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ATDAISIGGVDLADPDTYVGGMPHGAFRELRRHAPVAWHPYGDNPGFWALTGYDEVLAVSRDSRTWSSQT TGVFLDVPAPEDSYQLSLMMLTMDPPRHTALRALVSRGFTPRHLARLNARTADMARDILDAALQRGECEF VDDVAGALPSYVIAELLGIPLDDGRRLYALTEIMNTRPLHDPELMQTQVELFGYAGDLAASKRAAPGDDI ATALLHAEVDGQRLTDLEFNLFFMLLLNAGGDTTRNLVAAGTLALIEHPEQWARLAADPSLMPTAIEEML RWTSPVNVFTRTATRDTEVGGVPLRAGERVAMFYPSANRDEKHFADPDRFDIGRAPNHHLAFGGGGTHFC LGASLARVEATAIFGEILTRTAHIELAGPVERVRSVLMNGIRSMPVRLTPASVPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0246 | - | - | 100% (406) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_5151 | - | 9e-86 | 42.82% (397) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_1302 | - | 1e-80 | 40.19% (413) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3575c | cyp125 | 5e-77 | 40.34% (409) | cytochrome P450 125 |
| M. gilvum PYR-GCK | Mflv_0425 | - | 0.0 | 83.00% (406) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3545c | cyp125 | 6e-77 | 40.34% (409) | cytochrome P450 125 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-49 | 34.85% (330) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3825 | - | 5e-80 | 39.13% (414) | cytochrome P450 |
| M. marinum M | MMAR_3761 | cyp268A2 | 6e-77 | 43.30% (388) | cytochrome P450 268A2 Cyp268A2 |
| M. avium 104 | MAV_1339 | - | 8e-80 | 43.62% (392) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_5853 | - | 3e-83 | 41.46% (398) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_4132 | - | 6e-81 | 40.85% (399) | PUTATIVE putative cytochrome P450 |
| M. ulcerans Agy99 | MUL_4106 | cyp125A7 | 4e-77 | 40.89% (406) | cytochrome P450 125A7 Cyp125A7 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0246|M.vanbaalenii_PYR-1 ---------------MATDAISIGGVDLADPDTYVGGMP--HGAFRELRR
Mflv_0425|M.gilvum_PYR-GCK ---------------MPADAITLGGADLADPDTYLAGMP--YDAFRTLRR
Mb3575c|M.bovis_AF2122/97 MSWNHQSVEIAVRRTTVPSPNLPPGFDFTDPAIYAERLP--VAEFAELRS
Rv3545c|M.tuberculosis_H37Rv MSWNHQSVEIAVRRTTVPSPNLPPGFDFTDPAIYAERLP--VAEFAELRS
MUL_4106|M.ulcerans_Agy99 ----------------MPCPNLPPGFDFTDPDIYAERLP--VEEFAELRS
MSMEG_5853|M.smegmatis_MC2_155 -------------MATMNTCPFGNGYDFTDPDVLFRGIP--VEEFAVLRK
MMAR_3761|M.marinum_M ------------MTAISASVRPYDTIDLSSRAFWASSASQRESSFSELRA
TH_4132|M.thermoresistible__bu ----------MTVQPVTDTTWDVKHVNVFDPQWWVDGPP--HDLFKRMRA
MAB_3825|M.abscessus_ATCC_1997 -------------MATALSEIEEAGRVLADPAAYADELR-LHAAMTLLRR
MAV_1339|M.avium_104 --------------MQTHPPLRSPSFPLHSPDFYAGNPY---PAYRELRA
MLBr_02088|M.leprae_Br4923 ---MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTR
.
Mvan_0246|M.vanbaalenii_PYR-1 HAPVAWHPYG--------DNPGFWALTGYDEVLAVSRDS-RTWSSQTTG-
Mflv_0425|M.gilvum_PYR-GCK EAPVAWHPQV--------DKPGFWALTGYDEIYAVSRDS-ETWSSQATG-
Mb3575c|M.bovis_AF2122/97 AAPIWWNGQDPGKGG-GFHDGGFWAITKLNDVKEISRHS-DVFSSYENGV
Rv3545c|M.tuberculosis_H37Rv AAPIWWNGQDPGKGG-GFHDGGFWAITKLNDVKEISRHS-DVFSSYENGV
MUL_4106|M.ulcerans_Agy99 SEPIWWDEQFPGQGG-GFHDGGFWAITKLKDVKEVSRRS-DVFSSYENGV
MSMEG_5853|M.smegmatis_MC2_155 TAPVWWNQQ--GES--IFDDGGYWVISRHEDIKTISRDGGEVWSTNAKGA
MMAR_3761|M.marinum_M ERPVSWHPPVEDALIQDPNDPGFWAVTRRADIVAVSRTN-EVFLSGNG--
TH_4132|M.thermoresistible__bu ESPVHWYQFADGEGY----GPGYWSLFRHADIATVSHDT-ETFSSNRGG-
MAB_3825|M.abscessus_ATCC_1997 EQPVTKVITD--------DYRPFWAVTKHDDIMAVERDN-ALWINEPRPL
MAV_1339|M.avium_104 TAPVCWNDVT-----------NFWALLKYEDIRFVSSNP-ALFTSTRG--
MLBr_02088|M.leprae_Br4923 ADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHP----LSASDRL
*. . : .
