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SDDNDFHDQYARALRAYLASRDEASLAVGHELGRRALQEQISLLEIIEQHVRLVFEISQDVRIDAPIALE FLLQLLVPLDVATRGFIDGNRRYAEQRARAEGLADRDKFRNALVNSLQEGFFVADHEGSVIEVNNAFIEI LGFPAEGLPYRWPHPWLVDPKTASEQIGVVLRTGSAEYETPIRHADGHLAWVKVSINAVKDSGSDRDAYV GTIRDVTAERAFAARESAVLRLATAVAVAKSVDELLSITLDECSTAIDVQRVVAVSWPSGDGDPAVQVAG RPAASSWRELDPWLRDTFAEARHQLPLTAKTVDHPDNPGKSRGLVAVLSGAGDLALWLELRTPRWVSGED RLLVTVLIGHLSLALQHVRQFENARETSLTLQRAMLPPVQPPPGFAVRYEPAVPPLEIGGDWYDVLPIGD HRIGIVVGDCVGRGLPAAAIMGQLRSSARALLINGAEPAVLLDQLDSAASLIPNAYCTTVFLAILDTETG VLQYSNAGHMPAVLAGPEPGTTTLLTDAASVPLAVRREDPRPQATRLLPPGSTLMLFTDGLVERKHEPID DGIGRAAEVLAQTMTLPLDTVADEVLRELAPAAGYDDDVAMVIYRHQQSPLRIETAATADQLVRIRHRLA DWLGAAGITGELAADIVLVVNEACTNCVEHAYRGFVAGTMVLDARLGEGEVHTRITDYGSWKTPAANPVN SGRGLPLMKALSQAMELRTSATGTVADITFRRPAE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0430 | - | - | 100% (736) | stage II sporulation protein E (SpoIIE) |
| M. avium 104 | MAV_2108 | - | 9e-94 | 37.34% (533) | stage II sporulation protein E (SpoIIE) |
| M. avium 104 | MAV_1619 | - | 9e-46 | 30.99% (384) | anti-anti-sigma factor |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1399c | - | 5e-45 | 31.25% (384) | hypothetical protein Mb1399c |
| M. gilvum PYR-GCK | Mflv_4423 | - | 1e-123 | 41.16% (639) | multi-sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv1364c | - | 2e-44 | 31.25% (384) | hypothetical protein Rv1364c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_5186 | - | 0.0 | 72.33% (730) | sensor-component of a two-component regulator |
| M. smegmatis MC2 155 | MSMEG_6131 | - | 4e-10 | 27.56% (254) | magnesium or manganese-dependent protein phosphatase |
| M. thermoresistible (build 8) | TH_2781 | - | 0.0 | 58.68% (726) | PUTATIVE stage II sporulation protein E (SpoIIE) |
| M. ulcerans Agy99 | MUL_3853 | rsbU | 2e-46 | 31.25% (384) | regulator of sigma subunit, anti-anti-sigma factor RsbU |
| M. vanbaalenii PYR-1 | Mvan_1931 | - | 1e-125 | 41.50% (641) | multi-sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MAV_0430|M.avium_104 --------------------------------------------------
MMAR_5186|M.marinum_M --------------------------------------------------
TH_2781|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK ----------------------------MNWAQTPLGPTSEWPQSLQTAA
Mvan_1931|M.vanbaalenii_PYR-1 MTGDGRGESFSPAGIFADGGEVGRDHARVDWAATPLGPPSRWPQSLLTAA
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MAV_0430|M.avium_104 --------------------------------------------------
MMAR_5186|M.marinum_M --------------------------------------------------
TH_2781|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK NILLSSRFPMWMAWGPDLTFFCNDAYRNVTLGRKYPWALGRPASEVWAEI
Mvan_1931|M.vanbaalenii_PYR-1 SILLSSRFPMWMAWGPELTFFCNDAYRRDTLGRKYPWALGRPASEVWAEI
