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VGAGILERMFDGTSDAGLIDAIAEAKRQENAATARRLFAIGELDTRRAIDLAECNFWRTDPFEEVCAEVS AALRISRSRANWQVHLARVLRDRIPKVAAVFAQGDIDFRIVTKIATRTELVDPAAMPALDDVLARRCPNW MRLSEPKLEERIDQCILRLDPDGQRVTKRSEDSRYFTVQPADTPGMANAQGYLPAHDAAGFDKRLDAIAA TVCPNDPRTPDQRRADALGALGRYRDTLDCQCGREDCTAVAERDAVNNAMIHVLAEQSTLDGGNEPGYLP GFGMLPAHMVREVAKTATTKPVTIPKDKAQSGYRPNAELTEFIRWRDLTCRFPGCDAPAMAADIDHTRPY PQGPTHPSNTKLYCRTHHLIKTFYTGPNGWTDRQLPDGTIEFTAPTGHIYTTEPQGAALFPVLGTPTGEL NLPPQQDEPHPNRGVMMPKRRQTREQDRADRINAERRERAELNAEQQRQRQAWLADNYEPPPF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5026 | - | - | 100% (483) | hypothetical protein MSMEG_5026 |
| M. smegmatis MC2 155 | MSMEG_3957 | - | 1e-87 | 37.45% (534) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_5106 | - | 2e-51 | 41.27% (315) | HNH endonuclease |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0528 | - | 2e-98 | 44.33% (476) | 13E12 repeat family protein |
| M. gilvum PYR-GCK | Mflv_3596 | - | 1e-147 | 56.01% (466) | hypothetical protein Mflv_3596 |
| M. tuberculosis H37Rv | Rv0515 | - | 2e-98 | 44.33% (476) | 13E12 repeat family protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 2e-84 | 41.12% (484) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_1213 | - | 2e-99 | 42.77% (491) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_4456 | - | 1e-101 | 43.23% (495) | 13e12 repeat-containing protein |
| M. thermoresistible (build 8) | TH_0334 | - | 5e-95 | 50.83% (362) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_2679 | - | 4e-88 | 41.87% (449) | 13e12 repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_3778 | - | 1e-142 | 54.62% (476) | hypothetical protein Mvan_3778 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3596|M.gilvum_PYR-GCK ------------------------------MDAMTSAARCESRAAAERLA
Mvan_3778|M.vanbaalenii_PYR-1 ----------MFAYAE----------PAELIDAMSSAARAESAAIARRLE
MSMEG_5026|M.smegmatis_MC2_155 --MGAGILERMFDGTS----------DAGLIDAIAEAKRQENAATARRLF
TH_0334|M.thermoresistible__bu ----------MFESLD----------DGAVVDSIAAASREQSAACGREML
Mb0528|M.bovis_AF2122/97 --MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAAAQLV
Rv0515|M.tuberculosis_H37Rv --MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAAAQLV
MAV_4456|M.avium_104 ---MCEDATAWFDELMERCYPSATPESAALVQRIGVFARVENRAAAEQLA
MMAR_1213|M.marinum_M MRAQALRPTVSVDQHMIEHVFDTD--SSAPLTRITAAARAEARAAAERLA
MUL_2679|M.ulcerans_Agy99 -----------MDQHIIEYVFDTD--DSAPLTRITAAARAEARAAAERLA
MAB_4752|M.abscessus_ATCC_1997 ----------MFDELG----------DVELIDLIASAQRAEAQACARKLD
: : * : * . .:
Mflv_3596|M.gilvum_PYR-GCK AVASLYRVRK---SMYVEAGLWRTDVFEAVAAEVSAAQNISRWRAGSQVR
Mvan_3778|M.vanbaalenii_PYR-1 AVAALFRSRK---CDYAEAGFLHTDVYEAVAAEVSAAQNISRSRAGYQVE
MSMEG_5026|M.smegmatis_MC2_155 AIGELDTRRA---IDLAECNFWRTDPFEEVCAEVSAALRISRSRANWQVH
TH_0334|M.thermoresistible__bu AIGELYARRAP--EDDTERANWAIDGHANVVAEISAALNISRGRAAGRLQ
Mb0528|M.bovis_AF2122/97 ALGELFAYR---WSRCGGREEWVMDTMAAVAAEVAAALRISQGLAASRLR
Rv0515|M.tuberculosis_H37Rv ALGELFAYR---WSRCGGREEWVMDTMAAVAAEVAAALRISQGLAASRLR
MAV_4456|M.avium_104 AIGELFAYR---LSRCSECEDWAVDTEAAVSAEVAAQLRIGQGLAAAKVR
MMAR_1213|M.marinum_M AIGDLFRLR---LSQHGNREDWVADTCDAVAAEVAAALNTSVAMGHSNLR
MUL_2679|M.ulcerans_Agy99 AIGDLFRLR---LSQHGNREDWVADTCDAVAAEVAAALNTSVAMGHSNLR
MAB_4752|M.abscessus_ATCC_1997 AIGVLVDRHA-DLGKPDERDHHALDRWDRVASEVAAAQGITHALASSQMR
*:. * : * * :*::* . .:.
