For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TAADPRPPDLATLTGLRSGKGRFYPEFRVTAQRLDRVLAALDTISRALVQTVEGPENLVRAVAEAARAHL DADWVLLALADGALPEASVRHLILDSGGAAYAFEGLSGARDPGPSLPDAVLNRLNDILRGQLAEFRLPVI ESRHAHVPIELDGEVIGAFAAWTPPRRTLDATDGMVMRILAGQTAVALQNSALFSKSVTLLAQSEARNAE LLATQRELGAAQRHQVLNSERHRIARELHDSVAQTVLSAGMQIEVCRSEIDASGRNRELVDRLDLAKHLT RSATEQLRSAIYALNQPGDAYRSSLTEMLGQLATVHMPEDLRVTLRVDGSAAELPGEVEHALLRIAGEAL FNTAMHGNATRAIVRLSYRDDAVSLSIADDGTGDPAKLRLMLRMAEATDVDGRHRGLANMRARAREHGGT FDVYRSRIGGVRVVARIPRVSESVTS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5475 | - | - | 100% (447) | histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_1413 | - | 1e-16 | 23.91% (368) | GAF sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_1357 | - | 2e-15 | 27.13% (435) | GAF sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3156c | devS | 2e-12 | 23.21% (418) | two component sensor histidine kinase DEVS |
| M. gilvum PYR-GCK | Mflv_3844 | - | 1e-18 | 25.81% (430) | GAF sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv3132c | devS | 8e-13 | 23.21% (418) | two component sensor histidine kinase DEVS |
| M. leprae Br4923 | MLBr_02124 | - | 8e-07 | 29.41% (204) | sensor histidine kinase |
| M. abscessus ATCC 19977 | MAB_3890c | - | 3e-17 | 28.87% (239) | histidine kinase response regulator |
| M. marinum M | MMAR_3479 | - | 1e-19 | 30.45% (266) | two-component sensor histidine kinase |
| M. avium 104 | MAV_4108 | - | 3e-19 | 26.12% (402) | GAF family protein |
| M. smegmatis MC2 155 | MSMEG_6238 | - | 1e-163 | 79.89% (378) | putative two-component system sensor kinase |
| M. thermoresistible (build 8) | TH_0388 | - | 3e-16 | 28.38% (229) | TWO COMPONENT SENSOR HISTIDINE KINASE DEVS |
| M. ulcerans Agy99 | MUL_2422 | devS | 3e-15 | 24.59% (431) | two component sensor histidine kinase DevS |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5475|M.vanbaalenii_PYR-1 ------------------------MTAADPRPPDLATLTGLRSGKGRFYP
MSMEG_6238|M.smegmatis_MC2_155 --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 -------MTTGGLVDENDG---AAMRPLRHTLSQLRLHELLVEVQDRVEQ
Rv3132c|M.tuberculosis_H37Rv -------MTTGGLVDENDG---AAMRPLRHTLSQLRLHELLVEVQDRVEQ
MUL_2422|M.ulcerans_Agy99 MTDEPHPQDAGPSLGVPSG---DGLRPLRLTLSQLRLRELLVEVQERVEQ
Mflv_3844|M.gilvum_PYR-GCK -------MHDGAVADADDHRARDGARPVRTTLSQLRLRELLTEVQDRVEQ
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 -------------MVEDVG---AQPNRVTAELAHLQLRELLAEVQGRIEQ
MMAR_3479|M.marinum_M --------------------------------MHAQLDELLAA-------