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MAV_0430|M.avium_104 --------------------------------------------------
MMAR_5186|M.marinum_M --------------------------------------------------
TH_2781|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK WDDIGPRIERVLSTGVATWDTSLLLFLERSGYTEESYHTFSYSPLRDDDG
Mvan_1931|M.vanbaalenii_PYR-1 WDDIGPRIERVLSTGQATWDTALLLFLERSGYPEETYHTFSYSPLRDDDG
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MAV_0430|M.avium_104 --------------------------------------------------
MMAR_5186|M.marinum_M --------------------------------------------------
TH_2781|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK AVVGMLCVVSEDTLQVIGERRMATLRDLGSDPSVVRTEGEILSFVDRQLA
Mvan_1931|M.vanbaalenii_PYR-1 RVVGMLCVVSEDTVRVIGERRMATLRDLGSDLSLVRSEVDILRFADEQLG
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MAV_0430|M.avium_104 --------------------------------------------------
MMAR_5186|M.marinum_M --------------------------------------------------
TH_2781|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK QNLRDLPFTLTYLFDDDGSAHLAGMSGITGDHPAAPDVLTGADGELWPVG
Mvan_1931|M.vanbaalenii_PYR-1 HNLRDLPFTLTYLFDGDGSARLAGTSGIAPEHPAVPTRLSADGGGIWPVA
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MAV_0430|M.avium_104 --------------------------------------------------
MMAR_5186|M.marinum_M --------------------------------------------------
TH_2781|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK PPAGGETVLLEVDTAPYPAMPTGDWREPPRQVLIVPLLQQGAAPTGFLVA
Mvan_1931|M.vanbaalenii_PYR-1 EPARSESVLVDLDGDSYPSLPTGDWREPPAQALVVPLLHQGGSPSGFLVV
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MAV_0430|M.avium_104 --------------------------------------------------
MMAR_5186|M.marinum_M --------------------------------------------------
TH_2781|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK GLNRYRVLDDAYRGFVALVAGHIAAGIGLSRSYRTQQMRAEELAELDRAK
Mvan_1931|M.vanbaalenii_PYR-1 GLNRYRLLDDGYRGFLTLVAGHIAAGIGLARSYRAQQRRAEELAELDRVK
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MAV_0430|M.avium_104 --------------------------------------------------
MMAR_5186|M.marinum_M --------------------------------------------------
TH_2781|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK TTFFSNISHEFRTPLTLILDPVSELRRADTLGDAARQELDVVWRNGLRLN
Mvan_1931|M.vanbaalenii_PYR-1 TTFFSNISHEFRTPLTLILDPVSELRRAESIDEPVRRELDVVWRNGLRLT
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MAV_0430|M.avium_104 --------------------------------------------------
MMAR_5186|M.marinum_M --------------------------------------------------
TH_2781|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK KLVNTLLDFSRIEAGRTQAHYQPVDLGAVTAELASVFRSAIERAGLVFDV
Mvan_1931|M.vanbaalenii_PYR-1 KLVNTLLDFSRIEAGRTQARYQPVDLGALTAELASMFRSAVERAGLTFDI
