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MAVGRCAIPRFDQAASGSAINGGQVHLSDGSTSPARQLPAPWPGDAGAAAEGRAGVCCRGNRLPHVSDVG VSHRFDHRPAGVGAGGCRAGAAGAGLAVDDPGQLAAAIDRIVAVADPDAVRQVRERARDREVSIWNSADG MGEVYAQLYATDAQALDARLNALVATVCAGDPRSTDQRRADALGALAAGADRLACRCDNPDCAAEGRPVS AVVIHVVAEQASVKGHGQAPAALLGGDGLIPAELVAELAKTAGLQPIPVPAGTEPGYRPSVKLAAFVRAR DLTCRAPGCDRPATQCDLDHTIAFADGGATHAANLKCLCRLHHLLATFCGWRAQQLPDGTVIWTLPGNQT YVTTPGSALLFPALCTPTGDPPAPEPARADRRGQRTAMMPRRASTRTQNRAHCIAAERHRNHQARRIAQA AVIATETHGPPPDPDDDPPPF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0393 | - | - | 100% (441) | CONSERVED 13E12 REPEAT FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv0336 | - | e-113 | 60.98% (346) | 13E12 repeat family protein |
| M. tuberculosis H37Rv | Rv0515 | - | e-112 | 60.69% (346) | 13E12 repeat family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0399 | - | 0.0 | 100.00% (441) | 13E12 repeat family protein |
| M. gilvum PYR-GCK | Mflv_5065 | - | 1e-71 | 42.20% (372) | hypothetical protein Mflv_5065 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 5e-60 | 41.57% (332) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_5187 | - | 1e-105 | 57.97% (345) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_3457 | - | 1e-114 | 60.64% (343) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_5026 | - | 1e-66 | 43.99% (341) | hypothetical protein MSMEG_5026 |
| M. thermoresistible (build 8) | TH_0334 | - | 4e-46 | 45.41% (218) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_1813 | - | 2e-90 | 61.09% (275) | 13e12 repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0728 | - | 7e-72 | 41.75% (412) | hypothetical protein Mvan_0728 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5026|M.smegmatis_MC2_155 -------------MGAGILERMFDG--------------------TSDAG
TH_0334|M.thermoresistible__bu ---------------------MFES--------------------LDDGA
MAB_4752|M.abscessus_ATCC_1997 ---------------------MFDE--------------------LGDVE
Mflv_5065|M.gilvum_PYR-GCK -----------------MFDTMHRG--------------------LGEAD
Mvan_0728|M.vanbaalenii_PYR-1 -----------------MFDVLVPDPA--------------DLAALSDAE
Rv0393|M.tuberculosis_H37Rv ---------------------MAVGR------------------------
Mb0399|M.bovis_AF2122/97 ---------------------MAVGR------------------------
MMAR_5187|M.marinum_M -----------------MFESMGVAAGVDHPCDALAERRQLRTPTAESAR
MAV_3457|M.avium_104 MVEHMFEYVVASRSTPEAVALLDRAR------------------------
