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AEAARTHLDAEWVLLALADGALQEALPRHLILDADGHAYSYDGVSGAEVPDHLPDAVLNRLNDILRGHLA QFRYPVIEPHHAHVPIELNGGVIGAFAAWTPVHRTLDDTDETVMRILSSQTAVALQNCALFQRSQALLAQ SEARNAELLATQRELGAAQRHQVLDNERHRIARELHDSVSQTVLSAGMQIEVCRSEAMALPGTQDLVDRL DTAKTLTRSASEQLRSAIYALNHPEDAGRSTLPELLEQLATVHMPEDLRVSLKVEGAVAELPSEVEHALL RIAGEALFNTAMHGNATRAIVRLRYRPTAVSLSISDDGTGDPAKLRMALRMADATDVDGHHRGLANMLAR CREHGGTFAVQRSRIGGVRVVATIPRTEGNRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6238 | - | - | 100% (383) | putative two-component system sensor kinase |
| M. smegmatis MC2 155 | MSMEG_4968 | - | 3e-14 | 30.04% (233) | two-component system sensor kinase |
| M. smegmatis MC2 155 | MSMEG_1493 | - | 4e-14 | 26.51% (298) | sensor histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0868 | - | 2e-10 | 28.18% (220) | two component sensor kinase |
| M. gilvum PYR-GCK | Mflv_5015 | - | 1e-15 | 25.50% (302) | GAF sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0845 | - | 1e-10 | 28.51% (249) | two component sensor kinase |
| M. leprae Br4923 | MLBr_02124 | - | 9e-07 | 24.79% (242) | sensor histidine kinase |
| M. abscessus ATCC 19977 | MAB_3890c | - | 1e-15 | 25.71% (245) | histidine kinase response regulator |
| M. marinum M | MMAR_3479 | - | 6e-15 | 26.81% (235) | two-component sensor histidine kinase |
| M. avium 104 | MAV_4108 | - | 1e-14 | 23.72% (312) | GAF family protein |
| M. thermoresistible (build 8) | TH_4203 | - | 2e-15 | 26.62% (308) | PUTATIVE sensor histidine kinase |
| M. ulcerans Agy99 | MUL_0350 | - | 2e-12 | 29.63% (243) | two component sensor kinase |
| M. vanbaalenii PYR-1 | Mvan_5475 | - | 1e-163 | 79.89% (378) | histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6238|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5475|M.vanbaalenii_PYR-1 --------------------------------------------MTAADP
MMAR_3479|M.marinum_M --------------------------------------------------
MAV_4108|M.avium_104 --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 --------------------------------------------MVEDVG
Mb0868|M.bovis_AF2122/97 --------------------------------------MPSYGNLGRLGG
Rv0845|M.tuberculosis_H37Rv --------------------------------------MPSYGNLGRLGG
MUL_0350|M.ulcerans_Agy99 MMNSRQREADRRQFAPSCRRQDESAGQSLGQRRTERSPNPSCANYGQLVG
Mflv_5015|M.gilvum_PYR-GCK --------------------------------------------------
TH_4203|M.thermoresistible__bu --------------------------------------------------
MLBr_02124|M.leprae_Br4923 -----------------------------------------MNILSRIFA
MSMEG_6238|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5475|M.vanbaalenii_PYR-1 RPPDLATLTGLRSGKGRFYPEFR--------VTAQRLDRVLAALDTISRA
MMAR_3479|M.marinum_M ----------MHAQLDELLAARD------------QMEQLLRVIVEIG--
MAV_4108|M.avium_104 ---------MTGNRFDELAAARD------------QTEKLLRVIAEIG--
MAB_3890c|M.abscessus_ATCC_199 AQPNRVTAELAHLQLRELLAEVQGRIEQIVDGTRGRMDALLDAVMAVS--
Mb0868|M.bovis_AF2122/97 -RHEYGVLVAMTSSAELDRVRWAHQLRSYRIASVLRIGVVGLMVAAMV--
