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GRPRSRRARRTGRRPEHHRRADLKPNPPRRRAAGSAAQRVRPVPRRPDQRPAGPHHRLAHRPDHRPRPDG RRRRRTRRPDHHLGPAVGRQNRTGHRRPRRPPRPRRRPLHQELAGVPHPGIRHPRRQPRTHHHLGPHLRG DAAAAQRRIDDMAHSVCPDDPRTLDDRRIEAYTALLAGITTLTCHCGNDDCEATAAPRPGRDTTIYVLTD TTTGNTPAADQADQNTRDRNEAEPATDTTGKAKNENEAAREGEREDAAASEDRDGTEQTPAAKQNVRPHT AQCRSAYVFGAGLAPTALLEAMCEGATIREITHPGPDSAPEPRYTPSPALAAYIRCRDLTCRFPHCDTPA TLADIDHTVPYPVGPTHPSNLKTLCRFHHLLKTFWLGATGWRDRQYPDGTIEWTAPTGHTYTTYPGSRLL FPALCAPTATLWTGEPPQTTLSARRGAMMPKRRNTRAHNRSRYIEAQRRRNRSEKICTTRSTDIARGRDI LYRNTLHQFHPPGHEPDYGNDPPPF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5774 | - | - | 100% (516) | HNH endonuclease |
| M. vanbaalenii PYR-1 | Mvan_0728 | - | e-123 | 58.93% (375) | hypothetical protein Mvan_0728 |
| M. vanbaalenii PYR-1 | Mvan_0426 | - | 1e-70 | 43.60% (344) | hypothetical protein Mvan_0426 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2126 | - | 1e-67 | 43.62% (337) | hypothetical protein Mb2126 |
| M. gilvum PYR-GCK | Mflv_0179 | - | 1e-109 | 57.14% (350) | hypothetical protein Mflv_0179 |
| M. tuberculosis H37Rv | Rv2100 | - | 1e-67 | 43.62% (337) | hypothetical protein Rv2100 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 1e-28 | 40.98% (183) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_2226 | - | 1e-56 | 38.67% (375) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_4456 | - | 2e-59 | 38.11% (391) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_5106 | - | 6e-73 | 44.44% (369) | HNH endonuclease |
| M. thermoresistible (build 8) | TH_0334 | - | 1e-29 | 34.63% (231) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_1813 | - | 2e-50 | 39.74% (302) | 13e12 repeat-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2226|M.marinum_M -----------------------------------------MFEYWYASR
MUL_1813|M.ulcerans_Agy99 --------------------------------------------------
MAV_4456|M.avium_104 ------------------------------MCEDATAWFDELMERCYPS-
MAB_4752|M.abscessus_ATCC_1997 ------------------------------------------------MF
TH_0334|M.thermoresistible__bu ------------------------------------------------MF
Mb2126|M.bovis_AF2122/97 MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL
Rv2100|M.tuberculosis_H37Rv MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL
MSMEG_5106|M.smegmatis_MC2_155 --------------------------------------------MQIAEF
Mflv_0179|M.gilvum_PYR-GCK --------------------------------------MFDSSVPEPAAL
Mvan_5774|M.vanbaalenii_PYR-1 ------------------------------------MGRPRSRRARRTGR
MMAR_2226|M.marinum_M PTAESNALLERAREASRREAAAAAERLDVVGALFVLR--CRESGDRAEWA
MUL_1813|M.ulcerans_Agy99 --------MERAREASRREAAAAAERLDVVGALFVLR--CRESGDRAEWA
MAV_4456|M.avium_104 ATPESAALVQRIGVFARVENRAAAEQLAAIGELFAYR--LSRCSECEDWA
MAB_4752|M.abscessus_ATCC_1997 DELGDVELIDLIASAQRAEAQACARKLDAIGVLVDRHADLGKPDERDHHA
TH_0334|M.thermoresistible__bu ESLDDGAVVDSIAAASREQSAACGREMLAIGELYARR-APEDDTERANWA
Mb2126|M.bovis_AF2122/97 CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGRR---TGADQRADWA
Rv2100|M.tuberculosis_H37Rv CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGRR---TGADQRADWA
MSMEG_5106|M.smegmatis_MC2_155 SALSDLELEGQARGWAQAEASASAHKHAAMAEMFIRATSTPSADERRWWF
Mflv_0179|M.gilvum_PYR-GCK AGLSDAELVDAAGAAARAENAVCARKLAVMAELFTRR-VDLAPEDRLNWW
Mvan_5774|M.vanbaalenii_PYR-1 RPEHHRRADLKPNPPRRRAAGSAAQRVRPVPRRPDQR--PAGPHHRLAHR
: .... : .
