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ARSIPADRFSAIVAASARVFIAHGYQRTQVQDVADALALAKGTLYGYAQGKAALFAAAVRYGDAQEALPL ASELPVAAPVAGEIAAVVSARLAGEVTDMRLTHALRATLPPGATTGDARAELAGIVTDLYSRLARHRIAL KLVDRCAPELPDLAEVWFGTGRNAQVDAVQAYLVHRERAGLLILPGPAPMVARTIVELCALWAVHLHFDP SPEPWSIVQPGVIDDDAIAATLAEFVVRATTASSD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0330c | - | - | 100% (246) | hypothetical protein Rv0330c |
| M. tuberculosis H37Rv | Rv1534 | - | 2e-07 | 26.29% (232) | transcriptional regulator |
| M. tuberculosis H37Rv | Rv1963c | mce3R | 1e-05 | 27.08% (96) | transcriptional repressor (probably TETR-family) MCE3R |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0337c | - | 1e-137 | 100.00% (246) | hypothetical protein Mb0337c |
| M. gilvum PYR-GCK | Mflv_0013 | - | 1e-07 | 39.29% (56) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00717 | - | 2e-05 | 29.87% (77) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4574c | - | 2e-05 | 34.29% (70) | TetR family transcriptional regulator |
| M. marinum M | MMAR_2873 | mce3R | 9e-06 | 27.08% (96) | TetR family transcriptional regulator |
| M. avium 104 | MAV_0474 | - | 3e-06 | 32.14% (140) | TetR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_0815 | - | 1e-05 | 28.72% (94) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_4573 | - | 7e-07 | 31.71% (82) | PUTATIVE putative transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_2880 | mce3R | 2e-06 | 30.09% (113) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_3994 | - | 1e-07 | 30.32% (155) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0013|M.gilvum_PYR-GCK -------------MAVRKKPTRARG---AGRSVRVCRMAASVGVRD----
MSMEG_0815|M.smegmatis_MC2_155 MHAPENSSTGQGAMALRNDTTASRLSMLRGWSMCVLDQMTPTYVNDRSPW
MMAR_2873|M.marinum_M --------------------------------------------------
MUL_2880|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3994|M.vanbaalenii_PYR-1 --------------------------------------------------
Rv0330c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0337c|M.bovis_AF2122/97 --------------------------------------------------
MAV_0474|M.avium_104 -------------MFPLRDRLAAELPFDSG--------------------
MLBr_00717|M.leprae_Br4923 --------------------------------------------------
MAB_4574c|M.abscessus_ATCC_199 -------------MQPVPEAS-----------------------------
TH_4573|M.thermoresistible__bu --------------------------------------------------
Mflv_0013|M.gilvum_PYR-GCK ------------------------------ARRRPKDRKQQIARASAEAF
