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VTDFDYIIVGAGSAGCVLAHRLSEDPRVNVLLIEAGGRDRSPMIRIPKGVGKILGDPKLTWHFPVRPIGP SQIVEQWVRGKTLGGSSSVNGMVYNRGSAPDYDALAALGNPAWGWDHILPAFRAIENHELGPDPTRGTGG PLEISVDAHLPRICHDVIAAGEKLGWSATDDVNGSDAARIGPAPRTIRNGQRVSSARAFLHPVAHRPNLT IATDTTVNRILFKADKAIGVQATTSKGGAAVCTAGREVLLSLGSISTPRLLQLSGIGDRSLLRGLGIDTL ADSPNVGRRMREHRCFALQFRLDRPVGYNRQLSTPLRQAFTAARYLATRRGPLAGAAFDVIGFFKTSPEL ERPDAQILMAPFSLAPYEQGKEATVERDPGIQAIGYLLRPDSEGSVAITSSDPEAPLDIDPGFLITTHDR EKGAALFRTMRRLFSQSPVADHLVAETRPGADVSSDQAIIDAALTQGYCGYHAIGTCAMGPEDDDVVDSA LRVRGVRNLRIMDCSVMPTMVSGNLNGPVMAMAWRASDLILSGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5894 | - | - | 100% (534) | glucose-methanol-choline oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_2938 | - | 7e-71 | 34.09% (572) | glucose-methanol-choline oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_0327 | - | 4e-61 | 31.84% (537) | glucose-methanol-choline oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1310 | - | 4e-77 | 36.04% (541) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1255 | - | 1e-180 | 57.22% (533) | glucose-methanol-choline oxidoreductase |
| M. tuberculosis H37Rv | Rv1279 | - | 4e-77 | 36.04% (541) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0250 | - | 6e-73 | 34.73% (547) | GMC-type oxidoreductase |
| M. marinum M | MMAR_2954 | - | 1e-75 | 34.87% (565) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. avium 104 | MAV_4980 | - | 6e-52 | 30.87% (460) | choline dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0526 | - | 1e-175 | 54.80% (531) | oxidoreductase, GMC family protein |
| M. thermoresistible (build 8) | TH_4204 | - | 1e-174 | 55.74% (531) | PUTATIVE glucose-methanol-choline oxidoreductase |
| M. ulcerans Agy99 | MUL_4004 | - | 1e-67 | 33.58% (542) | dehydrogenase fad flavoprotein GMC oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1310|M.bovis_AF2122/97 --MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKNRFIGVP
Rv1279|M.tuberculosis_H37Rv --MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKNRFIGVP
MUL_4004|M.ulcerans_Agy99 --MDIECDYVVVGTGSAGAAVVNRLSADSGTSVVALEAGPSDKNRFIGIP
MAB_0250|M.abscessus_ATCC_1997 MVEDLAADFVIVGAGSAGAPLATRLSERTNDQVLVLEAGPKDKDMGIHIP
MSMEG_0526|M.smegmatis_MC2_155 ---MTSYDYIIAGAGSAGCVLANRLSEDPRIKVLLLEAGGSDRNPLFSIP
TH_4204|M.thermoresistible__bu ---MSSYDYIIAGSGSAGCVLANRLSADPKVSVLLIEAGGFDRNPLFSIP
Mflv_1255|M.gilvum_PYR-GCK -MAVTGYDYIVVGAGSAGCVLANRLSADPAIRVLLLEAGRGDRNLWLHIP
Mvan_5894|M.vanbaalenii_PYR-1 ---MTDFDYIIVGAGSAGCVLAHRLSEDPRVNVLLIEAGGRDRSPMIRIP