Mflv_3596|M.gilvum_PYR-GCK MAVSLYERLPQVAEVFYRGDIDQRMVQLTLSRT-ETVDDAIIAELDAALA
Mvan_3778|M.vanbaalenii_PYR-1 MAVSLYTRLPKVAEAFARGDIDLRMVQIVLART-KNVEDDVIGGLDKAIA
MSMEG_5026|M.smegmatis_MC2_155 LARVLRDRIPKVAAVFAQGDIDFRIVTKIATRT-ELVDPAAMPALDDVLA
TH_0334|M.thermoresistible__bu LAIDLRERLPRVAAVFAAGDIDFRMVSALVNRSRNVVDPDLLARLDAALA
Mb0528|M.bovis_AF2122/97 YARAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDAQLA
Rv0515|M.tuberculosis_H37Rv YARAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDAQLA
MAV_4456|M.avium_104 YARAMRERLPRVGEVFRAGEIDFRLFATIVYRTDLITDRRVLAAVDAELA
MMAR_1213|M.marinum_M YARAMRERLPQLGAEFRAGGIDFRLFRTIVFRTDLITDSDALAAVDARLA
MUL_2679|M.ulcerans_Agy99 YARAMRERLPQLGAEFRAGGIDFRLFRTIVFRTDLITESDALAAVDARLA
MAB_4752|M.abscessus_ATCC_1997 YAQVLRHRLRAVAERFAAGDLDFRTVALIINRTELVDDEAVVARVDAAIV
* : *: . * * :. . *: : : :* :.
Mflv_3596|M.gilvum_PYR-GCK RRIVKWMRFSKDKLRDRLDQWVAKFDPAGVRVPPAAKDNRYFDVTP-DVP
Mvan_3778|M.vanbaalenii_PYR-1 PKLSRWMRLSKNDLRDRVDLWVADFDPAAVRVPPEAKDNRYFDVTP-DVP
MSMEG_5026|M.smegmatis_MC2_155 RRCPNWMRLSEPKLEERIDQCILRLDPDGQRVTKRSEDSRYFTVQPADTP
TH_0334|M.thermoresistible__bu AWSPKWMKLSGPTLNERIDMWVERFDPTGVREPRSPGEDRYVVVTP-AGQ
Mb0528|M.bovis_AF2122/97 ANVARWPSMTKARLAGQVDKIVARADADAVRRRKEYQAQRQFWVGE-SQD
Rv0515|M.tuberculosis_H37Rv ANVARWPSMTKARLAGQVDKIVARADADAVRRRKEYQAQRQFWVGE-SQD
MAV_4456|M.avium_104 ATAARWPSMTRARLAARVDAVVAKADADAVRRTEKQAASRHVWIAE-MGE
MMAR_1213|M.marinum_M IKAPRWPSMTSWKLATEVDRVVAKFDRDAVRRSRRDAADRYVDCAP-LEP
MUL_2679|M.ulcerans_Agy99 IKAPRWPSMTSWKLATEVDRVVAKFDRDAVRRSRRDAADRYVDCAP-LEP
MAB_4752|M.abscessus_ATCC_1997 RALPRWARWSHKRITAALDALVLHFDQDAVRRNRSATDKRHLEIRP-LGN
.* : : :* : * . * .* .