Mvan_0246|M.vanbaalenii_PYR-1 --VFLDVPAPE---DSYQLSLMMLTMDPPRHTALRALVSRGFTPRHLARL
Mflv_0425|M.gilvum_PYR-GCK --VFLDVPAPE---DSYQLALMMLTMDPPRHTALRALVSRGFTPRHVARL
Mb3575c|M.bovis_AF2122/97 IPRFKNDIARE---DIEVQRFVMLNMDAPHHTRLRKIISRGFTPRAVGRL
Rv3545c|M.tuberculosis_H37Rv IPRFKNDIARE---DIEVQRFVMLNMDAPHHTRLRKIISRGFTPRAVGRL
MUL_4106|M.ulcerans_Agy99 IPRFKNDIARE---DIDVQRFVMLNMDAPHHTRLRKIISRGFTPRAIGRL
MSMEG_5853|M.smegmatis_MC2_155 VMRLPDGVTAE---QLDLTKALLINHDAPEHTRLRKLVSRLFTPRSVAAL
MMAR_3761|M.marinum_M --VLFENVPAE---LLEAS-QSFLAMDPPRHTKLRKLVSAAFTPRQVRRI
TH_4132|M.thermoresistible__bu --LFIHPDQML---SLDVLTNMLNFMDPPTHTRYRKILARVFTPAAVAKM
MAB_3825|M.abscessus_ATCC_1997 LMNLEQEAELDKQAAMGIELKTLVHIDDPKHRVLRAIGADWFRPKAMRDM
MAV_1339|M.avium_104 -ITIPDPQLPN-----PVQQGSLIFTDPPRHRQLRKLINSGFTRRRVSVL
MLBr_02088|M.leprae_Br4923 KATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQAL
: . : * * * * : * : :
Mvan_0246|M.vanbaalenii_PYR-1 NARTADMARDILDAALQRGEC-EFVDDVAGALPSYVIAELLGIPLDDGRR
Mflv_0425|M.gilvum_PYR-GCK GARTADMARAIVDDALAHGQC-EFVDEVAGALPSYVIAELLGIPLEDGRR
Mb3575c|M.bovis_AF2122/97 HDELQERAQKIAAEAAAAGSG-DFVEQVSCELPLQAIAGLLGVPQEDRGK
Rv3545c|M.tuberculosis_H37Rv HDELQERAQKIAAEAAAAGSG-DFVEQVSCELPLQAIAGLLGVPQEDRGK
MUL_4106|M.ulcerans_Agy99 HDELNDRAQNIAKAAAAAGSG-DFVEQVSCELPLQAIAGLLGIPQEDRGK
MSMEG_5853|M.smegmatis_MC2_155 EEKLAVAAHDIVAEAKAEGSG-NFVEDIAMKLPLLAIADLIGVPEADREK
MMAR_3761|M.marinum_M EDSIKINAKGIVDELRMAGGGVDFVEHCAKELPIRTLSDMVGIPEADRER
TH_4132|M.thermoresistible__bu EDGIRARVNRIIDKVIEAGRC-DFVEDIAVPIPLGILMELMGAPEEDMPK
MAB_3825|M.abscessus_ATCC_1997 KLRTDELANRYVNKLLEAGGSCDFAQDIAVHFPLYVIMSLLGIPESDFDR
MAV_1339|M.avium_104 EPKIREIVRGILDG-IERGAVHEFAEQIAAPLPTRMIAELIGAPPDDWEQ
MLBr_02088|M.leprae_Br4923 EGDIAALVDSLLDKGAAAGQF-DVIADLAFPLAVAVICRLLGVPYEDAPE
. * :. . : :. : ::* * * .
