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MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAAAQLVALGELFAYRWSRCGGREEWVMD TMAAVAAEVAAALRISQGLAASRLRYARAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAV DAQLAANVARWPSMTKARLAGQVDKIVARADADAVRRRKEYQAQRQFWVGESQDGVCQIGGSLLAVDAHA LDARLSALAGTVCEHDPRSREQRRADALGALAGGADRLGCGCGRADCAAGKRPAAPPVVIHLIAEAATIN GTGSAPASQMNADGLITAELVAELAKTATLVPLVHPGDAPPEPGYAPSKALADFVRCRDLTCRWPGCDEP ATNCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFWGWRDQQLPDGTLILTSPSGHTYVSTPGSALLFP SLCHFSGGIPAPEADPPYDHCDQRTAMMPKRRRTRAQDRAYRIATERRQNHAARQRAQVLTQTAAATDTH GPPPDPNDDPPPF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0336 | - | - | 100% (503) | CONSERVED 13E12 REPEAT FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv0515 | - | 0.0 | 99.80% (503) | 13E12 repeat family protein |
| M. tuberculosis H37Rv | Rv0393 | - | e-113 | 60.98% (346) | 13E12 repeat family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0528 | - | 0.0 | 99.80% (503) | 13E12 repeat family protein |
| M. gilvum PYR-GCK | Mflv_1180 | - | 1e-99 | 40.42% (522) | hypothetical protein Mflv_1180 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 2e-83 | 40.21% (470) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_5187 | - | 0.0 | 73.17% (492) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_4456 | - | 0.0 | 66.93% (499) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_5026 | - | 3e-98 | 44.33% (476) | hypothetical protein MSMEG_5026 |
| M. thermoresistible (build 8) | TH_0334 | - | 5e-73 | 43.54% (356) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_1813 | - | 1e-126 | 52.98% (453) | 13e12 repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0728 | - | 1e-101 | 41.15% (520) | hypothetical protein Mvan_0728 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5026|M.smegmatis_MC2_155 MGAGILER--MFDGTSD---------------AGLIDAIAEAKRQENAAT
TH_0334|M.thermoresistible__bu ----------MFESLDD---------------GAVVDSIAAASREQSAAC
Mflv_1180|M.gilvum_PYR-GCK MFDNLVPEPAALAGLSD---------------AELVDAAGAAARAENAVC
Mvan_0728|M.vanbaalenii_PYR-1 MFDVLVPDPADLAALSD---------------AELLDAATATTRAENAVC
Rv0336|M.tuberculosis_H37Rv --MPSPEAIAHFDERFECHAPR-----TTRVSAAFIDRICSATRAENRAA
Mb0528|M.bovis_AF2122/97 --MPSPEAIAHFDERFECHAPR-----TTRVSAAFIDRICSATRAENRAA
MMAR_5187|M.marinum_M -MFESMGVAAGVDHPCDALAERRQLRTPTAESARWVQRIGAAARAENRAA
MAV_4456|M.avium_104 ---MCEDATAWFDELMERCYPS-----ATPESAALVQRIGVFARVENRAA
MUL_1813|M.ulcerans_Agy99 -----------------------------------MERAREASRREAAAA
MAB_4752|M.abscessus_ATCC_1997 ----------MFDELGD---------------VELIDLIASAQRAEAQAC
:: * : .
