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M. smegmatis MC2 155 MSMEG_6483 (-)

annotation: methyltransferase type 11
coordinates: 6544983 - 6545705
length: 240

LTVDFDRLGVGPGTSVIDVGCGAGRHTFEAFRRGAHVIGFDQNVADLNSVDEMLQAMAEAGEAPATAKGE
AVKGDALDLPYEDGTFDCVIASEILEHVPEDDRAISELVRVLKPGGSLAITVPRWLPEKICWLLSDEYHA
NEGGHIRIYKADELRDKVLAHGLELTHTHHEHALHSPYWWLKCLVGTEKNDHPAVKAYHQLLVWDMMGRP
WLTRTAESALNPLIGKSVALYFTKPDARG*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_6483--100% (240)methyltransferase type 11
M. smegmatis MC2 155MSMEG_0098-4e-1434.90% (149) methyltransferase
M. smegmatis MC2 155MSMEG_2329-1e-1031.48% (108) methyltransferase, UbiE/COQ5 family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1440c-6e-1134.51% (113) putative methyltransferase
M. gilvum PYR-GCKMflv_1100-1e-12487.29% (236) methyltransferase type 11
M. tuberculosis H37RvRv1405c-6e-1134.51% (113) putative methyltransferase
M. leprae Br4923MLBr_00551-3e-1135.40% (113) putative methyltransferase
M. abscessus ATCC 19977MAB_3381c-3e-1031.48% (108) hypothetical protein MAB_3381c
M. marinum MMMAR_2924-1e-10370.17% (238) SAM-dependent methyltransferase
M. avium 104MAV_2756-1e-10270.21% (235) methyltransferase
M. thermoresistible (build 8)TH_0087-1e-11477.08% (240) methyltransferase type 11
M. ulcerans Agy99MUL_1900-3e-1030.56% (108) hypothetical protein MUL_1900
M. vanbaalenii PYR-1Mvan_5717-1e-12587.39% (238) methyltransferase type 11

CLUSTAL 2.0.9 multiple sequence alignment


Mb1440c|M.bovis_AF2122/97           ----------MTIDTPAREDQTLAATHRAMWALGDYALMAEEVMAPLGPI
Rv1405c|M.tuberculosis_H37Rv        ----------MTIDTPAREDQTLAATHRAMWALGDYALMAEEVMAPLGPI
MLBr_00551|M.leprae_Br4923          ----------MNLYTPIHEDQSLAAIHRAMWALGDYALMAEEVMAPLGPI
Mflv_1100|M.gilvum_PYR-GCK          ----------------------------------------------MLTV
Mvan_5717|M.vanbaalenii_PYR-1       ----------------------------------------------MLTV
MSMEG_6483|M.smegmatis_MC2_155      ----------------------------------------------MLTV
TH_0087|M.thermoresistible__bu      ----------------------------------------------MLTV
MMAR_2924|M.marinum_M               ----------------------------------------------MLTV
MAV_2756|M.avium_104                ----------------------------------------------MLTV
MAB_3381c|M.abscessus_ATCC_199      MTEITGL--DGQPTTKATAEQVAAAFEDNKLAQILYHDWEAETYDEKWSI
MUL_1900|M.ulcerans_Agy99           MTRSSEIPADAAPNPHATAEEVEAARHDSKLAQVLYHDWEAENYDEKWSI
                                                                                    .:

Mb1440c|M.bovis_AF2122/97           LVAAAGIG------------------PGVRVLDVAAGSGNISLPAAKTGA
Rv1405c|M.tuberculosis_H37Rv        LVAAAGIG------------------PGVRVLDVAAGSGNISLPAAKTGA
MLBr_00551|M.leprae_Br4923          LVTATGIR------------------PGMQVLDVAAGSGNISLPAAKTGA
Mflv_1100|M.gilvum_PYR-GCK          DFDRLGVG------------------AGTKVIDVGCGAGRHTFEAFRRGA
Mvan_5717|M.vanbaalenii_PYR-1       DFDRLGVG------------------AGTKVIDVGCGAGRHTFEAFRRGA
MSMEG_6483|M.smegmatis_MC2_155      DFDRLGVG------------------PGTSVIDVGCGAGRHTFEAFRRGA
TH_0087|M.thermoresistible__bu      DYDRLGIG------------------PGVSVIDVGCGLGRHSFEAYRRGA
MMAR_2924|M.marinum_M               DFDRLGIG------------------PGATVIDVGCGAGRHAFEAYRCGA
MAV_2756|M.avium_104                DFDRLGIG------------------PSSKVIDVGCGAGRHAFEAYRRGA
MAB_3381c|M.abscessus_ATCC_199      SYDQRCIDYARGRFDAIVPVEDQRELPYDRALELGCGTGFFLLNLMQAGV
MUL_1900|M.ulcerans_Agy99           SYDQRCVEYARGRFDAIVPAQVHADLPYERALELGCGTGFFLLNLIQAGV
                                          :                   .   .:::..* *   :   : *.