MMAR_2226|M.marinum_M TDTWEAVAAQVAAALRTSVAMGSSYLRYAMAMRNRLPKVGQAFRAGDIDY
MUL_1813|M.ulcerans_Agy99 TDTWEAVGAQVAAALRTSVAMGSSYLRYAMAMRNRLPKVGQAFRAEDIDY
MAV_4456|M.avium_104 VDTEAAVSAEVAAQLRIGQGLAAAKVRYARAMRERLPRVGEVFRAGEIDF
MAB_4752|M.abscessus_ATCC_1997 LDRWDRVASEVAAAQGITHALASSQMRYAQVLRHRLRAVAERFAAGDLDF
TH_0334|M.thermoresistible__bu IDGHANVVAEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFAAGDIDF
Mb2126|M.bovis_AF2122/97 CDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLGA
Rv2100|M.tuberculosis_H37Rv CDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLGA
MSMEG_5106|M.smegmatis_MC2_155 VDPDAAVGAQLGAAQGITAWAALHQAQRGVALRDRLPKVNEVFAAGLVSE
Mflv_0179|M.gilvum_PYR-GCK VDPDAAVAAEIAAAVTITQGLATHQTYRAVVLRDRLPKVGALFLQGLLSE
Mvan_5774|M.vanbaalenii_PYR-1 PDHRPRPDGRRRRRTRRPDHHLGPAVGRQNRTGHRRPRRPPRPRRRPLHQ
* .. * :
MMAR_2226|M.marinum_M RAFQTIVFRTDLITDAEVLAKVDAQLAALLARCPAVTRGRLSVAVDQVVA
MUL_1813|M.ulcerans_Agy99 RAFQTIVFRTDLITDAEVLAKVDAQLAALLARCPAVTRGRLSVAVDQVVA
MAV_4456|M.avium_104 RLFATIVYRTDLITDRRVLAAVDAELAATAARWPSMTRARLAARVDAVVA
MAB_4752|M.abscessus_ATCC_1997 RTVALIINRTELVDDEAVVARVDAAIVRALPRWARWSHKRITAALDALVL
TH_0334|M.thermoresistible__bu RMVSALVNRSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNERIDMWVE
Mb2126|M.bovis_AF2122/97 RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID
Rv2100|M.tuberculosis_H37Rv RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID
MSMEG_5106|M.smegmatis_MC2_155 MIVRNICWSTALMLEPDKLALIDAELAAQISGWGKLTLKEIDNTIDDLIL
Mflv_0179|M.gilvum_PYR-GCK LLVRAIITRTDLITDPELIAAVDADLAADILRWGPQSAKKTEAAIDHIVE
Mvan_5774|M.vanbaalenii_PYR-1 ELAGVPHPG---IRHPRRQPRTHHHLGPHLRGDAAAAQRRIDDMAHSVCP
: . . . : : .
