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VTSYDYIIAGAGSAGCVLANRLSEDPRIKVLLLEAGGSDRNPLFSIPKGSGKLFDSEKHMWHYSTEPFGP NPHAEQWMRGKVLGGSSSINGMIYNRGTRADYDGLERLGNKGWGWDDILPIFKRFEDNEFGPSATRGVGG PLHISIPRDPDPLCEEMLAAAEASGLTRVQDINEHDTERIGYATSTIRNGRRVSAATAFLKPALGRPNLT VRTSATVGRILFEGTRAVGVDVTGTSGTTQVRASREVIVSLGSLNSPVLLQLSGIGPREVLRSAGVQVFI EHDRVGRGLREHRCATLRFDLIEDLGYNKQLASSVAQALTGLRYLATRRGPLGAPSFDIVGFVKTRADVD RPDGQIMMGPYTLPPYNVGEPVTIQRQAGLSCLGMVLRPTSEGALEITSSGPRPSVRIEPNYLGSEHDRT ATADLLRRMRAVFAESPIAERISHETFPGPGVATDDELVDSALDGGYCGYHAVGTCAMGPGDDAVVDDRL RVRGVDGLRVVDCSVLPTMVAGNLNGPIMAVAWRAADFILDR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0526 | - | - | 100% (532) | oxidoreductase, GMC family protein |
| M. smegmatis MC2 155 | MSMEG_3375 | - | 7e-77 | 34.76% (561) | alcohol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3444 | - | 5e-69 | 34.46% (531) | choline dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1310 | - | 1e-79 | 36.75% (536) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1255 | - | 0.0 | 75.47% (530) | glucose-methanol-choline oxidoreductase |
| M. tuberculosis H37Rv | Rv1279 | - | 1e-79 | 36.75% (536) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0250 | - | 3e-76 | 35.83% (533) | GMC-type oxidoreductase |
| M. marinum M | MMAR_4141 | - | 1e-80 | 37.15% (533) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. avium 104 | MAV_4980 | - | 2e-58 | 32.90% (459) | choline dehydrogenase |
| M. thermoresistible (build 8) | TH_4204 | - | 0.0 | 75.28% (530) | PUTATIVE glucose-methanol-choline oxidoreductase |
| M. ulcerans Agy99 | MUL_4004 | - | 4e-80 | 37.15% (533) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_5894 | - | 1e-175 | 54.80% (531) | glucose-methanol-choline oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1310|M.bovis_AF2122/97 --MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKNRFIGVP
Rv1279|M.tuberculosis_H37Rv --MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKNRFIGVP
MMAR_4141|M.marinum_M --MDIECDYVVVGTGSAGAAVVNRLSADSGTSVVALEAGPSDKNRFIGIP
MUL_4004|M.ulcerans_Agy99 --MDIECDYVVVGTGSAGAAVVNRLSADSGTSVVALEAGPSDKNRFIGIP