MSMEG_5026|M.smegmatis_MC2_155 ARRLFAIGELDTRRA-IDLAE-CNFWRTDPFEEVCAEVSAALRISRSRAN
TH_0334|M.thermoresistible__bu GREMLAIGELYARRAPEDDTE-RANWAIDGHANVVAEISAALNISRGRAA
Mflv_1180|M.gilvum_PYR-GCK ARKLAVMAELFTRRVDLAPED-RLNWWVDPDAAVAAEIAAAVTITQGLAT
Mvan_0728|M.vanbaalenii_PYR-1 ARKLAVMAELFIRRTTLAPQD-RLDWWVDPEAAVTAELAAAHHITQGLAT
Rv0336|M.tuberculosis_H37Rv AAQLVALGELFAYR--WSRCGGREEWVMDTMAAVAAEVAAALRISQGLAA
Mb0528|M.bovis_AF2122/97 AAQLVALGELFAYR--WSRCGGREEWVMDTMAAVAAEVAAALRISQGLAA
MMAR_5187|M.marinum_M AAQLIEIGQLFAYR--LSRCSETEDWAVDTMEAVAAEVAAGLRISQGLAA
MAV_4456|M.avium_104 AEQLAAIGELFAYR--LSRCSECEDWAVDTEAAVSAEVAAQLRIGQGLAA
MUL_1813|M.ulcerans_Agy99 AERLDVVGALFVLR--CRESGDRAEWATDTWEAVGAQVAAALRTSVAMGS
MAB_4752|M.abscessus_ATCC_1997 ARKLDAIGVLVDRHADLGKPDERDHHALDRWDRVASEVAAAQGITHALAS
. .: :. * : * * ::::* . .
MSMEG_5026|M.smegmatis_MC2_155 WQVHLARVLRDRIPKVAAVFAQGDIDFRIVTKIATRT-ELVDPAAMPALD
TH_0334|M.thermoresistible__bu GRLQLAIDLRERLPRVAAVFAAGDIDFRMVSALVNRSRNVVDPDLLARLD
Mflv_1180|M.gilvum_PYR-GCK HQTYRAVVLRDRLPKVGALFLAGLLSELLVRAIITRTDLITDPELIAAVD
Mvan_0728|M.vanbaalenii_PYR-1 HQAYRAVVLRDRLPKIGALFLQGLLSELLVRAIITRTGLITDPDLIAAVD
Rv0336|M.tuberculosis_H37Rv SRLRYARAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVD
Mb0528|M.bovis_AF2122/97 SRLRYARAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVD
MMAR_5187|M.marinum_M SRLRYARALRERLPKTGAVFAAGQIDLRAFQTIVFRTDLIVDPQVMAAVD
MAV_4456|M.avium_104 AKVRYARAMRERLPRVGEVFRAGEIDFRLFATIVYRTDLITDRRVLAAVD
MUL_1813|M.ulcerans_Agy99 SYLRYAMAMRNRLPKVGQAFRAEDIDYRAFQTIVFRTDLITDAEVLAKVD
MAB_4752|M.abscessus_ATCC_1997 SQMRYAQVLRHRLRAVAERFAAGDLDFRTVALIINRTELVDDEAVVARVD
* :*.*: . * :. . : *: : * :. :*
MSMEG_5026|M.smegmatis_MC2_155 DVLARRCPNWMRLSEPKLEERIDQCILRLDPDGQRVTKRSEDSRYFTVQ-
TH_0334|M.thermoresistible__bu AALAAWSPKWMKLSGPTLNERIDMWVERFDPTGVREPRSPGEDRYVVVT-
Mflv_1180|M.gilvum_PYR-GCK ADLAADILRWGPQSAKKTEAAIDHIVERHDPDAVRQSRAGDLDRAIEIGN
Mvan_0728|M.vanbaalenii_PYR-1 ADLATDILDWGPLSVKATEAEIDAIIDRHDPDAVRKSRAPETGRTVQFGN
Rv0336|M.tuberculosis_H37Rv AQLAANVARWPSMTKARLAGQVDKIVARADADAVRRRKEYQAQRQFWVGE
Mb0528|M.bovis_AF2122/97 AQLAANVARWPSMTKARLAGQVDKIVARADADAVRRRKEYQAQRQFWVGE
MMAR_5187|M.marinum_M ALVALNVGRWPSMTKARLSGQIDAIVARADADAVRRRKERHADREIWIGQ
MAV_4456|M.avium_104 AELAATAARWPSMTRARLAARVDAVVAKADADAVRRTEKQAASRHVWIAE
MUL_1813|M.ulcerans_Agy99 AQLAALLARCPAVTRGRLSVAVDQVVADVDRDVVRRVAEAADGRFVDVDV
MAB_4752|M.abscessus_ATCC_1997 AAIVRALPRWARWSHKRITAALDALVLHFDQDAVRRNRSATDKRHLEIRP
:. : :* : * * * . .
