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MFEGLVESAVRSRGAAAIGAWARMENAAAARRLFAMADLLEAKLADKDSAERDQWCLDNWDAVSAEVAAA QNVSPGVASNELLDAWAMRERLPRVAEVFATGAISYRLARTVVKRTRLIADRDARAKVDVEIAAQLTAWG SLSVAKQEAEIDDWVDRFDPSAVVRAEGSSRSRHVDVIPAKNGSGVCYVEAVLHSHDGEALDRRLEELAR SVCDRDPRTKDQLRSDAIGAMAAKADRLMCLCGIDDCEAAQRTPSAVVVHVIAHEDSLTDDTPFAGHGER PPDAAVEPDVHPGEDPDEKAGQDAAEAHDLQPDGEPRQEPGSGRGKDLLAPPPATGPAKTKPAMILGGGM LPAPLLAATVAHTATIKRLVHPGQSPPEPRYTPSQKLADFVRCRDMTCRFPGCDVPADRCDLDHTIAYPA GPTQASNLKALCRKHHLLKTFWGWRDAQDCDGTVVWTSPGGQVFTTHPGSRLLFPALCRPTAPVVVSSAD LAPAPGRPSGLGMPRRKQTRAQARARRIAEQRRENEALLKTVQDDAPPF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0426 | - | - | 100% (539) | hypothetical protein Mvan_0426 |
| M. vanbaalenii PYR-1 | Mvan_0728 | - | e-105 | 41.73% (532) | hypothetical protein Mvan_0728 |
| M. vanbaalenii PYR-1 | Mvan_3176 | - | 2e-85 | 37.48% (571) | hypothetical protein Mvan_3176 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2126 | - | 1e-107 | 42.31% (527) | hypothetical protein Mb2126 |
| M. gilvum PYR-GCK | Mflv_0314 | - | 0.0 | 68.65% (539) | hypothetical protein Mflv_0314 |
| M. tuberculosis H37Rv | Rv2100 | - | 1e-107 | 42.31% (527) | hypothetical protein Rv2100 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 2e-41 | 37.21% (258) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_1213 | - | 4e-86 | 40.27% (519) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_4456 | - | 1e-80 | 40.16% (513) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_5106 | - | 1e-104 | 39.50% (562) | HNH endonuclease |
| M. thermoresistible (build 8) | TH_0334 | - | 4e-45 | 39.72% (287) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_2679 | - | 1e-81 | 40.28% (509) | 13e12 repeat-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1213|M.marinum_M ----------------------------MRAQALRPTVSVDQHMIEHVFD
MUL_2679|M.ulcerans_Agy99 ---------------------------------------MDQHIIEYVFD
MAV_4456|M.avium_104 --------------------------------MCEDATAWFDELMERCYP
TH_0334|M.thermoresistible__bu -----------------------------------------------MFE
MAB_4752|M.abscessus_ATCC_1997 -----------------------------------------------MFD
Mvan_0426|M.vanbaalenii_PYR-1 ---------------------------------------MFEGLVESAVR
Mflv_0314|M.gilvum_PYR-GCK ---------------------------------------MFEELIDAAGR
Mb2126|M.bovis_AF2122/97 MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL
Rv2100|M.tuberculosis_H37Rv MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL
MSMEG_5106|M.smegmatis_MC2_155 -----------------------------------------MQIAEFSAL
MMAR_1213|M.marinum_M ---TDSSAPLTRITAAARAEARAAAERLAAIGDLFRLRLSQHG--NREDW
MUL_2679|M.ulcerans_Agy99 ---TDDSAPLTRITAAARAEARAAAERLAAIGDLFRLRLSQHG--NREDW
MAV_4456|M.avium_104 SATPESAALVQRIGVFARVENRAAAEQLAAIGELFAYRLSRCS--ECEDW
TH_0334|M.thermoresistible__bu S--LDDGAVVDSIAAASREQSAACGREMLAIGELYARRAPEDDT-ERANW
MAB_4752|M.abscessus_ATCC_1997 E--LGDVELIDLIASAQRAEAQACARKLDAIGVLVDRHADLGKPDERDHH
Mvan_0426|M.vanbaalenii_PYR-1 S------RGAAAIGAWARMENAAAARRLFAMADLLEAKLADKDSAERDQW