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MAV_0430|M.avium_104 --------------------------------------------------
MMAR_5186|M.marinum_M --------------------------------------------------
TH_2781|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK DCPPLGEEAYVDLDMWEKVIFNLLSNALKFTFEGSVSVTARRDGRGAVIT
Mvan_1931|M.vanbaalenii_PYR-1 DCDPLDEVVYVDRDMWEKVIFNLLSNALKFTFEGAVSVRVRRDGHQAVVV
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MAV_0430|M.avium_104 --------------------------------------------------
MMAR_5186|M.marinum_M --------------------------------------------------
TH_2781|M.thermoresistible__bu --------------------------------------------------
Mflv_4423|M.gilvum_PYR-GCK VSDTGTGVPADEMPRLFERFHRIENTRARSNEGSGIGLALVKELVGLHGG
Mvan_1931|M.vanbaalenii_PYR-1 VADTGTGVPADEMPRLFERFHRIENAKARSNEGSGIGLALVKELIGLHGG
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MAV_0430|M.avium_104 -MSDD------NDFHDQY---------------------ARALRAYLASR
MMAR_5186|M.marinum_M -MTETGDFGAVDAFQTQY---------------------ADALRAYLDTR
TH_2781|M.thermoresistible__bu -MSPD--------FGARY---------------------AAALAAYLEDS
Mflv_4423|M.gilvum_PYR-GCK TIEADSAESRGTTFTIRLPWGAGHLPADAVASQPRERRPGNTVDAYVEEA
Mvan_1931|M.vanbaalenii_PYR-1 TIVADSAEGQGTAFTIRMPFGAAHLPDDALAPVGDGREAAGGADAYVEEA
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 ---------------------------------MLLLDLLRQRTYSFVRS
MAV_0430|M.avium_104 D------------------------------EASLAVGHELGRRALQEQI
MMAR_5186|M.marinum_M D------------------------------ENSLAVGHEFGRRALQEQI
TH_2781|M.thermoresistible__bu S------------------------------ERRLAVAHDLGRQALLGRI
Mflv_4423|M.gilvum_PYR-GCK LRWTPDGVREYVAESAQPTTGPEKPIGTGTLARVLVADDNADMREYLGRL
Mvan_1931|M.vanbaalenii_PYR-1 LRWIPADT-EADDESAHAPTGS----VTAASARVLVADDNADMREYLTRL
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 -------MAAEMDWDKTVGAAEDVR-------------------------
Rv1364c|M.tuberculosis_H37Rv -------MAAEMDWDKTVGAAEDVR-------------------------
MUL_3853|M.ulcerans_Agy99 VHRRDGYMAAEMDWDKNVGTANTVR-------------------------
MAV_0430|M.avium_104 S-----LLEIIEQHVRLVFEISQD-----------VRID-----------
MMAR_5186|M.marinum_M S-----ILDIIENHFRLLDEISPN-----------PGSD-----------
TH_2781|M.thermoresistible__bu S-----VLQIVEDHVRLVDELSRR-----------QPVD-----------
Mflv_4423|M.gilvum_PYR-GCK LRSDGYAVEAVVDGWQALEAIRAEPPDLVISDVMMPRLDGLGLVAELRAD
Mvan_1931|M.vanbaalenii_PYR-1 LRSDGYRVDAVADGLEALEAIRAGAPDIVVSDVMMPRLDGLGLVAELRAD
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 ----RIFEHIPAILVGLEGPDHRFVAVNAAYRGFSPLLDTVGQPAR----
Rv1364c|M.tuberculosis_H37Rv ----RIFEHIPAILVGLEGPDHRFVAVNAAYRGFSPLLDTVGQPAR----
MUL_3853|M.ulcerans_Agy99 ----RIFENVPTMLVGLEGPEHRFVAANAAYRRFSPTFTAVGQPAR----
MAV_0430|M.avium_104 --APIALEFLLQLLVPLDVATRGFIDGNRRYAEQRARAEGLADRD-----
