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MFEYWYASRPTAESNALLERAREASRREAAAAAERLDVVGALFVLRCRESGDRAEWATDTWEAVAAQVAA ALRTSVAMGSSYLRYAMAMRNRLPKVGQAFRAGDIDYRAFQTIVFRTDLITDAEVLAKVDAQLAALLARC PAVTRGRLSVAVDQVVADVDRDAVRRVAEAADGRFVDVDVIADGSGLAALTGSVLATAGRAFDRRLDELA NTVCAADPRTREQRRADAVGALVAGSDRLACGCTSADCTAAARSAPSNVVIHVVADQSTVDGTGHTPAVL LGAEGLIPASLIAELAKVATLRPLMRPSGRPESGYAPSAGLAEFVRCRDLTCRAPGCDQPAVCCDLDHTV AYGDGGHTHASNLKCLCRKHHLLKTFWDWRDLQLPDGTVIWLLPDGHTYVTTPGSALLFPNLCVPTGGLP PIVGTAGSPRAGRAARMPTRARTRAQNRANRIDTERRCNRRALEAVGGVHADRYDTPEPTIGPDEPPPF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2226 | - | - | 100% (489) | 13e12 repeat-containing protein |
| M. marinum M | MMAR_1213 | - | e-142 | 57.08% (480) | 13e12 repeat-containing protein |
| M. marinum M | MMAR_5187 | - | e-139 | 54.34% (484) | 13e12 repeat-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0528 | - | 1e-139 | 55.40% (491) | 13E12 repeat family protein |
| M. gilvum PYR-GCK | Mflv_0314 | - | 1e-102 | 44.24% (486) | hypothetical protein Mflv_0314 |
| M. tuberculosis H37Rv | Rv0336 | - | 1e-140 | 56.03% (489) | 13E12 repeat family protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 1e-86 | 41.21% (478) | hypothetical protein MAB_4752 |
| M. avium 104 | MAV_3457 | - | 1e-175 | 65.10% (490) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_5026 | - | 9e-94 | 42.92% (487) | hypothetical protein MSMEG_5026 |
| M. thermoresistible (build 8) | TH_0334 | - | 1e-71 | 41.39% (360) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_1813 | - | 0.0 | 97.82% (412) | 13e12 repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_3778 | - | 3e-90 | 42.56% (484) | hypothetical protein Mvan_3778 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2226|M.marinum_M --------MFEY---WYASRPTAESNALLERAREASRREAAAAAERLDVV
MUL_1813|M.ulcerans_Agy99 ----------------------------MERAREASRREAAAAAERLDVV
MAV_3457|M.avium_104 ----MVEHMFEY---VVASRSTPEAVALLDRAREAARAEARAAAARLVAV
Mb0528|M.bovis_AF2122/97 MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAAAQLVAL
Rv0336|M.tuberculosis_H37Rv MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAAAQLVAL
MAB_4752|M.abscessus_ATCC_1997 --------MFDELG----------DVELIDLIASAQRAEAQACARKLDAI
MSMEG_5026|M.smegmatis_MC2_155 MGAGILERMFDG----------TSDAGLIDAIAEAKRQENAATARRLFAI
Mvan_3778|M.vanbaalenii_PYR-1 --------MFAY----------AEPAELIDAMSSAARAESAAIARRLEAV
TH_0334|M.thermoresistible__bu --------MFES----------LDDGAVVDSIAAASREQSAACGREMLAI
