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MTSGRRVLITGAGQGVGRGLALAFGAAGAEVLVNDLHRERSENVVDEIRAAGGSATPAPFDVCDYASVVT AVAATGPVDVLVNNAGNAGAEGFGGRARFADTEPVDWDSFLRVNLYGVLHCTRAVLPTMIANTWGRILTV VSDAGRTGDPGGAVYGAAKAGAAGLMRSVALENGRFNVTANNISLGTMRTPLTEPLWAEHGDSPQAKEIL RNYAIRRPGVPDDVTELALLLASDHGSWITGQTICVNGGYSFGL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5171 | - | - | 100% (254) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4185 | - | 1e-32 | 32.93% (249) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4209 | - | 8e-29 | 32.94% (252) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0792 | - | 9e-29 | 35.04% (254) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1586 | - | 1e-123 | 83.46% (254) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0769 | - | 3e-29 | 35.43% (254) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 3e-20 | 33.33% (237) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0833 | - | 7e-30 | 33.73% (252) | Short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4715 | - | 7e-28 | 32.13% (249) | 3-oxoacyl- |
| M. avium 104 | MAV_1395 | - | 2e-35 | 35.37% (246) | 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0655 | - | 1e-110 | 76.19% (252) | glucose 1-dehydrogenase, putative |
| M. thermoresistible (build 8) | TH_2435 | - | 1e-33 | 35.51% (245) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0315 | fabG2 | 3e-29 | 34.15% (246) | 3-oxoacyl- |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_5171|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1586|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0655|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4715|M.marinum_M --------------------------------------------------
MUL_0315|M.ulcerans_Agy99 --------------------------------------------------
MAV_1395|M.avium_104 --------------------------------------------------
TH_2435|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_5171|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1586|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0655|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4715|M.marinum_M --------------------------------------------------
MUL_0315|M.ulcerans_Agy99 --------------------------------------------------
MAV_1395|M.avium_104 --------------------------------------------------
TH_2435|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_5171|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1586|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0655|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4715|M.marinum_M --------------------------------------------------
MUL_0315|M.ulcerans_Agy99 --------------------------------------------------
MAV_1395|M.avium_104 --------------------------------------------------
TH_2435|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_5171|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1586|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0655|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4715|M.marinum_M --------------------------------------------------
MUL_0315|M.ulcerans_Agy99 --------------------------------------------------
MAV_1395|M.avium_104 --------------------------------------------------
TH_2435|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_5171|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1586|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0655|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4715|M.marinum_M --------------------------------------------------
MUL_0315|M.ulcerans_Agy99 --------------------------------------------------
MAV_1395|M.avium_104 --------------------------------------------------
TH_2435|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_5171|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1586|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0655|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4715|M.marinum_M --------------------------------------------------
MUL_0315|M.ulcerans_Agy99 --------------------------------------------------
MAV_1395|M.avium_104 --------------------------------------------------
TH_2435|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
Mb0792|M.bovis_AF2122/97 ------------------------MFDSKVAIVTGAAQGIGQAYAQALAR
Rv0769|M.tuberculosis_H37Rv ------------------------MFDSKVAIVTGAAQGIGQAYAQALAR
MAB_0833|M.abscessus_ATCC_1997 --------------MNRETFSRLFDLTGRTAIVTGGTRGIGRALAEGYAC
Mvan_5171|M.vanbaalenii_PYR-1 ------------------------MTSGRRVLITGAGQGVGRGLALAFGA
Mflv_1586|M.gilvum_PYR-GCK ------------------------MTS-RRVLITGAGQGVGRGLASAFAD
MSMEG_0655|M.smegmatis_MC2_155 ------------------MAVQLDLTG-RRVLITGAGQGVGRGLALAFAS
MMAR_4715|M.marinum_M -----------------MK----------TAVVTGGASGIGLAIARRLRA
MUL_0315|M.ulcerans_Agy99 -----------------MRPDSSPSWCTITSVVTGGASGIGLAIARRLSA
MAV_1395|M.avium_104 -----------------------------MAVVTGGGSGIGRAIVERLAH
TH_2435|M.thermoresistible__bu --------------------------------VTGGASGLGRAIAARLGD
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
:**. *:* .
