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LTVDFDRLGVGAGTKVIDVGCGAGRHTFEAFRRGADVVGFDQSVSDLNDVDEILQAMKEQGEVPASAKGE AVKGDALDLPYADGTFDCVIASEILEHVPEDDRAIAELVRVLKPGGALAITVPRWLPERICWALSDEYHA NEGGHIRIYRADELRDKVLAHGLALTHIHHAHALHSPYWWLKCAVGTEKTNHPAVAAYHKLLVWDMMGRP WLTRTAEAALNPLIGKSVALYFRKPAAADA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5717 | - | - | 100% (241) | methyltransferase type 11 |
| M. vanbaalenii PYR-1 | Mvan_0109 | - | 4e-11 | 33.33% (162) | methyltransferase type 11 |
| M. vanbaalenii PYR-1 | Mvan_4620 | - | 9e-10 | 26.49% (185) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1440c | - | 5e-10 | 32.17% (115) | putative methyltransferase |
| M. gilvum PYR-GCK | Mflv_1100 | - | 1e-134 | 92.95% (241) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv1405c | - | 5e-10 | 32.17% (115) | putative methyltransferase |
| M. leprae Br4923 | MLBr_00551 | - | 8e-10 | 32.17% (115) | putative methyltransferase |
| M. abscessus ATCC 19977 | MAB_3381c | - | 4e-09 | 32.35% (102) | hypothetical protein MAB_3381c |
| M. marinum M | MMAR_2924 | - | 1e-103 | 70.54% (241) | SAM-dependent methyltransferase |
| M. avium 104 | MAV_2756 | - | 1e-103 | 71.49% (235) | methyltransferase |
| M. smegmatis MC2 155 | MSMEG_6483 | - | 1e-125 | 87.39% (238) | methyltransferase type 11 |
| M. thermoresistible (build 8) | TH_0087 | - | 1e-112 | 78.01% (241) | methyltransferase type 11 |
| M. ulcerans Agy99 | MUL_0820 | - | 3e-10 | 37.04% (108) | methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1440c|M.bovis_AF2122/97 -MTIDTPAREDQTLAATHRAMWALGDYALMAEEVMAP-------LGPILV
Rv1405c|M.tuberculosis_H37Rv -MTIDTPAREDQTLAATHRAMWALGDYALMAEEVMAP-------LGPILV
MLBr_00551|M.leprae_Br4923 -MNLYTPIHEDQSLAAIHRAMWALGDYALMAEEVMAP-------LGPILV
Mvan_5717|M.vanbaalenii_PYR-1 --------------------------------------------MLTVDF
Mflv_1100|M.gilvum_PYR-GCK --------------------------------------------MLTVDF
MSMEG_6483|M.smegmatis_MC2_155 --------------------------------------------MLTVDF
TH_0087|M.thermoresistible__bu --------------------------------------------MLTVDY
MMAR_2924|M.marinum_M --------------------------------------------MLTVDF
MAV_2756|M.avium_104 --------------------------------------------MLTVDF
MUL_0820|M.ulcerans_Agy99 -MTNHHPRFGLQHSGESRDYLPAAGHDALLPAYDLLSRLLGMNKIHRTLI
MAB_3381c|M.abscessus_ATCC_199 MTEITGLDGQPTTKATAEQVAAAFEDNKLAQILYHDWEAETYDEKWSISY
Mb1440c|M.bovis_AF2122/97 AAAGIGPGV------------------RVLDVAAGSGNISLPAAKTG--A
Rv1405c|M.tuberculosis_H37Rv AAAGIGPGV------------------RVLDVAAGSGNISLPAAKTG--A
MLBr_00551|M.leprae_Br4923 TATGIRPGM------------------QVLDVAAGSGNISLPAAKTG--A
Mvan_5717|M.vanbaalenii_PYR-1 DRLGVGAGT------------------KVIDVGCGAGRHTFEAFRRG--A
Mflv_1100|M.gilvum_PYR-GCK DRLGVGAGT------------------KVIDVGCGAGRHTFEAFRRG--A
MSMEG_6483|M.smegmatis_MC2_155 DRLGVGPGT------------------SVIDVGCGAGRHTFEAFRRG--A
TH_0087|M.thermoresistible__bu DRLGIGPGV------------------SVIDVGCGLGRHSFEAYRRG--A