MMAR_2954|M.marinum_M MSPVAEFDFIIVGAGSAGCLLANRLSANPDHRVLVIEAGGKDNWFWIKVP
MAV_4980|M.avium_104 --------------------------------------------------
Mb1310|M.bovis_AF2122/97 AAFSKLFRS-EIDWDYLTEPQPELDGREIYWPRGKVLGGSSSMNAMMWVR
Rv1279|M.tuberculosis_H37Rv AAFSKLFRS-EIDWDYLTEPQPELDGREIYWPRGKVLGGSSSMNAMMWVR
MUL_4004|M.ulcerans_Agy99 AAFPKLFRS-EVDWDYTTEPEPQLGGREIYWPRDKVLGGSSSMNAMMWVR
MAB_0250|M.abscessus_ATCC_1997 AAFSKLFRS-DVDWDYLTEPQPQLNNRQIYWPRGKTLGGSSSMNAMMWVR
MSMEG_0526|M.smegmatis_MC2_155 KGSGKLFDSEKHMWHYSTEP-FGPNPHAEQWMRGKVLGGSSSINGMIYNR
TH_4204|M.thermoresistible__bu KGSGKLFDSERHMWHYETTP-FGPGRHTEQWMRGKVLGGSSSVNGMIYNR
Mflv_1255|M.gilvum_PYR-GCK KGAGKLFDSERHMWHYETTP-FGPDAHVEQWMRGKVIGGSSAVNGMIYNR
Mvan_5894|M.vanbaalenii_PYR-1 KGVGKILGDPKLTWHFPVRP-IGPSQIVEQWVRGKTLGGSSSVNGMVYNR
MMAR_2954|M.marinum_M VGYLYTIANPRTDWCFTTEADPGLAGRSIHYARGRVIGGCSSINAMIHMR
MAV_4980|M.avium_104 --------------------MQTAIGRAVPFARGRGIGGSSTINAMVFAR
: *.: :**.*::*.*: *
Mb1310|M.bovis_AF2122/97 GFASDYDEWAAR-AGPRWSYA------DVLGYFRRIENVTAAWHFVSGDD
Rv1279|M.tuberculosis_H37Rv GFASDYDEWAAR-AGPRWSYA------DVLGYFRRIENVTAAWHFVSGDD
MUL_4004|M.ulcerans_Agy99 GFAADYDEWARL-AGSHWSYG------ELLGYFRQIEDVTAAWHFVNGDD
MAB_0250|M.abscessus_ATCC_1997 GFAADYDDWAQV-AGEQWSFA------NIAPYFKRIEAVEG----ATESD
MSMEG_0526|M.smegmatis_MC2_155 GTRADYDGLERL-GNKGWGWD------DILPIFKRFEDNEFG----PSAT
TH_4204|M.thermoresistible__bu GNRADYDGLEQL-GNKGWGWD------DILPIFKQFEDNEFG----PSPT
Mflv_1255|M.gilvum_PYR-GCK GHRADYDALEQM-GNKGWGWD------EILPIFKGFEDHEFG----PSAT
Mvan_5894|M.vanbaalenii_PYR-1 GSAPDYDALAAL-GNPAWGWD------HILPAFRAIENHELG----PDPT
MMAR_2954|M.marinum_M GQASDYDLWAQATGDQRWLWGGPDSSGETLAIYKKLENYFGG----ADDW
MAV_4980|M.avium_104 GHRDSYSRWRDN-GAAGWSFD------ELLPYFKRSESTCGK----DPSL
* .*. . * : . :: *
Mb1310|M.bovis_AF2122/97 SGVTGPLHISRQRSPRSVTAAWLAAARECGFAAAR-PNSPRPEGFCETVV
Rv1279|M.tuberculosis_H37Rv SGVTGPLHISRQRSPRSVTAAWLAAARECGFAAAR-PNSPRPEGFCETVV
MUL_4004|M.ulcerans_Agy99 SGVTGPLQISRQRSPSPLTAAWLAATRDCGFAPVQ-PNSAEPEGFCETIV
MAB_0250|M.abscessus_ATCC_1997 EGTDGALKISKQRSPRSSTAAWLEAVKEAGFDVER-ANTPEPKGFSETMV
MSMEG_0526|M.smegmatis_MC2_155 RGVGGPLHISIPRDPDPLCEEMLAAAEASGLTRVQDINEHDTERIGYATS
TH_4204|M.thermoresistible__bu RGAGGPLHISVPRDADPLCDEMIDAGTVAGLHRVEDINESDDERIGYATA
Mflv_1255|M.gilvum_PYR-GCK RGTGGPLHISVPRDPDPLCEDMIEAATGAGMWRVRDINESDGERIGYATS
Mvan_5894|M.vanbaalenii_PYR-1 RGTGGPLEISVDAHLPRICHDVIAAGEKLGWSATDDVNGSDAARIGPAPR
MMAR_2954|M.marinum_M HGAGGEIRVERPRVHWKILDAWQAAAAQVGIAPIDEFNRGDNAGSAYFHV
MAV_4980|M.avium_104 RGQDGPMAVAPAAHPNPVLVACLCAAIQQGYPRAADISGGLEVGFGFTDL
* * : : * * .