Rv0845|M.tuberculosis_H37Rv -RHEYGVLVAMTSSAELDRVRWAHQLRSYRIASVLRIGVVGLMVAAMV--
MUL_0350|M.ulcerans_Agy99 SCRLYGVPVVVTSDAELARVRRTHQLRAYRIGSVLRIGVVLFMVAAML--
Mflv_5015|M.gilvum_PYR-GCK -------------------------MTRPLLTADRELALLRELIQAAS--
TH_4203|M.thermoresistible__bu ----------VTSGPHPDPVR---DLSEQLLTADRELVLLRELIQAAS--
MLBr_02124|M.leprae_Br4923 RTPSLRTRVVVATAIGAAIPVLIVGTVVWVGITNDRKERLDRKLDEAA--
MSMEG_6238|M.smegmatis_MC2_155 --------------MAEAARTHLDAEWVLLALADGALQEALPRHLILDAD
Mvan_5475|M.vanbaalenii_PYR-1 LVQTVEGPENLVRAVAEAARAHLDADWVLLALADGALPEASVRHLILDSG
MMAR_3479|M.marinum_M ---SDLDLDATLRRIVLAARELTSAPYGALAVRDPEGTLIRFIHAGMDDD
MAV_4108|M.avium_104 ---AGLDLDATLHRIISAARELTSAPYGALAVRDWHANLISFVHEGMDAE
MAB_3890c|M.abscessus_ATCC_199 ---SGLELDATLREIVCAASELVSARYGALGVVGSDEKLAEFVYEGIDEA
Mb0868|M.bovis_AF2122/97 ---VGTSRSEWPQQIVLIGVYAVAALWALLLAYSASRRFFALRRFRSMGR
Rv0845|M.tuberculosis_H37Rv ---VGTSRSEWPQQIVLIGVYAVAALWALLLAYSASRRFFALRRFRSMGR
MUL_0350|M.ulcerans_Agy99 ---VGTPRREWGAQTALICVYAFAALWALALAFRRSRPMVSLDRFANIAR
Mflv_5015|M.gilvum_PYR-GCK ---SGPGVEPLAAASARMITASTDSDVCFVHVLDDTERSLTLAGATPPFD
TH_4203|M.thermoresistible__bu ---RGPGVEPLAAAAARMITAATASDVCFVHVLDDTERSLTLAGATPPFD
MLBr_02124|M.leprae_Br4923 ----GFAIPFVPRGLDEIPRSPNDQDAIITVRRGNLVKSNFDITLPKLTN
MSMEG_6238|M.smegmatis_MC2_155 GHAYSYDGVSGAEVP-DHLPDAVLNRLNDILRGHLAQFRYPVIEP----H
Mvan_5475|M.vanbaalenii_PYR-1 GAAYAFEGLSGARDPGPSLPDAVLNRLNDILRGQLAEFRLPVIES----R
MMAR_3479|M.marinum_M VARRIGHLPVGKGVLGVSLVETPALRLDDLT-MHPAACGFPEHHPP-MRA
MAV_4108|M.avium_104 TVRRIGHHPVGKGLLSLSLLDTPALRMDDLT-AHPAAAGFPEHHPA-MRA
MAB_3890c|M.abscessus_ATCC_199 TRDLIGPLPTGHGVLGVVIDEAKPLRLRDIA-AHPASVGFPANHPP-MRT
Mb0868|M.bovis_AF2122/97 LEPFAFTAVDVLILTGFQLLSTDGIYPLLIMILLPVLVGLDVSTRRAAVV
Rv0845|M.tuberculosis_H37Rv LEPFAFTAVDVLILTGFQLLSTDGIYPLLIMILLPVLVGLDVSTRRAAVV
MUL_0350|M.ulcerans_Agy99 YEPLAFTAVDVLALTGFQLLSTDGIYSLLIMTLLPVLVALDISSRRAAVV
Mflv_5015|M.gilvum_PYR-GCK SEVGKIRLPLGQGISGWVASHRQPVVIRRDKESDPRYLPFQSLRGRDFTS
TH_4203|M.thermoresistible__bu KEVGKIRLPLGQGISGWVASHREPVVITENKEADPRYLPFQSLRGRDFTS
MLBr_02124|M.leprae_Br4923 DYADTYLRGVRYRVRTVEIPAPEPTSIAVGATYDATVAETNNLHRR--VL
MSMEG_6238|M.smegmatis_MC2_155 HAHVPIELNGGVIG-AFAAWTPVHRTLDDTDETVMRILSSQTAVALQNCA
Mvan_5475|M.vanbaalenii_PYR-1 HAHVPIELDGEVIG-AFAAWTPPRRTLDATDGMVMRILAGQTAVALQNSA
MMAR_3479|M.marinum_M FLAVPITIRGTVFGSLYLTHVDPGRKFSESDEFAARALAFAAGVAIDNAQ
MAV_4108|M.avium_104 FLAVPITIRGAVFGNLYLTHVDEARVFSDADEMAARALAFAAAVAIDNAQ
MAB_3890c|M.abscessus_ATCC_199 FLGVPVQVRGEVFGRLYLTEKLDGQEFTEDDEVVVRALAGAAGIAIENAR
Mb0868|M.bovis_AF2122/97 LACTLVGFAVAVLGDPVMLRAIGWPETIFRFALYAFLCATALMVVRIEER
Rv0845|M.tuberculosis_H37Rv LACTLVGFAVAVLGDPVMLRAIGWPETIFRFALYAFLCATALMVVRIEER
MUL_0350|M.ulcerans_Agy99 LALTLVGFGLALAQDPVVIRMNGWPEAIFRFGLYAFLCATALMVVRSEER
Mflv_5015|M.gilvum_PYR-GCK MVSVPMETDPGGLVGVLNVHTVAERDFTDRDVELLLVIGRLIAGAMHQAR
TH_4203|M.thermoresistible__bu MVSVPMETDPGGLVGVLNVHTVERREFTRRDVDLLLVIGRLIAGGLHQAR
MLBr_02124|M.leprae_Br4923 LICGFAIAAAAVFAWLLAAFAVRPFKQLAQQTRSVDAGGEAPRVEVHGAT
.