MSMEG_5026|M.smegmatis_MC2_155 PADTPGMANAQGYLPAHDAAGFDKRLDAIAATVCPNDPRTPDQRRADALG
TH_0334|M.thermoresistible__bu PAG-QGMVDVSARLTFEAGFAFXTRLDQIAATVCRDDPRTADQRRADAMA
Mflv_1180|M.gilvum_PYR-GCK PGDAPGYTTVWARMFAGDAAAGQRTLTAMAYSVCDNDPRTLDERRNDALT
Mvan_0728|M.vanbaalenii_PYR-1 PGDAPGYTSMWARMYASDAAAADRTLTALAYSVCDNDPRTLDERRNDAHT
Rv0336|M.tuberculosis_H37Rv SQDG--VCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADALG
Mb0528|M.bovis_AF2122/97 SQDG--VCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADALG
MMAR_5187|M.marinum_M DADG--ISRIDGSMFTIDAHALDRRLSALAATVCAQDPRSREQRRADALG
MAV_4456|M.avium_104 MGEG--LSHLEGTVSSPDAHALDKRLDALAATVCEHDPRTGEQRRADALG
MUL_1813|M.ulcerans_Agy99 IADGSGLAALAGSVLATAGRAFDRRLDELANTVCAADPRTREQRRADAVG
MAB_4752|M.abscessus_ATCC_1997 LGNGEPVAEVWGTLQAVHAVALDKRLDLLAGTVCPADPRSKTQRRADAVG
. : . . * :* :** ***: :** **
MSMEG_5026|M.smegmatis_MC2_155 ALGRYRDTLDCQCGREDCTAVAERDAVNNAMIHVLAEQSTLD--------
TH_0334|M.thermoresistible__bu AMSEGQNRLVCGCGSEDCPADPADTAATRLVINVIAEQATVE--------
Mflv_1180|M.gilvum_PYR-GCK ALFHGITTLACRCGHTDCDAATNPRPPRELTVYALTDQTTADSASEEPRG
Mvan_0728|M.vanbaalenii_PYR-1 ALLTGITTLACQCGNPDCHASTNPRPPRDITVYALTDHTTTT--------
Rv0336|M.tuberculosis_H37Rv ALAGGADRLGCGCGRADCAAGKRPAAPP-VVIHLIAEAATIN--------
Mb0528|M.bovis_AF2122/97 ALAGGADRLGCGCGRADCAAGKRPAAPP-VVIHLIAEAATIN--------
MMAR_5187|M.marinum_M VLAAGGDRLGCRCGLPDCAAGARPAAQP-VVIHVIAERATLD--------
MAV_4456|M.avium_104 ALAAGADRLGCRCGRADCAAGTRPAAGP-VVIHLIAERASVE--------
MUL_1813|M.ulcerans_Agy99 ALVAGSDRLACGCTSADCTAAARSAPSK-VVIHVVADQSTVD--------
MAB_4752|M.abscessus_ATCC_1997 ALTQGLNRMRCACGHPDCSG-RDTADVP-VVVNVVINQSTLA--------
.: : * * ** . : : : ::
MSMEG_5026|M.smegmatis_MC2_155 ----------------------GGNE-------PGYLPGFG-MLPAHMVR
TH_0334|M.thermoresistible__bu ----------------------GRSDN------PGYLPGYG-AVPASILR
Mflv_1180|M.gilvum_PYR-GCK DATDADASAGDAQPATPTAPKPRRSKPTLLPGRSGYLFGSG-FMSAPLFD
Mvan_0728|M.vanbaalenii_PYR-1 DTGDADTTT-DTKPPTPPAPQPRRSKPILIPGRPAYLFGAG-FMPAPLFD
Rv0336|M.tuberculosis_H37Rv ----------------------GTGSA------PASQMNADGLITAELVA
