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MPLVPTRAGTLAYHVRGSGPTVVLLPAALHDHHDFDAVSADLARHHRVVAVDWPGCGDSPPAPDPHAVTA PVLADGLEDLVAGLGEEPVVLIGNSVGGFAAARLAIRRPHRVAGLVLVNTGGFLPINPIMRLFCRTLGTP QVARRILPAFIRLYMQADNDLARAARDRAVTRAKTTSGVAMTAALWRSFATDAHDLRRDADKLTAPALIV WGSRDTAIPLPIGRATHTALPRARFETLPTGHVPFASAPQDFLAILRPFLTRTLGTTAGSPHQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5882 | - | - | 100% (273) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_2445 | - | 2e-19 | 27.24% (268) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_2912 | - | 2e-16 | 30.29% (274) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2734 | - | 1e-20 | 28.11% (281) | hydrolase |
| M. gilvum PYR-GCK | Mflv_3952 | - | 4e-20 | 27.88% (269) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv2715 | - | 1e-20 | 28.11% (281) | hydrolase |
| M. leprae Br4923 | MLBr_02269 | - | 6e-09 | 24.63% (268) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_3034 | - | 3e-23 | 30.14% (282) | hydrolase |
| M. marinum M | MMAR_1997 | - | 7e-21 | 28.41% (271) | hydrolase |
| M. avium 104 | MAV_3609 | - | 7e-23 | 29.54% (281) | hydrolase |
| M. smegmatis MC2 155 | MSMEG_6037 | - | 6e-15 | 31.98% (247) | 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase |
| M. thermoresistible (build 8) | TH_1741 | - | 4e-17 | 33.33% (240) | 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE BPHD |
| M. ulcerans Agy99 | MUL_3358 | - | 4e-21 | 28.41% (271) | hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2734|M.bovis_AF2122/97 ------MTERKRN--LRPVR------------------DVAPPTLQFRTV
Rv2715|M.tuberculosis_H37Rv ------MTERKRN--LRPVR------------------DVAPPTLQFRTV
MMAR_1997|M.marinum_M ------MTERKRN--LRPVR------------------EVTAPSLQFRTI
MUL_3358|M.ulcerans_Agy99 ------MTERKRN--LRPVR------------------EVTAPSLQFRTI
MAV_3609|M.avium_104 ------MTERKRKNTLRPVR------------------EVSAPRLEFRTI
Mflv_3952|M.gilvum_PYR-GCK ------MTARTPN--LRPVR------------------ELT-PTLRYCTI
MAB_3034|M.abscessus_ATCC_1997 ------MNPPPRL--LRPVPDTEHIDGVDGGGDTPSAATSTRPRLAFRTI
MSMEG_6037|M.smegmatis_MC2_155 ------MVTATQEITFESTS--------------------RFADVQAGEL
TH_1741|M.thermoresistible__bu MTSYIQEAENQVEITFESTS--------------------RYAEVKAGDR
Mvan_5882|M.vanbaalenii_PYR-1 --------------------------------------------MPLVPT
MLBr_02269|M.leprae_Br4923 --------------------------------------------------
Mb2734|M.bovis_AF2122/97 HGYRRAFRIAG--SGPAILLIHGIGDNSTTWNGVH---AKLAQRFTVIAP
Rv2715|M.tuberculosis_H37Rv HGYRRAFRIAG--SGPAILLIHGIGDNSTTWNGVH---AKLAQRFTVIAP