MAV_4108|M.avium_104 -------------------------------MTGNRFDELAAA-------
MLBr_02124|M.leprae_Br4923 ---------------------------------MNILSRIFAR-------
Mvan_5475|M.vanbaalenii_PYR-1 EFRVTAQRLDRVLAALDTISRALVQTVEGPENLVRAVAEAARAHLDADWV
MSMEG_6238|M.smegmatis_MC2_155 ------------------------------------MAEAARTHLDAEWV
Mb3156c|M.bovis_AF2122/97 IVEG-RDRLDGLVEAMLVVT-----AGLDLEATLRAIVHSATSLVDARYG
Rv3132c|M.tuberculosis_H37Rv IVEG-RDRLDGLVEAMLVVT-----AGLDLEATLRAIVHSATSLVDARYG
MUL_2422|M.ulcerans_Agy99 IVEG-RDRLDGLVEAMLVVT-----SGLELDATLRTIVHSATNLVDARYC
Mflv_3844|M.gilvum_PYR-GCK IIRG-RDRLDGLVEAMLAVT-----SGLELDETLRTIVHTAIELVDAQYG
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 IVDGTRGRMDALLDAVMAVS-----SGLELDATLREIVCAASELVSARYG
MMAR_3479|M.marinum_M -----RDQMEQLLRVIVEIG-----SDLDLDATLRRIVLAARELTSAPYG
MAV_4108|M.avium_104 -----RDQTEKLLRVIAEIG-----AGLDLDATLHRIISAARELTSAPYG
MLBr_02124|M.leprae_Br4923 -----TPSLRTRVVVATAIG------AAIPVLIVGTVVWVGITNDRKERL
Mvan_5475|M.vanbaalenii_PYR-1 LLALADGALPEASVRHLILDSGGAAYAFEGLSGARDPGPSLPDAVLNRLN
MSMEG_6238|M.smegmatis_MC2_155 LLALADGALQEALPRHLILDADGHAYSYDGVSGAEVP-DHLPDAVLNRLN
Mb3156c|M.bovis_AF2122/97 AMEVHDRQHRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLD
Rv3132c|M.tuberculosis_H37Rv AMEVHDRQHRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLD
MUL_2422|M.ulcerans_Agy99 ALEVHDRDKRVLQFVYEGIDEDTVARIGHLPEGLGIIGLLIDEPKPLRLE
Mflv_3844|M.gilvum_PYR-GCK ALGVRGHDQELVEFIYEGIDEPMRERIGHLPEGRGVLGVLINDPKPIRLE
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 ALGVVGSDEKLAEFVYEGIDEATRDLIGPLPTGHGVLGVVIDEAKPLRLR
MMAR_3479|M.marinum_M ALAVRDPEGTLIRFIHAGMDDDVARRIGHLPVGKGVLGVSLVETPALRLD
MAV_4108|M.avium_104 ALAVRDWHANLISFVHEGMDAETVRRIGHHPVGKGLLSLSLLDTPALRMD
MLBr_02124|M.leprae_Br4923 DRKLDEAAGFAIPFVPRGLDEIPRSPNDQDAIITVRRGNLVKSNFDITLP
Mvan_5475|M.vanbaalenii_PYR-1 DILRGQLAEFRLPVIES---RHAHVPIELDGEVIG-AFAAWTPPRRTLDA
MSMEG_6238|M.smegmatis_MC2_155 DILRGHLAQFRYPVIEP---HHAHVPIELNGGVIG-AFAAWTPVHRTLDD
Mb3156c|M.bovis_AF2122/97 DVS-AHPASIGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSD
Rv3132c|M.tuberculosis_H37Rv DVS-AHPASIGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSD
MUL_2422|M.ulcerans_Agy99 DIS-QHPASIGFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSD
Mflv_3844|M.gilvum_PYR-GCK DIS-RHADSVGFPPNHPPMRTFLGVPVRIRDEVFGNLYLTEKSDGQPFSE
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 DIA-AHPASVGFPANHPPMRTFLGVPVQVRGEVFGRLYLTEKLDGQEFTE
MMAR_3479|M.marinum_M DLT-MHPAACGFPEHHPPMRAFLAVPITIRGTVFGSLYLTHVDPGRKFSE
MAV_4108|M.avium_104 DLT-AHPAAAGFPEHHPAMRAFLAVPITIRGAVFGNLYLTHVDEARVFSD
