEAIGLTGITLVCQD
MAV_0357|M.avium_104 VCPDLVGFGRSDK--PTRREDHSYARHVEWMRAVAFDVLDLHNVTLVGQD
Mb2610|M.bovis_AF2122/97 VACDLIGMGASDKLSPSGPDRYSYGEQRDFLFALWDTLDLGDHVVLVLHD
Rv2579|M.tuberculosis_H37Rv VACDLIGMGASDKLSPSGPDRYSYGEQRDFLFALWDALDLGDHVVLVLHD
TH_1615|M.thermoresistible__bu VACDLIGMGGSEKLSPSGPDRYHYGEHRDYLFALWEELELGDRVVLVLHD
MSMEG_6837|M.smegmatis_MC2_155 VACDLIGMGASDKLDGSGPDSYHYHENRDYLFALWDALDLGDRVTLVLHD
MMAR_0112|M.marinum_M IAPDLIGQGDSDKLDDTGPGSYRFVEHRHYLDGLLDQLDLGDDVVLVIHD
MUL_3979|M.ulcerans_Agy99 LAPDLIGMGASG---TSPTFSYQFADHVRYLDAWFEAVGITENVVLVVHD
MAB_0528c|M.abscessus_ATCC_199 IAPDQRGYGRSS--MPAHIDDYNIEALSDDLLGILDDVGAG-KATFVGHD
MLBr_00862|M.leprae_Br4923 VRYDNRGVGQSS--VPKPVSAYTMTRFADDFAAVIDELSPDRPVHVLAHD
: * * * * : . .: :*
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 WGGLIGLRLVGEH--PDRFA-----RVVAANTTLP-------------TG
MAV_0357|M.avium_104 WGGLIGLRLAAEH--PERFA-----RMVVANTGLP-------------NG
Mb2610|M.bovis_AF2122/97 WGSALGFDWANQH--RDRVQGIAFMEAIVTPMTWA-------------DW
Rv2579|M.tuberculosis_H37Rv WGSALGFDWANQH--RDRVQGIAFMEAIVTPMTWA-------------DW
TH_1615|M.thermoresistible__bu WGSVLGFDWANHH--RDRVQGIAHMESIVTPLTWA-------------DW
MSMEG_6837|M.smegmatis_MC2_155 WGGALGFDWANRH--RDRVAGIVHMETVSVPMEWD-------------DF
MMAR_0112|M.marinum_M WGSALGFDWANRH--RERIGGIAFMEAIVRPVTWA-------------EW
MUL_3979|M.ulcerans_Agy99 WGSALGFYRALRY--PEQIAGIAYMDAPVQPRTWA-------------GF
MAB_0528c|M.abscessus_ATCC_199 WGAVVTWHTALAV--PERVSGVVGLSVPFTRRSQVPPTQ---------AW
MLBr_00862|M.leprae_Br4923 WGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSGLRRPWRPRTF
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 DQRPGEAFLAWQ----RFSQETPDFAVGHIVNGGCVSTLAP---------
MAV_0357|M.avium_104 DQPMADVWWRFR----EAITSAPQLNIGAFVQGGCRRRLSD---------
Mb2610|M.bovis_AF2122/97 PPAVRGVFQGFRSPQGEPMALEHNIFVERVLPGAILRQLSD---------
Rv2579|M.tuberculosis_H37Rv PPAVRGVFQGFRSPQGEPMALEHNIFVERVLPGAILRQLSD---------
TH_1615|M.thermoresistible__bu EDPARSVFQGLRTPEGERMVLEENIFVEAMLPRGVHRTLSD---------
MSMEG_6837|M.smegmatis_MC2_155 PDEVAQMFRGLRSPQGEEMVLENNAFIEGVLPSIVMRTLSE---------
MMAR_0112|M.marinum_M PESAAGIFRGFRSDAGEQMVIDKNLFVEAVLPGSILRGLTP---------
MUL_3979|M.ulcerans_Agy99 TDYEP-LMRALRTEQGERMALAENVFVEKVVPGGVQRQLTE---------
MAB_0528c|M.abscessus_ATCC_199 NKLFGDNFFYILYFQEPGVADADLNRDPATTMRRMMAGMAR---------
MLBr_00862|M.leprae_Br4923 ARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMVDNISTDQIHH
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 -----EVIAAYDAPFPDDSYKAGARQFPTLVPTSPDDPAAPANRAAWE--
MAV_0357|M.avium_104 -----AERAGYDAPFPSDEYCAGPRAMPTLVPTSPEDPAAAANKAAWA--
Mb2610|M.bovis_AF2122/97 -----EEMNHYRRPFVNGGEDRRPTLSWPRNLPIDGEPAEVVALVNEY--
Rv2579|M.tuberculosis_H37Rv -----EEMNHYRRPFVNGGEDRRPTLSWPRNLPIDGEPAEVVALVNEY--
TH_1615|M.thermoresistible__bu -----EEMAHYREPFRDRGEGRRPTLTWPRNVPIDGEPADVAAIVADY--
MSMEG_6837|M.smegmatis_MC2_155 -----EEMIHYRRPFLNAGEDRRPTLSWPRDVPLAGEPAEVVAVIEDF--
MMAR_0112|M.marinum_M -----AEHDEYRRPFVEP-RHRRPTLSWPREIPIEGEPADVHQIASDY--
MUL_3979|M.ulcerans_Agy99 -----EEMAVYRKPYPTP-QSRIPTLLWAREIPVEGEPADVQAMVQEY--
MAB_0528c|M.abscessus_ATCC_199 -----IDGATMIAPGPAGFVERMPDPGELPEWLSQDELDHYITEFARTGF
MLBr_00862|M.leprae_Br4923 SATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQLIVNTMDRYV
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 ------------------VLRTFDRPFLCAFSDSDPITRGADAPLRKFIP
MAV_0357|M.avium_104 ------------------KLAVSPTPMLVAFSDSDPITGPMAAIFQREMR
Mb2610|M.bovis_AF2122/97 ------------------RSWLEETDMPKLFINAEPGAIITG--RIRDYV
Rv2579|M.tuberculosis_H37Rv ------------------RSWLEETDMPKLFINAEPGAIITG--RIRDYV
TH_1615|M.thermoresistible__bu ------------------AVWLAEGDVPKLFVNAEPGAIVRG--RVRDFV
MSMEG_6837|M.smegmatis_MC2_155 ------------------GEWLATSDIPKLFIRADPGVIQGKQ-RILDIV
MMAR_0112|M.marinum_M ------------------AQWLPTADFPKLFINAEPGAILTG--PQREFC
MUL_3979|M.ulcerans_Agy99 ------------------ADFLSRSDIPKLLIVAEPGAILHEGGSELDFA
MAB_0528c|M.abscessus_ATCC_199 TGGLNWYRNFDRNWALTERLAGANVVVPSLFIAGAADPVLGFTDHAGSAK
MLBr_00862|M.leprae_Br4923 RPYG-----YDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHDLADLV
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 GAQG-----------------RPEVTIAGGG-HFLQEDKGPELA------
MAV_0357|M.avium_104 GAQG-----------------IDHPLIRGAG-HFLQEDAGAELA------
Mb2610|M.bovis_AF2122/97 RSWP-----------------NQTEITVPGV-HFVQEDSPEEIG------