Mflv_0314|M.gilvum_PYR-GCK S------RGAAAIGAWARIENAAVAQRLSAMADLLESRLTDKDSAERDQW
Mb2126|M.bovis_AF2122/97 CR-SDDGALVAAIEDCARVEAAASARRLSAIAELTGRRTG---ADQRADW
Rv2100|M.tuberculosis_H37Rv CR-SDDGALVAAIEDCARVEAAASARRLSAIAELTGRRTG---ADQRADW
MSMEG_5106|M.smegmatis_MC2_155 S----DLELEGQARGWAQAEASASAHKHAAMAEMFIRATSTPSADERRWW
: : * ... *:. : :
MMAR_1213|M.marinum_M VADTCDAVAAEVAAALNTSVAMGHSNLRYARAMRERLPQLGAEFRAGGID
MUL_2679|M.ulcerans_Agy99 VADTCDAVAAEVAAALNTSVAMGHSNLRYARAMRERLPQLGAEFRAGGID
MAV_4456|M.avium_104 AVDTEAAVSAEVAAQLRIGQGLAAAKVRYARAMRERLPRVGEVFRAGEID
TH_0334|M.thermoresistible__bu AIDGHANVVAEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFAAGDID
MAB_4752|M.abscessus_ATCC_1997 ALDRWDRVASEVAAAQGITHALASSQMRYAQVLRHRLRAVAERFAAGDLD
Mvan_0426|M.vanbaalenii_PYR-1 CLDNWDAVSAEVAAAQNVSPGVASNELLDAWAMRERLPRVAEVFATGAIS
Mflv_0314|M.gilvum_PYR-GCK CLDNWDAVSAEVAAGQHTSLGVASNELLDAWTLRRRLPRVAEVFASGAIS
Mb2126|M.bovis_AF2122/97 ACDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLG
Rv2100|M.tuberculosis_H37Rv ACDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLG
MSMEG_5106|M.smegmatis_MC2_155 FVDPDAAVGAQLGAAQGITAWAALHQAQRGVALRDRLPKVNEVFAAGLVS
* . :::.* . . . :. ** : * :* :.
MMAR_1213|M.marinum_M FRLFRTIVFRTDLITDSDALAAVDARLAIKAPRWPSMTSWKLATEVDRVV
MUL_2679|M.ulcerans_Agy99 FRLFRTIVFRTDLITESDALAAVDARLAIKAPRWPSMTSWKLATEVDRVV
MAV_4456|M.avium_104 FRLFATIVYRTDLITDRRVLAAVDAELAATAARWPSMTRARLAARVDAVV
TH_0334|M.thermoresistible__bu FRMVSALVNRSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNERIDMWV
MAB_4752|M.abscessus_ATCC_1997 FRTVALIINRTELVDDEAVVARVDAAIVRALPRWARWSHKRITAALDALV
Mvan_0426|M.vanbaalenii_PYR-1 YRLARTVVKRTRLIADRDARAKVDVEIAAQLTAWGSLSVAKQEAEIDDWV
Mflv_0314|M.gilvum_PYR-GCK YRLVKSVVKRTRLVVDPEVMAKIDAEIAAHIRGWGPLSVAKHEAEIDHWV
Mb2126|M.bovis_AF2122/97 ARLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWI
Rv2100|M.tuberculosis_H37Rv ARLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWI
MSMEG_5106|M.smegmatis_MC2_155 EMIVRNICWSTALMLEPDKLALIDAELAAQISGWGKLTLKEIDNTIDDLI
: : : : : :*. :. * : :* :
MMAR_1213|M.marinum_M AKFDRDAVRRSRRDAADRYVDCAPLEPG--MALVNGQVFAATAEALARRL
MUL_2679|M.ulcerans_Agy99 AKFDRDAVRRSRRDAADRYVDCAPLEPG--MALVNRQVFSATAEALARRL
MAV_4456|M.avium_104 AKADADAVRRTEKQAASRHVWIAEMGEG--LSHLEGTVSSPDAHALDKRL
TH_0334|M.thermoresistible__bu ERFDPTGVREPRSPGEDRYVVVTPAGQG--MVDVSARLTFEAGFAFXTRL
MAB_4752|M.abscessus_ATCC_1997 LHFDQDAVRRNRSATDKRHLEIRPLGNGEPVAEVWGTLQAVHAVALDKRL
Mvan_0426|M.vanbaalenii_PYR-1 DRFDPSAVVRAEGSSRSRHVDVIPAKNGSGVCYVEAVLHSHDGEALDRRL
Mflv_0314|M.gilvum_PYR-GCK DLYDPAAVVHAESAARSRHVDVTPAADGSGTCFVEAVLYAHDGEVMDRRL
Mb2126|M.bovis_AF2122/97 DRYDPGALRRSRISARTRDLCIGDPDEDAGTAALWGRLYATDAAMLDRRL
Rv2100|M.tuberculosis_H37Rv DRYDPGALRRSRISARTRDLCIGDPDEDAGTAALWGRLYATDAAMLDRRL
MSMEG_5106|M.smegmatis_MC2_155 LKHDPASFRRGRASRRGRYFDIGSPTDAPGVLTVTGRLQAHLGNAYDARI
* .. . . * . : : . *:
MMAR_1213|M.marinum_M DELAKTVCADDPRTVVQRRADALGTLAAGQDRLICDCGRTDCPAAGAPQQ
MUL_2679|M.ulcerans_Agy99 DELAKTVCADDPRTVVQRRADALGTLAAGQDRLICDCGRTDCPAAGAPQQ
MAV_4456|M.avium_104 DALAATVCEHDPRTGEQRRADALGALAAGADRLGCRCGRADC-AAGTRPA