MLBr_02124|M.leprae_Br4923 KLT-NDYADTYLRGVRYRVRTVEIPAPEPTSIAVGATYDATVAETNNLHR
Mvan_5475|M.vanbaalenii_PYR-1 TDGMVMRILAGQTAVALQNSALFSK-------------------------
MSMEG_6238|M.smegmatis_MC2_155 TDETVMRILSSQTAVALQNCALFQR-------------------------
Mb3156c|M.bovis_AF2122/97 DDEVLVQALAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPA
Rv3132c|M.tuberculosis_H37Rv DDEVLVQALAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPA
MUL_2422|M.ulcerans_Agy99 DDELLVQALAAAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEPA
Mflv_3844|M.gilvum_PYR-GCK DDEVLVQALAAAAGIAIDNARLYAQSQARQSWIEATRDIGTELLSGIDPA
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 DDEVVVRALAGAAGIAIENARLYQHARRREQWQRATADITAELLGGVDPG
MMAR_3479|M.marinum_M SDEFAARALAFAAGVAIDNAQVFERERTAVKWMEASREITTALMSSTESR
MAV_4108|M.avium_104 ADEMAARALAFAAAVAIDNAQVFERERMSVKWIEASREITTALLSRTEPH
MLBr_02124|M.leprae_Br4923 RVLLICGFAIAAAAVFAWLLAAFAVR------------------------
Mvan_5475|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6238|M.smegmatis_MC2_155 --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 T-VFRLVAAEALKLTAADAALVAVPVDEDMPAA-DVGELLVIETVGSAVA
Rv3132c|M.tuberculosis_H37Rv T-VFRLVAAEALKLTAADAALVAVPVDEDMPAA-DVGELLVIETVGSAVA
MUL_2422|M.ulcerans_Agy99 S-VFRLVAEEALKLTSADAALVAIPVDEDVPAS-EVAQLLVIETVGNAVA
Mflv_3844|M.gilvum_PYR-GCK G-VFRRVADRAQKLSGAAATLVAVPDDPDLPVG-EVAELTVAASAGETIA
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 K-ALHLVASSAALLAEADFAFIALPAGDEE----DTAELVVAVCEGKGAE
MMAR_3479|M.marinum_M REPLQLIAQRACTLTDAEQAIVLVPVESDLATD-EIDTLVVSAAVGLHAE
MAV_4108|M.avium_104 RRPMQLIAERACALTDAEQAIVLVPADPEQPGNPEVDTLVVSAAVGLPAA
MLBr_02124|M.leprae_Br4923 --------------------------------------------------
Mvan_5475|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6238|M.smegmatis_MC2_155 --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 STVGRTIPVAGAVLREVFVNGIPRRVDRVDLEGLD-ELADAGPALLLPLR
Rv3132c|M.tuberculosis_H37Rv SIVGRTIPVAGAVLREVFVNGIPRRVDRVDLEGLD-ELADAGPALLLPLR
MUL_2422|M.ulcerans_Agy99 AAEGCTIAVAGTALAEVLLDSAPRQVDKIAVEDVD-ELGDMGPALVLPLR
Mflv_3844|M.gilvum_PYR-GCK AAHD-PIPVAGTAIGDAFVHRTPGMTDRADIG----IGATVGPALLLPLR
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 VLNDKLIPIDGSTSGSTFIDHEPRNVGRLAVNLAEGTDLAFGPALVLPLG
MMAR_3479|M.marinum_M EVVGQQVPVRGSTCGDVFRSGEPLISEAFSYPIEAFTDVAQRSAIVMPLS
MAV_4108|M.avium_104 DVLGQRVPVRGSTSGAVFKSGEPLITDEFRYPIQAFTDAGRRPAIVMPLR
MLBr_02124|M.leprae_Br4923 --------------------------------------------------
Mvan_5475|M.vanbaalenii_PYR-1 ----------------------SVTLLAQSEARNAELLATQRELGAAQRH