Mb1310|M.bovis_AF2122/97 TQRRGARFSTADAYLKPAMRRKNLRVLTGATATRVVID------------
Rv1279|M.tuberculosis_H37Rv TQRRGARFSTADAYLKPAMRRKNLRVLTGATATRVVID------------
MUL_4004|M.ulcerans_Agy99 TQRRGSRWSTVDAYLRPAMGRRNLSILTGATATRIVIH------------
MAB_0250|M.abscessus_ATCC_1997 CQHGGRRWSTADGYLKPGLRRRNLNVVTDAQARRVLFD------------
MSMEG_0526|M.smegmatis_MC2_155 TIRNGRRVSAATAFLKPALGRPNLTVRTSATVGRILFE------------
TH_4204|M.thermoresistible__bu TIKNGRRVSAARAFLKPALRRANLSVRTRAVAQRILLA------------
Mflv_1255|M.gilvum_PYR-GCK TIRGGRRVSAATAFLKPVLHRPNLTVRTGATVRRVLFD------------
Mvan_5894|M.vanbaalenii_PYR-1 TIRNGQRVSSARAFLHPVAHRPNLTIATDTTVNRILFK------------
MMAR_2954|M.marinum_M NQRRGRRWSMADAFLHPVAHRPNLTIYTQTQALKLLVDNQVREDQRRGAW
MAV_4980|M.avium_104 NIVDGKRQSAADAYLLPALDRPNLEFHSGATVHRLRIR------------
* * * . .:* * * ** . : : . :: .
Mb1310|M.bovis_AF2122/97 ---GDRAVGVEYQSD-GQTRIVYARREVVLCAGAVNSPQLLMLSGIGDRD
Rv1279|M.tuberculosis_H37Rv ---GDRAVGVEYQSD-GQTRIVYARREVVLCAGAVNSPQLLMLSGIGDRD
MUL_4004|M.ulcerans_Agy99 ---GTRATGVEYQRE-GQHCTVHARREVVLCGGAVNSPQLLMLSGIGDRS
MAB_0250|M.abscessus_ATCC_1997 ---GIRAVGVEYVRD-GITHTVHARREVILSGGAINSPQLLMLSGIGEAT
MSMEG_0526|M.smegmatis_MC2_155 ---GTRAVGVDVTGT-SGTTQVRASREVIVSLGSLNSPVLLQLSGIGPRE
TH_4204|M.thermoresistible__bu ---GGRAVGLEIASR-GRTGKVYATREVIIAMGSLNTPKLLQLSGIGPRE
Mflv_1255|M.gilvum_PYR-GCK ---GERADGVEIATG-AGTEQVRAAREVVLSLGSLNSPKLLQLSGIGPSD
Mvan_5894|M.vanbaalenii_PYR-1 ---ADKAIGVQATTSKGGAAVCTAGREVLLSLGSISTPRLLQLSGIGDRS
MMAR_2954|M.marinum_M ATAQHRATGVRLLKD-GQIVDVRARREVILSAGAIGSPQLMQASGLGPAG
MAV_4980|M.avium_104 ---GSRCTGVEYTTA-EGRQVTAAAREIILCAGAIGSPHLLLASGIGPPN
:. *: * **:::. *::.:* *: **:*
Mb1310|M.bovis_AF2122/97 HLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDS------LFAAEKPG
Rv1279|M.tuberculosis_H37Rv HLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDS------LFAAEKPG
MUL_4004|M.ulcerans_Agy99 HLADHGIETVYHAPEVGQNLLDHLITPLGFDVAGDS------LAAAEKPM
MAB_0250|M.abscessus_ATCC_1997 RLGELGIPVVHDAPQVGQNLLDHLCCPVGYAVKSDS------LFGAEKPL
MSMEG_0526|M.smegmatis_MC2_155 VLRSAGVQVFIEHDRVGRGLREHRCATLRFDLIEDLGYNKQLASSVAQAL