TH_0334|M.thermoresistible__bu DQIAATVCRDDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCPADPADTA
MAB_4752|M.abscessus_ATCC_1997 DLLAGTVCPADPRSKTQRRADAVGALTQGLNRMRCACGHPDC--SGRDTA
Mvan_0426|M.vanbaalenii_PYR-1 EELARSVCDRDPRTKDQLRSDAIGAMAAKADRLMCLCGIDDCEAAQRTP-
Mflv_0314|M.gilvum_PYR-GCK DDMARGVCLADPRTHEQRRADALAAIMNKADRLSCLCGAEDCEAGARTT-
Mb2126|M.bovis_AF2122/97 TEMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPSGAGNDE
Rv2100|M.tuberculosis_H37Rv TEMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPSGAGNDE
MSMEG_5106|M.smegmatis_MC2_155 AELIEGVCPDDPRTLNELRHDALGAILD-QTTLACECEDPDCVRGREQSS
: ** ***: : * **:.:: : * * **
MMAR_1213|M.marinum_M -PSRVVIHVVAGRET-----------------------------------
MUL_2679|M.ulcerans_Agy99 -PSRVVIHVVAGCQT-----------------------------------
MAV_4456|M.avium_104 -AGPVVIHLIAERAS-----------------------------------
TH_0334|M.thermoresistible__bu -ATRLVINVIAEQAT-----------------------------------
MAB_4752|M.abscessus_ATCC_1997 -DVPVVVNVVINQST-----------------------------------
Mvan_0426|M.vanbaalenii_PYR-1 --SAVVVHVIAHEDS----------------LTDDTPFAGHGERPPDAAV
Mflv_0314|M.gilvum_PYR-GCK --SSVVVHVIAEESS----------------LTDDTPVALNGDKP--ASP
Mb2126|M.bovis_AF2122/97 RAAGVVIHVVA-----------------------DASALDAQPDPHLSGD
Rv2100|M.tuberculosis_H37Rv RAAGVVIHVVA-----------------------DASALDAQPDPHLSGD
MSMEG_5106|M.smegmatis_MC2_155 RGH-LVVHVIAREDTVTAAQHAATTTNTPDDAPSDTPAADTEPAEPAEPA
:*::::
MMAR_1213|M.marinum_M -----------------------------------------------VDG
MUL_2679|M.ulcerans_Agy99 -----------------------------------------------VDG
MAV_4456|M.avium_104 -----------------------------------------------VEG
TH_0334|M.thermoresistible__bu -----------------------------------------------VEG
MAB_4752|M.abscessus_ATCC_1997 -----------------------------------------------LAG
Mvan_0426|M.vanbaalenii_PYR-1 EPDVHPGEDPDEKAGQDAAEAHDLQPDGEPRQEPGSGRGKDLLAPPPATG
Mflv_0314|M.gilvum_PYR-GCK EP----------------------EPESEPKPEPS--RFESLLGPVPAAG
Mb2126|M.bovis_AF2122/97 EP------------------------PSRP-LTPETTLFEALTPDPEPDP
Rv2100|M.tuberculosis_H37Rv EP------------------------PSRP-LTPETTLFEALTPDPEPDP
MSMEG_5106|M.smegmatis_MC2_155 EP------------------------VDDPDIAPAATATETAT-DTEPDA
MMAR_1213|M.marinum_M AG-----------------------------EAPGVLPG-----------
MUL_2679|M.ulcerans_Agy99 AG-----------------------------EAPGVLPG-----------
MAV_4456|M.avium_104 TG-----------------------------GGPAVEVGA----------
TH_0334|M.thermoresistible__bu RS-----------------------------DNPGYLPG-----------
MAB_4752|M.abscessus_ATCC_1997 SD-----------------------------DCPAHVPG-----------
Mvan_0426|M.vanbaalenii_PYR-1 PA----------------------------KTKPAMILGG----------
Mflv_0314|M.gilvum_PYR-GCK PA----------------------------KTNPAVVLGG----------
Mb2126|M.bovis_AF2122/97 PA----------------------------THAPAELITT----------
Rv2100|M.tuberculosis_H37Rv PA----------------------------THAPAELITT----------
MSMEG_5106|M.smegmatis_MC2_155 PAPTDTADSAATETDCDPESVSVTEFTDNSSDTPAAFLDPDEHPLDRVPP
*.