MSMEG_0815|M.smegmatis_MC2_155 VRAFDRIGGPVYRDHMARTPLGPTTSGSVAVRRRPKDRKAQIARASAEAF
MMAR_2873|M.marinum_M -----------------------MDSVVAPVRRRPKDRKQQILEQAVGLF
MUL_2880|M.ulcerans_Agy99 -----------------------MDSVVAPVRRRPKDRKQQILEQAVGLF
Mvan_3994|M.vanbaalenii_PYR-1 -----------------------------MVRRRPKDRKQQILDQAVRLF
Rv0330c|M.tuberculosis_H37Rv -----------------------------MARSIPADRFSAIVAASARVF
Mb0337c|M.bovis_AF2122/97 -----------------------------MARSIPADRFSAIVAASARVF
MAV_0474|M.avium_104 -----------------------------LRDRNKMRTRLRLNSEAIRLF
MLBr_00717|M.leprae_Br4923 -------------------------MTTARRRLSPEDRRAELLALGAEVF
MAB_4574c|M.abscessus_ATCC_199 --------------------------KAGSSSQRRAGRREELVAVASKLF
TH_4573|M.thermoresistible__bu --------------------MATQRATADVEEQHESDRRDQILEAANACF
: . *
Mflv_0013|M.gilvum_PYR-GCK SELGYHAVSMEDIASRVGVTAASLYRHYSGKYDLFRAAVLNLGEQLVSAT
MSMEG_0815|M.smegmatis_MC2_155 SALGYHGVSMEAIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDCT
MMAR_2873|M.marinum_M IDRGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
MUL_2880|M.ulcerans_Agy99 IDRGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
Mvan_3994|M.vanbaalenii_PYR-1 IDRGFHSVKLEDIAEASGVTARALYRHYDNKQALLAAAIRAGQEQYQSAR
Rv0330c|M.tuberculosis_H37Rv IAHGYQRTQVQDVADALALAKGTLYGYAQGKAALFAAAVRYG--DAQEAL
Mb0337c|M.bovis_AF2122/97 IAHGYQRTQVQDVADALALAKGTLYGYAQGKAALFAAAVRYG--DAQEAL
MAV_0474|M.avium_104 AERGYDDTSVQDIADAAEVSLRTLFRYFSGKDEILFARDYDLSEFFDNLS
MLBr_00717|M.leprae_Br4923 GKRPYDEVRIDEIAERAGVSRALMYHYFPDKRAFFAAVVKDEADRLYAAT
MAB_4574c|M.abscessus_ATCC_199 AARGYHGTRMDDIADVAGLNKATVYHYFASKALILYEIYFKAAEETLACL
TH_4573|M.thermoresistible__bu AQLGIHRTSVQDVARAANVSRGTVYRYFEDRTILIEAAIEYGAQKFYQEI
. . :: :* : :: : .: ::
Mflv_0013|M.gilvum_PYR-GCK AFAD----DESGDSPEELWERIVAALADAAIKTRASGGLYRWEARFLQES
MSMEG_0815|M.smegmatis_MC2_155 AFADTADAPENSEDAREQLRLLAAALTDTSLANRESGGLYRWEARYLNED
MMAR_2873|M.marinum_M RLTE-----GEQEPTPRPLSVDLPDLIAAAVASRSLTVLWQREARYLNDA
MUL_2880|M.ulcerans_Agy99 RLTE-----GEQEPTPRPLSVDLPDLIAAAVASRSLTVLSQREARYLNDA
Mvan_3994|M.vanbaalenii_PYR-1 PPAG-----GEAESPHRALSAELPDLVTAAVASRSLTVLWQREARYLDAA
Rv0330c|M.tuberculosis_H37Rv PLAS-----------ELPVAAPVAGEIAAVVSARLAG-----EVTDMRLT
Mb0337c|M.bovis_AF2122/97 PLAS-----------ELPVAAPVAGEIAAVVSARLAG-----EVTDMRLT
MAV_0474|M.avium_104 ---------------RQPAAVPALHAIRTAYT----------QQRALTRE
MLBr_00717|M.leprae_Br4923 NIPP-------------PAGLTMFEEVRVGVLAYMAYHKQNPEAAWAAYV
MAB_4574c|M.abscessus_ATCC_199 QDDP-------RWSARESLYQCTSRMLALIFSNREQGAVYFQENPFLSEW
TH_4573|M.thermoresistible__bu AAAM-------------AKKSTLAEQLGAMAETHAKILLDHRTRNRLMTD
