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MLTVDFDRLGIGPSSKVIDVGCGAGRHAFEAYRRGADVVAFDQNEAELRSVDTVLRAMADSGEAPAGASA TVVVGDALKLPYPDQTFDCVIASEILEHIPHDDAAIAELIRVLKVGGTLAVSVPRWLPERVCWLLSDEYH SNEGGHVRIYRASDLRAKILSGGMTLTHAHHAHALHSPFWWLKCAVGVHNTDHRAVAAYHKLLVWDLMRR PKITQLAESLLNPLVGKSVAMYFVKRQDAKSQATAGYSIASV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2756 | - | - | 100% (252) | methyltransferase |
| M. avium 104 | MAV_4584 | ubiE | 8e-10 | 35.65% (115) | ubiquinone/menaquinone biosynthesis methyltransferase |
| M. avium 104 | MAV_5229 | - | 9e-09 | 33.33% (108) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1440c | - | 2e-09 | 32.14% (112) | putative methyltransferase |
| M. gilvum PYR-GCK | Mflv_1100 | - | 1e-103 | 70.59% (238) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv1405c | - | 2e-09 | 32.14% (112) | putative methyltransferase |
| M. leprae Br4923 | MLBr_02273 | ubiE | 5e-08 | 33.63% (113) | ubiquinone/menaquinone biosynthesis methyltransferase |
| M. abscessus ATCC 19977 | MAB_3381c | - | 3e-08 | 27.62% (105) | hypothetical protein MAB_3381c |
| M. marinum M | MMAR_2924 | - | 1e-120 | 81.27% (251) | SAM-dependent methyltransferase |
| M. smegmatis MC2 155 | MSMEG_6483 | - | 1e-102 | 70.21% (235) | methyltransferase type 11 |
| M. thermoresistible (build 8) | TH_0087 | - | 1e-103 | 73.22% (239) | methyltransferase type 11 |
| M. ulcerans Agy99 | MUL_1801 | - | 1e-08 | 33.33% (120) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_5717 | - | 1e-102 | 71.49% (235) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1440c|M.bovis_AF2122/97 --------MTIDTPAREDQTLAATHRAMWALGDYALMAEEVMAPLGPILV
Rv1405c|M.tuberculosis_H37Rv --------MTIDTPAREDQTLAATHRAMWALGDYALMAEEVMAPLGPILV
MUL_1801|M.ulcerans_Agy99 --------MTIDTPIREDVSLAATHRAMWALGDYALMAEEVMAPLGPILV
MAV_2756|M.avium_104 --------------------------------------------MLTVDF
MMAR_2924|M.marinum_M --------------------------------------------MLTVDF
Mflv_1100|M.gilvum_PYR-GCK --------------------------------------------MLTVDF
Mvan_5717|M.vanbaalenii_PYR-1 --------------------------------------------MLTVDF
MSMEG_6483|M.smegmatis_MC2_155 --------------------------------------------MLTVDF
TH_0087|M.thermoresistible__bu --------------------------------------------MLTVDY
MLBr_02273|M.leprae_Br4923 -------MPPGSVDVVSRAALDKDPRDVVAMFDDVAHRYDLTNTVLSLGQ
MAB_3381c|M.abscessus_ATCC_199 MTEITGLDGQPTTKATAEQVAAAFEDNKLAQILYHDWEAETYDEKWSISY
.:
Mb1440c|M.bovis_AF2122/97 AA------------------AGIGPGVRVLDVAAGSGNISLPAAKTGATV
Rv1405c|M.tuberculosis_H37Rv AA------------------AGIGPGVRVLDVAAGSGNISLPAAKTGATV
MUL_1801|M.ulcerans_Agy99 AA------------------AGIGPGVRVLDVAAGSGNISLPAAKSGATV
MAV_2756|M.avium_104 DR------------------LGIGPSSKVIDVGCGAGRHAFEAYRRGADV
MMAR_2924|M.marinum_M DR------------------LGIGPGATVIDVGCGAGRHAFEAYRCGADV
Mflv_1100|M.gilvum_PYR-GCK DR------------------LGVGAGTKVIDVGCGAGRHTFEAFRRGADV
Mvan_5717|M.vanbaalenii_PYR-1 DR------------------LGVGAGTKVIDVGCGAGRHTFEAFRRGADV
MSMEG_6483|M.smegmatis_MC2_155 DR------------------LGVGPGTSVIDVGCGAGRHTFEAFRRGAHV
TH_0087|M.thermoresistible__bu DR------------------LGIGPGVSVIDVGCGLGRHSFEAYRRGAHI
MLBr_02273|M.leprae_Br4923 DRYWRRATR---------SALRIGPGQKVLDLAAGTAVSTAELSKSGAWC
MAB_3381c|M.abscessus_ATCC_199 DQRCIDYARGRFDAIVPVEDQRELPYDRALELGCGTGFFLLNLMQAGVAR
. .:::..* . : *.
Mb1440c|M.bovis_AF2122/97 ISTD--------LTPELLQRSQARAAQQGLTLQYQEANAQALPFADDEFD
Rv1405c|M.tuberculosis_H37Rv ISTD--------LTPELLQRSQARAAQQGLTLQYQEANAQALPFADDEFD
MUL_1801|M.ulcerans_Agy99 VSTD--------LTSELLQRSKARAAAQELTLDYQEANAQALPFGDSEFD
MAV_2756|M.avium_104 VAFDQNEAELRSVDTVLRAMADSGEAPAGASATVVVGDALKLPYPDQTFD
MMAR_2924|M.marinum_M VAFDRDAAELRAVDTMLRAMAQTGEAPAAASAKVVLGDALALPYPDGTFD
Mflv_1100|M.gilvum_PYR-GCK IGFDQSASDLNDVDEILQAMKEQGEAPASAKGEAVKGDALELPYADGTFD
Mvan_5717|M.vanbaalenii_PYR-1 VGFDQSVSDLNDVDEILQAMKEQGEVPASAKGEAVKGDALDLPYADGTFD
MSMEG_6483|M.smegmatis_MC2_155 IGFDQNVADLNSVDEMLQAMAEAGEAPATAKGEAVKGDALDLPYEDGTFD
TH_0087|M.thermoresistible__bu VAFDQNAEELNEVDTILQAMAEQREAPAGARAEVVKGDALDLPYADGTFD
MLBr_02273|M.leprae_Br4923 VAAD--------FSVRMLATGGARKVPK------VAADATQLPFSDGVFD
MAB_3381c|M.abscessus_ATCC_199 RGSVT------DLSPGMVKVATRTGQELGLDVDGRVADAERIPYDDNTFD
. . : .:* :*: * **
Mb1440c|M.bovis_AF2122/97 TVISAIGVMFAPDHQAAADELVRVCRPGG--TIGVISWTCEGFFGRMLAT
Rv1405c|M.tuberculosis_H37Rv TVISAIGVMFAPDHQAAADELVRVCRPGG--TIGVISWTCEGFFGRMLAT
MUL_1801|M.ulcerans_Agy99 TVISAIGVMFAPDHQCSANELARVCKTGG--TIGVISWTPEGFFGRMLAT
MAV_2756|M.avium_104 CVIASEILEHIPHDDAAIAELIRVLKVGGTLAVSVPRWLPERVC---WLL
MMAR_2924|M.marinum_M CVIASEILEHVPQDDAAIAELVRVLKVGGTLAISVPRWLPERVC---WLL
Mflv_1100|M.gilvum_PYR-GCK CVIASEILEHVPADDKAISELVRVLKPGGALAITVPRWLPERIC---WAL
Mvan_5717|M.vanbaalenii_PYR-1 CVIASEILEHVPEDDRAIAELVRVLKPGGALAITVPRWLPERIC---WAL
MSMEG_6483|M.smegmatis_MC2_155 CVIASEILEHVPEDDRAISELVRVLKPGGSLAITVPRWLPEKIC---WLL
TH_0087|M.thermoresistible__bu RVIASEILEHVPEDDRAIAELVRVLKPGGKLVVTVPRWLPERIC---WLL
MLBr_02273|M.leprae_Br4923 AVTISFGLRNIADYQAALREMARVTRPGGQLVVCEFSTP-----------
MAB_3381c|M.abscessus_ATCC_199 LVVGHAVLHHIPDVELSLREVLRVLKPGGRFVFAGEPTTVGNLYARALAD
* : . : : *: ** : ** ..