MMAR_1213|M.marinum_M -----DGIIPAEIVRELAKS-AKLQPMSTPILA--ETGYVPSPALMDFVR
MUL_2679|M.ulcerans_Agy99 -----DGIIPAEIVRELAKS-AKLQPMSTPILA--ETGYVPSPALMDFVR
MAV_4456|M.avium_104 -----EGLLPAQLVAELAAS-ARLMPLVHPADAPPENRYTPSAALADFVR
TH_0334|M.thermoresistible__bu -----YGAVPASILRAKAAT-ATLRPVALPQPCA-EAGYRPSAALTRFIR
MAB_4752|M.abscessus_ATCC_1997 -----FGVLAAESARAAVAG-TPTRNLTDSRST----GYRPSAKLAAFVR
Mvan_0426|M.vanbaalenii_PYR-1 ------GMLPAPLLAATVAHTATIKRLVHPGQSPPEPRYTPSQKLADFVR
Mflv_0314|M.gilvum_PYR-GCK ------GLLPGPLLAATLAQTATIRRLVHPGDSPAEPRYVPSAKLADFVR
Mb2126|M.bovis_AF2122/97 ----GGGVVPAPLLAELIRGGATISQVRHPGDLAAEPHYRPSAKLAEFVR
Rv2100|M.tuberculosis_H37Rv ----GGGVVPAPLLAELIRGGATISQVRHPGDLAAEPHYRPSAKLAEFVR
MSMEG_5106|M.smegmatis_MC2_155 AVLFGGGVLPAYALAEIINN-ATIRPLKHPGDTAPEDRYIPSRALADYVR
* :.. : : . * ** * ::*
MMAR_1213|M.marinum_M ARDLTCRAPGCDRPATQCDVDHTIPYSDGGATHPSNLKCLCRKHHLLKTF
MUL_2679|M.ulcerans_Agy99 ARDLTCRAPGCDRPATQCDVDHTIPYSDGGATHPSNLKCLCRKHHLLKTF
MAV_4456|M.avium_104 CRDLTCRWPGCDRPATECDLDHTIPYAEGGPTHASNLKCYCRTHHLVKTF
TH_0334|M.thermoresistible__bu CRDLTCRFPGCDAPAAVCQIDHTIPYPAG-PTHPSNLKLLCVFHCRQAEL
MAB_4752|M.abscessus_ATCC_1997 SRDQLCRFPGCEAVADRADIDHTVPWATGGPTTGANLKALCRKHHLLKTF
Mvan_0426|M.vanbaalenii_PYR-1 CRDMTCRFPGCDVPADRCDLDHTIAYPAG-PTQASNLKALCRKHHLLKTF
Mflv_0314|M.gilvum_PYR-GCK CRDMTCRFPGCDVAAYSCDLDHTIAYPVG-PTQASNLACLCRKHHLLKTF
Mb2126|M.bovis_AF2122/97 MRDLTCRFPGCDVPAEFCDIDHSAPWPLG-PTHPSNLKCACRKHHLLKTF
Rv2100|M.tuberculosis_H37Rv MRDLTCRFPGCDVPAEFCDIDHSAPWPLG-PTHPSNLKCACRKHHLLKTF
MSMEG_5106|M.smegmatis_MC2_155 CRDLTCRFPGCDKPADRCDLDHTVPYPAG-PTHASNLKCLCRFHHLLKTF
** ** ***: * .::**: .:. * .* :** * * :
MMAR_1213|M.marinum_M WG----WHDKQLPDATVIWSLPDGQTYVTTPGSA--WLLPGLFAPSPELP
MUL_2679|M.ulcerans_Agy99 WG----WHDEQLPDATVIWSLPDGQTYVTTPGSA--WLLPGLFAPSPELP
MAV_4456|M.avium_104 WG----WREQQLPDATLILTSPAGRTYVTTPGSA--LLFPSLCVPTGEPA