TH_4204|M.thermoresistible__bu VLDAAGVPVYLDRANVGRRMREHRCATLRFDLREDLGYNRLLATGTGQAL
Mflv_1255|M.gilvum_PYR-GCK VLGAAGVPVLVERDNVGRRMREHRCATLRYRLKEDLGYNKLLATNVGQAL
Mvan_5894|M.vanbaalenii_PYR-1 LLRGLGIDTLADSPNVGRRMREHRCFALQFRLDRPVGYNRQLSTPLRQAF
MMAR_2954|M.marinum_M LLAEHQVPVAVDLPGVGENLQDHLQLRTIYRVRGARTVNTLYRNWISRAG
MAV_4980|M.avium_104 HLRSFRVDVALELPGVGANLQDHPIVPLVYRAARPVP-------------
* : . . ** : :* :
Mb1310|M.bovis_AF2122/97 QLISYLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELI-FAPAPFYDEA-
Rv1279|M.tuberculosis_H37Rv QLISYLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELI-FAPAPFYDEA-
MUL_4004|M.ulcerans_Agy99 QLINYLLRRRGMLTSNVGEAYGFVRSRPGLDLPDLELI-FAPAPFYDEG-
MAB_0250|M.abscessus_ATCC_1997 QLANYFLRHRGMLTSNVGEAYGFLRSHPNLTLPDLELI-FAPAPFFDEG-
MSMEG_0526|M.smegmatis_MC2_155 TGLRYLATRRGPLGAPSFDIVGFVKTRADVDRPDGQIM-MGPYTLPPYN-
TH_4204|M.thermoresistible__bu TGAKYLATRKGPLAAPSFDVVGFVKTQPGLDRPDGQIM-LGPWTIPPYNQ
Mflv_1255|M.gilvum_PYR-GCK TGMKYLATRKGPLAAPSFDVVGFVKDRPDSERPLGQVM-MGPWTLPPYN-
Mvan_5894|M.vanbaalenii_PYR-1 TAARYLATRRGPLAGAAFDVIGFFKTSPELERPDAQIL-MAPFSLAPYE-
MMAR_2954|M.marinum_M MGLQYLLLRSGPLTMPPSTLGAFAKSDPALASPDLEWH-VQPLSLPKFG-
MAV_4980|M.avium_104 -----------AGRYNHGELLGLIRRHATGGPPEIQIFGVDSADVPGLG-
.: : . * : . . .
Mb1310|M.bovis_AF2122/97 ---LVP-PAGHGVVFGPILVAPQSRGQITLRSADPHAKPVIEPRYLSDLG
Rv1279|M.tuberculosis_H37Rv ---LVP-PAGHGVVFGPILVAPQSRGQITLRSADPHAKPVIEPRYLSDLG
MUL_4004|M.ulcerans_Agy99 ---LPAHPPGHGVVFGPILVAPQSRGQITLRSADPHAKPIIEARYLSDPG
MAB_0250|M.abscessus_ATCC_1997 ---IGV-ATEHAIVMGPILLKPESSGEITLTSPDPLAKPRIDPRYLSDPA
MSMEG_0526|M.smegmatis_MC2_155 VGEPVTIQRQAGLSCLGMVLRPTSEGALEITSSGPRPSVRIEPNYLGSEH
TH_4204|M.thermoresistible__bu SGEPVVIPRQAGVSALGMALRPTSEGTVEITAVDPAAPLRIDPNYLGSDA
Mflv_1255|M.gilvum_PYR-GCK TGEPVVIEREPGISCLGMVLRPTSQGYVEITSADPGAALRITPNYLTTEH
Mvan_5894|M.vanbaalenii_PYR-1 QGKEATVERDPGIQAIGYLLRPDSEGSVAITSSDPEAPLDIDPGFLITTH
MMAR_2954|M.marinum_M ----EPLHRFGAITPSVCNLRPSSRGHVRITSGDPLTKPKILCNYLSTDQ
MAV_4980|M.avium_104 --------GADGYVLGVSVMQPVSRGRVGLSGPTIQEPPAIDPNYLSDDR
. : * * * : : . * :*
Mb1310|M.bovis_AF2122/97 GVDRAAMMAGLRICARIAQARPLRDLLGSIARPRNSTELDEATLELALAT