Mb1440c|M.bovis_AF2122/97 IRPYRPSVSADLPPSALWG------REAYVTGLLGDGVTGLKTARGLLEV
Rv1405c|M.tuberculosis_H37Rv IRPYRPSVSADLPPSALWG------REAYVTGLLGDGVTGLKTARGLLEV
MUL_1801|M.ulcerans_Agy99 IRPYRPSLSAALPPSALWG------REAYARGLFGNHVSDIQTQRGQLEV
MAV_2756|M.avium_104 SDEYHSNEGGHVR---IYR------ASDLRAKILSGGMTLTHAHHAHALH
MMAR_2924|M.marinum_M SDEYHSNEGGHVR---VYR------ASELREKITRHPMALTHAHHAHALH
Mflv_1100|M.gilvum_PYR-GCK SDEYHANEGGHIR---IYR------ADELRDKVLAHGLTLTHTHHSHALH
Mvan_5717|M.vanbaalenii_PYR-1 SDEYHANEGGHIR---IYR------ADELRDKVLAHGLALTHIHHAHALH
MSMEG_6483|M.smegmatis_MC2_155 SDEYHANEGGHIR---IYK------ADELRDKVLAHGLELTHTHHEHALH
TH_0087|M.thermoresistible__bu SDEYHANEGGHVR---IYR------ADELRDKITRHGLRLTHRHHAHALH
MLBr_02273|M.leprae_Br4923 -------------------------TNALVANVYTEYLMRALPQVARLVS
MAB_3381c|M.abscessus_ATCC_199 LTWKATVQAMKLPGLESWRRPQEELDENSRAAALEWVVDLHTFDPADLEK
. :
Mb1440c|M.bovis_AF2122/97 KRFDTAQAVHDYFKNNYGPTIEAYAH-IGDNAVLAAELDRQLVELAAQYL
Rv1405c|M.tuberculosis_H37Rv KRFDTAQAVHDYFKNNYGPTIEAYAH-IGDNAVLAAELDRQLVELAAQYL
MUL_1801|M.ulcerans_Agy99 TRFQTAQAVHDYFKNHYGPTIEAYAN-IGDNAVLAAELDAQLVELADQYL
MAV_2756|M.avium_104 SPFWWLKCAVGVHNTDH-RAVAAYHK-LLVWDLMRRPKITQLAESLLNPL
MMAR_2924|M.marinum_M SPFWWLKCAVGVSNADH-PLVSAYHK-LLVWDLMRRPRVTRMAESVLNPL
Mflv_1100|M.gilvum_PYR-GCK SPFWWLKCAVGTEKNDH-PAVAAYHK-LLVWDMMSQPWLTRTAEAALNPL
Mvan_5717|M.vanbaalenii_PYR-1 SPYWWLKCAVGTEKTNH-PAVAAYHK-LLVWDMMGRPWLTRTAEAALNPL
MSMEG_6483|M.smegmatis_MC2_155 SPYWWLKCLVGTEKNDH-PAVKAYHQ-LLVWDMMGRPWLTRTAESALNPL
TH_0087|M.thermoresistible__bu SPFWWLKCAVGTNNDRH-FAVRAYHQ-LLVWDMVRRPWVTRWAEEMLNPL
MLBr_02273|M.leprae_Br4923 SNPDAYIYLAES--------IRAWPD-QVTLACQLSR--TGWASPRWRNL
MAB_3381c|M.abscessus_ATCC_199 MAANAGAVAVRTASEEFTAAMLGWPVRTFESTVPPGKLGWGWAKFAFNGW
: .: .. .
Mb1440c|M.bovis_AF2122/97 SDGVMEWEYLLLTAEKR--------------
Rv1405c|M.tuberculosis_H37Rv SDGVMEWEYLLLTAEKR--------------
MUL_1801|M.ulcerans_Agy99 TDGVMEWEYLVLTGTKK--------------
MAV_2756|M.avium_104 VGKSVAMYFVKRQDAKSQATAGYSIASV---
MMAR_2924|M.marinum_M VGKSVAMYFDKRESAQSPADLGHSVASA---
Mflv_1100|M.gilvum_PYR-GCK IGKSVALYFRKPADTDA--------------
Mvan_5717|M.vanbaalenii_PYR-1 IGKSVALYFRKPAAADA--------------
MSMEG_6483|M.smegmatis_MC2_155 IGKSVALYFTKPDARG---------------
TH_0087|M.thermoresistible__bu IGKSVALYFDKPEVAGADS------------
MLBr_02273|M.leprae_Br4923 TGGIVALHAADKPVR----------------
MAB_3381c|M.abscessus_ATCC_199 KALSWVDENVWRHVVPKGWYYNVMITGIKPS