Mflv_3596|M.gilvum_PYR-GCK G--MAFAGGVLTARDAAALDQRLEAMADTVCANDPRTWNQRRADAAGALG
Mvan_3778|M.vanbaalenii_PYR-1 G--MAFAGGLLNARDAAALDQRLEAIAATVCSNDPRSHNNLRADAAGALG
MSMEG_5026|M.smegmatis_MC2_155 G--MANAQGYLPAHDAAGFDKRLDAIAATVCPNDPRTPDQRRADALGALG
TH_0334|M.thermoresistible__bu G--MVDVSARLTFEAGFAFXTRLDQIAATVCRDDPRTADQRRADAMAAMS
Mb0528|M.bovis_AF2122/97 G--VCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADALGALA
Rv0515|M.tuberculosis_H37Rv G--VCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADALGALA
MAV_4456|M.avium_104 G--LSHLEGTVSSPDAHALDKRLDALAATVCEHDPRTGEQRRADALGALA
MMAR_1213|M.marinum_M G--MALVNGQVFAATAEALARRLDELAKTVCADDPRTVVQRRADALGTLA
MUL_2679|M.ulcerans_Agy99 G--MALVNRQVFSATAEALARRLDELAKTVCADDPRTVVQRRADALGTLA
MAB_4752|M.abscessus_ATCC_1997 GEPVAEVWGTLQAVHAVALDKRLDLLAGTVCPADPRSKTQRRADAVGALT
* : : . .: **. :* *** ***: : **** .::
Mflv_3596|M.gilvum_PYR-GCK RGEATLACQCGGDDCPAVALRESAAKVVIHILAEQATVEGRSDDPGYLS-
Mvan_3778|M.vanbaalenii_PYR-1 RGESTLTCECGAEDCPAAVLRESAAQVVIHILAEQATVDGDGDKAGYLP-
MSMEG_5026|M.smegmatis_MC2_155 RYRDTLDCQCGREDCTAVAERDAVNNAMIHVLAEQSTLDG-GNEPGYLP-
TH_0334|M.thermoresistible__bu EGQNRLVCGCGSEDCPADPADTAATRLVINVIAEQATVEGRSDNPGYLP-
Mb0528|M.bovis_AF2122/97 GGADRLGCGCGRADCAAGKRPAAPP-VVIHLIAEAATINGTGSAPASQMN
Rv0515|M.tuberculosis_H37Rv GGADRLGCGCGRADCAAGKRPAAPP-VVIHLIAEAATINGTGSAPASQMN
MAV_4456|M.avium_104 AGADRLGCRCGRADCAAGTRPAAGP-VVIHLIAERASVEGTGGGPAVEVG
MMAR_1213|M.marinum_M AGQDRLICDCGRTDCPAAGAPQQPSRVVIHVVAGRETVDGAGEAPGVLP-
MUL_2679|M.ulcerans_Agy99 AGQDRLICDCGRTDCPAAGAPQQPSRVVIHVVAGCQTVDGAGEAPGVLP-
MAB_4752|M.abscessus_ATCC_1997 QGLNRMRCACGHPDCSG--RDTADVPVVVNVVINQSTLAGSDDCPAHVP-
: * ** **.. ::::: :: * . ..
Mflv_3596|M.gilvum_PYR-GCK GFGVLPAEEVRAAARTAKLVPVSQPG-TEPETGYKPSAKLRDYLRWRDLT
Mvan_3778|M.vanbaalenii_PYR-1 GFGVLPAEEVRAAAKTAKLKPVRLPG-AEPEKGYRPSAGLKDFLQWRDLT
MSMEG_5026|M.smegmatis_MC2_155 GFGMLPAHMVREVAKTATTKPVTIPK-DKAQSGYRPNAELTEFIRWRDLT
TH_0334|M.thermoresistible__bu GYGAVPASILRAKAATATLRPVALPQ-PCAEAGYRPSAALTRFIRCRDLT
Mb0528|M.bovis_AF2122/97 ADGLITAELVAELAKTATLVPLVHPGDAPPEPGYAPSKALADFVRCRDLT
Rv0515|M.tuberculosis_H37Rv ADGLITAELVAELAKTATLVPLVHPGDAPPEPGYAPSKALADFVRCRDLT
MAV_4456|M.avium_104 AEGLLPAQLVAELAASARLMPLVHPADAPPENRYTPSAALADFVRCRDLT
MMAR_1213|M.marinum_M GDGIIPAEIVRELAKSAKLQPMSTP--ILAETGYVPSPALMDFVRARDLT
MUL_2679|M.ulcerans_Agy99 GDGIIPAEIVRELAKSAKLQPMSTP--ILAETGYVPSPALMDFVRARDLT
MAB_4752|M.abscessus_ATCC_1997 GFGVLAAESARAAVAGTPTRNLTDS----RSTGYRPSAKLAAFVRSRDQL
. * :.* . : : . . * *. * ::: **
Mflv_3596|M.gilvum_PYR-GCK CRFPGCDAPVEGCDVDHTTPWPFG-VTHASGTKHYCRTHHLIKTFYGGPS
Mvan_3778|M.vanbaalenii_PYR-1 CRFPGCDAPVERCDVDHTTRWPFG-VTHASGLKHYCRTHHVIKTFLTGVY
MSMEG_5026|M.smegmatis_MC2_155 CRFPGCDAPAMAADIDHTRPYPQG-PTHPSNTKLYCRTHHLIKTFYTGPN