MMAR_5186|M.marinum_M --RSVALEFLLQTLAALDVATRGFLDGTKRYEEQRARAEDLAHRD-----
TH_2781|M.thermoresistible__bu --TDTALQFLLQALAAVDVAVRGYLEGTRRYEQQRARAEGLAGRD-----
Mflv_4423|M.gilvum_PYR-GCK RRTAAVPVLLLSARAGQEASISGLQAGADDYLVKPFAAAELLARVRANIQ
Mvan_1931|M.vanbaalenii_PYR-1 RRTAATPVLLLSARAGQQESISGLRAGADDYLVKPFAAAELLARVRTNVE
MSMEG_6131|M.smegmatis_MC2_155 ----------------MRAPFDRVIASPVDLTGPGQRRLSLLLVE-----
. :
Mb1399c|M.bovis_AF2122/97 ---------EVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDYDGSGV
Rv1364c|M.tuberculosis_H37Rv ---------EVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDYDGSGV
MUL_3853|M.ulcerans_Agy99 ---------EVYPELESQQIYHMLDRVYETGEPQSGAEWRLQADFDGSGI
MAV_0430|M.avium_104 ---------KFRNALVNSLQEGFFVADHEGSVIEVNNAFIEILGFPAEGL
MMAR_5186|M.marinum_M ---------KFRSALVNSLQEGFFVADDEGAVIDMNSAFAEILGYPPEGL
TH_2781|M.thermoresistible__bu ---------TFRSALVNAMQEAFFVMDRTGSVIDINEAFAEITGYDGHDL
Mflv_4423|M.gilvum_PYR-GCK LARLREGHARWRTALVDSLQEAFFVCDEHGAVVEINPAFTEILGYDSTGL
Mvan_1931|M.vanbaalenii_PYR-1 LARLRHHHAQWRTALVDSLQEAFFVCDADGAVIEINPAFTEILGYDRAGL
MSMEG_6131|M.smegmatis_MC2_155 ----------------DDRADAILVEELIADAPDIDFVWAKSMSDAERTL
. :: : . : . :
Mb1399c|M.bovis_AF2122/97 EERYFDFVVTPRRRADGSIEGVQLIVDDVTSRVRARQAAEARVEELSERY
Rv1364c|M.tuberculosis_H37Rv EERYFDFVVTPRRRADGSIEGVQLIVDDVTSRVRARQAAEARVEELSERY
MUL_3853|M.ulcerans_Agy99 DERYFDFLVTPRRREDGSIEGVQILFDDVTTRVRARLAAEARVEELSERY
MAV_0430|M.avium_104 PYRWPHPWLVDP-------KTASEQIGVVL-RTG-SAEYETPIRHADGHL
MMAR_5186|M.marinum_M PYRWPHPWLVDR-------KSAAQQQERVR-HEG-SADYETPVRHQDGHL
TH_2781|M.thermoresistible__bu PYRWPHPWVVDE-------PRADEDLLELL-QHG-RVQLERQIRHRSGHL
Mflv_4423|M.gilvum_PYR-GCK PYPLMHPWWPLKGSDAEANRRVEEAFGSFM-RDPHGTLTEVPVTHRDGHR
Mvan_1931|M.vanbaalenii_PYR-1 PYRPMHPWWPSADNDPDAHRQVAEAFDSLL-GNRRGTITAVPVTHRDGHR
MSMEG_6131|M.smegmatis_MC2_155 ADHRPDCVLLDLN------------------------------------L
.
Mb1399c|M.bovis_AF2122/97 RNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDTAAG--GDWFDAL
Rv1364c|M.tuberculosis_H37Rv RNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDTAAG--GDWFDAL
MUL_3853|M.ulcerans_Agy99 RHLRDSAIVMQQALLAPSVPVVSGPDIAAQYLVAAQDTAAG--GDWFDAV
MAV_0430|M.avium_104 AWVKVSINAVKDSGSDRDAYVGTIRDVTAERAFAARESAVLRLATAVAVA
MMAR_5186|M.marinum_M SWVAVSINAVRGSGSDRDVYVGTVRDITAERAFAARESAVLRLATSVSVA
TH_2781|M.thermoresistible__bu AWVAISVNVVNPNGT---AFVGTMRDITAAHKAAARESALTRLATAAGVA
Mflv_4423|M.gilvum_PYR-GCK LYVTVTFSHADDPETGRDVIVGTLRDVTAERYIVQRESALASLNEKLAQA
Mvan_1931|M.vanbaalenii_PYR-1 LWVTATFAHAEDPETGGDVVVGTVRDVSAEHFVVQRETALASLNESLAQA
MSMEG_6131|M.smegmatis_MC2_155 PDAAGIDALHHLGKLDARIPIIVLTGLNDEHFGVS-------------AV
: .: .
Mb1399c|M.bovis_AF2122/97 ALGDRLVLVVGDVVGHGVEAAAVMSQLRTA----------LRMQISTGYT
Rv1364c|M.tuberculosis_H37Rv ALGDRLVLVVGDVVGHGVEAAAVMSQLRTA----------LRMQISAGYT