MMAR_1997|M.marinum_M HGYKRAFRIAG--SGPAILLIHGIGDNSTTWTGIH---AKLAQRFTVIAP
MUL_3358|M.ulcerans_Agy99 HGYKRAFRIAG--SGPAILLIHGIGDNSTTWTGIH---AKLAQRFTVIAP
MAV_3609|M.avium_104 HGYRRAYRIAG--SGPAILLIHGIGDNSTTWNTVQ---AKLAQRFTVIAP
Mflv_3952|M.gilvum_PYR-GCK HGYRRAYRIAG--SGPAILLIHGIGDNSTTWAGVQ---TQLAQRFTVIAP
MAB_3034|M.abscessus_ATCC_1997 HGYRRAYRIAG--SGPVLLLIHGIGDNSATWDSVH---AQLAEHFTVIAP
MSMEG_6037|M.smegmatis_MC2_155 A-MRLHYHEAGDPSAQTIVLLHGGGPGAASWSNFGRNIAVLAEHFHVLAV
TH_1741|M.thermoresistible__bu D-MRLHYHEAGIGHAQKVVLLHGGGPGASSWSNFGRNIAVLARHFHVIAV
Mvan_5882|M.vanbaalenii_PYR-1 RAGTLAYHVRG--SGPTVVLLPAALHDHHDFDAVS---ADLARHHRVVAV
MLBr_02269|M.leprae_Br4923 -MINLAYEDRG--TGEPVVFIAGRGGAGRTWQPHQVP-AFLAAGYRVITF
:. * . :::: . : : ** . *::
Mb2734|M.bovis_AF2122/97 DLLGHGQSD-KPRADYSVAAY-ANGMRDLLSVLDIE-RVTIVGHSLGGGV
Rv2715|M.tuberculosis_H37Rv DLLGHGQSD-KPRADYSVAAY-ANGMRDLLSVLDIE-RVTIVGHSLGGGV
MMAR_1997|M.marinum_M DLLGHGRSD-KPRADYSIAAY-ANGMRDLLSVLDIE-RVTIIGHSLGGGV
MUL_3358|M.ulcerans_Agy99 DLLGHGRSD-KPRADYSIAAY-ANGMRDLLSVLDIE-RVTIIGHSLGGGV
MAV_3609|M.avium_104 DLLGHGQSD-KPRADYSVAAY-ANGMRDLLAVLDIE-RVTIVGHSLGGGV
Mflv_3952|M.gilvum_PYR-GCK DLLGHGKSD-KPRADYSVAAY-ANGMRDLLSVLNID-SATVVGHSLGGGV
MAB_3034|M.abscessus_ATCC_1997 DLLGHGQSD-KPRADYSVAAY-ANGMRDLLAVLDIE-RVTVVGHSLGGGV
MSMEG_6037|M.smegmatis_MC2_155 DQPGYGLSD-KHTEHEQYNRYSAKAVRGLLDHLGVEGRVPLLGNSLGGGT
TH_1741|M.thermoresistible__bu DQPGYGHSD-KHTEHEQYNRYSATALLALFDHLGIE-RADLVGNSLGGGT
Mvan_5882|M.vanbaalenii_PYR-1 DWPGCGDSPPAPDPHAVTAPVLADGLEDLVAGLGEE-PVVLIGNSVGGFA
MLBr_02269|M.leprae_Br4923 DNRGIGATENTEGFTTQTMVADTAVLIESLGAVPAR----IVGVSMGSFI
* * * : : : . : ::* *:*.
Mb2734|M.bovis_AF2122/97 AMQFAYQFPQLVDRLILVSAGGVTKDVNIVFRLASLPMGSEAMALLRLPL
Rv2715|M.tuberculosis_H37Rv AMQFAYQFPQLVDRLILVSAGGVTKDVNIVFRLASLPMGSEAMALLRLPL
MMAR_1997|M.marinum_M AMQFAYQFPQLVDRLILVGAGGVTKDVNVVFRLASLPMGAEALALLRLPM
MUL_3358|M.ulcerans_Agy99 AMQFAYQFPQLVDRLILVGAGGVTKDVNVVFRLASLPMGAEALALLRLPM
MAV_3609|M.avium_104 AMQFAYQFPHLVERLILVGAGGVTKDVNFVLRWASLPLGSEAIALLRLPL
Mflv_3952|M.gilvum_PYR-GCK AMQFAYQFPQLVDRLILVGAGGVTKDVNIALRAASLPMGTEALALLRLPL
MAB_3034|M.abscessus_ATCC_1997 AMQFTYQFPHLVERLILVAPGGVTKDVNIVLRCASLPFIGDALGLLRLPM
MSMEG_6037|M.smegmatis_MC2_155 AVRFALDYPDRAGKLVLMGPGGLS------VNLFAPDPTEGVKALAKFNV
TH_1741|M.thermoresistible__bu AVRFALDHPKRAGRLVLMGPGGLS------VNMFAPDPTEGVKLLARFNA
Mvan_5882|M.vanbaalenii_PYR-1 AARLAIRRPHRVAGLVLVNTGGFLP-INPIMRLFCRTLGTPQVARRILPA
MLBr_02269|M.leprae_Br4923 AQELMVARPELVRAAVLMATRGRLDRTRQFFHAAEAEFHDSGIQLP--SG
* .: *. . :*: . * ..