Mflv_0314|M.gilvum_PYR-GCK --------MFEELID------AAGRSRGAAAIGAWARIENAAVAQRLSAM
* : * . .: .:
MMAR_2226|M.marinum_M GALFVLRCRESG---DRAEWATDTWEAVAAQVAAALRTSVAMGSSYLRYA
MUL_1813|M.ulcerans_Agy99 GALFVLRCRESG---DRAEWATDTWEAVGAQVAAALRTSVAMGSSYLRYA
MAV_3457|M.avium_104 AELLVLRCRETG---ERADWAADAWEAVAAQVGAALGCSVAMGHSYLRYA
Mb0528|M.bovis_AF2122/97 GELFAYRWSRCG---GREEWVMDTMAAVAAEVAAALRISQGLAASRLRYA
Rv0336|M.tuberculosis_H37Rv GELFAYRWSRCG---GREEWVMDTMAAVAAEVAAALRISQGLAASRLRYA
MAB_4752|M.abscessus_ATCC_1997 G-VLVDRHADLGKPDERDHHALDRWDRVASEVAAAQGITHALASSQMRYA
MSMEG_5026|M.smegmatis_MC2_155 GELDTRRA-IDL--AECNFWRTDPFEEVCAEVSAALRISRSRANWQVHLA
Mvan_3778|M.vanbaalenii_PYR-1 AALFRSRK-CDY--AEAGFLHTDVYEAVAAEVSAAQNISRSRAGYQVEMA
TH_0334|M.thermoresistible__bu GELYARRAPEDD--TERANWAIDGHANVVAEISAALNISRGRAAGRLQLA
Mflv_0314|M.gilvum_PYR-GCK ADLLESRLTDKD-SAERDQWCLDNWDAVSAEVAAGQHTSLGVASNELLDA
. : * * * :::.*. : . . : *
MMAR_2226|M.marinum_M MAMRNRLPKVGQAFRAGDIDYRAFQTIVFRTDLITDAEVLAKVDAQLAAL
MUL_1813|M.ulcerans_Agy99 MAMRNRLPKVGQAFRAEDIDYRAFQTIVFRTDLITDAEVLAKVDAQLAAL
MAV_3457|M.avium_104 MAMRERLPQVGAVFAAGGIDYRAFQTLVFRTDLITDAQVLARVDATLAVL
Mb0528|M.bovis_AF2122/97 RAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDAQLAAN
Rv0336|M.tuberculosis_H37Rv RAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDAQLAAN
MAB_4752|M.abscessus_ATCC_1997 QVLRHRLRAVAERFAAGDLDFRTVALIINRTELVDDEAVVARVDAAIVRA
MSMEG_5026|M.smegmatis_MC2_155 RVLRDRIPKVAAVFAQGDIDFRIVTKIATRT-ELVDPAAMPALDDVLARR
Mvan_3778|M.vanbaalenii_PYR-1 VSLYTRLPKVAEAFARGDIDLRMVQIVLART-KNVEDDVIGGLDKAIAPK
TH_0334|M.thermoresistible__bu IDLRERLPRVAAVFAAGDIDFRMVSALVNRSRNVVDPDLLARLDAALAAW
Mflv_0314|M.gilvum_PYR-GCK WTLRRRLPRVAEVFASGAISYRLVKSVVKRTRLVVDPEVMAKIDAEIAAH
: *: .. * :. . : *: : : :* :.
MMAR_2226|M.marinum_M LARCPAVTRGRLSVAVDQVVADVDRDAVRRVAEAADGRFVDVDV-IADGS
MUL_1813|M.ulcerans_Agy99 LARCPAVTRGRLSVAVDQVVADVDRDVVRRVAEAADGRFVDVDV-IADGS
MAV_3457|M.avium_104 VSRRPSLTRGGLAAAVDRVVAAVDADAVRRARDAVTGRYLDVR---ANES
Mb0528|M.bovis_AF2122/97 VARWPSMTKARLAGQVDKIVARADADAVRRRKEYQAQRQFWVG---ESQD
Rv0336|M.tuberculosis_H37Rv VARWPSMTKARLAGQVDKIVARADADAVRRRKEYQAQRQFWVG---ESQD
MAB_4752|M.abscessus_ATCC_1997 LPRWARWSHKRITAALDALVLHFDQDAVRRNRSATDKRHLEIRP-LGNGE
MSMEG_5026|M.smegmatis_MC2_155 CPNWMRLSEPKLEERIDQCILRLDPDGQRVTKRSEDSRYFTVQPA--DTP
Mvan_3778|M.vanbaalenii_PYR-1 LSRWMRLSKNDLRDRVDLWVADFDPAAVRVPPEAKDNRYFDVTP---DVP
TH_0334|M.thermoresistible__bu SPKWMKLSGPTLNERIDMWVERFDPTGVREPRSPGEDRYVVVTP---AGQ
Mflv_0314|M.gilvum_PYR-GCK IRGWGPLSVAKHEAEIDHWVDLYDPAAVVHAESAARSRHVDVTP-AADGS