MUL_1813|M.ulcerans_Agy99 ---------------------MERAR------------------------
:
MSMEG_5026|M.smegmatis_MC2_155 LIDAIAEAKRQENAATARRLFAIGELDTRRA-IDL-AECNFWRTDPFEEV
TH_0334|M.thermoresistible__bu VVDSIAAASREQSAACGREMLAIGELYARRAPEDD-TERANWAIDGHANV
MAB_4752|M.abscessus_ATCC_1997 LIDLIASAQRAEAQACARKLDAIGVLVDRHADLGKPDERDHHALDRWDRV
Mflv_5065|M.gilvum_PYR-GCK LLAAIEQAAREEAQAGARRLAAIAEL-VDLTVDED-DERGMWAFDPWKNA
Mvan_0728|M.vanbaalenii_PYR-1 LLDAATATTRAENAVCARKLAVMAELFIRRTTLAP-QDRLDWWVDPEAAV
Rv0393|M.tuberculosis_H37Rv ------CAIPRFDQAASGSAINGGQVHLS---------------DGSTSP
Mb0399|M.bovis_AF2122/97 ------CAIPRFDQAASGSAINGGQVHLS---------------DGSTSP
MMAR_5187|M.marinum_M WVQRIGAAARAENRAAAAQLIEIGQLFAYRLSRCS--ETEDWAVDTMEAV
MAV_3457|M.avium_104 ------EAARAEARAAAARLVAVAELLVLRCRETG--ERADWAADAWEAV
MUL_1813|M.ulcerans_Agy99 ------EASRREAAAAAERLDVVGALFVLRCRESG--DRAEWATDTWEAV
: . . . : *
MSMEG_5026|M.smegmatis_MC2_155 CAEVSAALRISRSRANWQVHLARVLRDRIPKVAAVFAQGDIDFRIVTKIA
TH_0334|M.thermoresistible__bu VAEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFAAGDIDFRMVSALV
MAB_4752|M.abscessus_ATCC_1997 ASEVAAAQGITHALASSQMRYAQVLRHRLRAVAERFAAGDLDFRTVALII
Mflv_5065|M.gilvum_PYR-GCK ACHIGAALSISERRASAQMCIATALRYRLPQIAALYVQGRLSTRLISEIT
Mvan_0728|M.vanbaalenii_PYR-1 TAELAAAHHITQGLATHQAYRAVVLRDRLPKIGALFLQGLLSELLVRAII
Rv0393|M.tuberculosis_H37Rv ARQLPAPWPGDAGAAAEGRAGVCCRGNRLPHVSDVGVSHRFDHRPAG---
Mb0399|M.bovis_AF2122/97 ARQLPAPWPGDAGAAAEGRAGVCCRGNRLPHVSDVGVSHRFDHRPAG---
MMAR_5187|M.marinum_M AAEVAAGLRISQGLAASRLRYARALRERLPKTGAVFAAGQIDLRAFQTIV
MAV_3457|M.avium_104 AAQVGAALGCSVAMGHSYLRYAMAMRERLPQVGAVFAAGGIDYRAFQTLV
MUL_1813|M.ulcerans_Agy99 GAQVAAALRTSVAMGSSYLRYAMAMRNRLPKVGQAFRAEDIDYRAFQTIV
.: * . . *: . :.
MSMEG_5026|M.smegmatis_MC2_155 TRT-ELVDPAAMPALDDVLARRCPNWMRLSEPKLEERIDQCILRLDPDGQ
TH_0334|M.thermoresistible__bu NRSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNERIDMWVERFDPTGV
MAB_4752|M.abscessus_ATCC_1997 NRTELVDDEAVVARVDAAIVRALPRWARWSHKRITAALDALVLHFDQDAV
Mflv_5065|M.gilvum_PYR-GCK WRTGLVAD-DVIATVDAALAGKAEKWGPLSEDKLIDAINTVIARHDPDAV
Mvan_0728|M.vanbaalenii_PYR-1 TRTGLITDPDLIAAVDADLATDILDWGPLSVKATEAEIDAIIDRHDPDAV
Rv0393|M.tuberculosis_H37Rv ------VGAGGCRAGAAGAGLAVD-----DPGQLAAAIDRIVAVADPDAV
Mb0399|M.bovis_AF2122/97 ------VGAGGCRAGAAGAGLAVD-----DPGQLAAAIDRIVAVADPDAV
MMAR_5187|M.marinum_M FRTDLIVDPQVMAAVDALVALNVGRWPSMTKARLSGQIDAIVARADADAV
MAV_3457|M.avium_104 FRTDLITDAQVLARVDATLAVLVSRRPSLTRGGLAAAVDRVVAAVDADAV
MUL_1813|M.ulcerans_Agy99 FRTDLITDAEVLAKVDAQLAALLARCPAVTRGRLSVAVDQVVADVDRDVV