Mvan_0246|M.vanbaalenii_PYR-1 LYALTEIMNTRPLHDPELMQTQ-----------VELFGYAGDLAASKRAA
Mflv_0425|M.gilvum_PYR-GCK LYTLTDIMNTRPLHDPELVAAQ-----------MQMFEYAAELAARKRSE
Mb3575c|M.bovis_AF2122/97 LFHWSNEMTGNEDPEYAHIDPKASS--------AELIGYAMKMAEEKAKN
Rv3545c|M.tuberculosis_H37Rv LFHWSNEMTGNEDPEYAHIDPKASS--------AELIGYAMKMAEEKAKN
MUL_4106|M.ulcerans_Agy99 LFDWSNEMTGTEDPEFAHIDAKASS--------VELIGYAMKMAEEKAKN
MSMEG_5853|M.smegmatis_MC2_155 IFAWSNAIINTDDPDFD-SDPTVAN--------AELMGYAYTMAEERRRC
MMAR_3761|M.marinum_M VAHAADALVSWADPRYLNGREPLAVLFENQ---MYLHQVAASLAAERRDR
TH_4132|M.thermoresistible__bu FYYWTEAIEQAIRDPEPNTGVEVFD--------EMGAYLTEQIERQTTEA
MAB_3825|M.abscessus_ATCC_1997 MLKLTQELFGGDDSEFQRGTTPEEQ-LMAL---LDFFGYFSGLTASRRQH
MAV_1339|M.avium_104 FRAWSDAATGTADPEIELDPAVAAG---------QLYEYFQRLIAARRAR
MLBr_02088|M.leprae_Br4923 FGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGT
. : :
Mvan_0246|M.vanbaalenii_PYR-1 PGDDIATALLHAEVDGQRLTDLEFNLFFMLLLNAGGDTTRNLVAAGTLAL
Mflv_0425|M.gilvum_PYR-GCK PGDDIATALLHAEVDGRRLTDLEFNLFFLLLINAGGDTTRNLVAAGTLAL
Mb3575c|M.bovis_AF2122/97 PADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAF
Rv3545c|M.tuberculosis_H37Rv PADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAF
MUL_4106|M.ulcerans_Agy99 PGDDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAF
MSMEG_5853|M.smegmatis_MC2_155 PADDIVTRLVQADVSGESLGEVEFAFFVILLAVAGNETTRNAITHGMNAF
MMAR_3761|M.marinum_M PGDDLFSALVNAEVDGDRLADADVAAFFVLLAVAGNDTTRQTISHGLKAL
TH_4132|M.thermoresistible__bu VEDSLVMRLRNAEVDGEKLTDVEIVMFFGLLTFAGNDTTRNTASAGLRTL
MAB_3825|M.abscessus_ATCC_1997 PTDDLASTIANARVDGELLSDVDTASYYTIIATAGHDTTSATIAGGLEAL
MAV_1339|M.avium_104 PRADLLSVLAEAEIDEHRLTDEDLLNFAFLLLVAGNETTRNLIALGTLAL
MLBr_02088|M.leprae_Br4923 PGEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAM
.: : . . * : : :: ** :** : . ::
Mvan_0246|M.vanbaalenii_PYR-1 IEHPEQ-WARLAADPSLMPTAIEEMLRWTSPVNVFTRTATRDTEVGGVPL
Mflv_0425|M.gilvum_PYR-GCK IEHPDQ-WRRLAADPSLMPTAVEEMLRWTSPVTVFSRTATRDTDVGGIRL
Mb3575c|M.bovis_AF2122/97 AEHPDQ--WELYKKVRPE-TAADEIVRWATPVTAFQRTALRDYELSGVQI
Rv3545c|M.tuberculosis_H37Rv AEHPDQ--WELYKKVRPE-TAADEIVRWATPVTAFQRTALRDYELSGVQI
MUL_4106|M.ulcerans_Agy99 ADNPEQ--WELYKRERPG-TAADEIVRWATPVTSFQRTALEDYELSGVQI
MSMEG_5853|M.smegmatis_MC2_155 FENPDQ--WELFKRERPI-TAVDEIVRWATPVHCFQRTAVVDTEIGGVPI
MMAR_3761|M.marinum_M TDFPSQKAWLLADFDTRIGTAVEELVRWATPVMTFRRTAAADFELGGQLI
TH_4132|M.thermoresistible__bu LEHPDA-LQQLYDDAALIPNAIEEILRYTSVVQWFARTATRDVELGGQKI