: :* : * * . :
MMAR_2226|M.marinum_M GLAALTGSVLATAGRAFDRRLDELANTVCAADPRTREQRRADAVGALVAG
MUL_1813|M.ulcerans_Agy99 GLAALAGSVLATAGRAFDRRLDELANTVCAADPRTREQRRADAVGALVAG
MAV_3457|M.avium_104 GMAWVEGNVLGPDGHALDRRLDELASGVCAGDPRSRAQRRADALGALAAG
Mb0528|M.bovis_AF2122/97 GVCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADALGALAGG
Rv0336|M.tuberculosis_H37Rv GVCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADALGALAGG
MAB_4752|M.abscessus_ATCC_1997 PVAEVWGTLQAVHAVALDKRLDLLAGTVCPADPRSKTQRRADAVGALTQG
MSMEG_5026|M.smegmatis_MC2_155 GMANAQGYLPAHDAAGFDKRLDAIAATVCPNDPRTPDQRRADALGALGRY
Mvan_3778|M.vanbaalenii_PYR-1 GMAFAGGLLNARDAAALDQRLEAIAATVCSNDPRSHNNLRADAAGALGRG
TH_0334|M.thermoresistible__bu GMVDVSARLTFEAGFAFXTRLDQIAATVCRDDPRTADQRRADAMAAMSEG
Mflv_0314|M.gilvum_PYR-GCK GTCFVEAVLYAHDGEVMDRRLDDMARGVCLADPRTHEQRRADALAAIMNK
. : . : **. :* ** ***: : **** .*:
MMAR_2226|M.marinum_M SDRLACGCTSADCTAAARSAP-SNVVIHVVADQSTVDGT-----------
MUL_1813|M.ulcerans_Agy99 SDRLACGCTSADCTAAARSAP-SKVVIHVVADQSTVDGT-----------
MAV_3457|M.avium_104 AGRLACGCGSPDCPSAAAPAPRSTVVIHVVAEQATVAGR-----------
Mb0528|M.bovis_AF2122/97 ADRLGCGCGRADCAAGKRPAA-PPVVIHLIAEAATINGT-----------
Rv0336|M.tuberculosis_H37Rv ADRLGCGCGRADCAAGKRPAA-PPVVIHLIAEAATINGT-----------
MAB_4752|M.abscessus_ATCC_1997 LNRMRCACGHPDCSG--RDTADVPVVVNVVINQSTLAGS-----------
MSMEG_5026|M.smegmatis_MC2_155 RDTLDCQCGREDCTAVAERDAVNNAMIHVLAEQSTLDG------------
Mvan_3778|M.vanbaalenii_PYR-1 ESTLTCECGAEDCPAAVLRESAAQVVIHILAEQATVDGD-----------
TH_0334|M.thermoresistible__bu QNRLVCGCGSEDCPADPADTAATRLVINVIAEQATVEGR-----------
Mflv_0314|M.gilvum_PYR-GCK ADRLSCLCGAEDCEAGARTTS--SVVVHVIAEESSLTDDTPVALNGDKPA
. : * * ** . . ::::: : ::: .
MMAR_2226|M.marinum_M ------------------------------GHTPAVLLGAEGLIPASLIA
MUL_1813|M.ulcerans_Agy99 ------------------------------GHTPAVLLGAEGLIPASLIA
MAV_3457|M.avium_104 ------------------------------GATPAVVAGLDGLIPAQVIA
Mb0528|M.bovis_AF2122/97 ------------------------------GSAPASQMNADGLITAELVA
Rv0336|M.tuberculosis_H37Rv ------------------------------GSAPASQMNADGLITAELVA
MAB_4752|M.abscessus_ATCC_1997 ------------------------------DDCPAHVPGFG-----VLAA
MSMEG_5026|M.smegmatis_MC2_155 ------------------------------GNEPGYLPGFG-MLPAHMVR
Mvan_3778|M.vanbaalenii_PYR-1 ------------------------------GDKAGYLPGFG-VLPAEEVR
TH_0334|M.thermoresistible__bu ------------------------------SDNPGYLPGYG-AVPASILR
Mflv_0314|M.gilvum_PYR-GCK SPEPEPESEPKPEPSRFESLLGPVPAAGPAKTNPAVVLGGGLLPGPLLAA
.. .