MUL_3853|M.ulcerans_Agy99 ALGDRLVLIVGDVVGHGVEAAAVMSQLRTA----------LRLQIAAGRS
MAV_0430|M.avium_104 KSVDELLSITLDECSTAIDVQRVVAVSWPS-------GDGDPAVQVAGRP
MMAR_5186|M.marinum_M KSVSEVLSITLEECRTAVDVQRVVAVMWPP-------SDGEPTVQVAGEP
TH_2781|M.thermoresistible__bu TSVSEVLSIMLDECRPAIDSRRVIAVTWAR-------EDAEPTIQVVGDP
Mflv_4423|M.gilvum_PYR-GCK DTLDDAVLAAAEEFSSIWSARRVVAATWPD-EPDGEHESDAPSLTVVGAP
Mvan_1931|M.vanbaalenii_PYR-1 DTLGDAVRAATAEFAAVWRARRVLAVTWPDGYPVDTETPVDPHLVCAGEP
MSMEG_6131|M.smegmatis_MC2_155 ASGAQDYLVKGRVEPEMLRRAVLYAIERKR--------------------
: :
Mb1399c|M.bovis_AF2122/97 VVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGEFQYCTAGHPPPLLVTA
Rv1364c|M.tuberculosis_H37Rv VVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGEFQYCTAGHPPPLLVTA
MUL_3853|M.ulcerans_Agy99 IGEALEALDAFHEHVPGSNSATLCVGSLDFTTGEFQYCTAGHPPPLVVTA
MAV_0430|M.avium_104 AASSWRELDPWLRDTFAEARHQLPLTAKTVDHPDNPGKSRG-LVAVLSGA
MMAR_5186|M.marinum_M AESSWRALDPQLRETFLGARAQLPLTARPIEWPDSPGRAQG-LVAVLSGT
TH_2781|M.thermoresistible__bu PASTWADLDESLRTTLLAARDWPPLTVQPVSDAG-QNTSRG-IVAVLSGT
Mflv_4423|M.gilvum_PYR-GCK --ATWDGLPGSARELILTLRRDH------LLAPHTSDAGAA-GVALRHPR
Mvan_1931|M.vanbaalenii_PYR-1 --ARWSDLPAHTRERITALRDDD------LLDPDTSTAGAA-GVALQHPQ
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 DASARYVEPTGAGPLGSGTGFPVRSEVLNIGDAILFYTDGLIERPG----
Rv1364c|M.tuberculosis_H37Rv DASARYVEPTGAGPLGSGTGFPVRSEVLNIGDAILFYTDGLIERPG----
MUL_3853|M.ulcerans_Agy99 EAKARYLEPSGAGPLGSDTGFPVRTELIGVGDVVLLYTDGLIERPG----
MAV_0430|M.avium_104 GDLALWLELRTPRWVSGEDRLLVTVLIGHLSLALQHVRQFENARETSLTL
MMAR_5186|M.marinum_M ADVALWLELGAPRWVTAEDRLLVTVLVGHLSLAIGHVRQFESARETSLTL
TH_2781|M.thermoresistible__bu PATVLWLEHRVPRPVGIDGRRLINALVGHVSLAVQHVRRFEIARESSLTL
Mflv_4423|M.gilvum_PYR-GCK GVLVLYVELPEQRLFTAEDDTLLTVLAGRLGQGLQRVHQIDQQRETALAL
Mvan_1931|M.vanbaalenii_PYR-1 GVLVIYVELFERRRFTAEDHTLLTVLAGRLGQGLQRVQQIDQQRETALAL
MSMEG_6131|M.smegmatis_MC2_155 -AELTSVDLHASQLRAQENARLERGLLPSP--------------------
::
Mb1399c|M.bovis_AF2122/97 -RPLEASTAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLELLLRSTG
Rv1364c|M.tuberculosis_H37Rv -RPLEASTAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLELLLRSTG
MUL_3853|M.ulcerans_Agy99 -RPLGASTAEFADLAANITSG-GGFVIDAQSRPIDRLCSETLELLLRSTG
MAV_0430|M.avium_104 QRAMLPPVQPPPGFAVRYEPAVPPLEIGGDWYDVLPIGDHRIGIVVGDCV
MMAR_5186|M.marinum_M QRAMLPPVKPPPGFAVRYEPAVPPLEIGGDWYDVLPIGEHRIGIVVGDCV
TH_2781|M.thermoresistible__bu QRAMLPDIVPPPGFAVRYEPAVRPLEIGGDWYDVLPLDDHQIGIIVGDCV
Mflv_4423|M.gilvum_PYR-GCK QHAILGPSLSS-AFAVRYQPATRPLQVGGDWYDVVDLEDGRIGLIVGDCV
Mvan_1931|M.vanbaalenii_PYR-1 QHAILGPALSG-GFAVRYQPATRPLQVGGDWYDVVDLDDGRIALIVGDCV
MSMEG_6131|M.smegmatis_MC2_155 ----LLMEGSGVDIVVEARPSRQHALIGGDFYDVVQTPDRTVHVMIGDVA
:.. .. :.. : . : ::: .