Mflv_0013|M.gilvum_PYR-GCK DQAISNEQIRLVNRRLQRPLSALRPELDSRQRWTVTASVLSAIGSICDHR
MSMEG_0815|M.smegmatis_MC2_155 DQAALNAQMRTVHHRIQRPLQQLRPELISRERWMLSTATLSVIGSVVDHR
MMAR_2873|M.marinum_M DRIEVRRRINAIVAGMRESVLLEVPGLSPAHSELRAWAVSSTLTSLGRHS
MUL_2880|M.ulcerans_Agy99 DRIEVRRRINAIVAGMRESVLLEVPGLSPAHSELRAWAVSSTLTSLGRHS
Mvan_3994|M.vanbaalenii_PYR-1 ERAEVRRRIHAIVTGIEQSLRVEVPDLSPRHAELRAWAVSSVITSLGRHS
Rv0330c|M.tuberculosis_H37Rv HALRATLPPGATTGDARAELAGIVTDLYSR---------------LARHR
Mb0337c|M.bovis_AF2122/97 HALRATLPPGATTGDARAELAGIVTDLYSR---------------LARHR
MAV_0474|M.avium_104 ETDVILQFRRAVAG--NAALQGRFLDLQHR----------------FRHQ
MLBr_00717|M.leprae_Br4923 G---LGRSDPVLLGIDDEAKNRQMEHIMSR---------------IGDVV
MAB_4574c|M.abscessus_ATCC_199 LSPEQVAEIRTREDMVQERVQNIIERGIASG-------------------
TH_4573|M.thermoresistible__bu DAELMRHMIADADAAVRRTTEFLMPYVQQAK-------------------
Mflv_0013|M.gilvum_PYR-GCK AKLPVNDMRRLLVSLARRLR-DADLPPVSAREKPGRRAAPSVGPAGEYEA
MSMEG_0815|M.smegmatis_MC2_155 GKLPAGQIREVLGEIVESVL-AADLPELPELGAAAAPATTPVVSAAKYEA
MMAR_2873|M.marinum_M LTLPAEELKERLYQACMAAARTPPVCELEPLGTAAGGRDGQDVLFSRYET
MUL_2880|M.ulcerans_Agy99 LTLPAEELKERLYQACMAAARTPPVCELEPLGTAAGGRDGQDVLFSRYET
Mvan_3994|M.vanbaalenii_PYR-1 LTLAKDELHRLLFGACMAVARTPPVGPLEPDVAPP---NDERALFSRHET
Rv0330c|M.tuberculosis_H37Rv IALKLVDR------------------------------------------
Mb0337c|M.bovis_AF2122/97 IALKLVDR------------------------------------------
MAV_0474|M.avium_104 LARALAKR------------------------------------------
MLBr_00717|M.leprae_Br4923 SVVPESKLHP----------------------------------------
MAB_4574c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4573|M.thermoresistible__bu --------------------------------------------------
Mflv_0013|M.gilvum_PYR-GCK ILAAALRLFHEHGFRETGMDDIASAIGLPASTIYRYFSGKSAVLSTIYRR
MSMEG_0815|M.smegmatis_MC2_155 LLNESMRLFNKNGYRDTTMEDIAAAVGMPASGIYRYFSGKADILAAGFRR
MMAR_2873|M.marinum_M LLATGARLFRAQGYPAVSTSEIGKGAGIAGPGLYRSFSSKQAILDALIRR
MUL_2880|M.ulcerans_Agy99 LLATGARLFRAQGYPAVSTSEIGKGAGIAGPGLYRSFSSKQAILDALIRR
Mvan_3994|M.vanbaalenii_PYR-1 LLAAGARLFRAQGYPAVSTSEIGKGVGIAGPGLYRSFSSKQAILDALITR
Rv0330c|M.tuberculosis_H37Rv -----------------------CAPELPDLAEVWFGTGRNAQVDAVQAY
Mb0337c|M.bovis_AF2122/97 -----------------------CAPELPDLAEVWFGTGRNAQVDAVQAY
MAV_0474|M.avium_104 -----------------------AGRRKPTEADEVAAATAQTLLDLAFSR
MLBr_00717|M.leprae_Br4923 --------------------DIERDLRVIVHGWLAFTFEVCRQRIMDPST
MAB_4574c|M.abscessus_ATCC_199 -------------------EFVECDSHVMALGYIGMVLGSYRWLNPSGRR