Mb1440c|M.bovis_AF2122/97           TVISTD--------LTPELLQRSQARAAQQGLTLQYQEANAQALPFADDE
Rv1405c|M.tuberculosis_H37Rv        TVISTD--------LTPELLQRSQARAAQQGLTLQYQEANAQALPFADDE
MLBr_00551|M.leprae_Br4923          TIVSTD--------LTPELLQRSQARATELGLTLEYREADAQALPFGDGE
Mflv_1100|M.gilvum_PYR-GCK          DVIGFDQSASDLNDVDEILQAMKEQGEAPASAKGEAVKGDALELPYADGT
Mvan_5717|M.vanbaalenii_PYR-1       DVVGFDQSVSDLNDVDEILQAMKEQGEVPASAKGEAVKGDALDLPYADGT
MSMEG_6483|M.smegmatis_MC2_155      HVIGFDQNVADLNSVDEMLQAMAEAGEAPATAKGEAVKGDALDLPYEDGT
TH_0087|M.thermoresistible__bu      HIVAFDQNAEELNEVDTILQAMAEQREAPAGARAEVVKGDALDLPYADGT
MMAR_2924|M.marinum_M               DVVAFDRDAAELRAVDTMLRAMAQTGEAPAAASAKVVLGDALALPYPDGT
MAV_2756|M.avium_104                DVVAFDQNEAELRSVDTVLRAMADSGEAPAGASATVVVGDALKLPYPDQT
MAB_3381c|M.abscessus_ATCC_199      ARRGSVT------DLSPGMVKVATRTGQELGLDVDGRVADAERIPYDDNT
MUL_1900|M.ulcerans_Agy99           ARRGSVT------DLSPGMVKVATRNGQSLGLDIDGRVADAEGIPYDDDT
                                       .          :   :                   .:*  :*: *  

Mb1440c|M.bovis_AF2122/97           FDTVISAIGVMFAPDHQAAADELVRVCRPGG--TIGVISWTCEGFFGRML
Rv1405c|M.tuberculosis_H37Rv        FDTVISAIGVMFAPDHQAAADELVRVCRPGG--TIGVISWTCEGFFGRML
MLBr_00551|M.leprae_Br4923          FDVVMSAIGVMFAPDHRRAASELVRVCRPNG--TIGVISWTQEGFFGRML
Mflv_1100|M.gilvum_PYR-GCK          FDCVIASEILEHVPADDKAISELVRVLKPGGALAITVPRWLPERIC---W
Mvan_5717|M.vanbaalenii_PYR-1       FDCVIASEILEHVPEDDRAIAELVRVLKPGGALAITVPRWLPERIC---W
MSMEG_6483|M.smegmatis_MC2_155      FDCVIASEILEHVPEDDRAISELVRVLKPGGSLAITVPRWLPEKIC---W
TH_0087|M.thermoresistible__bu      FDRVIASEILEHVPEDDRAIAELVRVLKPGGKLVVTVPRWLPERIC---W
MMAR_2924|M.marinum_M               FDCVIASEILEHVPQDDAAIAELVRVLKVGGTLAISVPRWLPERVC---W
MAV_2756|M.avium_104                FDCVIASEILEHIPHDDAAIAELIRVLKVGGTLAVSVPRWLPERVC---W
MAB_3381c|M.abscessus_ATCC_199      FDLVVGHAVLHHIPDVELSLREVLRVLKPGGRFVFAGEPTTVGNLYARAL
MUL_1900|M.ulcerans_Agy99           FDLVVGHAVLHHIPDVELSLREVMRVLKPGGRFVFAGEPTTVGNEYARTL
                                    ** *:.   : . *    :  *::** : .*  ..               