Mb1399c|M.bovis_AF2122/97 YNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQLREWLAEIGADHSD
Rv1364c|M.tuberculosis_H37Rv YNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQLREWLAEIGADHSD
MUL_3853|M.ulcerans_Agy99 YNDDITLLAVQRRAPTPPLNITEDATIHAARAIRSRLRQWLSEIGADSGD
MAV_0430|M.avium_104 GRGLPAAAIMGQLRSSARALLINGAEPAVLLDQLDSAASLIPNAYCTTVF
MMAR_5186|M.marinum_M GRGLPAAAIMGQLRSSARALLLTGAQPALLLEQLDAAASLIPDAYCTTVF
TH_2781|M.thermoresistible__bu GRGLPAAAVMGQLRSSARALLLSGAEPARLLENLDAVAALIPDAYCATVL
Mflv_4423|M.gilvum_PYR-GCK GHGLAAATVMGQLRSACRALLLEHPSPAAALSALDRFAARLPGARCTTAF
Mvan_1931|M.vanbaalenii_PYR-1 GHGLAAAAIMGQLRSACRALLLEHPSPAAALSGLDRFAARLPGARCTTAF
MSMEG_6131|M.smegmatis_MC2_155 GHGPDEAALGVALRIGWRALTFAGLRGNERMRQLDRILTTERPGKGIFAT
..
Mb1399c|M.bovis_AF2122/97 IADIVHAISEFVENAVEHGYATDVSKGIVVEAALAGDGNVRASVIDRGQW
Rv1364c|M.tuberculosis_H37Rv IADIVHAISEFVENAVEHGYATDVSKGIVVAAALAGDGNVRASVIDRGQW
MUL_3853|M.ulcerans_Agy99 ISDIVHAISEFVENAVEHGYSTDVSDGLAVAAALGGDGKLRVAVIDHGTW
MAV_0430|M.avium_104 LAILDTETGVLQYSNAGHMPAVLAGPEPGTTTLLTDAASVPLAVRREDPR
MMAR_5186|M.marinum_M LAILDTESGILDYSNAGHMPAVLAEPKSGP-VLLTDARSVPLAVRRVEPR
TH_2781|M.thermoresistible__bu LAVLDTESGTLRYSNAGHVPALLAGPGPHA-TVLTDGASVPLGVQQNRPR
Mflv_4423|M.gilvum_PYR-GCK CAVLDPRIGEVVYSCAGHPPPIMVTADRTT-ELLEGARATPLGLKNPPHR
Mvan_1931|M.vanbaalenii_PYR-1 CAVLDPETGEVVYSCAGHPPPILIGADRST-RLLEEARATPLGLKNPPHR
MSMEG_6131|M.smegmatis_MC2_155 LCSVALEPDSGRFTVVRAGHPGLLVHGNGTVDWLEPRPGAALGLG-AREW
. : . . . . * .:
Mb1399c|M.bovis_AF2122/97 KDHRDGARGRGRGLAMAEALVSEAR--IMHGAGGTTATLTHRLSRPARFV
Rv1364c|M.tuberculosis_H37Rv KDHRDGARGRGRGLAMAEALVSEAR--IMHGAGGTTATLTHRLSRPARFV
MUL_3853|M.ulcerans_Agy99 KHHREGERGRGRGLAMAEALVSETH--VSHDGAGTTATVVHRLSRPAQFV
MAV_0430|M.avium_104 PQATRLLPPGSTLMLFTDGLVERKHEPIDDGIGRAAEVLAQTMTLPLDTV
MMAR_5186|M.marinum_M PEATQVLPPGSTLLLFTDGLVERRYESIDEGLGRVADVVADSVMLPIDAV
TH_2781|M.thermoresistible__bu PQVSRQLTPGSTLMLYTDGLVERRDSPIDTGMDRACQVLTAMLDAEPEAV
Mflv_4423|M.gilvum_PYR-GCK TEARVTMPARATLLLYTDGLVERRRESIDDGIARATDVVQGNRATDLDQL
Mvan_1931|M.vanbaalenii_PYR-1 TEARETMAPRATLLLYTDGLVERRRESIDDGIARAAGVVEDNRATALDEL
MSMEG_6131|M.smegmatis_MC2_155 PVNHYELPEGHGLLLLTDGLFEGHAGRGDERLGESGLLAVAR--------
: ::.*..