MSMEG_6238|M.smegmatis_MC2_155 ----------------------SQALLAQSEARNAELLATQRELGAAQRH
Mb3156c|M.bovis_AF2122/97 ARGTVAGVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRE
Rv3132c|M.tuberculosis_H37Rv ARGTVAGVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRE
MUL_2422|M.ulcerans_Agy99 ATDAVAGVVVLLHPSSPESVTEEQLEMMAAFADQAALALQLATSQRRMRE
Mflv_3844|M.gilvum_PYR-GCK APDAVPGVLIVLRSVGAQPFRSDELDMLAAFADQAAQAWQLASTQHRLRE
TH_0388|M.thermoresistible__bu -------VLVVCRAEEGRPFTDEQLEILVTFADQAALAWQLAATQRRMRE
MAB_3890c|M.abscessus_ATCC_199 GGESTAGVLILLRTVGAIAFDEEQLDMAASFAGQAALALEQAEVRLAKHE
MMAR_3479|M.marinum_M AHEKVAGVIAVARGADQPPFDARCLDLVSQFATHAAIALLLASGREDARQ
MAV_4108|M.avium_104 ARDEVVGVIAIARGTEQPPFDESYLDLVRDFATHAAIALVLAAAREDARQ
MLBr_02124|M.leprae_Br4923 PFKQLAQQTRSVDAGGEAPRVEVHGATEAVEIAEAMRGMLQRIWNEQNRT
.* :
Mvan_5475|M.vanbaalenii_PYR-1 QVLNSERHRIARELHDSVAQTVLSAGMQIEVCRSEIDASGRNRELVDRLD
MSMEG_6238|M.smegmatis_MC2_155 QVLDNERHRIARELHDSVSQTVLSAGMQIEVCRSEAMALPGTQDLVDRLD
Mb3156c|M.bovis_AF2122/97 LDVLTDRDRIARDLHDHVIQRLFAIGLALQGAVPHERN----PEVQQRLS
Rv3132c|M.tuberculosis_H37Rv LDVLTDRDRIARDLHDHVIQRLFAIGLALQGAVPHERN----PEVQQRLS
MUL_2422|M.ulcerans_Agy99 LDVVTERDRIARDLHDHVIQRLFAIGLALQGSVPRTRE----PKVQQRLS
Mflv_3844|M.gilvum_PYR-GCK LGILTDRDRIARDLHDHVIQRLFAVGLSLQGSIARARS----EEVQQRLS
TH_0388|M.thermoresistible__bu LDVLSDRDRIARDLHDHVIQRLFAVGLTLQGTIPRARS----TEVQQRLS
MAB_3890c|M.abscessus_ATCC_199 LDVLADRDRIARDLHDHVIQRLFAVGLAMQSTHRRSVD----PTVAARLA
MMAR_3479|M.marinum_M LTILAERERIAHDLHDHVIQRLFASGMDLQGTLARARS----PEVIDRLN
MAV_4108|M.avium_104 LAVLAERERIAHDLHDHVIQRLFAAGMDLQGTLARARS----PEVADRLN
MLBr_02124|M.leprae_Br4923 KEALASARDFAAVSSHELRTPLTAMRTNLEVLATLDLADDQRKEVLGDVI
. :* . : : : :: : :
Mvan_5475|M.vanbaalenii_PYR-1 LAKHLTRSATEQLR-SAIYALNQPGDAYRSSLTEMLGQLATVHMPEDLRV
MSMEG_6238|M.smegmatis_MC2_155 TAKTLTRSASEQLR-SAIYALNHPEDAGRSTLPELLEQLATVHMPEDLRV
Mb3156c|M.bovis_AF2122/97 DVVDDLQDVIQEIR-TTIYDLHGASQGITRLRQRIDAAVAQFA-DSGLRT
Rv3132c|M.tuberculosis_H37Rv DVVDDLQDVIQEIR-TTIYDLHGASQGITRLRQRIDAAVAQFA-DSGLRT
MUL_2422|M.ulcerans_Agy99 EVIDDLQGVIQEIR-TTIFDLHGSSQGVTRLRQRIDAAVAAFG-SSGLRT
Mflv_3844|M.gilvum_PYR-GCK ANVDDLQSVIQEIR-TAIFDLHGGSSAVTRLRQRLDAAVAAFP-ESGVRT
TH_0388|M.thermoresistible__bu ECIDDLQAVIGEIR-TTIFDLHGGPATGSQIRQRIGEAANQFS-DAGVRT
MAB_3890c|M.abscessus_ATCC_199 DHIDQLHEVIQEIR-TAIFDLHTNDE---SLRATLRSTINELTAETGLRV
MMAR_3479|M.marinum_M RTVDDLQTIIEEIR-STIFQLKSPSGRDGGFRQRIQQVVADLTEHRDVVT
MAV_4108|M.avium_104 RTLDDLQTIIEEIR-TTIFALRSPAAVAGDFRHRIQRVIAELTENRDLVT