TH_4573|M.thermoresistible__bu -----------------------ERGEVGSGVDVKAASEWLARIIYSFTT
Mflv_0013|M.gilvum_PYR-GCK AADRVSGDMGAILAMAPD--ERTAVGQLIDAYVWRTFAEPELAYVYYAEQ
MSMEG_0815|M.smegmatis_MC2_155 AADRLSADMAEILAAGGE--PEDVLAALIDDYVTRSFDRPELEHVYYTER
MMAR_2873|M.marinum_M LDEWRSLECIRALRANRQ--AAQRLRGLVEGHVRISLDAPDLVAVCVTEL
MUL_2880|M.ulcerans_Agy99 LDEWRSLECIRALRANRQ--AAQRLRGLVEGHVRISLDAPDLVAVCATEL
Mvan_3994|M.vanbaalenii_PYR-1 LDEWWSLACIRVLRTDTE--AAECLRALVAGRVQISLDDPDLVAMSVTEL
Rv0330c|M.tuberculosis_H37Rv LVHRERAGLLILPGPAPM--VARTIVELCALWAVHLHFDPSPEPWSIVQP
Mb0337c|M.bovis_AF2122/97 LVHRERAGLLILPGPAPM--VARTIVELCALWAVHLHFDPSPEPWSIVQP
MAV_0474|M.avium_104 WTDRGGRGSLAHLVDR----MFATLDEIIGDTGESTVTA-----------
MLBr_00717|M.leprae_Br4923 DADRLADSCAHALLDAIA--RVPEISKELADAMAIARQPPQ---------
MAB_4574c|M.abscessus_ATCC_199 SAQEIAVEFSTTLLRGLIRDEATRINDPLGVASATSLDGAR---------
TH_4573|M.thermoresistible__bu VNEGLTFDMS----------KPATVRRYVERFAVNGLR------------
. :
Mflv_0013|M.gilvum_PYR-GCK LNVPAEDRAALHNIQRSIVEGWARQVVAARPDLSVREARFAVHAGLGLVV
MSMEG_0815|M.smegmatis_MC2_155 LNMTPADQKILRDLQRSAVESWVNVVMPVRPHWSAGQARFAVHAAMALVI
MMAR_2873|M.marinum_M NHASGDVRDGYLRNQADRDTLWIDLIGELVPQTSSVEARLLVAAAISFIE
MUL_2880|M.ulcerans_Agy99 NHASGDVRDGYLRNQADRDTLWIDLIGELVPQTSSVEARLLVAAAISFIE
Mvan_3994|M.vanbaalenii_PYR-1 SFASEEVRDRYMRNQADREAVWIELIGKLVPQTAPAEARLLVGAANSFID
Rv0330c|M.tuberculosis_H37Rv GVIDDDA-------------------------IAATLAEFVVRATTASSD
Mb0337c|M.bovis_AF2122/97 GVIDDDA-------------------------IAATLAEFVVRATTASSD
MAV_0474|M.avium_104 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 --------------------------------------------------
MAB_4574c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4573|M.thermoresistible__bu --------------------------------------------------
Mflv_0013|M.gilvum_PYR-GCK DIGRLERFADTESSRRLIGRLLRVLLLPEHA--------
MSMEG_0815|M.smegmatis_MC2_155 DLGRLMGYRNSEQARAVVSTMVDLVLLGRYRLRTALPAR
MMAR_2873|M.marinum_M DVARTWHLTRYAAVADEITAIALSILTSRS---------
MUL_2880|M.ulcerans_Agy99 DVARTWHLTRYAAVADEITEIALSILTSRS---------
Mvan_3994|M.vanbaalenii_PYR-1 DAVRTWHLTRYAGIADEITAITLSILTSRQ---------
Rv0330c|M.tuberculosis_H37Rv ---------------------------------------
Mb0337c|M.bovis_AF2122/97 ---------------------------------------
MAV_0474|M.avium_104 ---------------------------------------
MLBr_00717|M.leprae_Br4923 ---------------------------------------
MAB_4574c|M.abscessus_ATCC_199 ---------------------------------------
TH_4573|M.thermoresistible__bu ---------------------------------------