TH_0334|M.thermoresistible__bu CRFPGCDAPAAVCQIDHTIPYPAG-PTHPSNLKLLCVFHCRQAELR----
Mb0528|M.bovis_AF2122/97 CRWPGCDEPATNCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFWG---
Rv0515|M.tuberculosis_H37Rv CRWPGCDEPATNCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFWG---
MAV_4456|M.avium_104 CRWPGCDRPATECDLDHTIPYAEGGPTHASNLKCYCRTHHLVKTFWG---
MMAR_1213|M.marinum_M CRAPGCDRPATQCDVDHTIPYSDGGATHPSNLKCLCRKHHLLKTFWG---
MUL_2679|M.ulcerans_Agy99 CRAPGCDRPATQCDVDHTIPYSDGGATHPSNLKCLCRKHHLLKTFWG---
MAB_4752|M.abscessus_ATCC_1997 CRFPGCEAVADRADIDHTVPWATGGPTTGANLKALCRKHHLLKTFGQ---
** ***: . .::*** :. * * :. * * * :
Mflv_3596|M.gilvum_PYR-GCK GWRDAQSPDGTVVVIAPTGHVYSTEAHGAGLFPKLAEPTAPLPPPTSTQE
Mvan_3778|M.vanbaalenii_PYR-1 GWRDEQRRDGTVVLTAPTGHVYTTEPLGGLLFPTLATPTAPLPDVEVPED
MSMEG_5026|M.smegmatis_MC2_155 GWTDRQLPDGTIEFTAPTGHIYTTEPQGAALFPVLGTPTGELNLPPQQDE
TH_0334|M.thermoresistible__bu -FTHDQHKHQSSCLPA-----YFQRPHG-----------------PATRR
Mb0528|M.bovis_AF2122/97 -WRDQQLPDGTLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPP
Rv0515|M.tuberculosis_H37Rv -WRDQQLPDGTLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPP
MAV_4456|M.avium_104 -WREQQLPDATLILTSPAGRTYVTTPGSALLFPSLCVPTG-EPARPVAAG
MMAR_1213|M.marinum_M -WHDKQLPDATVIWSLPDGQTYVTTPGSAWLLPGLFAPSPELPPPARKPQ
MUL_2679|M.ulcerans_Agy99 -WHDEQLPDATVIWSLPDGQTYVTTPGSAWLLPGLFAPSPELPPPPR---
MAB_4752|M.abscessus_ATCC_1997 -WTELQEPDGTVIWKSPTGHRYATTPVSWFLFPALT--------------
: . * . : * . .
Mflv_3596|M.gilvum_PYR-GCK P---SDKSAMMPRRKRTREQDRRARIERERRQRIELDAEE---------E
Mvan_3778|M.vanbaalenii_PYR-1 D---PDKAAMMPRR-RTREQERRARIARERRQRIEINAER---------E
MSMEG_5026|M.smegmatis_MC2_155 PH--PNRGVMMPKRRQTREQDRADRINAERRERAELNAEQ---------Q
TH_0334|M.thermoresistible__bu P----------PSARGLREAVPRQGVDPRR-----VSGQ-----------
Mb0528|M.bovis_AF2122/97 YDHCDQRTAMMPKRRRTRAQDRAYRIATERRQNHAARQRAQVLTQTAAAT
Rv0515|M.tuberculosis_H37Rv YDHCDQRTAMMPKRRRTRAQDRAYRIATERRQNHAARQRAQVLTQTAAAT
MAV_4456|M.avium_104 SQPCGERTAMMPTRRRTRGQNRAARVAAERRANRAAR-LARATRPAPAAS
MMAR_1213|M.marinum_M -DHCGNRDAMMPKRARTRAQSSAARIAAERNHNMTSRQARRRRWEECYFG
MUL_2679|M.ulcerans_Agy99 ------------------SEATGSLRKPRRDDAQTRPNSRPK------LG
MAB_4752|M.abscessus_ATCC_1997 -------------RHHTRQQARDRRRRTERNLNREQR-----------LQ
.*
Mflv_3596|M.gilvum_PYR-GCK RQRQAWLAETYEPPPF
Mvan_3778|M.vanbaalenii_PYR-1 RQHQAWLAATYEPPPF
MSMEG_5026|M.smegmatis_MC2_155 RQRQAWLADNYEPPPF
TH_0334|M.thermoresistible__bu ----------------
Mb0528|M.bovis_AF2122/97 DTHGPPPDHNDDPPPF
Rv0515|M.tuberculosis_H37Rv DTHGPPPDHNDDPPPF
MAV_4456|M.avium_104 QSWPAGHGPDADPPPF
MMAR_1213|M.marinum_M PRDASASDDEEPPPF-
MUL_2679|M.ulcerans_Agy99 RTHCDRTQPQHD----
MAB_4752|M.abscessus_ATCC_1997 REAALAALAAKDPPPF