MMAR_2226|M.marinum_M DVDRDAVRRVAEAADGRFVDVDVIADGSGLAALTGSVLATAGRAFDRRLD
MUL_1813|M.ulcerans_Agy99 DVDRDVVRRVAEAADGRFVDVDVIADGSGLAALAGSVLATAGRAFDRRLD
MAV_4456|M.avium_104 KADADAVRRTEKQAASRHVWIAEMGEG--LSHLEGTVSSPDAHALDKRLD
MAB_4752|M.abscessus_ATCC_1997 HFDQDAVRRNRSATDKRHLEIRPLGNGEPVAEVWGTLQAVHAVALDKRLD
TH_0334|M.thermoresistible__bu RFDPTGVREPRSPGEDRYVVVTPAGQG--MVDVSARLTFEAGFAFXTRLD
Mb2126|M.bovis_AF2122/97 RYDPGALRRSRISARTRDLCIGDPDEDAGTAALWGRLYATDAAMLDRRLT
Rv2100|M.tuberculosis_H37Rv RYDPGALRRSRISARTRDLCIGDPDEDAGTAALWGRLYATDAAMLDRRLT
MSMEG_5106|M.smegmatis_MC2_155 KHDPASFRRGRASRRGRYFDIGSPTDAPGVLTVTGRLQAHLGNAYDARIA
Mflv_0179|M.gilvum_PYR-GCK RHDPDAVRQTRQHDVGRTIEIGNPGDAPGYTTVWARMFAGDAAAGHRTLT
Mvan_5774|M.vanbaalenii_PYR-1 DDPRTLDDRRIEAYTALLAGITTLTCHCGNDDCEATAAPRPGRDTTIYVL
. : . . :
MMAR_2226|M.marinum_M ELANTVCAADPRTREQRRADAVGALVAGSDRLACGCTSADC--TAAARSA
MUL_1813|M.ulcerans_Agy99 ELANTVCAADPRTREQRRADAVGALVAGSDRLACGCTSADC--TAAARSA
MAV_4456|M.avium_104 ALAATVCEHDPRTGEQRRADALGALAAGADRLGCRCGRADC--AAGTRPA
MAB_4752|M.abscessus_ATCC_1997 LLAGTVCPADPRSKTQRRADAVGALTQGLNRMRCACGHPDC--SGRD-TA
TH_0334|M.thermoresistible__bu QIAATVCRDDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCP-ADPADTA
Mb2126|M.bovis_AF2122/97 EMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPSGAGNDER
Rv2100|M.tuberculosis_H37Rv EMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPSGAGNDER
MSMEG_5106|M.smegmatis_MC2_155 ELIEGVCPDDPRTLNELRHDALGAILD-QTTLACECEDPDCV-RGREQSS
Mflv_0179|M.gilvum_PYR-GCK TMAYSVCDNDPRTLDERRNDALTALFHGITTLACRCGNGDCD-AATNPRP
Mvan_5774|M.vanbaalenii_PYR-1 TDTTTGNTPAADQADQNTRDRNEAEPATDTTGKAKNENEAAREGEREDAA
. : * * . .
MMAR_2226|M.marinum_M PSNVVIHVVADQSTVDG---------------------------------
MUL_1813|M.ulcerans_Agy99 PSKVVIHVVADQSTVDG---------------------------------
MAV_4456|M.avium_104 AGPVVIHLIAERASVEG---------------------------------
MAB_4752|M.abscessus_ATCC_1997 DVPVVVNVVINQSTLAG---------------------------------
TH_0334|M.thermoresistible__bu ATRLVINVIAEQATVEG---------------------------------
Mb2126|M.bovis_AF2122/97 AAGVVIHVVADASALDAQPDPHLSGDEPPSRPLTPETTLFEALTPDPEPD
Rv2100|M.tuberculosis_H37Rv AAGVVIHVVADASALDAQPDPHLSGDEPPSRPLTPETTLFEALTPDPEPD
MSMEG_5106|M.smegmatis_MC2_155 RGHLVVHVIAREDTVTAAQHAATTTNTPDDAPSDTPAADTEPAEPAEPAE
Mflv_0179|M.gilvum_PYR-GCK PRELTVYALTDQTTANIEETTANDADADGGRNAGNGDGDAQPPAPKP---
Mvan_5774|M.vanbaalenii_PYR-1 ASEDRDGTEQTPAAKQNVRP------------------------------
:
MMAR_2226|M.marinum_M --------------------------------------------------
MUL_1813|M.ulcerans_Agy99 --------------------------------------------------
MAV_4456|M.avium_104 --------------------------------------------------