. :: : *
MSMEG_5026|M.smegmatis_MC2_155 RVTKRSEDSRYFTVQPADT-PGMANAQGYLPAHDAAGFDKRLDAIAATVC
TH_0334|M.thermoresistible__bu REPRSPGEDRYVVVTPAG--QGMVDVSARLTFEAGFAFXTRLDQIAATVC
MAB_4752|M.abscessus_ATCC_1997 RRNRSATDKRHLEIRPLGNGEPVAEVWGTLQAVHAVALDKRLDLLAGTVC
Mflv_5065|M.gilvum_PYR-GCK RRTKEALKKRDVHIGAHEDTDDVTTIWGLLLPPDAAAYTARIAALVKGLC
Mvan_0728|M.vanbaalenii_PYR-1 RKSRAPETGRTVQFGNPGDAPGYTSMWARMYASDAAAADRTLTALAYSVC
Rv0393|M.tuberculosis_H37Rv RQVRERARDR--EVSIWNSADGMGEVYAQLYATDAQALDARLNALVATVC
Mb0399|M.bovis_AF2122/97 RQVRERARDR--EVSIWNSADGMGEVYAQLYATDAQALDARLNALVATVC
MMAR_5187|M.marinum_M RRRKERHADR--EIWIGQDADGISRIDGSMFTIDAHALDRRLSALAATVC
MAV_3457|M.avium_104 RRARDAVTGRYLDVR--ANESGMAWVEGNVLGPDGHALDRRLDELASGVC
MUL_1813|M.ulcerans_Agy99 RRVAEAADGRFVDVDVIADGSGLAALAGSVLATAGRAFDRRLDELANTVC
* * . . : . . : :. :*
MSMEG_5026|M.smegmatis_MC2_155 PNDPRTPDQRRADALGALGRYRDTLDCQCGREDCTAVAERDAVNNAMIHV
TH_0334|M.thermoresistible__bu RDDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCPADPADTAATRLVINV
MAB_4752|M.abscessus_ATCC_1997 PADPRSKTQRRADAVGALTQGLNRMRCACGHPDCSGR--DTADVPVVVNV
Mflv_5065|M.gilvum_PYR-GCK DADPRSAGERRSDAMGAIGRGENQLACRCGSPNCTASGPSTSPVVITVIA
Mvan_0728|M.vanbaalenii_PYR-1 DNDPRTLDERRNDAHTALLTGITTLACQCGNPDCHASTNPRPPRDITVYA
Rv0393|M.tuberculosis_H37Rv AGDPRSTDQRRADALGALAAGADRLACRCDNPDCAAEGRPVS--AVVIHV
Mb0399|M.bovis_AF2122/97 AGDPRSTDQRRADALGALAAGADRLACRCDNPDCAAEGRPVS--AVVIHV
MMAR_5187|M.marinum_M AQDPRSREQRRADALGVLAAGGDRLGCRCGLPDCAAGARPAAQ-PVVIHV
MAV_3457|M.avium_104 AGDPRSRAQRRADALGALAAGAGRLACGCGSPDCPSAAAPAPRSTVVIHV
MUL_1813|M.ulcerans_Agy99 AADPRTREQRRADAVGALVAGSDRLACGCTSADCTAAARSAP-SKVVIHV
***: :** ** .: : * * :* . . : .
MSMEG_5026|M.smegmatis_MC2_155 LAEQSTLDGGNE----------------------------PGYLPGFGML
TH_0334|M.thermoresistible__bu IAEQATVEGRSDN---------------------------PGYLPGYGAV
MAB_4752|M.abscessus_ATCC_1997 VINQSTLAGSDDC---------------------------PAHVPGFGVL
Mflv_5065|M.gilvum_PYR-GCK DQAAVDTAQQLIADQDAEQQNTTATTAEPTCTK---DPG-SALLPGAQIL
Mvan_0728|M.vanbaalenii_PYR-1 LTDHTTTTDTGDADTTTDTKPPTPPAPQPRRSKPILIPGRPAYLFGAGFM
Rv0393|M.tuberculosis_H37Rv VAEQASVKGHGQA---------------------------PAALLGGDGL
Mb0399|M.bovis_AF2122/97 VAEQASVKGHGQA---------------------------PAALLGGDGL
MMAR_5187|M.marinum_M IAERATLDGDGGA---------------------------PAWEVGADGL
MAV_3457|M.avium_104 VAEQATVAGRGAT---------------------------PAVVAGLDGL
MUL_1813|M.ulcerans_Agy99 VADQSTVDGTGHT---------------------------PAVLLGAEGL
