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VTATQEITFESTSRFADVQAGELAMRLHYHEAGDPSAQTIVLLHGGGPGAASWSNFGRNIAVLAEHFHVL AVDQPGYGLSDKHTEHEQYNRYSAKAVRGLLDHLGVEGRVPLLGNSLGGGTAVRFALDYPDRAGKLVLMG PGGLSVNLFAPDPTEGVKALAKFNVEPTRENLEAFLRIMVFDQKLITPELVEERFAIASTPESLAATRAM GKSFAGADFELGMMWREVYKLRQPVLLIWGREDRVNPLDGALVAVKQIPRVQLHVFGQCGHWAQVEKFDE FNKLTIDFLGG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6037 | - | - | 100% (292) | 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase |
| M. smegmatis MC2 155 | MSMEG_2900 | - | 1e-59 | 40.41% (292) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase |
| M. smegmatis MC2 155 | MSMEG_4867 | - | 5e-27 | 30.14% (282) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3600c | bphD | 1e-138 | 80.76% (291) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. gilvum PYR-GCK | Mflv_1464 | - | 1e-136 | 83.16% (285) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3569c | bphD | 1e-138 | 80.76% (291) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3810 | - | 4e-52 | 36.64% (292) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_5064 | bphD | 1e-135 | 80.56% (288) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. avium 104 | MAV_0592 | - | 1e-137 | 79.93% (294) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase |
| M. thermoresistible (build 8) | TH_1741 | - | 1e-140 | 84.15% (284) | 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE BPHD |
| M. ulcerans Agy99 | MUL_4140 | bphD | 1e-134 | 80.21% (288) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. vanbaalenii PYR-1 | Mvan_5307 | - | 1e-139 | 84.67% (287) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3600c|M.bovis_AF2122/97 -------MTATEELTFESTSRFAEVDVDG-PLKLHYHEAGV---GNDQTV
Rv3569c|M.tuberculosis_H37Rv -------MTATEELTFESTSRFAEVDVDG-PLKLHYHEAGV---GNDQTV
MMAR_5064|M.marinum_M ---MTVTQSKTAEHTFESTSRYAEVDVDG-PLKLHYHEAGV---GNDQTV
MUL_4140|M.ulcerans_Agy99 ---MTVTQSKTAEHTFESTSRYAEVDVDG-PLKLHYHEAGV---GNDQTV
MAV_0592|M.avium_104 -------MTATEELTFESTSRFAEVDVDG-PLKLHYHEAGLSFKGTGRTV
MSMEG_6037|M.smegmatis_MC2_155 ------MVTATQEITFESTSRFADVQAGELAMRLHYHEAGD---PSAQTI
Mflv_1464|M.gilvum_PYR-GCK MTSFAAEAAQQQEITFESTSRYAQVR---EDMRLHYHEAGV---GNPKTV
Mvan_5307|M.vanbaalenii_PYR-1 MTSFAAEAAQQQEITFESTSRFAQVR---EDMRLHYHEAGD---PESPTV
TH_1741|M.thermoresistible__bu MTSYIQEAENQVEITFESTSRYAEVKAGDRDMRLHYHEAGI---GHAQKV
MAB_3810|M.abscessus_ATCC_1997 -----------MDVTYEGTKRELATDEG----TLRYHEAGT--AGEGEPL
: *:*.*.* . *:***** :
Mb3600c|M.bovis_AF2122/97 VLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRAEHGQFN
Rv3569c|M.tuberculosis_H37Rv VLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRAEHGQFN
MMAR_5064|M.marinum_M VLLHGGGPGASSWSNFARNIEVLAQQFHVLAVDQPGYGHSDKRAEHGQFN
MUL_4140|M.ulcerans_Agy99 VLLHGGGPGASSWSNFARNIEVLAQQFHVLAVDQPGYGHSDKRAEHGQFN
MAV_0592|M.avium_104 VLLHGGGPGAASWTNFGRNIPVLARHFHVLAVDQPGYGLSDKRAEHGQFN
MSMEG_6037|M.smegmatis_MC2_155 VLLHGGGPGAASWSNFGRNIAVLAEHFHVLAVDQPGYGLSDKHTEHEQYN
Mflv_1464|M.gilvum_PYR-GCK VLLHGGGPGASSWSNFGRNIPVLAKHFHVLAVDQPGYGHSDKHTEHEQYN
Mvan_5307|M.vanbaalenii_PYR-1 VLLHGGGPGASSWSNFGKNIPVLAEHFHVLAVDQPGYGHSDKHTEHEQYN
TH_1741|M.thermoresistible__bu VLLHGGGPGASSWSNFGRNIAVLARHFHVIAVDQPGYGHSDKHTEHEQYN
MAB_3810|M.abscessus_ATCC_1997 ILLHGSGPGVTGWRNYRGNLGVFAKHFHTYVLEFPGFGVSDAVPGHPVLT
:****.***.:.* *: *: *:*.:**. .:: **:* ** . * .
Mb3600c|M.bovis_AF2122/97 RYAAMALKGLFDQLGLG-RVPLVGNSLGGGTAVRFALDYPARAGRLVLMG
Rv3569c|M.tuberculosis_H37Rv RYAAMALKGLFDQLGLG-RVPLVGNSLGGGTAVRFALDYPARAGRLVLMG
MMAR_5064|M.marinum_M HYAARALKELFDQLGLG-RVPLVGNSLGGGTAVRFALDYPDRAGRLVLMG
MUL_4140|M.ulcerans_Agy99 HYAARALKELFDQLGLG-RVLLVGNSLGGGTAVRFALDYPDRAGRLVLMG
MAV_0592|M.avium_104 RYAARALNGLFEQLELG-RVPLVGNSLGGGTAVRFALDYPDKAGRLVLMG
MSMEG_6037|M.smegmatis_MC2_155 RYSAKAVRGLLDHLGVEGRVPLLGNSLGGGTAVRFALDYPDRAGKLVLMG
Mflv_1464|M.gilvum_PYR-GCK RYSATALLNLFDHLGIE-KAALVGNSLGGGTAVRFALDNGKRAGKLVLMG
Mvan_5307|M.vanbaalenii_PYR-1 RYSATALLNLFDYLGIE-RAALVGNSLGGGTAVRFALDNGKRAGKLVLMG
TH_1741|M.thermoresistible__bu RYSATALLALFDHLGIE-RADLVGNSLGGGTAVRFALDHPKRAGRLVLMG
MAB_3810|M.abscessus_ATCC_1997 --AGASVIRFMDGLGIS-SAAVVGNSMGGVVGINLAIKHPDRITKLVTIG
:. :: ::: * : . ::***:** ..:.:*:. : :** :*
Mb3600c|M.bovis_AF2122/97 PGGLSINLFAPDPTEGVKRLSKFSVAPTRENLEAFLRVMVYDKNLITPEL
Rv3569c|M.tuberculosis_H37Rv PGGLSINLFAPDPTEGVKRLSKFSVAPTRENLEAFLRVMVYDKNLITPEL
MMAR_5064|M.marinum_M PGGLSINLFAPDPTEGVKRLGKFSVAPTRENLEAFLRVMVYDQKLITPEL
MUL_4140|M.ulcerans_Agy99 PGGLSINLFAPDPTEGVKRLGKFSVAPTRENLEAFLRVMVYDQKLITPEL
MAV_0592|M.avium_104 PGGLSINLFAPDPTEGVKRLGKFSAEPTRENLEAFLRVMVYDQKLITDEL
MSMEG_6037|M.smegmatis_MC2_155 PGGLSVNLFAPDPTEGVKALAKFNVEPTRENLEAFLRIMVFDQKLITPEL
Mflv_1464|M.gilvum_PYR-GCK PGGLSVNLFSPDPTEGVKLLGRFAAEPTRENIEKFLRIMVFDQAMITPEL
Mvan_5307|M.vanbaalenii_PYR-1 PGGLSVNLFSPDPTEGVKLLGKFAAEPTRENIEKFLRIMVFDQNMITPEL
TH_1741|M.thermoresistible__bu PGGLSVNMFAPDPTEGVKLLARFNAEPTRENLEAFLRIMVYDQSLITEEL
MAB_3810|M.abscessus_ATCC_1997 --GVGPNIFSPSPSEGLRLLQEFTDNPDRDKLIRWLNSMVWDPAVVTDEL
*:. *:*:*.*:**:: * .* * *::: :*. **:* ::* **
Mb3600c|M.bovis_AF2122/97 VDQRFALASTPESLTATRAMG--KSFAG-----ADFEAGMMWREVYRLRQ
Rv3569c|M.tuberculosis_H37Rv VDQRFALASTPESLTATRAMG--KSFAG-----ADFEAGMMWREVYRLRQ
MMAR_5064|M.marinum_M VDQRFELARTPESLAATRAMG--KSFAA-----ADFELGMMWREVYKLRQ
MUL_4140|M.ulcerans_Agy99 VDQRFELARTPESLAATRAMG--KSFAA-----ADFELGMMWREVYKLRQ
MAV_0592|M.avium_104 IDERFALASTPESLAATRAMG--MSFAG-----ADFELGMMWREVHRLRQ
MSMEG_6037|M.smegmatis_MC2_155 VEERFAIASTPESLAATRAMG--KSFAG-----ADFELGMMWREVYKLRQ
Mflv_1464|M.gilvum_PYR-GCK VEERFQIASTPESLAATKAMG--KSFAG-----ADFELGMMWRDVYKLRQ
Mvan_5307|M.vanbaalenii_PYR-1 VEERFQIASTPESLAATKAMG--KSFAG-----ADFELGMMWRDVYKLRQ
TH_1741|M.thermoresistible__bu IDERFAIAATPESLAATRAMG--KSFMG-----PDFELGMMWRDAYKLRQ
MAB_3810|M.abscessus_ATCC_1997 IEERWEAAINPDAHKTAQLMYGSKAFAMQQQFLANADIPPYWAMMHKIKC
:::*: * .*:: ::: * :* .: : * ::::
Mb3600c|M.bovis_AF2122/97 PVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWVQVEKFDEFNK
Rv3569c|M.tuberculosis_H37Rv PVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWVQVEKFDEFNK
MMAR_5064|M.marinum_M PVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWAQVEKFDEFNR
MUL_4140|M.ulcerans_Agy99 PVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWAQVEKFDEFNR
MAV_0592|M.avium_104 PVLLIWGREDRVNPLDGALVALKTIARAQLHVFGQCGHWAQVEKFDEFNK
MSMEG_6037|M.smegmatis_MC2_155 PVLLIWGREDRVNPLDGALVAVKQIPRVQLHVFGQCGHWAQVEKFDEFNK
Mflv_1464|M.gilvum_PYR-GCK RVLLIWGREDRVNPLDGALVALKQIPRVQLHVFGQCGHWAQLEKFDEFNK
Mvan_5307|M.vanbaalenii_PYR-1 RVLLIWGREDRVNPLDGALVALKQIPRVQLHVFGQCGHWAQLEKFDEFNK
TH_1741|M.thermoresistible__bu RVLLIWGREDRVNPLDGALVALKQIPRVQLHVFGQCGHWAQVEKFDEFNR
MAB_3810|M.abscessus_ATCC_1997 PTLLTWGRDDRVSPPDMAIVPMRLIPNAELHIFPNSGHWVMIEAKQAFEQ
.** ***:***.* * *:*.:: *...:**:* :.***. :* : *::
Mb3600c|M.bovis_AF2122/97 LTIEFLGGGR-----
Rv3569c|M.tuberculosis_H37Rv LTIEFLGGGR-----
MMAR_5064|M.marinum_M LTIDFLGGAR-----
MUL_4140|M.ulcerans_Agy99 LTIDFLGGAR-----
MAV_0592|M.avium_104 LTIDFLGGA------
MSMEG_6037|M.smegmatis_MC2_155 LTIDFLGG-------
Mflv_1464|M.gilvum_PYR-GCK LTIDFLTN-------
Mvan_5307|M.vanbaalenii_PYR-1 LTIDFLGGG------
TH_1741|M.thermoresistible__bu LTIDFLEDGAKEAKS
MAB_3810|M.abscessus_ATCC_1997 TVVDFLRR-------
.::**