MAB_0250|M.abscessus_ATCC_1997 MVEDLAADFVIVGAGSAGAPLATRLSERTNDQVLVLEAGPKDKDMGIHIP
MSMEG_0526|M.smegmatis_MC2_155 ---MTSYDYIIAGAGSAGCVLANRLSEDPRIKVLLLEAGGSDRNPLFSIP
TH_4204|M.thermoresistible__bu ---MSSYDYIIAGSGSAGCVLANRLSADPKVSVLLIEAGGFDRNPLFSIP
Mflv_1255|M.gilvum_PYR-GCK -MAVTGYDYIVVGAGSAGCVLANRLSADPAIRVLLLEAGRGDRNLWLHIP
Mvan_5894|M.vanbaalenii_PYR-1 ---MTDFDYIIVGAGSAGCVLAHRLSEDPRVNVLLIEAGGRDRSPMIRIP
MAV_4980|M.avium_104 --------------------------------------------------
Mb1310|M.bovis_AF2122/97 AAFSKLFRS-EIDWDYLTEPQPELDGREIYWPRGKVLGGSSSMNAMMWVR
Rv1279|M.tuberculosis_H37Rv AAFSKLFRS-EIDWDYLTEPQPELDGREIYWPRGKVLGGSSSMNAMMWVR
MMAR_4141|M.marinum_M AAFPKLFRS-EVDWDYTTEPEPQLGGREIYWPRGKVLGGSSSMNAMMWVR
MUL_4004|M.ulcerans_Agy99 AAFPKLFRS-EVDWDYTTEPEPQLGGREIYWPRDKVLGGSSSMNAMMWVR
MAB_0250|M.abscessus_ATCC_1997 AAFSKLFRS-DVDWDYLTEPQPQLNNRQIYWPRGKTLGGSSSMNAMMWVR
MSMEG_0526|M.smegmatis_MC2_155 KGSGKLFDSEKHMWHYSTEPFG-PNPHAEQWMRGKVLGGSSSINGMIYNR
TH_4204|M.thermoresistible__bu KGSGKLFDSERHMWHYETTPFG-PGRHTEQWMRGKVLGGSSSVNGMIYNR
Mflv_1255|M.gilvum_PYR-GCK KGAGKLFDSERHMWHYETTPFG-PDAHVEQWMRGKVIGGSSAVNGMIYNR
Mvan_5894|M.vanbaalenii_PYR-1 KGVGKILGDPKLTWHFPVRPIG-PSQIVEQWVRGKTLGGSSSVNGMVYNR
MAV_4980|M.avium_104 --------------------MQTAIGRAVPFARGRGIGGSSTINAMVFAR
: *.: :****::*.*:: *
Mb1310|M.bovis_AF2122/97 GFASDYDEWAARAGPRWSYADVLGYFRRIENVTAAWHFVSGDDSGVTGPL
Rv1279|M.tuberculosis_H37Rv GFASDYDEWAARAGPRWSYADVLGYFRRIENVTAAWHFVSGDDSGVTGPL
MMAR_4141|M.marinum_M GFAADYDEWARLAGSHWSYGELLGYFRQIEDVTAAWHFVNGDDSGVTGPL
MUL_4004|M.ulcerans_Agy99 GFAADYDEWARLAGSHWSYGELLGYFRQIEDVTAAWHFVNGDDSGVTGPL
MAB_0250|M.abscessus_ATCC_1997 GFAADYDDWAQVAGEQWSFANIAPYFKRIEAVEG----ATESDEGTDGAL
MSMEG_0526|M.smegmatis_MC2_155 GTRADYDGLERLGNKGWGWDDILPIFKRFEDNEFG----PSATRGVGGPL
TH_4204|M.thermoresistible__bu GNRADYDGLEQLGNKGWGWDDILPIFKQFEDNEFG----PSPTRGAGGPL
Mflv_1255|M.gilvum_PYR-GCK GHRADYDALEQMGNKGWGWDEILPIFKGFEDHEFG----PSATRGTGGPL
Mvan_5894|M.vanbaalenii_PYR-1 GSAPDYDALAALGNPAWGWDHILPAFRAIENHELG----PDPTRGTGGPL
MAV_4980|M.avium_104 GHRDSYSRWRDNGAAGWSFDELLPYFKRSESTCGK----DPSLRGQDGPM
* .*. . *.: .: *: * * *.:
Mb1310|M.bovis_AF2122/97 HISRQRSPRSVTAAWLAAARECGFAAAR-PNSPRPEGFCETVVTQRRGAR
Rv1279|M.tuberculosis_H37Rv HISRQRSPRSVTAAWLAAARECGFAAAR-PNSPRPEGFCETVVTQRRGAR
MMAR_4141|M.marinum_M QISRQRSPSPLTAAWLAATRDCGFPPVQ-PNSAEPEGFCETIVTQRRGSR
MUL_4004|M.ulcerans_Agy99 QISRQRSPSPLTAAWLAATRDCGFAPVQ-PNSAEPEGFCETIVTQRRGSR
MAB_0250|M.abscessus_ATCC_1997 KISKQRSPRSSTAAWLEAVKEAGFDVER-ANTPEPKGFSETMVCQHGGRR
MSMEG_0526|M.smegmatis_MC2_155 HISIPRDPDPLCEEMLAAAEASGLTRVQDINEHDTERIGYATSTIRNGRR
TH_4204|M.thermoresistible__bu HISVPRDADPLCDEMIDAGTVAGLHRVEDINESDDERIGYATATIKNGRR
Mflv_1255|M.gilvum_PYR-GCK HISVPRDPDPLCEDMIEAATGAGMWRVRDINESDGERIGYATSTIRGGRR
Mvan_5894|M.vanbaalenii_PYR-1 EISVDAHLPRICHDVIAAGEKLGWSATDDVNGSDAARIGPAPRTIRNGQR
MAV_4980|M.avium_104 AVAPAAHPNPVLVACLCAAIQQGYPRAADISGGLEVGFGFTDLNIVDGKR
:: : * * . : : * *
Mb1310|M.bovis_AF2122/97 FSTADAYLKPAMRRKNLRVLTGATATRVVIDGDRAVGVEYQSD-GQTRIV
Rv1279|M.tuberculosis_H37Rv FSTADAYLKPAMRRKNLRVLTGATATRVVIDGDRAVGVEYQSD-GQTRIV
MMAR_4141|M.marinum_M WSTVDAYLRPAMGRRNLSILTGATATRIVIHGTRATGIEYQRE-GQHCTV
MUL_4004|M.ulcerans_Agy99 WSTVDAYLRPAMGRRNLSILTGATATRIVIHGTRATGVEYQRE-GQHCTV
MAB_0250|M.abscessus_ATCC_1997 WSTADGYLKPGLRRRNLNVVTDAQARRVLFDGIRAVGVEYVRD-GITHTV
MSMEG_0526|M.smegmatis_MC2_155 VSAATAFLKPALGRPNLTVRTSATVGRILFEGTRAVGVDVTGT-SGTTQV
TH_4204|M.thermoresistible__bu VSAARAFLKPALRRANLSVRTRAVAQRILLAGGRAVGLEIASR-GRTGKV
Mflv_1255|M.gilvum_PYR-GCK VSAATAFLKPVLHRPNLTVRTGATVRRVLFDGERADGVEIATG-AGTEQV
Mvan_5894|M.vanbaalenii_PYR-1 VSSARAFLHPVAHRPNLTIATDTTVNRILFKADKAIGVQATTSKGGAAVC
MAV_4980|M.avium_104 QSAADAYLLPALDRPNLEFHSGATVHRLRIRGSRCTGVEYTTA-EGRQVT
*:. .:* * * ** . : : . *: : . :. *::
Mb1310|M.bovis_AF2122/97 YARREVVLCAGAVNSPQLLMLSGIGDRDHLAEHDIDTVYHAPEVGCNLLD
Rv1279|M.tuberculosis_H37Rv YARREVVLCAGAVNSPQLLMLSGIGDRDHLAEHDIDTVYHAPEVGCNLLD
MMAR_4141|M.marinum_M HARREVVLCGGAVNSPQLLMLSGIGDRSHLADHGIETVYHAPEVGQNLLD
MUL_4004|M.ulcerans_Agy99 HARREVVLCGGAVNSPQLLMLSGIGDRSHLADHGIETVYHAPEVGQNLLD
MAB_0250|M.abscessus_ATCC_1997 HARREVILSGGAINSPQLLMLSGIGEATRLGELGIPVVHDAPQVGQNLLD
MSMEG_0526|M.smegmatis_MC2_155 RASREVIVSLGSLNSPVLLQLSGIGPREVLRSAGVQVFIEHDRVGRGLRE
TH_4204|M.thermoresistible__bu YATREVIIAMGSLNTPKLLQLSGIGPREVLDAAGVPVYLDRANVGRRMRE
Mflv_1255|M.gilvum_PYR-GCK RAAREVVLSLGSLNSPKLLQLSGIGPSDVLGAAGVPVLVERDNVGRRMRE
Mvan_5894|M.vanbaalenii_PYR-1 TAGREVLLSLGSISTPRLLQLSGIGDRSLLRGLGIDTLADSPNVGRRMRE
MAV_4980|M.avium_104 AAAREIILCAGAIGSPHLLLASGIGPPNHLRSFRVDVALELPGVGANLQD
* **:::. *::.:* ** **** * : . . ** : :
Mb1310|M.bovis_AF2122/97 HLVTVLGFDVEKDS------LFAAEKPGQLISYLLRRRGMLTSNVGEAYG
Rv1279|M.tuberculosis_H37Rv HLVTVLGFDVEKDS------LFAAEKPGQLISYLLRRRGMLTSNVGEAYG
MMAR_4141|M.marinum_M HLITPLGFDVAGDS------LAAAEKPMQLINYLLRRRGMLTSNVGEAYG
MUL_4004|M.ulcerans_Agy99 HLITPLGFDVAGDS------LAAAEKPMQLINYLLRRRGMLTSNVGEAYG
MAB_0250|M.abscessus_ATCC_1997 HLCCPVGYAVKSDS------LFGAEKPLQLANYFLRHRGMLTSNVGEAYG
MSMEG_0526|M.smegmatis_MC2_155 HRCATLRFDLIEDLGYNKQLASSVAQALTGLRYLATRRGPLGAPSFDIVG
TH_4204|M.thermoresistible__bu HRCATLRFDLREDLGYNRLLATGTGQALTGAKYLATRKGPLAAPSFDVVG
Mflv_1255|M.gilvum_PYR-GCK HRCATLRYRLKEDLGYNKLLATNVGQALTGMKYLATRKGPLAAPSFDVVG
Mvan_5894|M.vanbaalenii_PYR-1 HRCFALQFRLDRPVGYNRQLSTPLRQAFTAARYLATRRGPLAGAAFDVIG
MAV_4980|M.avium_104 HPIVPLVYRAARPVP------------------------AGRYNHGELLG
* : : : *
Mb1310|M.bovis_AF2122/97 FVRSRPELKLPDLELIFAP---APFYDEALVP--PAGHGVVFGPILVAPQ
Rv1279|M.tuberculosis_H37Rv FVRSRPELKLPDLELIFAP---APFYDEALVP--PAGHGVVFGPILVAPQ
MMAR_4141|M.marinum_M FVRSRPGLDLPDLELIFAP---APFYDEGLPAH-PPGHGVVFGPILVAPQ
MUL_4004|M.ulcerans_Agy99 FVRSRPGLDLPDLELIFAP---APFYDEGLPAH-PPGHGVVFGPILVAPQ
MAB_0250|M.abscessus_ATCC_1997 FLRSHPNLTLPDLELIFAP---APFFDEGIGV--ATEHAIVMGPILLKPE
MSMEG_0526|M.smegmatis_MC2_155 FVKTRADVDRPDGQIMMGPYTLPPYN-VGEPVTIQRQAGLSCLGMVLRPT
TH_4204|M.thermoresistible__bu FVKTQPGLDRPDGQIMLGPWTIPPYNQSGEPVVIPRQAGVSALGMALRPT
Mflv_1255|M.gilvum_PYR-GCK FVKDRPDSERPLGQVMMGPWTLPPYN-TGEPVVIEREPGISCLGMVLRPT
Mvan_5894|M.vanbaalenii_PYR-1 FFKTSPELERPDAQILMAPFSLAPYE-QGKEATVERDPGIQAIGYLLRPD
MAV_4980|M.avium_104 LIRRHATGGPPEIQIFGVD--------SADVPGLGGADGYVLGVSVMQPV
:.: . * ::: . . : *
Mb1310|M.bovis_AF2122/97 SRGQITLRSADPHAKPVIEPRYLSDLGGVDRAAMMAGLRICARIAQARPL
Rv1279|M.tuberculosis_H37Rv SRGQITLRSADPHAKPVIEPRYLSDLGGVDRAAMMAGLRICARIAQARPL
MMAR_4141|M.marinum_M SRGQITLRSADPHAKPIIEARYLSDPGGVDRAAMMEGLRICARIAQAPAL
MUL_4004|M.ulcerans_Agy99 SRGQITLRSADPHAKPIIEARYLSDPGGVDRAAMMEGLRICARIAQAPAL