Mb0792|M.bovis_AF2122/97 EGASVVVADINADGAAAVAKQIVADGGTVIHVPVDVSDEDSAKAMVDRAV
Rv0769|M.tuberculosis_H37Rv EGASVVVADINADGAAAVAKQIVADGGTAIHVPVDVSDEDSAKAMVDRAV
MAB_0833|M.abscessus_ATCC_1997 AGANVVVASRKPEACTEAVERLRSLGARALGVPTHTGDIHSLEELVRATA
Mvan_5171|M.vanbaalenii_PYR-1 AGAEVLVNDLHRERSENVVDEIRAAGGSATPAPFDVCDYASVVTAVAAT-
Mflv_1586|M.gilvum_PYR-GCK SGAEVLVNDLHLERCQQVADEIRAAGGTAVPTPFDVCDYESVVAAVTEH-
MSMEG_0655|M.smegmatis_MC2_155 AGAAVVVNDLRAERAEAVADEIRAEGGTATAAAFDVTDFDAVTAAVTAA-
MMAR_4715|M.marinum_M DGIDVATLDLKTPDGE-------------LAFSADVTNRSQVDAALTAIR
MUL_0315|M.ulcerans_Agy99 DGTDVATLDLKTPDGG-------------LAFSADVTNRSQVDAALAAIR
MAV_1395|M.avium_104 DGHRVAVLDVNEEAAEKVAARVAADGAHAIAVPTDVAESASVAAAFESVR
TH_2435|M.thermoresistible__bu DGHRVAVLDIDHAAAEQTAAELRAHGGDAVAVGADVADQDAVHDAFAAIR
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVS
* * . . .. :
Mb0792|M.bovis_AF2122/97 GAFGGIDYLVN---NAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVLVCT
Rv0769|M.tuberculosis_H37Rv GAFGGIDYLVN---NAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVLVCT
MAB_0833|M.abscessus_ATCC_1997 EEFGGIDIVVN---NAAN---ALTEPVGAFTVDGWDKSFGVNLRGPVFLV
Mvan_5171|M.vanbaalenii_PYR-1 ---GPVDVLVNNAGNAGAEGFGGRARFADTEPVDWDSFLRVNLYGVLHCT
Mflv_1586|M.gilvum_PYR-GCK ---GPVDVLVNNAGNAGADGFGNRAKFADTAPADWEPFLRVNLYGVLHCT
MSMEG_0655|M.smegmatis_MC2_155 ---GHVDILVNNAGNAGAEGFASRAPFAETAPEDWEPFLRVNLYGVLHCT
MMAR_4715|M.marinum_M QRLGPVTILVN---AAGLDGFK---RFSNITFEDWQRVIDVNLNGVFHTI
MUL_0315|M.ulcerans_Agy99 QRLGPVTILVN---AAGLDGFK---RFSNITFEDWQRVIDVNLNGVFHTI
MAV_1395|M.avium_104 RALGSVQVLVT---SAAITGFK---PFAEITIEDWNRHLAVNLTGTFLCL
TH_2435|M.thermoresistible__bu GSLGPVHILVT---SAAIAGFT---RFDEITLDEWNRYLAVNLTGTFLCV
MLBr_00862|M.leprae_Br4923 AKHGVPDIVVN---NAGIGQAG---RFLDTPPEEFDRVLAVNLGGVVNCC
* :*. *. . :. : ** * .
Mb0792|M.bovis_AF2122/97 RAVYKHMAKRGGG-AIVNQSSTAAWLYSN---FYGLAKVGVNGLTQQLAR
Rv0769|M.tuberculosis_H37Rv RAVYKHMAKRGGG-AIVNQSSTAAWLYSN---FYGLAKVGVNGLTQQLAR
MAB_0833|M.abscessus_ATCC_1997 QAALPHLVASPHA-AVLNVVSVGAFMFGQGVSMYSAAKAALVSYTRSAAA
Mvan_5171|M.vanbaalenii_PYR-1 RAVLPTMIANTWG-RILTVVSDAGRTGDPGGAVYGAAKAGAAGLMRSVAL
Mflv_1586|M.gilvum_PYR-GCK RAVLPAMITNTWG-RILTIVSDAGRTGDPGGAVYGASKAAAAGLTRSVAL
MSMEG_0655|M.smegmatis_MC2_155 RAVLPSMIDHTWG-RVLTIVSDAGRTGDANGATYAAAKAGAAGLTRSLAL
MMAR_4715|M.marinum_M QAVLPDMVAAGWG-RIVNISSSSTHSGTPYMTHYVAAKSAVNGLTKALAL
MUL_0315|M.ulcerans_Agy99 QAVLPDMVAAGWG-RIVNISSSSTHSGTPYMTHYVAAKSAVNGLTKALAL
MAV_1395|M.avium_104 QAALPDMVEAGWG-RVVTISSTAAQTGSPRQGHYSASKGGVIALTRTIAL
TH_2435|M.thermoresistible__bu QAALTDMVADGWG-RIVTISSAAGQQGAHRQGHYAATKGGVIALTKTVAL
MLBr_00862|M.leprae_Br4923 RAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRA
:* : . ::. * . * :* .