Rv2579|M.tuberculosis_H37Rv RSWP-----------------NQTEITVPGV-HFVQEDSPEEIG------
TH_1615|M.thermoresistible__bu RSWP-----------------NQTEITVAGR-HYIQEDSPDEIG------
MSMEG_6837|M.smegmatis_MC2_155 RSWP-----------------NQTEITVPGT-HFLQEDSADQIG------
MMAR_0112|M.marinum_M RSWT-----------------NLTEVTVPGS-HFIQEDSPHEIG------
MUL_3979|M.ulcerans_Agy99 RSWP-----------------NQREVKVAGR-HFLQEDSPDAIG------
MAB_0528c|M.abscessus_ATCC_199 YRTD-----------------NRGDLLIDGAGHWIQQERPLEVN------
MLBr_00862|M.leprae_Br4923 DGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALARRGAEV
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 ----------------------------------AVVVDFIAANPV----
MAV_0357|M.avium_104 ----------------------------------GHIVEFLRR-------
Mb2610|M.bovis_AF2122/97 ----------------------------------AAIAQFVRQLRSAAGV
Rv2579|M.tuberculosis_H37Rv ----------------------------------AAIAQFVRRLRSAAGV
TH_1615|M.thermoresistible__bu ----------------------------------AAIADFVRKLRG----
MSMEG_6837|M.smegmatis_MC2_155 ----------------------------------EAIASFVREIRAGDNL
MMAR_0112|M.marinum_M ----------------------------------QAIADWLSSLG-----
MUL_3979|M.ulcerans_Agy99 ----------------------------------AAVRAFVLDVRERQDG
MAB_0528c|M.abscessus_ATCC_199 ----------------------------------AALLAFLREVVH----
MLBr_00862|M.leprae_Br4923 VVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVSAKHGV
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_0357|M.avium_104 --------------------------------------------------
Mb2610|M.bovis_AF2122/97 --------------------------------------------------
Rv2579|M.tuberculosis_H37Rv --------------------------------------------------
TH_1615|M.thermoresistible__bu --------------------------------------------------
MSMEG_6837|M.smegmatis_MC2_155 HREAAPEMNSAS--------------------------------------
MMAR_0112|M.marinum_M --------------------------------------------------
MUL_3979|M.ulcerans_Agy99 ADRA----------------------------------------------
MAB_0528c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 PDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQRLVERG
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_0357|M.avium_104 --------------------------------------------------
Mb2610|M.bovis_AF2122/97 --------------------------------------------------
Rv2579|M.tuberculosis_H37Rv --------------------------------------------------
TH_1615|M.thermoresistible__bu --------------------------------------------------
MSMEG_6837|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0112|M.marinum_M --------------------------------------------------
MUL_3979|M.ulcerans_Agy99 --------------------------------------------------
MAB_0528c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 TGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAVGVGLTT
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_0357|M.avium_104 --------------------------------------------------
Mb2610|M.bovis_AF2122/97 --------------------------------------------------
Rv2579|M.tuberculosis_H37Rv --------------------------------------------------
TH_1615|M.thermoresistible__bu --------------------------------------------------
MSMEG_6837|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0112|M.marinum_M --------------------------------------------------
MUL_3979|M.ulcerans_Agy99 --------------------------------------------------
MAB_0528c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 ICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRLRRYGPDKVADT
Mflv_4004|M.gilvum_PYR-GCK -----------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 -----------------------------------------
MAV_0357|M.avium_104 -----------------------------------------
Mb2610|M.bovis_AF2122/97 -----------------------------------------
Rv2579|M.tuberculosis_H37Rv -----------------------------------------
TH_1615|M.thermoresistible__bu -----------------------------------------
MSMEG_6837|M.smegmatis_MC2_155 -----------------------------------------
MMAR_0112|M.marinum_M -----------------------------------------
MUL_3979|M.ulcerans_Agy99 -----------------------------------------
MAB_0528c|M.abscessus_ATCC_199 -----------------------------------------
MLBr_00862|M.leprae_Br4923 ILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIRVI