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VTVTYSRSMTPSSSTAAAPQLDTSRGERTRSAILDASRRLFLERGYAGTPINAITEACGISRAGFYTYFK DKREIFNVLGKTAYHDALAVIAEWAEAPEPLGPADIRVWVGHYFDYMDQHGAFVLASAHSAPDDDEFRNS RNRMVTRASWKLGQAIAGGGGVHSPDVVGVAVMGLLDRAWHTVHRQTVAVDRSEMIAVVAEMIVAMTRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1852 | - | - | 100% (209) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_2578 | - | 3e-93 | 83.84% (198) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_2546 | - | 8e-32 | 36.32% (190) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0310 | - | 5e-10 | 36.36% (77) | TetR/ACRR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4467 | - | 1e-12 | 33.08% (133) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0302 | - | 5e-10 | 36.36% (77) | TetR/ACRR family transcriptional regulator |
| M. leprae Br4923 | MLBr_01070 | - | 4e-05 | 27.13% (129) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2290 | - | 3e-09 | 52.08% (48) | transcriptional regulator TetR |
| M. marinum M | MMAR_1492 | - | 6e-12 | 30.25% (162) | transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_2071 | - | 2e-11 | 33.61% (122) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_3297 | - | 2e-30 | 38.34% (193) | PUTATIVE transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_2448 | - | 1e-11 | 29.63% (162) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_1893 | - | 1e-12 | 34.71% (121) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1852|M.avium_104 MTVTYSRSMTPSSSTAAAPQLDTSRGERTRSAILDASRRLFLERGYAGTP
TH_3297|M.thermoresistible__bu -----------MDSDAAAPGVRKS--DRTRLTILDAARVAFARKGFSGVT
Mflv_4467|M.gilvum_PYR-GCK ------------MPPGS-SDALSAKGRQTRDALAQAARKLFAERGFHGTT
Mvan_1893|M.vanbaalenii_PYR-1 ------------MPPGP-AESLSAKGRQTRDAIEQAARKLFAERGFHGTT
MMAR_1492|M.marinum_M ------------MPARQESRELSSKGRQTRQAIEQAARKLFAERGFHGTT
MUL_2448|M.ulcerans_Agy99 ------------MPARQESRELSSKGRQTRQAIEQVARKLFAERGFHGTT
MSMEG_2071|M.smegmatis_MC2_155 ----------------MASGELGSKGRQTRTAIELAARKLFAERGFHGTT
Mb0310|M.bovis_AF2122/97 --------------MGVPAKKKQQQGERSRESILDATERLMATKGYAATS
Rv0302|M.tuberculosis_H37Rv --------------MGVPAKKKQQQGERSRESILDATERLMATKGYAATS
MLBr_01070|M.leprae_Br4923 MIVVGNFTQSNYVPASRGRRSSQLSGDDREQAILAVAERLLAERPLGDFS
MAB_2290|M.abscessus_ATCC_1997 -------------MSESKPGRRERYAALTRSAIVEAARMLFVERGFDDTS
. :: .:. : : .
MAV_1852|M.avium_104 INAITEACGISRAGFYTYFKDKREIFNVLGKTAYHDALA-VIAEWAEAPE
TH_3297|M.thermoresistible__bu IRDITDLAGVTRANFYYYFKDKTELFVELGTATYREVLE-VIETFSDTAS
Mflv_4467|M.gilvum_PYR-GCK LSDITSAAGKSPAAFYRYFSDKEDLLAALAESFLHEVVA-PSGLSVPLPE
Mvan_1893|M.vanbaalenii_PYR-1 LGDITSAAGKSPAVFYRYFADKEDLLAALAESFLHDVVA-PSGLSVPLPE
MMAR_1492|M.marinum_M LADITSAAGKSSAVFYRYFTDKEDLLAALAQSFLHDVVT-PSGVSLQLPD
MUL_2448|M.ulcerans_Agy99 LADITSAAGKSSAVFYRYFTDKEDLLAALAQSFLHDVVT-PSGVSLQLPD
MSMEG_2071|M.smegmatis_MC2_155 LADITSAAGKSPAVFYRYFTDKEDLLAALAESFLHDVVE-PSGLNLHLPD
Mb0310|M.bovis_AF2122/97 ISDIRDACGLAPSSIYWHFGSKEGVLAAMMERGAQRFFA-AIPTWDEAHG
Rv0302|M.tuberculosis_H37Rv ISDIRDACGLAPSSIYWHFGSKEGVLAAMMERGAQRFFA-AIPTWDEAHG
MLBr_01070|M.leprae_Br4923 VDELAKGAGISRPTFYFYFPSKNAVLLSLLDDLNMKSRS-AVEALAEQLP
MAB_2290|M.abscessus_ATCC_1997 VDDIAEAAQVSKGAIYHHFKDKQEIFIDVYRDATKGVIENVVKVLIDVPA
: : . . : :* :* .* :: :
MAV_1852|M.avium_104 PLG------PADIRVWVGHYFDYMDQHGAFVLASAHSAPDDDEFRNSRNR
TH_3297|M.thermoresistible__bu ---------PVIIDQWVSRYFTYLDRNGAFVIRSEEDMPQDGAFRTAVAR
Mflv_4467|M.gilvum_PYR-GCK SPDD-----DAFFTAVVTGYWTMFKQNIGIMIAVAQLAATQPRFTLVQNE
Mvan_1893|M.vanbaalenii_PYR-1 SPDD-----DAFFTMVVTGYWTMFKQNIGIMIAVAQLAATQSRFALVQNE
MMAR_1492|M.marinum_M SPDD-----DTFFTAVVTGYWNIFKQNIGIMIAVDQLAATQQRFAAVQNQ
MUL_2448|M.ulcerans_Agy99 SPDD-----DTFFTAVVTGYWNIFKQNIGIMIAVDQLAATQQRFAAVQNQ
MSMEG_2071|M.smegmatis_MC2_155 SPDD-----AEFFTSVVTGYWNMFKQNIGIMIAVAQLAATQQRFAEVQNS
Mb0310|M.bovis_AF2122/97 PVEQRSERQLTELVSLQSQHPDFLRLFYLLSMERSQDPVVAAVVRRVRNT
Rv0302|M.tuberculosis_H37Rv PVEQRSERQLTELVSLQSQHPDFLRLFYLLSMERSQDPAVAAVVRRVRNT
MLBr_01070|M.leprae_Br4923 ADP------AAVWRSAITAFFEVCGTHRAVAVAGAAAKATSPEVRRLWST
MAB_2290|M.abscessus_ATCC_1997 GSWN---RIEAAASAVIKGYTDNREPR--VLVRQVMGVLGAERTQALEGE
. . :
MAV_1852|M.avium_104 MVTR----ASWKLGQAIAGGGG----VHSPDVVGVAVMGLLDRAWHTVHR
TH_3297|M.thermoresistible__bu SHRR----AAQALGQQIAKASSTP-LAADEAATGLVVMAMLERSWLIHHN
Mflv_4467|M.gilvum_PYR-GCK FRRFGMDIVAASVRRAQEQGYGTE-LNPEHTAAAIALLFENFTTVFVGAS
Mvan_1893|M.vanbaalenii_PYR-1 FRRFGMDIVAASVRRAQEQGYGRE-LNAEHTAAAIALLFENFTTVFVGAS
MMAR_1492|M.marinum_M FRRFGMDIIAASVRHAQDQGYGTE-LNPDHTAVAIALLFENFTSVLVGTS
MUL_2448|M.ulcerans_Agy99 FRRFGMDIIAASVRHAQDQGYGTE-LNPDHTAVAIALLFENFTSVLVGTS
MSMEG_2071|M.smegmatis_MC2_155 FRRFGIDIVVASVRRAQEQGHAVG-LVPEHIGAAIALLFENFTTVFVGSS
Mb0310|M.bovis_AF2122/97 AIARFRDSITHLLPSDIPPGKADL-VVAELTAFAVALSDGVYFAGHLEPD
Rv0302|M.tuberculosis_H37Rv AIARFRDSITHLLPSDIPPGKADL-VVAELTAFAVALSDGVYFAGHLEPD
MLBr_01070|M.leprae_Br4923 VMQQWIDYNTAAIQAERKCGVAPDTIPAEDLAVALQLMTERVMAATFSDE
MAB_2290|M.abscessus_ATCC_1997 LALP---LIRTLLTEAEENGELRDLSIEKASQLIFRVLCESSLLIANSAD
: . . . :
MAV_1852|M.avium_104 Q-------TVAVDRSEMIAVVAEMIVAMTRR-------------------
TH_3297|M.thermoresistible__bu G-------VFDAPRDVVLAAASEVIRRLVEDDGRPGTSIQEILPRVSVEP
Mflv_4467|M.gilvum_PYR-GCK G------LGVQMTDQDAIATLSRIWKKTLYGY------------------
Mvan_1893|M.vanbaalenii_PYR-1 G------LDVDIDDEAAIATLSRIWKKTLYGY------------------
MMAR_1492|M.marinum_M GSSGPGGLGVTITDEDAITTLSRIWKKTLYGF------------------
MUL_2448|M.ulcerans_Agy99 GSSGPGGLGVTITDEDAITTLSRIWKKTLYGF------------------
MSMEG_2071|M.smegmatis_MC2_155 G------LGVELDDREAITTLATIWKKTLYGF------------------
Mb0310|M.bovis_AF2122/97 T------TDVERMYRRLRQALEALIPVLLEET------------------
Rv0302|M.tuberculosis_H37Rv T------TDVERMYRRLRQALEALIPVLLEET------------------
MLBr_01070|M.leprae_Br4923 K--------PLIPDKKVIDTLVHIWLASIYGS------------------
MAB_2290|M.abscessus_ATCC_1997 Y-----AEAAQEVETVMLCMFAGLRKPPAATRGRRKS-------------
:
MAV_1852|M.avium_104 ----------------------------------------------
TH_3297|M.thermoresistible__bu QRCRDGTQLEPGRAPAQQALASHRHASGSTWPHRPEVIRATGRTQT
Mflv_4467|M.gilvum_PYR-GCK ----------------------------------------------
Mvan_1893|M.vanbaalenii_PYR-1 ----------------------------------------------
MMAR_1492|M.marinum_M ----------------------------------------------
MUL_2448|M.ulcerans_Agy99 ----------------------------------------------
MSMEG_2071|M.smegmatis_MC2_155 ----------------------------------------------
Mb0310|M.bovis_AF2122/97 ----------------------------------------------
Rv0302|M.tuberculosis_H37Rv ----------------------------------------------
MLBr_01070|M.leprae_Br4923 ----------------------------------------------
MAB_2290|M.abscessus_ATCC_1997 ----------------------------------------------