MAB_4752|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0334|M.thermoresistible__bu --------------------------------------------------
Mb2126|M.bovis_AF2122/97 PP------------------------------------------------
Rv2100|M.tuberculosis_H37Rv PP------------------------------------------------
MSMEG_5106|M.smegmatis_MC2_155 PVDDPDIAPAATATETATDTEPDAPAPTDTADSAATETDCDPESVSVTEF
Mflv_0179|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5774|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_2226|M.marinum_M ---TGHTPAVLLGAEG---------------LIPASLIAELAK-----VA
MUL_1813|M.ulcerans_Agy99 ---TGHTPAVLLGAEG---------------LIPASLIAELAK-----VA
MAV_4456|M.avium_104 ---TGGGPAVEVGAEG---------------LLPAQLVAELAA-----SA
MAB_4752|M.abscessus_ATCC_1997 ---SDDCPAHVPGFG--------------------VLAAESAR-----AA
TH_0334|M.thermoresistible__bu ---RSDNPGYLPGYG----------------AVPASILRAKAA-----TA
Mb2126|M.bovis_AF2122/97 ---ATHAPAELITTGGG--------------VVPAPLLAELIRG----GA
Rv2100|M.tuberculosis_H37Rv ---ATHAPAELITTGGG--------------VVPAPLLAELIRG----GA
MSMEG_5106|M.smegmatis_MC2_155 TDNSSDTPAAFLDPDEHPLDRVPPAVLFGGGVLPAYALAEIIN-----NA
Mflv_0179|M.gilvum_PYR-GCK ---RRSKPTLLPGRSGYLFG---------SGFMPAPLFDALLDDALLDGA
Mvan_5774|M.vanbaalenii_PYR-1 -HTAQCRSAYVFGAG----------------LAPTALLEAMCEG-----A
. *
MMAR_2226|M.marinum_M TLRPLMRPS-GRP-ESGYAPSAGLAEFVRCRDLTCRAPGCDQPAVCCDLD
MUL_1813|M.ulcerans_Agy99 TLRPLMRPS-GRP-ESGYAPSAGLAEFVRCRDLTCRARGCDQPAVCCDLD
MAV_4456|M.avium_104 RLMPLVHPA-DAPPENRYTPSAALADFVRCRDLTCRWPGCDRPATECDLD
MAB_4752|M.abscessus_ATCC_1997 VAGTPTRNL-TDSRSTGYRPSAKLAAFVRSRDQLCRFPGCEAVADRADID
TH_0334|M.thermoresistible__bu TLRPVALPQ-PCA-EAGYRPSAALTRFIRCRDLTCRFPGCDAPAAVCQID
Mb2126|M.bovis_AF2122/97 TISQVRHPG-DLAAEPHYRPSAKLAEFVRMRDLTCRFPGCDVPAEFCDID
Rv2100|M.tuberculosis_H37Rv TISQVRHPG-DLAAEPHYRPSAKLAEFVRMRDLTCRFPGCDVPAEFCDID
MSMEG_5106|M.smegmatis_MC2_155 TIRPLKHPG-DTAPEDRYIPSRALADYVRCRDLTCRFPGCDKPADRCDLD
Mflv_0179|M.gilvum_PYR-GCK KIREILHPG-QAGPEPRYTPSTALADFIRCRDLTCRFPGCDTPATEADID
Mvan_5774|M.vanbaalenii_PYR-1 TIREITHPGPDSAPEPRYTPSPALAAYIRCRDLTCRFPHCDTPATLADID
. * ** *: ::* ** ** *: * .::*
MMAR_2226|M.marinum_M HTVAYGDGGHTHASNLKCLCRKHHLLKTFWD----WRDLQLPDGTVIWLL
MUL_1813|M.ulcerans_Agy99 HTVAYGDGGHTHASNLKCLCRKHHLLKTFWG----WRDLQLPDGTVIWLL
MAV_4456|M.avium_104 HTIPYAEGGPTHASNLKCYCRTHHLVKTFWG----WREQQLPDATLILTS
MAB_4752|M.abscessus_ATCC_1997 HTVPWATGGPTTGANLKALCRKHHLLKTFGQ----WTELQEPDGTVIWKS
TH_0334|M.thermoresistible__bu HTIPYPAG-PTHPSNLKLLCVFHCRQAELR------------------FT
Mb2126|M.bovis_AF2122/97 HSAPWPLG-PTHPSNLKCACRKHHLLKTFWTG---WRDVQLPDGTVIWTA
Rv2100|M.tuberculosis_H37Rv HSAPWPLG-PTHPSNLKCACRKHHLLKTFWTG---WRDVQLPDGTVIWTA