MSMEG_6238|M.smegmatis_MC2_155 LFQR--------------SQALLAQSEARN--------------------
Mvan_5475|M.vanbaalenii_PYR-1 LFSK--------------SVTLLAQSEARN--------------------
MMAR_3479|M.marinum_M VFERERTAVKWMEASREITTALMSSTESRREPLQLIAQRACTLTDAEQAI
MAV_4108|M.avium_104 VFERERMSVKWIEASREITTALLSRTEPHRRPMQLIAERACALTDAEQAI
MAB_3890c|M.abscessus_ATCC_199 LYQHARRREQWQRATADITAELLGGVDPGK-ALHLVASSAALLAEADFAF
Mb0868|M.bovis_AF2122/97 HTR-----------------------------------------------
Rv0845|M.tuberculosis_H37Rv HTR-----------------------------------------------
MUL_0350|M.ulcerans_Agy99 HAR-----------------------------------------------
Mflv_5015|M.gilvum_PYR-GCK LHR-----------------------------------------------
TH_4203|M.thermoresistible__bu LHR-----------------------------------------------
MLBr_02124|M.leprae_Br4923 EAVEIA--------------------------------------------
MSMEG_6238|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5475|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3479|M.marinum_M VLVPVESDLATD-EIDTLVVSAAVGLHAEEVVGQQVPVRGSTCGDVFRSG
MAV_4108|M.avium_104 VLVPADPEQPGNPEVDTLVVSAAVGLPAADVLGQRVPVRGSTSGAVFKSG
MAB_3890c|M.abscessus_ATCC_199 IALPAGDE----EDTAELVVAVCEGKGAEVLNDKLIPIDGSTSGSTFIDH
Mb0868|M.bovis_AF2122/97 --------------------------------------------------
Rv0845|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5015|M.gilvum_PYR-GCK --------------------------------------------------
TH_4203|M.thermoresistible__bu --------------------------------------------------
MLBr_02124|M.leprae_Br4923 --------------------------------------------------
MSMEG_6238|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5475|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3479|M.marinum_M EPLISEAFSYPIEAFTDVAQRSAIVMPLSAHEKVAGVIAVARGADQPPFD
MAV_4108|M.avium_104 EPLITDEFRYPIQAFTDAGRRPAIVMPLRARDEVVGVIAIARGTEQPPFD
MAB_3890c|M.abscessus_ATCC_199 EPRNVGRLAVNLAEGTDLAFGPALVLPLGGGESTAGVLILLRTVGAIAFD
Mb0868|M.bovis_AF2122/97 --------------------------------------------------
Rv0845|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5015|M.gilvum_PYR-GCK --------------------------------------------------
TH_4203|M.thermoresistible__bu --------------------------------------------------
MLBr_02124|M.leprae_Br4923 --------------------------------------------------
MSMEG_6238|M.smegmatis_MC2_155 -------------AELLATQRELGAAQRHQVLDNERHRIARELHDSVSQT
Mvan_5475|M.vanbaalenii_PYR-1 -------------AELLATQRELGAAQRHQVLNSERHRIARELHDSVAQT
MMAR_3479|M.marinum_M ARCLDLVSQFATHAAIALLLASGREDARQLTILAERERIAHDLHDHVIQR
MAV_4108|M.avium_104 ESYLDLVRDFATHAAIALVLAAAREDARQLAVLAERERIAHDLHDHVIQR
MAB_3890c|M.abscessus_ATCC_199 EEQLDMAASFAGQAALALEQAEVRLAKHELDVLADRDRIARDLHDHVIQR
Mb0868|M.bovis_AF2122/97 ------------SVAGLSALREELLAQTMTASEVLQRRIAEAIHDGPLQD
Rv0845|M.tuberculosis_H37Rv ------------SVAGLSALRAELLAQTMTASEVLQRRIAEAIHDGPLQD
MUL_0350|M.ulcerans_Agy99 ------------SVATLSVIREELLAQTMTASEVLQRRISESIHDGPLQD
Mflv_5015|M.gilvum_PYR-GCK ------------QLVARERAHENFVEQVIEAQELERRRLAGDIHDGISQR
TH_4203|M.thermoresistible__bu ------------QLVARERAHEIFVEQVIEAQELERRRLAADIHDGISQR
MLBr_02124|M.leprae_Br4923 ------------EAMRGMLQRIWNEQNRTKEALASARDFAAVSSHELRTP
:: .