MMAR_2924|M.marinum_M DRLGIGPGA------------------TVIDVGCGAGRHAFEAYRCG--A
MAV_2756|M.avium_104 DRLGIGPSS------------------KVIDVGCGAGRHAFEAYRRG--A
MUL_0820|M.ulcerans_Agy99 TQAELADCG------------------RILEIGCGTGNLAIKAKRAQPRA
MAB_3381c|M.abscessus_ATCC_199 DQRCIDYARGRFDAIVPVEDQRELPYDRALELGCGTGFFLLNLMQAGVAR
: :::..* * : :
Mb1440c|M.bovis_AF2122/97 TVISTD--------LTPELLQRSQARAAQQGLTLQYQEANAQALPFADDE
Rv1405c|M.tuberculosis_H37Rv TVISTD--------LTPELLQRSQARAAQQGLTLQYQEANAQALPFADDE
MLBr_00551|M.leprae_Br4923 TIVSTD--------LTPELLQRSQARATELGLTLEYREADAQALPFGDGE
Mvan_5717|M.vanbaalenii_PYR-1 DVVGFDQSVSDLNDVDEILQAMKEQGEVPASAKGEAVKGDALDLPYADGT
Mflv_1100|M.gilvum_PYR-GCK DVIGFDQSASDLNDVDEILQAMKEQGEAPASAKGEAVKGDALELPYADGT
MSMEG_6483|M.smegmatis_MC2_155 HVIGFDQNVADLNSVDEMLQAMAEAGEAPATAKGEAVKGDALDLPYEDGT
TH_0087|M.thermoresistible__bu HIVAFDQNAEELNEVDTILQAMAEQREAPAGARAEVVKGDALDLPYADGT
MMAR_2924|M.marinum_M DVVAFDRDAAELRAVDTMLRAMAQTGEAPAAASAKVVLGDALALPYPDGT
MAV_2756|M.avium_104 DVVAFDQNEAELRSVDTVLRAMADSGEAPAGASATVVVGDALKLPYPDQT
MUL_0820|M.ulcerans_Agy99 EVIGSD--------PDPRALQRAQRKTG-NVEEVRFDQGYAQRLPYADGE
MAB_3381c|M.abscessus_ATCC_199 RGSVTD--------LSPGMVKVATRTGQELGLDVDGRVADAERIPYDDNT
* . * :*: *
Mb1440c|M.bovis_AF2122/97 FDTVISAIGVMFAPDHQA--AADELVRVCRPGG--TIGVISWTCEGFFGR
Rv1405c|M.tuberculosis_H37Rv FDTVISAIGVMFAPDHQA--AADELVRVCRPGG--TIGVISWTCEGFFGR
MLBr_00551|M.leprae_Br4923 FDVVMSAIGVMFAPDHRR--AASELVRVCRPNG--TIGVISWTQEGFFGR
Mvan_5717|M.vanbaalenii_PYR-1 FDCVIASEILEHVPEDDR--AIAELVRVLKPGGALAITVPRWLPERIC--
Mflv_1100|M.gilvum_PYR-GCK FDCVIASEILEHVPADDK--AISELVRVLKPGGALAITVPRWLPERIC--
MSMEG_6483|M.smegmatis_MC2_155 FDCVIASEILEHVPEDDR--AISELVRVLKPGGSLAITVPRWLPEKIC--
TH_0087|M.thermoresistible__bu FDRVIASEILEHVPEDDR--AIAELVRVLKPGGKLVVTVPRWLPERIC--
MMAR_2924|M.marinum_M FDCVIASEILEHVPQDDA--AIAELVRVLKVGGTLAISVPRWLPERVC--
MAV_2756|M.avium_104 FDCVIASEILEHIPHDDA--AIAELIRVLKVGGTLAVSVPRWLPERVC--
MUL_0820|M.ulcerans_Agy99 FDRVLSSMMLHHLDEDAKSAAAAEAFRVLRPGG-----------------
MAB_3381c|M.abscessus_ATCC_199 FDLVVGHAVLHHIPDVEL--SLREVLRVLKPGGRFVFAGEPTTVGNLYAR
** *:. : . : * .** : .*
Mb1440c|M.bovis_AF2122/97 MLATIRPYRPSVSADLPPSALW-----------GREAYVTGLLGDGVTGL
Rv1405c|M.tuberculosis_H37Rv MLATIRPYRPSVSADLPPSALW-----------GREAYVTGLLGDGVTGL
MLBr_00551|M.leprae_Br4923 MLATIRPYRPSLSAALPPAALW-----------GREAYIRGLLDDTVTNV
Mvan_5717|M.vanbaalenii_PYR-1 -WALSDEYHANEGGHIR---IY-----------RADELRDKVLAHGLALT
Mflv_1100|M.gilvum_PYR-GCK -WALSDEYHANEGGHIR---IY-----------RADELRDKVLAHGLTLT
MSMEG_6483|M.smegmatis_MC2_155 -WLLSDEYHANEGGHIR---IY-----------KADELRDKVLAHGLELT
TH_0087|M.thermoresistible__bu -WLLSDEYHANEGGHVR---IY-----------RADELRDKITRHGLRLT
MMAR_2924|M.marinum_M -WLLSDEYHSNEGGHVR---VY-----------RASELREKITRHPMALT
MAV_2756|M.avium_104 -WLLSDEYHSNEGGHVR---IY-----------RASDLRAKILSGGMTLT
MUL_0820|M.ulcerans_Agy99 -----RLHLVDVGGDMS----------------AHDGLASRFIRHNLHVA
MAB_3381c|M.abscessus_ATCC_199 ALADLTWKATVQAMKLPGLESWRRPQEELDENSRAAALEWVVDLHTFDPA
. : . .