Mb1440c|M.bovis_AF2122/97           ATIRPYRPSVSADLPPSALWGREAYVTGLLGDGVTGLKTARGLLEVKRFD
Rv1405c|M.tuberculosis_H37Rv        ATIRPYRPSVSADLPPSALWGREAYVTGLLGDGVTGLKTARGLLEVKRFD
MLBr_00551|M.leprae_Br4923          ATIRPYRPSLSAALPPAALWGREAYIRGLLDDTVTNVKTERRQLEVKRFN
Mflv_1100|M.gilvum_PYR-GCK          ALSDEYHANEGGHIR---IYRADELRDKVLAHGLTLTHTHHSHALHSPFW
Mvan_5717|M.vanbaalenii_PYR-1       ALSDEYHANEGGHIR---IYRADELRDKVLAHGLALTHIHHAHALHSPYW
MSMEG_6483|M.smegmatis_MC2_155      LLSDEYHANEGGHIR---IYKADELRDKVLAHGLELTHTHHEHALHSPYW
TH_0087|M.thermoresistible__bu      LLSDEYHANEGGHVR---IYRADELRDKITRHGLRLTHRHHAHALHSPFW
MMAR_2924|M.marinum_M               LLSDEYHSNEGGHVR---VYRASELREKITRHPMALTHAHHAHALHSPFW
MAV_2756|M.avium_104                LLSDEYHSNEGGHVR---IYRASDLRAKILSGGMTLTHAHHAHALHSPFW
MAB_3381c|M.abscessus_ATCC_199      ADLTWKATVQAMKLPGLESWRRPQEELDENSRAAALEWVVDLHTFDPADL
MUL_1900|M.ulcerans_Agy99           STLTWRIATNVTKLPGLGGWRRPQEELDESSRAAALEAIVDLHTFAPEDL
                                           .     :     :                              

Mb1440c|M.bovis_AF2122/97           TAQAVHD---YFKNNYGPTIEAYAHIGDNAVLAAELDRQLVELAAQYLSD
Rv1405c|M.tuberculosis_H37Rv        TAQAVHD---YFKNNYGPTIEAYAHIGDNAVLAAELDRQLVELAAQYLSD
MLBr_00551|M.leprae_Br4923          SAEGVHN---YFKNHYGPTIEAYTNIGDNSVLAAELDAQLTELAQKYLTN
Mflv_1100|M.gilvum_PYR-GCK          WLKCAVG---TEKNDH-PAVAAYHKLLVWDMMSQPWLTRTAEAALNPLIG
Mvan_5717|M.vanbaalenii_PYR-1       WLKCAVG---TEKTNH-PAVAAYHKLLVWDMMGRPWLTRTAEAALNPLIG
MSMEG_6483|M.smegmatis_MC2_155      WLKCLVG---TEKNDH-PAVKAYHQLLVWDMMGRPWLTRTAESALNPLIG
TH_0087|M.thermoresistible__bu      WLKCAVG---TNNDRH-FAVRAYHQLLVWDMVRRPWVTRWAEEMLNPLIG
MMAR_2924|M.marinum_M               WLKCAVG---VSNADH-PLVSAYHKLLVWDLMRRPRVTRMAESVLNPLVG
MAV_2756|M.avium_104                WLKCAVG---VHNTDH-RAVAAYHKLLVWDLMRRPKITQLAESLLNPLVG
MAB_3381c|M.abscessus_ATCC_199      EKMAANAGAVAVRTASEEFTAAMLGWPVRTFESTVPPGKLGWGWAKFAFN
MUL_1900|M.ulcerans_Agy99           ERMAKNAGAIRVETASEEFSAAMFGWPVRTFESSVPPGRLGWNWARFAFN
                                                .        *        .       :      .   .

Mb1440c|M.bovis_AF2122/97           GVMEWEYLLLTAEKR------------------
Rv1405c|M.tuberculosis_H37Rv        GVMEWEYLLLTAEKR------------------
MLBr_00551|M.leprae_Br4923          STMGWEYLLLTAQKH------------------
Mflv_1100|M.gilvum_PYR-GCK          KSVALYFRKPADTDA------------------
Mvan_5717|M.vanbaalenii_PYR-1       KSVALYFRKPAAADA------------------
MSMEG_6483|M.smegmatis_MC2_155      KSVALYFTKPDARG-------------------
TH_0087|M.thermoresistible__bu      KSVALYFDKPEVAGADS----------------
MMAR_2924|M.marinum_M               KSVAMYFDKRESAQSPADLGHSVASA-------
MAV_2756|M.avium_104                KSVAMYFVKRQDAKSQATAGYSIASV-------
MAB_3381c|M.abscessus_ATCC_199      GWKALSWVDENVWRHVVPKGWYYNVMITGIKPS
MUL_1900|M.ulcerans_Agy99           GWKALGWMDANVWRHVAPKGWFYNVMVTGVKPS
                                          :