MSMEG_6238|M.smegmatis_MC2_155 VLSAGMQIEVCRSEAMALPGTQDLVDRLDTAKTLTRSASEQLR-SAIYAL
Mvan_5475|M.vanbaalenii_PYR-1 VLSAGMQIEVCRSEIDASGRNRELVDRLDLAKHLTRSATEQLR-SAIYAL
MMAR_3479|M.marinum_M LFASGMDLQGTLARARS----PEVIDRLNRTVDDLQTIIEEIR-STIFQL
MAV_4108|M.avium_104 LFAAGMDLQGTLARARS----PEVADRLNRTLDDLQTIIEEIR-TTIFAL
MAB_3890c|M.abscessus_ATCC_199 LFAVGLAMQSTHRRSVD----PTVAARLADHIDQLHEVIQEIR-TAIFDL
Mb0868|M.bovis_AF2122/97 VLAARQELIELDAVTPGD-------ERVGRALAGLQSASERLR-QATFEL
Rv0845|M.tuberculosis_H37Rv VLAARQELIELDAVTPGD-------ERVGRALAGLQSASERLR-QATFEL
MUL_0350|M.ulcerans_Agy99 VLAARQELIELRAAAPHD-------QRVSTALAGLQSASDLLR-QATFEL
Mflv_5015|M.gilvum_PYR-GCK LVTLSYRLDAAAQAAKSPADHAALTEQLDRARELADLTLQEAR-AAISGL
TH_4203|M.thermoresistible__bu LVTLSYRLDAAIRAVDDP---ATVTEQLSKARELADLTLEETR-AAISGL
MLBr_02124|M.leprae_Br4923 LTAMRTNLEVLATLDLADDQRKEVLGDVIRTQSRIEATLSALERLAQGEL
: : : : . . : *
MSMEG_6238|M.smegmatis_MC2_155 NHPEDAGRSTLPELLEQLATVHMPEDLRVSLKVEGAVAELPSEVEHALLR
Mvan_5475|M.vanbaalenii_PYR-1 NQPGDAYRSSLTEMLGQLATVHMPEDLRVTLRVDGSAAELPGEVEHALLR
MMAR_3479|M.marinum_M KSPSGRDGGFRQRIQQVVADLTEHRDVVTTIHMHGPMSAVQGELADHAEA
MAV_4108|M.avium_104 RSPAAVAGDFRHRIQRVIAELTENRDLVTTVRMDGPMTAVGAELAEHAEA
MAB_3890c|M.abscessus_ATCC_199 HTN---DESLRATLRSTINELTAETGLRVSVRMSGPLDVVPASTSGDAEA
Mb0868|M.bovis_AF2122/97 HPAVLEQVGLGPAVKQLAASTAQ-RSG-IKISTDIDYP-IRSGIDPIVFG
Rv0845|M.tuberculosis_H37Rv HPAVLEQVGLGPAVKQLAASTAQ-RSG-IKISTDIDYP-IRSGIDPIVFG
MUL_0350|M.ulcerans_Agy99 HPAVLEQVGLGAAVEQLASFHAQ-RSG-IRITDDVDYP-IRDEIDPIVFG
Mflv_5015|M.gilvum_PYR-GCK RPPVLDDLGLAGGLASLARSIPQ-IGI----ETDLDDTRLADHIELALYR
TH_4203|M.thermoresistible__bu RPPVLDDLGLSGGLASLAQSVGQ-LDIGVDIEVDLAETRLPDHIELALYR
MLBr_02124|M.leprae_Br4923 STSDDHVPVDITELLDRAAHDATRSYPELKVSLVPSPTCIIVGLPAGLRL
: :
MSMEG_6238|M.smegmatis_MC2_155 IAGEALFNTAMHGNATRAIVRLRYRPTAVS----LSISDDGTGDPAKLRM
Mvan_5475|M.vanbaalenii_PYR-1 IAGEALFNTAMHGNATRAIVRLSYRDDAVS----LSIADDGTGDPAKLRL
MMAR_3479|M.marinum_M VATEAISNAVRHSGAGRVTLDVS-VGDMFS----LEVVDDGCGISPDVSR