MSMEG_5106|M.smegmatis_MC2_155 HTVPYPAG-PTHASNLKCLCRFHHLLKTFWTGPRGWTDRQHPDGTIVWTS
Mflv_0179|M.gilvum_PYR-GCK HTVAHPVG-PTHASNLKCLCRFHHLLKTFWTGRGGWHDRQHPDGTITWTS
Mvan_5774|M.vanbaalenii_PYR-1 HTVPYPVG-PTHPSNLKTLCRFHHLLKTFWLGATGWRDRQYPDGTIEWTA
*: . * * :*** * * :
MMAR_2226|M.marinum_M PDGHTYVTTPGSA--LLFPNLCVPTGGLPPIVGTAG--------------
MUL_1813|M.ulcerans_Agy99 PDGHTYVTTPGSA--LLFPNLCVPTGELPPIVGTAGKPPRWPSGEDADPC
MAV_4456|M.avium_104 PAGRTYVTTPGSA--LLFPSLCVPTGEPARPVAAGS--------------
MAB_4752|M.abscessus_ATCC_1997 PTGHRYATTPVSW--FLFP-------------------------------
TH_0334|M.thermoresistible__bu HDQHKHQSS-----------------------------------------
Mb2126|M.bovis_AF2122/97 PNGHTYTTHPGSR--IFFPTWHTTTAELP---------------------
Rv2100|M.tuberculosis_H37Rv PNGHTYTTHPGSR--IFFPTWHTTTAELP---------------------
MSMEG_5106|M.smegmatis_MC2_155 PSGRQYTTVPGSHRRLSITELAAPTGALDLP-------------------
Mflv_0179|M.gilvum_PYR-GCK PTGHTYITHPGSR--LLFPTLCKPTATLWTG-------------------
Mvan_5774|M.vanbaalenii_PYR-1 PTGHTYTTYPGSR--LLFPALCAPTATLWTGEPPQTTLS-----------
: : :
MMAR_2226|M.marinum_M -SPRAGRAARMPTRARTRAQNRANRIDTERR---------CNRRALEAVG
MUL_1813|M.ulcerans_Agy99 PNPRTKPGESHRHRAPMQSQGTGSRRRRPRRPVRHPGAGNRSRRAAALLA
MAV_4456|M.avium_104 -QPCGERTAMMPTRRRTRGQNRAARVAAERR----------ANRAARLAR
MAB_4752|M.abscessus_ATCC_1997 ----------ALTRHHTRQQARDRRRRTERN----------LNREQRLQR
TH_0334|M.thermoresistible__bu ----------CLPAYFQRPHGPATRRPPSAR----------GLREAVPRQ
Mb2126|M.bovis_AF2122/97 ----------QTSTAAVNVDARGLMMPRRRR-----------TRAAELAH
Rv2100|M.tuberculosis_H37Rv ----------QTSTAAVNVDARGLMMPRRRR-----------TRAAELAH
MSMEG_5106|M.smegmatis_MC2_155 ----------ATPIPTADPDLRGVKMPKRRR-----------TRAQNTAR
Mflv_0179|M.gilvum_PYR-GCK ----------DPPQVPIR-ERRGAMMPRRAK-----------TRAHSRAV
Mvan_5774|M.vanbaalenii_PYR-1 ----ARRGAMMPKRRNTRAHNRSRYIEAQRR----------RNRSEKICT
. . *
MMAR_2226|M.marinum_M GVHADRYDTP---EPTIGPDEPPPF-----------------------
MUL_1813|M.ulcerans_Agy99 ATSLGTCQIPRRIAPRPGPSRSSRGCTDSGTRMGESSMSARPRACVAG
MAV_4456|M.avium_104 ATRPAPAASQS-WPAGHGPDADPPPF----------------------
MAB_4752|M.abscessus_ATCC_1997 EAALAALAAK-----------DPPPF----------------------
TH_0334|M.thermoresistible__bu GVDPRRVSGQ--------------------------------------
Mb2126|M.bovis_AF2122/97 RINAERALND----AYMAERNKPPSF----------------------
Rv2100|M.tuberculosis_H37Rv RINAERALND----AYMAERNKPPSF----------------------
MSMEG_5106|M.smegmatis_MC2_155 TIAAERQLND----DLVAEHNKPPPF----------------------
Mflv_0179|M.gilvum_PYR-GCK YITAQRRRNAA--ERADGPRGNDPPF----------------------
Mvan_5774|M.vanbaalenii_PYR-1 TRSTDIARGRDILYRNTLHQFHPPGHEPDYGNDPPPF-----------