Rv1279|M.tuberculosis_H37Rv GVDRAAMMAGLRICARIAQARPLRDLLGSIARPRNSTELDEATLELALAT
MUL_4004|M.ulcerans_Agy99 GVDRAAMMEGLRICARIAQAPALRGLLGPVARPHNSSELDEATLELALTT
MAB_0250|M.abscessus_ATCC_1997 GRDRAAMMFGLRTTARIAETPSMRAVLGKILRPRNPSDDLEETLVAALEN
MSMEG_0526|M.smegmatis_MC2_155 --DRTATADLLRRMRAVFAESPIAERISHETFPGPGVATDDELVDSALDG
TH_4204|M.thermoresistible__bu --DRETTANLLRRMRSVFEQSPIAERISHETFPGPHIRSDDELVDAALDG
Mflv_1255|M.gilvum_PYR-GCK --DRTATAALVRRMRSIFEQSPIAERISHETYPGPRVDSDEELVDAALEG
Mvan_5894|M.vanbaalenii_PYR-1 --DREKGAALFRTMRRLFSQSPVADHLVAETRPGADVSSDQAIIDAALTQ
MMAR_2954|M.marinum_M --DRQLAVRGLRMTRQIMAAPSLARYCPEELLPGPQLVSDEDLQKAAREL
MAV_4980|M.avium_104 --DMGLMIEGLRIGRKIGMSQALDPWRAEELAPGDD-AVDDAALRSYIQR
* .* : .: * :
Mb1310|M.bovis_AF2122/97 CSHTLYHPMGTCRMGSDEA--------SVVDPQLRVRGVDGLRVADASVM
Rv1279|M.tuberculosis_H37Rv CSHTLYHPMGTCRMGSDEA--------SVVDPQLRVRGVDGLRVADASVM
MUL_4004|M.ulcerans_Agy99 CSHTLYHPLGTCRMGSDEA--------SVVDRQLRVRGVDGLRVADASVM
MAB_0250|M.abscessus_ATCC_1997 NSHTLYHPVGTCRMGADDA--------SVVTPDLTVRGVQGLRVVDASVI
MSMEG_0526|M.smegmatis_MC2_155 -GYCGYHAVGTCAMGPGDD--------AVVDDRLRVRGVDGLRVVDCSVL
TH_4204|M.thermoresistible__bu -GYCGYHAIGTCAMGPSDD--------DVVDPQLRVRGVDGLRVVDCSVL
Mflv_1255|M.gilvum_PYR-GCK -GYCGYHAVGTCAMGPDDD--------DVVDSHLRVRGVDGLRVVDCSVM
Mvan_5894|M.vanbaalenii_PYR-1 -GYCGYHAIGTCAMGPEDD--------DVVDSALRVRGVRNLRIMDCSVM
MMAR_2954|M.marinum_M -GTTIFHPVGTCAMGAFDARGRPRSAATVLDTDCRVYRVAGLRVADASAM
MAV_4980|M.avium_104 SVASYFHPVGTCAMGTGPE--------SVVDNQLRLHGIDNLRVIDASVM
:*.:*** **. *: : : .**: *.*.:
Mb1310|M.bovis_AF2122/97 PSTVRGHTHAPSVLIGEKAADLIRS---
Rv1279|M.tuberculosis_H37Rv PSTVRGHTHAPSVLIGEKAADLIRS---
MUL_4004|M.ulcerans_Agy99 PSTVRGHTHAPSVLIGAKAADLIRN---
MAB_0250|M.abscessus_ATCC_1997 PSLIRGHTHAPSVLLGEKAADLILSPQP
MSMEG_0526|M.smegmatis_MC2_155 PTMVAGNLNGPIMAVAWRAADFILDR--
TH_4204|M.thermoresistible__bu PVMVAGNLNGPIMAVAWRAADLIRQDL-
Mflv_1255|M.gilvum_PYR-GCK PTIVAGNLNGPIMAMAWRAADFILHGR-
Mvan_5894|M.vanbaalenii_PYR-1 PTMVSGNLNGPVMAMAWRASDLILSGG-
MMAR_2954|M.marinum_M PTITSGNTNAPVMLVAERAARAILG---
MAV_4980|M.avium_104 PSLPSNNTAATVYAIAERGADLVRLG--
* .: .. :. :.: :