Mb2734|M.bovis_AF2122/97 VLPAVQIAGRIVGKAIGTTSLGHDLPNVLRILDDLPEPTASAAFGRTLRA
Rv2715|M.tuberculosis_H37Rv VLPAVQIAGRIVGKAIGTTSLGHDLPNVLRILDDLPEPTASAAFGRTLRA
MMAR_1997|M.marinum_M VLPTVQLAGKVLGMALGSTALGQDLPNVLRILDDLPEPTASSAFTRTLRA
MUL_3358|M.ulcerans_Agy99 VLPTVQLAGKVLGMALGSTALGQDLPNVLRILDDLPEPTASSAFTRTLRA
MAV_3609|M.avium_104 VLPAVQLMGRVLGTALGSTGLGRDLPNVLRILDDLPEPTASAAFSRTLRA
Mflv_3952|M.gilvum_PYR-GCK LLPTLRLLGRVGGPLLGNTRIGRDIPNMLRILADLPEPTASSAFARTLRS
MAB_3034|M.abscessus_ATCC_1997 AMPMLRLGGAVARATFGRASMARDIPDVLRVLADLPEPRASAAFTRTLRA
MSMEG_6037|M.smegmatis_MC2_155 EPTRENLEAFLRIMVFDQKLITPELVEERFAIASTPES---LAATRAMGK
TH_1741|M.thermoresistible__bu EPTRENLEAFLRIMVYDQSLITEELIDERFAIAATPES---LAATRAMGK
Mvan_5882|M.vanbaalenii_PYR-1 FIRLYMQADNDLARAARDRAVTRAKTTSG------------VAMTAALWR
MLBr_02269|M.leprae_Br4923 YNAKVRLLENLSRKTLNDDVAVADWIAMFN----------MWPIKSTPGL
. :
Mb2734|M.bovis_AF2122/97 VVDWRGQMVTMLDRCYLTEAIPVQIIWGTKDVVLPVRHAHMAHAAMPGSQ
Rv2715|M.tuberculosis_H37Rv VVDWRGQMVTMLDRCYLTEAIPVQIIWGTKDVVLPVRHAHMAHAAMPGSQ
MMAR_1997|M.marinum_M VVDWRGQIVTMLDRCYLTQAIPVQIIWGSRDAVVPVRHAEMAHAAMPGSK
MUL_3358|M.ulcerans_Agy99 VVDWRGQIVTMLDRCYLTQAIPVQIIWGSRDAVVPVRHAEMAHAAMPGSK
MAV_3609|M.avium_104 VVDWRGQIVTMLDRCYLTEAIPVQIVWGTKDVVVPVRHAWMAHAAMPGSR
Mflv_3952|M.gilvum_PYR-GCK VVDWRGQVVTMLDRCYLTQSVPVQLIWGSQDSVIPVSHAEMAHTAMPGSR
MAB_3034|M.abscessus_ATCC_1997 VVDWRGQVVTMLDRCYLTESVPVQLIWGSDDLVIPVSHGHLAHAAMPGSA
MSMEG_6037|M.smegmatis_MC2_155 SFAGADFELGMMWREVYKLRQPVLLIWGREDRVNPLDGALVAVKQIPRVQ
TH_1741|M.thermoresistible__bu SFMGPDFELGMMWRDAYKLRQRVLLIWGREDRVNPLDGALVALKQIPRVQ
Mvan_5882|M.vanbaalenii_PYR-1 SFATD---AHDLRRDADKLTAPALIVWGSRDTAIPLPIGRATHTALPRAR
MLBr_02269|M.leprae_Br4923 RCQTDVAPQNNRLPAYRSIAAPVLVIGFAEDVVTPPSLGREVADVLPNGR
. . :: * . * . . :*
Mb2734|M.bovis_AF2122/97 LEIFEGSGHFPFHDDPARFIDIVERFMDTTEPAEYDQAALRALLRRGGGE
Rv2715|M.tuberculosis_H37Rv LEIFEGSGHFPFHDDPARFIDIVERFMDTTEPAEYDQAALRALLRRGGGE
MMAR_1997|M.marinum_M LEVFEGSGHFPFHDDPARFIDIVLRFIDSTQPPEYDQAALRELLRTGGGE
MUL_3358|M.ulcerans_Agy99 LEVFEGSGHFPFHDDPARFIDIVLRFIDSTQPPEYDQAALRELLRTGGGE
MAV_3609|M.avium_104 LEIFEGSGHFPFHDDPARFIDVVERFIDSTEPAAYDQEALRRLLRSGGGA
Mflv_3952|M.gilvum_PYR-GCK LEIFEGAGHFPFHDEPDRFVELVEKFIDSTEPAVYDQEYLRTLLRTGTSE
MAB_3034|M.abscessus_ATCC_1997 LEIFDKSGHFPFHDDPERFIGIVRQFIASTEPGEYNEDELRRLLRTGVTE
MSMEG_6037|M.smegmatis_MC2_155 LHVFGQCGHWAQVEKFDEFNKLTIDFLGG---------------------
TH_1741|M.thermoresistible__bu LHVFGQCGHWAQVEKFDEFNRLTIDFLEDGAKEAKS--------------
Mvan_5882|M.vanbaalenii_PYR-1 FETLP-TGHVPFASAPQDFLAILRPFLTRTLGTTAGSPHQ----------
MLBr_02269|M.leprae_Br4923 YLQIPDAGHLGFFERPEAVNAAALQFFAGVKGEWP---------------
: ** . . *:
Mb2734|M.bovis_AF2122/97 ATVTGSADTRVAVLNAIGSNERSAT
Rv2715|M.tuberculosis_H37Rv ATVTGSADTRVAVLNAIGSNERSAT
MMAR_1997|M.marinum_M RTVSGPADTRVAVLSAMGSDERSAT
MUL_3358|M.ulcerans_Agy99 RTVSDPADTRVAVLSAMGSDERSAT
MAV_3609|M.avium_104 QAVTGPAPTRVAVLSAMGSDERSAT
Mflv_3952|M.gilvum_PYR-GCK NTLSGDVDTQVAVLDAIGADERSAT
MAB_3034|M.abscessus_ATCC_1997 HAISGAARTRMAVLDAMGTDERSAT
MSMEG_6037|M.smegmatis_MC2_155 -------------------------
TH_1741|M.thermoresistible__bu -------------------------
Mvan_5882|M.vanbaalenii_PYR-1 -------------------------
MLBr_02269|M.leprae_Br4923 -------------------------