.. * :
MSMEG_5026|M.smegmatis_MC2_155 PAH-MVREVAKTATTKPVTIPK--DKAQSGYRPNAELTEFIRWRDLTCRF
TH_0334|M.thermoresistible__bu PAS-ILRAKAATATLRPVALPQ--PCAEAGYRPSAALTRFIRCRDLTCRF
MAB_4752|M.abscessus_ATCC_1997 AAE-SARAAVAGTPTRNLTDSR--S---TGYRPSAKLAAFVRSRDQLCRF
Mflv_5065|M.gilvum_PYR-GCK PIPVLAEAIRSGAKITPLWLPG--PDPEPHYRPSAKLAAFIRSRDLFCRF
Mvan_0728|M.vanbaalenii_PYR-1 PAP-LFDALLAEATIREIIHPGNRSAPEPRYTPSQALAEFIRCRDLTCRF
Rv0393|M.tuberculosis_H37Rv IPAELVAELAKTAGLQPIPVP---AGTEPGYRPSVKLAAFVRARDLTCRA
Mb0399|M.bovis_AF2122/97 IPAELVAELAKTAGLQPIPVP---AGTEPGYRPSVKLAAFVRARDLTCRA
MMAR_5187|M.marinum_M VTPELVAELAKSAKLVPLRHPG-DVPPEPGYVPSKALADFVRCRDLTCRW
MAV_3457|M.avium_104 IPAQVIAELAASARLVPVAVP--EGGPEPGYTPSARLADFIRCRDLTCRA
MUL_1813|M.ulcerans_Agy99 IPASLIAELAKVATLRPLMRP--SGRPESGYAPSAGLAEFVRCRDLTCRA
: : . . * *. *: *:* ** **
MSMEG_5026|M.smegmatis_MC2_155 PGCDAPAMAADIDHTRPYPQG-PTHPSNTKLYCRTHHLIKTFYTGPNGWT
TH_0334|M.thermoresistible__bu PGCDAPAAVCQIDHTIPYPAG-PTHPSNLKLLCVFH--------------
MAB_4752|M.abscessus_ATCC_1997 PGCEAVADRADIDHTVPWATGGPTTGANLKALCRKHHLLKTFG----QWT
Mflv_5065|M.gilvum_PYR-GCK PGCDVSADRCDIDHVVPYPFG-PTHASNMHCKCRSHHLMKTFWGGPDGWR
Mvan_0728|M.vanbaalenii_PYR-1 PGCDKPATEADIDHTVPYPIG-PTHPSNLKCLCRFHHLLKTFWLGATGWH
Rv0393|M.tuberculosis_H37Rv PGCDRPATQCDLDHTIAFADGGATHAANLKCLCRLHHLLATFCG----WR
Mb0399|M.bovis_AF2122/97 PGCDRPATQCDLDHTIAFADGGATHAANLKCLCRLHHLLATFCG----WR
MMAR_5187|M.marinum_M PGCDHPALNCDLDHTIPYAQGGPTHASNLKCYCRTHHLVKTFWG----WH
MAV_3457|M.avium_104 PGCDRPAVDCDVDHTIPYAQGGPTHPSNLKCLCRGHHLLKTFWG----WR
MUL_1813|M.ulcerans_Agy99 RGCDQPAVCCDLDHTVAYGDGGHTHASNLKCLCRKHHLLKTFWG----WR
**: * .::**. .: * * :* : * *
MSMEG_5026|M.smegmatis_MC2_155 DRQLPDGTIEFTAPTGHIYTTEPQGAALFPVLGTPTGELNL---------
TH_0334|M.thermoresistible__bu ---CRQAELRFTHDQ-----HKHQSSCLPAYFQRPHG-------------
MAB_4752|M.abscessus_ATCC_1997 ELQEPDGTVIWKSPTGHRYATTPVSWFLFPALTRHHT-------------
Mflv_5065|M.gilvum_PYR-GCK ERQLPDGTVLWTTPAGTTYTTTPGSRLFFPAWDTTTAELPP---------
Mvan_0728|M.vanbaalenii_PYR-1 DRQHPDGTITWTAPTGHTYTTHPGSRLLFPTLCQPTATLWT---------
Rv0393|M.tuberculosis_H37Rv AQQLPDGTVIWTLPGNQTYVTTPGSALLFPALCTPTGDPPA---------
Mb0399|M.bovis_AF2122/97 AQQLPDGTVIWTLPGNQTYVTTPGSALLFPALCTPTGDPPA---------
MMAR_5187|M.marinum_M DQQLPDGTLILTSPAGHTYVTTPGSALLFPSLCHSTGGLPA---------
MAV_3457|M.avium_104 DRQLPDGTVIWTLPDGDTYVTTPGSALLFPTLCTPTGAVSP---------
MUL_1813|M.ulcerans_Agy99 DLQLPDGTVIWLLPDGHTYVTTPGSALLFPNLCVPTGELPPIVGTAGKPP
:. : . : .