MAV_4108|M.avium_104 VTAEAVSNAVRHSGASRLTVQIG-VADMFT----LDVIDNGRGIAAGNTR
MAB_3890c|M.abscessus_ATCC_199 VVREAVSNVVRHARARELSVTVS-VDDELV----IEVVDDGIGIP-DVVA
Mb0868|M.bovis_AF2122/97 VVRELLSNVVRHSGATTASVRLGITDE----KCVLDVADDGVGVTGDTMA
Rv0845|M.tuberculosis_H37Rv VVRELLSNVVRHSGATTASVRLGITDE----KCVLDVADDGVGVTGDTMA
MUL_0350|M.ulcerans_Agy99 VARELLSNVVQHSRARNASVALGISDG----VCVLDVADDGVGVSGETMA
Mflv_5015|M.gilvum_PYR-GCK IAQECLQNVVKHARASAARLTFAVDDN----TARLEIADDGVGFD--TFE
TH_4203|M.thermoresistible__bu IAQECLQNVVKHARARTARLTYAVDRGEHGEVARLEIVDDGVGFD--TFE
MLBr_02124|M.leprae_Br4923 AVDNAVANAVKHGGATRVQLSAVSSRAGVE----IAVDDNGSGVPEDERQ
. : : *.. *. * : : : *:* *
MSMEG_6238|M.smegmatis_MC2_155 ALRMADA----TDVDGHHRGLANMLARCREHGGTFAVQRSRIGGVRVVAT
Mvan_5475|M.vanbaalenii_PYR-1 MLRMAEA----TDVDGRHRGLANMRARAREHGGTFDVYRSRIGGVRVVAR
MMAR_3479|M.marinum_M RS-----------------GLANMRSRAEKLGGTCGITTPTEGGTRISWT
MAV_4108|M.avium_104 RS-----------------GLANMTRRAEQLGGSCEISSPPGGGTRVHWT
MAB_3890c|M.abscessus_ATCC_199 RS-----------------GLSGLANRAAQSGGTFSVSAMDTGGTRLVWS
Mb0868|M.bovis_AF2122/97 RRLG-----------EGHIGLASHRARVDAAGGVLVFLATP-RGTHVCVE
Rv0845|M.tuberculosis_H37Rv RRLG-----------EGHIGLASHRARVDAAGGVLVFLATP-RGTHVCVE
MUL_0350|M.ulcerans_Agy99 RRLG-----------QGHIGLASHRARVDAAGGSLVFLNTP-TGTHVCVR
Mflv_5015|M.gilvum_PYR-GCK HPLGSD--------EMGGYGLLSMAERAEIVGGRLNIRSRPGSGTTVTAT
TH_4203|M.thermoresistible__bu HPLGGD--------DMSGYGLLSMAERAEIVGGRLNIRSRPGAGTAVIAT
MLBr_02124|M.leprae_Br4923 VVFERFSRGSTASHSGSGLGLALVAQQAQLHGGTASLETSPLGGARLLLR
** : ** . *. :
MSMEG_6238|M.smegmatis_MC2_155 IPRTEGNRR-
Mvan_5475|M.vanbaalenii_PYR-1 IPRVSESVTS
MMAR_3479|M.marinum_M VPFGDL----
MAV_4108|M.avium_104 APLLDH----
MAB_3890c|M.abscessus_ATCC_199 APLP------
Mb0868|M.bovis_AF2122/97 LPLKR-----
Rv0845|M.tuberculosis_H37Rv LPLKR-----
MUL_0350|M.ulcerans_Agy99 IPLKG-----
Mflv_5015|M.gilvum_PYR-GCK IPLHQGGA--
TH_4203|M.thermoresistible__bu IPLPPATR--
MLBr_02124|M.leprae_Br4923 ISAPS-----
.