Mb0528|M.bovis_AF2122/97 ----------------------GTGSA------PASQMNADGLITAELVA
MMAR_5187|M.marinum_M ----------------------GDGGA------PAWEVGADGLVTPELVA
MAV_4456|M.avium_104 ----------------------GTGGG------PAVEVGAEGLLPAQLVA
MUL_1813|M.ulcerans_Agy99 ----------------------GTGHT------PAVLLGAEGLIPASLIA
MAB_4752|M.abscessus_ATCC_1997 ----------------------GSDDC------PAHVPGFG-----VLAA
. .. . :
MSMEG_5026|M.smegmatis_MC2_155 EVAKTATTKPVTIPK--DKAQSGYRPNAELTEFIRWRDLTCRFPGCDAPA
TH_0334|M.thermoresistible__bu AKAATATLRPVALPQ--PCAEAGYRPSAALTRFIRCRDLTCRFPGCDAPA
Mflv_1180|M.gilvum_PYR-GCK ALLDGAKIREIIHPG-QAGPEPRYTPSTALADFIRCRDLTCRFPGCDTPA
Mvan_0728|M.vanbaalenii_PYR-1 ALLAEATIREIIHPGNRSAPEPRYTPSQALAEFIRCRDLTCRFPGCDKPA
Rv0336|M.tuberculosis_H37Rv ELAKTATLVPLVHPG-DAPPEPGYAPSKALADFVRCRDLTCRWPGCDEPA
Mb0528|M.bovis_AF2122/97 ELAKTATLVPLVHPG-DAPPEPGYAPSKALADFVRCRDLTCRWPGCDEPA
MMAR_5187|M.marinum_M ELAKSAKLVPLRHPG-DVPPEPGYVPSKALADFVRCRDLTCRWPGCDHPA
MAV_4456|M.avium_104 ELAASARLMPLVHPA-DAPPENRYTPSAALADFVRCRDLTCRWPGCDRPA
MUL_1813|M.ulcerans_Agy99 ELAKVATLRPLMRPS-GRP-ESGYAPSAGLAEFVRCRDLTCRARGCDQPA
MAB_4752|M.abscessus_ATCC_1997 ESARAAVAGTPTRNL-TDSRSTGYRPSAKLAAFVRSRDQLCRFPGCEAVA
* . * *. *: *:* ** ** **: *
MSMEG_5026|M.smegmatis_MC2_155 MAADIDHTRPYPQG-PTHPSNTKLYCRTHHLIKTFYTGPNGWTDRQLPDG
TH_0334|M.thermoresistible__bu AVCQIDHTIPYPAG-PTHPSNLKLLCVFH-----------------CRQA
Mflv_1180|M.gilvum_PYR-GCK TEADIDHTVAHPVG-PTHASNLKCLCRFHHLLKTFWTGPGGWHDRQHPDG
Mvan_0728|M.vanbaalenii_PYR-1 TEADIDHTVPYPIG-PTHPSNLKCLCRFHHLLKTFWLGATGWHDRQHPDG
Rv0336|M.tuberculosis_H37Rv TNCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFWG----WRDQQLPDG
Mb0528|M.bovis_AF2122/97 TNCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFWG----WRDQQLPDG
MMAR_5187|M.marinum_M LNCDLDHTIPYAQGGPTHASNLKCYCRTHHLVKTFWG----WHDQQLPDG
MAV_4456|M.avium_104 TECDLDHTIPYAEGGPTHASNLKCYCRTHHLVKTFWG----WREQQLPDA
MUL_1813|M.ulcerans_Agy99 VCCDLDHTVAYGDGGHTHASNLKCLCRKHHLLKTFWG----WRDLQLPDG
MAB_4752|M.abscessus_ATCC_1997 DRADIDHTVPWATGGPTTGANLKALCRKHHLLKTFGQ----WTELQEPDG
.::*** . * * :* * * * :.