MSMEG_5026|M.smegmatis_MC2_155 ---------------PPQQDEPHPN-RGVMMPKRRQTREQDRADRINAER
TH_0334|M.thermoresistible__bu ----------------PATRRPPSA-RGLREAVPRQGVD---PRRVSGQ-
MAB_4752|M.abscessus_ATCC_1997 ----------------RQQARDRRR-RTERNLNREQRLQREAALAALAAK
Mflv_5065|M.gilvum_PYR-GCK ---------------MTTP--PPGAGREIQMPKRQRSRTADRAARIKAER
Mvan_0728|M.vanbaalenii_PYR-1 ---------------GEPPQVPQSQQRGAMMPRRRNTRAHNHAAYITAER
Rv0393|M.tuberculosis_H37Rv --------------PEP-ARADRRGQRTAMMPRRASTRTQNRAHCIAAER
Mb0399|M.bovis_AF2122/97 --------------PEP-ARADRRGQRTAMMPRRASTRTQNRAHCIAAER
MMAR_5187|M.marinum_M --------------AEADPPSDHCDQRSAMMPRRQRTRAQDRARRVATER
MAV_3457|M.avium_104 ---------------AKPDTEHRCGERTAMMPLRRHTRAHNRAHRITTER
MUL_1813|M.ulcerans_Agy99 RWPSGEDADPCPNPRTKPGESHRHRAPMQSQGTGSRRRRPRRPVRHPGAG
.
MSMEG_5026|M.smegmatis_MC2_155 RERAELNAEQQ----------------RQRQAWLADNYEPPPF-------
TH_0334|M.thermoresistible__bu --------------------------------------------------
MAB_4752|M.abscessus_ATCC_1997 --------------------------------------DPPPF-------
Mflv_5065|M.gilvum_PYR-GCK EHNGTQRNLEE--------------RPRRGQPPPDYGNDPPPF-------
Mvan_0728|M.vanbaalenii_PYR-1 RRNAQTRYATTGNTPPYLPRDHIPYQSSTGWREPDYGNDPPPF-------
Rv0393|M.tuberculosis_H37Rv HRNHQAR--------RIAQAAVIATETHGPPP--DPDDDPPPF-------
Mb0399|M.bovis_AF2122/97 HRNHQAR--------RIAQAAVIATETHGPPP--DPDDDPPPF-------
MMAR_5187|M.marinum_M RQNHHAR--------STQPGGQPRSAAPPTPPQSEPQSHPPPF-------
MAV_3457|M.avium_104 NHNRR-----------TRLTTHPATPGPAPPP--DPDDEPPPF-------
MUL_1813|M.ulcerans_Agy99 NRSRRAAALLA----ATSLGTCQIPRRIAPRP--GPSRSSRGCTDSGTRM
MSMEG_5026|M.smegmatis_MC2_155 ---------------
TH_0334|M.thermoresistible__bu ---------------
MAB_4752|M.abscessus_ATCC_1997 ---------------
Mflv_5065|M.gilvum_PYR-GCK ---------------
Mvan_0728|M.vanbaalenii_PYR-1 ---------------
Rv0393|M.tuberculosis_H37Rv ---------------
Mb0399|M.bovis_AF2122/97 ---------------
MMAR_5187|M.marinum_M ---------------
MAV_3457|M.avium_104 ---------------
MUL_1813|M.ulcerans_Agy99 GESSMSARPRACVAG