MMAR_2226|M.marinum_M ELAKVATLRPLMRP-SGRPESGYAPSAGLAEFVRCRDLTCRAPGCDQPAV
MUL_1813|M.ulcerans_Agy99 ELAKVATLRPLMRP-SGRPESGYAPSAGLAEFVRCRDLTCRARGCDQPAV
MAV_3457|M.avium_104 ELAASARLVPVAVP-EGGPEPGYTPSARLADFIRCRDLTCRAPGCDRPAV
Mb0528|M.bovis_AF2122/97 ELAKTATLVPLVHPGDAPPEPGYAPSKALADFVRCRDLTCRWPGCDEPAT
Rv0336|M.tuberculosis_H37Rv ELAKTATLVPLVHPGDAPPEPGYAPSKALADFVRCRDLTCRWPGCDEPAT
MAB_4752|M.abscessus_ATCC_1997 ESARAAVAGTPTRNLTDSRSTGYRPSAKLAAFVRSRDQLCRFPGCEAVAD
MSMEG_5026|M.smegmatis_MC2_155 EVAKTATTKPVTIP-KDKAQSGYRPNAELTEFIRWRDLTCRFPGCDAPAM
Mvan_3778|M.vanbaalenii_PYR-1 AAAKTAKLKPVRLP-GAEPEKGYRPSAGLKDFLQWRDLTCRFPGCDAPVE
TH_0334|M.thermoresistible__bu AKAATATLRPVALP-QPCAEAGYRPSAALTRFIRCRDLTCRFPGCDAPAA
Mflv_0314|M.gilvum_PYR-GCK TLAQTATIRRLVHPGDSPAEPRYVPSAKLADFVRCRDMTCRFPGCDVAAY
* * . * *. * *:: ** ** **: .
MMAR_2226|M.marinum_M CCDLDHTVAYGDGGHTHASNLKCLCRKHHLLKTFWD----WRDLQLPDGT
MUL_1813|M.ulcerans_Agy99 CCDLDHTVAYGDGGHTHASNLKCLCRKHHLLKTFWG----WRDLQLPDGT
MAV_3457|M.avium_104 DCDVDHTIPYAQGGPTHPSNLKCLCRGHHLLKTFWG----WRDRQLPDGT
Mb0528|M.bovis_AF2122/97 NCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFWG----WRDQQLPDGT
Rv0336|M.tuberculosis_H37Rv NCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFWG----WRDQQLPDGT
MAB_4752|M.abscessus_ATCC_1997 RADIDHTVPWATGGPTTGANLKALCRKHHLLKTFGQ----WTELQEPDGT
MSMEG_5026|M.smegmatis_MC2_155 AADIDHTRPYPQG-PTHPSNTKLYCRTHHLIKTFYTGPNGWTDRQLPDGT
Mvan_3778|M.vanbaalenii_PYR-1 RCDVDHTTRWPFG-VTHASGLKHYCRTHHVIKTFLTGVYGWRDEQRRDGT
TH_0334|M.thermoresistible__bu VCQIDHTIPYPAG-PTHPSNLKLLCVFHCRQAELR-----FTHDQHKHQS
Mflv_0314|M.gilvum_PYR-GCK SCDLDHTIAYPVG-PTQASNLACLCRKHHLLKTFWG----WRDVQYPDGT
.::*** : * * :. * * : : . * . :
MMAR_2226|M.marinum_M VIWLLPDGHTYVTTPGSALLFPNLCVPTGGLPPIVGTAG-----------
MUL_1813|M.ulcerans_Agy99 VIWLLPDGHTYVTTPGSALLFPNLCVPTGELPPIVGTAGKPPRWPSGEDA
MAV_3457|M.avium_104 VIWTLPDGDTYVTTPGSALLFPTLCTPTGAVSPAKPDTE-----------
Mb0528|M.bovis_AF2122/97 LILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPP-----------
Rv0336|M.tuberculosis_H37Rv LILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPP-----------
MAB_4752|M.abscessus_ATCC_1997 VIWKSPTGHRYATTPVSWFLFPALT-------------------------
MSMEG_5026|M.smegmatis_MC2_155 IEFTAPTGHIYTTEPQGAALFPVLGTPTGELNLPPQQDE-----------
Mvan_3778|M.vanbaalenii_PYR-1 VVLTAPTGHVYTTEPLGGLLFPTLATPTAPL-PDVEVPE-----------
TH_0334|M.thermoresistible__bu SCLPA-----YFQRPHG----PATRRP-----------------------
Mflv_0314|M.gilvum_PYR-GCK VLWTSPGGQTFTTHPGSRVLFPSLCRPTAPVAVDAGVRAP----------
: * . *
MMAR_2226|M.marinum_M ----SPRAGRAARMPTRARTRAQNRANRIDTERR---------CNRRALE
MUL_1813|M.ulcerans_Agy99 DPCPNPRTKPGESHRHRAPMQSQGTGSRRRRPRRPVRHPGAGNRSRRAAA
MAV_3457|M.avium_104 ----HRCGERTAMMPLRRHTRAHNRAHRITTERN---------HNRRTRL
Mb0528|M.bovis_AF2122/97 ---YDHCDQRTAMMPKRRRTRAQDRAYRIATERRQ-------NHAARQRA
Rv0336|M.tuberculosis_H37Rv ---YDHCDQRTAMMPKRRRTRAQDRAYRIATERRQ-------NHAARQRA
MAB_4752|M.abscessus_ATCC_1997 ----------------RHHTRQQARDRRRRTERN---------LNREQRL
MSMEG_5026|M.smegmatis_MC2_155 -----PHPNRGVMMPKRRQTREQDRADRINAERRE-----RAELNAEQQR
Mvan_3778|M.vanbaalenii_PYR-1 -----DDPDKAAMMPRRR-TREQERRARIARERRQ-----RIEINAERER
TH_0334|M.thermoresistible__bu --------------PSARGLREAVPRQGVDPRR----------VSGQ---
Mflv_0314|M.gilvum_PYR-GCK ----TPSAPSGLGMPRRTQTRAQVRARRIHDQR------------AENQA
: * .
MMAR_2226|M.marinum_M AVGGVHADRYDTP---EPTIGPDEPPPF----------------------
MUL_1813|M.ulcerans_Agy99 LLAATSLGTCQIPRRIAPRPGPSRSSRGCTDSGTRMGESSMSARPRACVA
MAV_3457|M.avium_104 TTHPATPG----P---APPPDPDDEPPPF---------------------
Mb0528|M.bovis_AF2122/97 QVLTQTAAATDTH---GPPPDHNDDPPPF---------------------
Rv0336|M.tuberculosis_H37Rv QVLTQTAAATDTH---GPPPDPNDDPPPF---------------------
MAB_4752|M.abscessus_ATCC_1997 QREAALAAL------------AAKDPPPF---------------------
MSMEG_5026|M.smegmatis_MC2_155 QRQAWLADN--------------YEPPPF---------------------
Mvan_3778|M.vanbaalenii_PYR-1 QHQAWLAAT--------------YEPPPF---------------------
TH_0334|M.thermoresistible__bu --------------------------------------------------
Mflv_0314|M.gilvum_PYR-GCK LLEGR------------------NHAPPF---------------------
MMAR_2226|M.marinum_M -
MUL_1813|M.ulcerans_Agy99 G
MAV_3457|M.avium_104 -
Mb0528|M.bovis_AF2122/97 -
Rv0336|M.tuberculosis_H37Rv -
MAB_4752|M.abscessus_ATCC_1997 -
MSMEG_5026|M.smegmatis_MC2_155 -
Mvan_3778|M.vanbaalenii_PYR-1 -
TH_0334|M.thermoresistible__bu -
Mflv_0314|M.gilvum_PYR-GCK -