Mb1399c|M.bovis_AF2122/97 TDTMVRRAAFQQTIDSEFVS-LVESGRIVVRGDVDSTTAATLDRQIAVES
Rv1364c|M.tuberculosis_H37Rv TDTMVRRAAFQQTIDSEFVS-LVESGRIVVRGDVDSTTAATLDRQIAVES
MUL_3853|M.ulcerans_Agy99 TDPVVSRAPNRPAIDSEFASTVTESGHIVVRGDVDSNTAPTLDRQIAVES
MAV_0430|M.avium_104 ADEVLRELAPAAGYDDDVAMVIYRHQQSPLRIETAATADQLVRIRHRLAD
MMAR_5186|M.marinum_M ADAVLSQLAPTGGYDDDVAMVAYRYQHGPLRIETSATPDQLVIVRRQLLS
TH_2781|M.thermoresistible__bu ADAMLDTLAPADGYDDDVAIVVYRHTFAPLRIELPATPDRLSEVRARLTG
Mflv_4423|M.gilvum_PYR-GCK ANVIMARLAPADGYHDDVALLLYRQP-EPLDLDFPADVAELAGSRTVLRG
Mvan_1931|M.vanbaalenii_PYR-1 ANAVMAGLAPADGYHDDVALLLYRQP-APLDLEFAADVAELAVGREALRG
MSMEG_6131|M.smegmatis_MC2_155 ------ALAATPGRDFVTSLINEAESRAQTHGGLSDDIAVIRVERSRR--
. . :
Mb1399c|M.bovis_AF2122/97 RSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPAH
Rv1364c|M.tuberculosis_H37Rv RSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPAH
MUL_3853|M.ulcerans_Agy99 RSGIASLTIDLSAVTHLGSAGVSALVTARDRARKQGGRCVLMAPPGSPAH
MAV_0430|M.avium_104 WLGAAGITGELAADIVLVVNEACTNCVEHAYRGFVAGTMVLDARLGEGEV
MMAR_5186|M.marinum_M WLQAAEVPDEQAGDIVLVVSEACTNCIEHAYRGQSVGTMLLDVEAADWAI
TH_2781|M.thermoresistible__bu WLTAAGAPELLISDIVLAVNEACTNSVEHAYRDREPGPMQVYADLRDGQI
Mflv_4423|M.gilvum_PYR-GCK WLDSAGVPQDQALDVLIAVGEALANAIEHGHRDDPGGRVRLRAVALPDRV
Mvan_1931|M.vanbaalenii_PYR-1 WLDRAGVGAEQSLDVLIATGEALANAIEHGHREQPRGPVRLRAIALPDRV
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 HVLSLVQ-----------------LPVVGADTEDIFAQE-----------
Rv1364c|M.tuberculosis_H37Rv HVLSLVQ-----------------LPVVGADTEDIFAQE-----------
MUL_3853|M.ulcerans_Agy99 HVLSLVQ-----------------IPVISGETENVFAED-----------
MAV_0430|M.avium_104 HTRITDYGSWKTPAANPVNS-GRGLPLMKALSQAMELRTSATGTVADITF
MMAR_5186|M.marinum_M HARVVDSGSWKKPAADPGNG-GRGMTLIRAISDEVEIDNSPGGTAIDMTF
TH_2781|M.thermoresistible__bu MLQVRDFGTWKTPEPNPRIR-GRGLPMMRAISADVQVDNTRSGTVVELTF
Mflv_4423|M.gilvum_PYR-GCK QLTIIDTGSWKAPDDVPALHRGRGIALMKALMQDVTIDSQTTGTTVHMNT
Mvan_1931|M.vanbaalenii_PYR-1 HVTVVDSGTWKPPATVPALHRGRGIALMRALMHDVTIDSQTTGTTVHMNA
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 ---------
Rv1364c|M.tuberculosis_H37Rv ---------
MUL_3853|M.ulcerans_Agy99 ---------
MAV_0430|M.avium_104 RRPAE----
MMAR_5186|M.marinum_M RLPSED---
TH_2781|M.thermoresistible__bu TLSGQPALT
Mflv_4423|M.gilvum_PYR-GCK RIA------
Mvan_1931|M.vanbaalenii_PYR-1 RIV------
MSMEG_6131|M.smegmatis_MC2_155 ---------