MLBr_02124|M.leprae_Br4923 RTQSRIEATLSALERLAQGELSTSDDHVPVDITELLDRAAHDATRSYPEL
. :. : * :
Mvan_5475|M.vanbaalenii_PYR-1 TLRVDGSAAELPGEVEHALLRIAGEALFNTAMHGNATRAIVRLSYRDDAV
MSMEG_6238|M.smegmatis_MC2_155 SLKVEGAVAELPSEVEHALLRIAGEALFNTAMHGNATRAIVRLRYRPTAV
Mb3156c|M.bovis_AF2122/97 SVQFVGPLSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVK-VDDDL
Rv3132c|M.tuberculosis_H37Rv SVQFVGPLSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVK-VDDDL
MUL_2422|M.ulcerans_Agy99 TVQFIGPLSVVDNVLADHAEAVVREAVSNAVRHAQATTLTVRVK-VDDDL
Mflv_3844|M.gilvum_PYR-GCK SMQCAGPLSVVDAGLADHAEAVVREAVSNAVRHAEASTVAVTVT-VEDDL
TH_0388|M.thermoresistible__bu RVQFAGPLSVISAVLADHAEAVVREAVSNAVRHGGATDLSVDVS-VDDDL
MAB_3890c|M.abscessus_ATCC_199 SVRMSGPLDVVPASTSGDAEAVVREAVSNVVRHARARELSVTVS-VDDEL
MMAR_3479|M.marinum_M TIHMHGPMSAVQGELADHAEAVATEAISNAVRHSGAGRVTLDVS-VGDMF
MAV_4108|M.avium_104 TVRMDGPMTAVGAELAEHAEAVTAEAVSNAVRHSGASRLTVQIG-VADMF
MLBr_02124|M.leprae_Br4923 KVSLVPSPTCIIVGLPAGLRLAVDNAVANAVKHGGATRVQLSAVSSRAGV
: . : . :*: *.. *. * : .
Mvan_5475|M.vanbaalenii_PYR-1 SLSIADDGTGDPAKLR----LMLRMAEATDVDGRHRGLANMRARAREHGG
MSMEG_6238|M.smegmatis_MC2_155 SLSISDDGTGDPAKLR----MALRMADATDVDGHHRGLANMLARCREHGG
Mb3156c|M.bovis_AF2122/97 CIEVTDNGRG-----------------LPD-EFTGSGLTNLRQRAEQAGG
Rv3132c|M.tuberculosis_H37Rv CIEVTDNGRG-----------------LPD-EFTGSGLTNLRQRAEQAGG
MUL_2422|M.ulcerans_Agy99 CIEVSDNGRG-----------------MPK-TYTSSGLTNLRRRAQEAGG
Mflv_3844|M.gilvum_PYR-GCK AITVTDDGRG-----------------IAA-DVTGSGLANLARRAQDVGG
TH_0388|M.thermoresistible__bu TIEVTDNGRG-----------------FPEGEVTESGLANLRHRARHAGG
MAB_3890c|M.abscessus_ATCC_199 VIEVVDDGIG-----------------IPD-VVARSGLSGLANRAAQSGG
MMAR_3479|M.marinum_M SLEVVDDGCG-----------------ISPDVSRRSGLANMRSRAEKLGG
MAV_4108|M.avium_104 TLDVIDNGRG-----------------IAAGNTRRSGLANMTRRAEQLGG
MLBr_02124|M.leprae_Br4923 EIAVDDNGSGVPEDERQVVFERFSRGSTASHSGSGLGLALVAQQAQLHGG
: : *:* * . **: : :. **
Mvan_5475|M.vanbaalenii_PYR-1 TFDVYRSRIG-GVRVVARIPRVSESVTS
MSMEG_6238|M.smegmatis_MC2_155 TFAVQRSRIG-GVRVVATIPRTEGNRR-
Mb3156c|M.bovis_AF2122/97 EFTLASVPGASGTVLRWSAPLSQ-----
Rv3132c|M.tuberculosis_H37Rv EFTLASVPGASGTVLRWSAPLSQ-----
MUL_2422|M.ulcerans_Agy99 QFTIESPAAGGGTLLRWSAPLIQ-----
Mflv_3844|M.gilvum_PYR-GCK SFSVR-RGAQVGTTLTWRAPLP------
TH_0388|M.thermoresistible__bu TLEVHNRPDG-GARLHWSVPLT------
MAB_3890c|M.abscessus_ATCC_199 TFSVSAMDTG-GTRLVWSAPLP------
MMAR_3479|M.marinum_M TCGITTPTEG-GTRISWTVPFGDL----
MAV_4108|M.avium_104 SCEISSPPGG-GTRVHWTAPLLDH----
MLBr_02124|M.leprae_Br4923 TASLETSPLG-GARLLLRISAPS-----
: *. : .