MSMEG_5026|M.smegmatis_MC2_155 TIEFTAPTGHIYTTEPQGAALFPVLGTPTGELNLPPQQDE----------
TH_0334|M.thermoresistible__bu ELRFTHDQ-----HKHQSSCLPAYFQRPHG-----PATRR----------
Mflv_1180|M.gilvum_PYR-GCK TITWTSPTGHTYITHPGSRLLFPTLCKPTATLWTGNPPQN----------
Mvan_0728|M.vanbaalenii_PYR-1 TITWTAPTGHTYTTHPGSRLLFPTLCQPTATLWTGEPPQV----------
Rv0336|M.tuberculosis_H37Rv TLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPP----------
Mb0528|M.bovis_AF2122/97 TLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPP----------
MMAR_5187|M.marinum_M TLILTSPAGHTYVTTPGSALLFPSLCHSTGGLPAAEADPP----------
MAV_4456|M.avium_104 TLILTSPAGRTYVTTPGSALLFPSLCVPTG-EPARPVAAG----------
MUL_1813|M.ulcerans_Agy99 TVIWLLPDGHTYVTTPGSALLFPNLCVPTGELPPIVGTAGKPPRWPSGED
MAB_4752|M.abscessus_ATCC_1997 TVIWKSPTGHRYATTPVSWFLFPALT------------------------
: . * . :
MSMEG_5026|M.smegmatis_MC2_155 PHPN-------------RGVMMP-----KRRQTR-------EQDRADRIN
TH_0334|M.thermoresistible__bu PPSA-------------RGLREA-----VPRQGV-------D---PRRVS
Mflv_1180|M.gilvum_PYR-GCK PTNNN------------RGSMMP-----RRTRTR-------AQNRATYIT
Mvan_0728|M.vanbaalenii_PYR-1 PQSQQ------------RGAMMP-----RRRNTR-------AHNHAAYIT
Rv0336|M.tuberculosis_H37Rv YDHCD-----------QRTAMMP-----KRRRTR-------AQDRAYRIA
Mb0528|M.bovis_AF2122/97 YDHCD-----------QRTAMMP-----KRRRTR-------AQDRAYRIA
MMAR_5187|M.marinum_M SDHCD-----------QRSAMMP-----RRQRTR-------AQDRARRVA
MAV_4456|M.avium_104 SQPCG-----------ERTAMMP-----TRRRTR-------GQNRAARVA
MUL_1813|M.ulcerans_Agy99 ADPCPNPRTKPGESHRHRAPMQSQGTGSRRRRPRRPVRHPGAGNRSRRAA
MAB_4752|M.abscessus_ATCC_1997 -----------------------------RHHTR-------QQARDRRRR
.
MSMEG_5026|M.smegmatis_MC2_155 AERRER-----AELNAEQQRQRQAWLADN----------------YEPPP
TH_0334|M.thermoresistible__bu GQ------------------------------------------------
Mflv_1180|M.gilvum_PYR-GCK AERTRN-----AAHRTDS--------PR----------------GNDPPP
Mvan_0728|M.vanbaalenii_PYR-1 AERRRN-----AQTRYATTGNTPPYLPRDHIPYQSSTGWREPDYGNDPPP
Rv0336|M.tuberculosis_H37Rv TERRQN-----HAARQRAQVLTQTAAATDTHGP-------PPDPNDDPPP
Mb0528|M.bovis_AF2122/97 TERRQN-----HAARQRAQVLTQTAAATDTHGP-------PPDHNDDPPP
MMAR_5187|M.marinum_M TERRQN-----HHARS-TQPGGQPRSAAPPTPP-------QSEPQSHPPP
MAV_4456|M.avium_104 AERRAN-----RAARL-ARATRPAPAASQSWPA-------GHGPDADPPP
MUL_1813|M.ulcerans_Agy99 ALLAATSLGTCQIPRRIAPRPGPSRSSRGCTDSGTRMG--ESSMSARPRA
MAB_4752|M.abscessus_ATCC_1997 TERNLN-----REQRLQREAALAALAAK------------------DPPP
MSMEG_5026|M.smegmatis_MC2_155 F---
TH_0334|M.thermoresistible__bu ----
Mflv_1180|M.gilvum_PYR-GCK F---
Mvan_0728|M.vanbaalenii_PYR-1 F---
Rv0336|M.tuberculosis_H37Rv F---
Mb0528|M.bovis_AF2122/97 F---
MMAR_5187|M.marinum_M F---
MAV_4456|M.avium_104 F---
MUL_1813|M.ulcerans_Agy99 CVAG
MAB_4752|M.abscessus_ATCC_1997 F---