MAB_0250|M.abscessus_ATCC_1997 SSGEITLTSPDPLAKPRIDPRYLSDPAGRDRAAMMFGLRTTARIAETPSM
MSMEG_0526|M.smegmatis_MC2_155 SEGALEITSSGPRPSVRIEPNYLGS--EHDRTATADLLRRMRAVFAESPI
TH_4204|M.thermoresistible__bu SEGTVEITAVDPAAPLRIDPNYLGS--DADRETTANLLRRMRSVFEQSPI
Mflv_1255|M.gilvum_PYR-GCK SQGYVEITSADPGAALRITPNYLTT--EHDRTATAALVRRMRSIFEQSPI
Mvan_5894|M.vanbaalenii_PYR-1 SEGSVAITSSDPEAPLDIDPGFLIT--THDREKGAALFRTMRRLFSQSPV
MAV_4980|M.avium_104 SRGRVGLSGPTIQEPPAIDPNYLSD--DRDMGLMIEGLRIGRKIGMSQAL
* * : : . * . :* * .* : .:
Mb1310|M.bovis_AF2122/97 RDLLGSIARPRNSTELDEATLELALATCSHTLYHPMGTCRMGSDEASVVD
Rv1279|M.tuberculosis_H37Rv RDLLGSIARPRNSTELDEATLELALATCSHTLYHPMGTCRMGSDEASVVD
MMAR_4141|M.marinum_M RGLLGPVARPHNSSELDEATLELALTTCSHTLYHPLGTCRMGSDEASVVD
MUL_4004|M.ulcerans_Agy99 RGLLGPVARPHNSSELDEATLELALTTCSHTLYHPLGTCRMGSDEASVVD
MAB_0250|M.abscessus_ATCC_1997 RAVLGKILRPRNPSDDLEETLVAALENNSHTLYHPVGTCRMGADDASVVT
MSMEG_0526|M.smegmatis_MC2_155 AERISHETFPGPGVATDDELVDSALDG-GYCGYHAVGTCAMGPGDDAVVD
TH_4204|M.thermoresistible__bu AERISHETFPGPHIRSDDELVDAALDG-GYCGYHAIGTCAMGPSDDDVVD
Mflv_1255|M.gilvum_PYR-GCK AERISHETYPGPRVDSDEELVDAALEG-GYCGYHAVGTCAMGPDDDDVVD
Mvan_5894|M.vanbaalenii_PYR-1 ADHLVAETRPGADVSSDQAIIDAALTQ-GYCGYHAIGTCAMGPEDDDVVD
MAV_4980|M.avium_104 DPWRAEELAPGDD-AVDDAALRSYIQRSVASYFHPVGTCAMGTGPESVVD
* : : : :*.:*** **. **
Mb1310|M.bovis_AF2122/97 PQLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS---
Rv1279|M.tuberculosis_H37Rv PQLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS---
MMAR_4141|M.marinum_M PQLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGAKAADLIRN---
MUL_4004|M.ulcerans_Agy99 RQLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGAKAADLIRN---
MAB_0250|M.abscessus_ATCC_1997 PDLTVRGVQGLRVVDASVIPSLIRGHTHAPSVLLGEKAADLILSPQP
MSMEG_0526|M.smegmatis_MC2_155 DRLRVRGVDGLRVVDCSVLPTMVAGNLNGPIMAVAWRAADFILDR--
TH_4204|M.thermoresistible__bu PQLRVRGVDGLRVVDCSVLPVMVAGNLNGPIMAVAWRAADLIRQDL-
Mflv_1255|M.gilvum_PYR-GCK SHLRVRGVDGLRVVDCSVMPTIVAGNLNGPIMAMAWRAADFILHGR-
Mvan_5894|M.vanbaalenii_PYR-1 SALRVRGVRNLRIMDCSVMPTMVSGNLNGPVMAMAWRASDLILSGG-
MAV_4980|M.avium_104 NQLRLHGIDNLRVIDASVMPSLPSNNTAATVYAIAERGADLVRLG--
* ::*: .**: *.**:* .: .. :. :.:*::