TH_0334|M.thermoresistible__bu RF----THDQHKHQSSCLP------AYFQRP-----------HGPATRRP
MAB_4752|M.abscessus_ATCC_1997 GQ----WTELQEPDGTVIWKSPTGHRYATTPVSW--FLFPALTRHHTRQQ
Mvan_0426|M.vanbaalenii_PYR-1 WG----WRDAQDCDGTVVWTSPGGQVFTTHPGSR--LLFPALCRPTAPVV
Mflv_0314|M.gilvum_PYR-GCK WG----WRDVQYPDGTVLWTSPGGQTFTTHPGSR--VLFPSLCRPTAPVA
Mb2126|M.bovis_AF2122/97 WTG---WRDVQLPDGTVIWTAPNGHTYTTHPGSR----IFFPTWHTTTAE
Rv2100|M.tuberculosis_H37Rv WTG---WRDVQLPDGTVIWTAPNGHTYTTHPGSR----IFFPTWHTTTAE
MSMEG_5106|M.smegmatis_MC2_155 WTGPRGWTDRQHPDGTIVWTSPSGRQYTTVPGSHRRLSITELAAPTGALD
: : :.: : : *
MMAR_1213|M.marinum_M PPARKPQDHCGNRDAMMPKRARTRAQSSAARIAAERNHNMTSRQARRRRW
MUL_2679|M.ulcerans_Agy99 PPPR--------------------SEATGSLRKPRRDDAQTRPNSRPK--
MAV_4456|M.avium_104 RPVAAGSQPCGERTAMMPTRRRTRGQNRAARVAAERRANRAARLARATRP
TH_0334|M.thermoresistible__bu PSAR------------------------GLREAVPRQGVDPRRVSGQ---
MAB_4752|M.abscessus_ATCC_1997 ARDR--------------------------RRRTERNLNREQRLQREA--
Mvan_0426|M.vanbaalenii_PYR-1 VSSADLAPAPGR-----------PSGLGMPRRKQTRAQARARRIAEQR--
Mflv_0314|M.gilvum_PYR-GCK VDAGVRAPTPSA-----------PSGLGMPRRTQTRAQVRARRIHDQR--
Mb2126|M.bovis_AF2122/97 LPQTSTAAVNVD-----------ARGLMMPRRRRTRAAELAHRINAER--
Rv2100|M.tuberculosis_H37Rv LPQTSTAAVNVD-----------ARGLMMPRRRRTRAAELAHRINAER--
MSMEG_5106|M.smegmatis_MC2_155 LPATPIPTADPD-----------LRGVKMPKRRRTRAQNTARTIAAER--
*
MMAR_1213|M.marinum_M EECYFGPRDASASDDEEPPPF
MUL_2679|M.ulcerans_Agy99 ----LGRTHCDRTQPQHD---
MAV_4456|M.avium_104 APAASQSWPAGHGPDADPPPF
TH_0334|M.thermoresistible__bu ---------------------
MAB_4752|M.abscessus_ATCC_1997 --------ALAALAAKDPPPF
Mvan_0426|M.vanbaalenii_PYR-1 ----RENEALLKTVQDDAPPF
Mflv_0314|M.gilvum_PYR-GCK ----AENQALLE-GRNHAPPF
Mb2126|M.bovis_AF2122/97 ----ALNDAYMA-ERNKPPSF
Rv2100|M.tuberculosis_H37Rv ----ALNDAYMA-ERNKPPSF
MSMEG_5106|M.smegmatis_MC2_155 ----QLNDDLVA-EHNKPPPF