Mb0792|M.bovis_AF2122/97 ELGGMKIRINAIAPGPIDTEATR----TVTPA------ELVKNMVQTIPL
Rv0769|M.tuberculosis_H37Rv ELGGMKIRINAIAPGPIDTEATR----TVTPA------ELVKNMVQTIPL
MAB_0833|M.abscessus_ATCC_1997 ELASRGVRVNALAPGAIDTDMVR----KTPPA------EVER-MANTNHL
Mvan_5171|M.vanbaalenii_PYR-1 ENGRFNVTANNISLGTMRTPLTEPLWAEHGDS------PQAKEILRNYAI
Mflv_1586|M.gilvum_PYR-GCK ENGRFNITANNISLGTMRTPMTEPLWADPANS------PQTKEILRNYAI
MSMEG_0655|M.smegmatis_MC2_155 ETGRYGITANNIALGTMRTPLTEPLWAEQADS------PQAKAILAGYAV
MMAR_4715|M.marinum_M EYGPSGITVNAVPPGFIDTPMLR-NAAAQGHL------GDIEQNIARTPV
MUL_0315|M.ulcerans_Agy99 EYGPSGITVNAVPPGFIDTPMLR-NAAAQGHL------GDIEQNIARTPV
MAV_1395|M.avium_104 EYAAHGITANTVPPFSVDTPMLR-AAQEAGNL------PPVKYLAKASPV
TH_2435|M.thermoresistible__bu DYAAKGITANTVPPFVIDSPMLR-EQQRRGTL------PPAEYLTRAIPM
MLBr_00862|M.leprae_Br4923 ELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRL
: : . : : : . :
Mb0792|M.bovis_AF2122/97 SRMGTPEDLVGMCLFLLSDSASWITGQIFNVDGGQIIRS-----------
Rv0769|M.tuberculosis_H37Rv SRMGTPEDLVGMCLFLLSDSASWITGQIFNVDGGQIIRS-----------
MAB_0833|M.abscessus_ATCC_1997 KRLGLPDEMVGTALLLTSDAGSYITGQTIIADGGLVAR------------
Mvan_5171|M.vanbaalenii_PYR-1 RRPGVPDDVTELALLLASDHGSWITGQTICVNGGYSFGL-----------
Mflv_1586|M.gilvum_PYR-GCK RRPGVPEDITELALLLAGEHGSWITGQTICVNGGYSFGL-----------
MSMEG_0655|M.smegmatis_MC2_155 RRPGLPEDVTHLAVLLASDHGSWITGQTIPVNGGYSFAL-----------
MMAR_4715|M.marinum_M RRIGKPEDIAAACAFLVSEEAGYITGQILGVNGGRNT-------------
MUL_0315|M.ulcerans_Agy99 RRIGKPEDIAAACAFLVSEEAGYITGQILGVNGGRNT-------------
MAV_1395|M.avium_104 GRLGTGEDIAAACAFLCSDEAGYITGQIIGVNGGEVI-------------
TH_2435|M.thermoresistible__bu GRLGVAEDVAAVCSFLCSDAAGYLTGQVIGVNGGAIR-------------
MLBr_00862|M.leprae_Br4923 RRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIR
* * . : : .. . *
Mb0792|M.bovis_AF2122/97 --
Rv0769|M.tuberculosis_H37Rv --
MAB_0833|M.abscessus_ATCC_1997 --
Mvan_5171|M.vanbaalenii_PYR-1 --
Mflv_1586|M.gilvum_PYR-GCK --
MSMEG_0655|M.smegmatis_MC2_155 --
MMAR_4715|M.marinum_M --
MUL_0315|M.ulcerans_Agy99 --
MAV_1395|M.avium_104 --
TH_2435|M.thermoresistible__bu --
MLBr_00862|M.leprae_Br4923 VI