Mb1440c|M.bovis_AF2122/97 KTARGLLEVKRFDTAQAVHDYFKNNYGPTIEAYAHIGDNAVLAAELDRQL
Rv1405c|M.tuberculosis_H37Rv KTARGLLEVKRFDTAQAVHDYFKNNYGPTIEAYAHIGDNAVLAAELDRQL
MLBr_00551|M.leprae_Br4923 KTERRQLEVKRFNSAEGVHNYFKNHYGPTIEAYTNIGDNSVLAAELDAQL
Mvan_5717|M.vanbaalenii_PYR-1 HIHHAHALHSPYWWLKCAVGTEKTNH-PAVAAYHKLLVWDMMGRPWLTRT
Mflv_1100|M.gilvum_PYR-GCK HTHHSHALHSPFWWLKCAVGTEKNDH-PAVAAYHKLLVWDMMSQPWLTRT
MSMEG_6483|M.smegmatis_MC2_155 HTHHEHALHSPYWWLKCLVGTEKNDH-PAVKAYHQLLVWDMMGRPWLTRT
TH_0087|M.thermoresistible__bu HRHHAHALHSPFWWLKCAVGTNNDRH-FAVRAYHQLLVWDMVRRPWVTRW
MMAR_2924|M.marinum_M HAHHAHALHSPFWWLKCAVGVSNADH-PLVSAYHKLLVWDLMRRPRVTRM
MAV_2756|M.avium_104 HAHHAHALHSPFWWLKCAVGVHNTDH-RAVAAYHKLLVWDLMRRPKITQL
MUL_0820|M.ulcerans_Agy99 GNLG--------------------------DGIRRLLD----TAGFDVAE
MAB_3381c|M.abscessus_ATCC_199 DLEKMAANAGAVAVRTASEEFTAAMLGWPVRTFESTVPPGKLGWGWAKFA
Mb1440c|M.bovis_AF2122/97 VELAAQYLSDGVMEWEYLLLTAEKR-----------
Rv1405c|M.tuberculosis_H37Rv VELAAQYLSDGVMEWEYLLLTAEKR-----------
MLBr_00551|M.leprae_Br4923 TELAQKYLTNSTMGWEYLLLTAQKH-----------
Mvan_5717|M.vanbaalenii_PYR-1 AEAALNPLIGKSVALYFRKPAAADA-----------
Mflv_1100|M.gilvum_PYR-GCK AEAALNPLIGKSVALYFRKPADTDA-----------
MSMEG_6483|M.smegmatis_MC2_155 AESALNPLIGKSVALYFTKPDARG------------
TH_0087|M.thermoresistible__bu AEEMLNPLIGKSVALYFDKPEVAGADS---------
MMAR_2924|M.marinum_M AESVLNPLVGKSVAMYFDKRESAQSPADLGHSVASA
MAV_2756|M.avium_104 AESLLNPLVGKSVAMYFVKRQDAKSQATAGYSIASV
MUL_0820|M.ulcerans_Agy99 VGAQRHPLLGRLVYYRATRPCA--------------
MAB_3381c|M.abscessus_ATCC_199 FNGWKALSWVDENVWRHVVPKGWYYNVMITGIKPS-