MAB_3825|M.abscessus_ATCC_1997 LEHPDQ-LARLRENPGLMPLAVDEMIRWVTPVKEFMRTATADTEIRGVPI
MAV_1339|M.avium_104 IAHPDQ-YRLLVEEPARIPLAVEEMLRWNSPVVHMARTATADVEIRGQRI
MLBr_02088|M.leprae_Br4923 LRNPSQ-WKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTL
*. * . :* :*: . : : *.* * : :
Mvan_0246|M.vanbaalenii_PYR-1 RAGERVAMFYPSANRDEKHFA-DPDRFDIGRAPNHHLAFGGGGTHFCLGA
Mflv_0425|M.gilvum_PYR-GCK REGERVAMFYPSANRDEKHFA-DPDRFDIGRMPNPHLAFGGGGTHFCLGA
Mb3575c|M.bovis_AF2122/97 KKGQRVVMFYRSANFDEEVFQ-DPFTFNILRNPNPHVGFGGTGAHYCIGA
Rv3545c|M.tuberculosis_H37Rv KKGQRVVMFYRSANFDEEVFQ-DPFTFNILRNPNPHVGFGGTGAHYCIGA
MUL_4106|M.ulcerans_Agy99 KKGQRVLMFYRSANFDEEVFE-DPFSFNILRNPNPHVGFGGTGAHYCIGA
MSMEG_5853|M.smegmatis_MC2_155 KAGQRAGLFYSSANYDEDVFD-DPFRFDILRDPNPHLGFGGNGAHYCIGA
MMAR_3761|M.marinum_M RAGEKVVMFYASGNWDEDAFC-HPERLDLSRSPNPHVGFGGGGVHFCLGA
TH_4132|M.thermoresistible__bu SEGDKVVMWYASGSRDEAVFD-DSDTFDIHRPKPDHQAFGGGGRHFCLGA
MAB_3825|M.abscessus_ATCC_1997 TEGESVLLSYPSGNRDEDIFT-DPFTFDIARDPNKHLAFG-FGVHFCLGA
MAV_1339|M.avium_104 RAGEVVVMLYGSANRDEDVFGPDSEEFDVTRHPNPHIAFG-CGEHSCVGA
MLBr_02088|M.leprae_Br4923 TEGDTMVLLLAAANRDPAVYS-RPDEFDPDRPSSRHLAFA-VGSHFCLGA
*: : :.. * : . :: * * .*. * * *:**
Mvan_0246|M.vanbaalenii_PYR-1 SLARVEATAIFGEILTRTAHIELAGPVERVRSVLMNGIRSMPVRLTPASV
Mflv_0425|M.gilvum_PYR-GCK SLARVEAAAIFRELITRTREIGLVGPVERVRSVLMNGIRSMPAQFTPAVV
Mb3575c|M.bovis_AF2122/97 NLARMTINLIFNAVADHMPDLKPISAPERLRSGWLNGIKHWQVDYTGRCP
Rv3545c|M.tuberculosis_H37Rv NLARMTINLIFNAVADHMPDLKPISAPERLRSGWLNGIKHWQVDYTGRCP
MUL_4106|M.ulcerans_Agy99 NLARMTINLIFNAVADHMPDLKPIAAPERLRSGWLNGIKHWQVDYTGKCP
MSMEG_5853|M.smegmatis_MC2_155 NLARMEIRLMFDEIADQIPDITKVGEPQRLRSGWINGVKDLQVSYRG---
MMAR_3761|M.marinum_M HLARAQLRAIFGELLVQLPDIQAG-DPVYVPGNFVHAIRSMPCTF-----
TH_4132|M.thermoresistible__bu SLARLELRIIFEEVLGRMKNLQLAGTTEILPSNWAYGLTKLPVTFTAGRR
MAB_3825|M.abscessus_ATCC_1997 ALARMEVNSFFSALLPRLESIEVDGNIERTSTIFVGGIKHLPIRYTLR--
MAV_1339|M.avium_104 QLARLEATVFFEELLRRYPRIELVGEVDRMRATMVPGVKRMPVRMGA---
MLBr_02088|M.leprae_Br4923 ALARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPVQV-----
*** : : : : .:
Mvan_0246|M.vanbaalenii_PYR-1 PA-
Mflv_0425|M.gilvum_PYR-GCK PA-
Mb3575c|M.bovis_AF2122/97 VAH
Rv3545c|M.tuberculosis_H37Rv VAH
MUL_4106|M.ulcerans_Agy99 VSH
MSMEG_5853|M.smegmatis_MC2_155 ---
MMAR_3761|M.marinum_M ---
TH_4132|M.thermoresistible__bu LES
MAB_3825|M.abscessus_ATCC_1997 ---
MAV_1339|M.avium_104 ---
MLBr_02088|M.leprae_Br4923 ---