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TRVAVVTGGASGMGEATCHELGRRGCKVAVLDLDGQAAQRVAEELRGDGVPALGVAADVTDRAAVEDAFA KVRTELGPVHILVTSAGLVDFAPFLEISPDRWQRLIEVNLNGTFHCAQVAIPDMLAAGWGRIVMISSSSA QRGSPGMAHYAASKGALISFTRSLAREYGPAGITVNNVPPSGIETPMQHQSQAAGFLPPNEQMAASIPVG HLGTGDDIAAAVGFLCSEEAGFITGQTLGVNGGSVMA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4185 | - | - | 100% (248) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4157 | - | 1e-63 | 51.67% (240) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_2620 | - | 2e-36 | 37.50% (256) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1519 | fabG1 | 7e-34 | 37.05% (251) | 3-oxoacyl- |
| M. gilvum PYR-GCK | Mflv_2469 | - | 1e-129 | 92.71% (247) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1483 | fabG1 | 7e-34 | 37.05% (251) | 3-oxoacyl- |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 2e-37 | 37.80% (246) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_2723c | - | 9e-35 | 34.43% (244) | 3-oxoacyl- |
| M. marinum M | MMAR_4715 | - | 1e-60 | 52.24% (245) | 3-oxoacyl- |
| M. avium 104 | MAV_3962 | - | 1e-107 | 76.73% (245) | NAD-dependent epimerase/dehydratase:Short-chain |
| M. smegmatis MC2 155 | MSMEG_0294 | fabG | 1e-104 | 75.30% (247) | 3-oxoacyl-(acyl-carrier-protein) reductase |
| M. thermoresistible (build 8) | TH_0026 | - | 3e-78 | 87.97% (158) | 3-oxoacyl-(acyl-carrier-protein) reductase, putative |
| M. ulcerans Agy99 | MUL_0315 | fabG2 | 4e-61 | 53.09% (243) | 3-oxoacyl- |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4185|M.vanbaalenii_PYR-1 -------------------MTRVAVVTGGASGMGEATCHELGRRGCKVAV
Mflv_2469|M.gilvum_PYR-GCK ------------------MSSRVAVVTGGASGMGESTCHELGRRGHKVAV
TH_0026|M.thermoresistible__bu --------------------------------------------------
MAV_3962|M.avium_104 --------------------MRVAVVTGGASGMGEATCHELGRRGMKIAV
MSMEG_0294|M.smegmatis_MC2_155 -------------------MNRVAVVTGGASGMGEATCHELGRRGHKVAV
MMAR_4715|M.marinum_M ----------MK----------TAVVTGGASGIGLAIARRLRADGIDVAT
MUL_0315|M.ulcerans_Agy99 ----------MRPDSSPSWCTITSVVTGGASGIGLAIARRLSADGTDVAT
Mb1519|M.bovis_AF2122/97 MTATATEG------AKPPFVSRSVLVTGGNRGIGLAIAQRLAADGHKVAV
Rv1483|M.tuberculosis_H37Rv MTATATEG------AKPPFVSRSVLVTGGNRGIGLAIAQRLAADGHKVAV
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
MAB_2723c|M.abscessus_ATCC_199 MTNA-------------EFVPRSVLVTGGNRGIGLAVAQRLAADGHKVAV
Mvan_4185|M.vanbaalenii_PYR-1 LDLDGQAAQRVAEELRGDGVPALGVAADVTDRAAVEDAFAKVRTELGPVH
Mflv_2469|M.gilvum_PYR-GCK LDLNGEAAQRVAEELRADGVTALGIAADVTDRAAVEDAFAKVRTELGPVH
TH_0026|M.thermoresistible__bu --------------------------------------------------
MAV_3962|M.avium_104 LDVDEHAAQRVTDDLRTGGATALGVGADVTDRAAVEQAFAKVRSELGPVT
MSMEG_0294|M.smegmatis_MC2_155 LDVDVDAAQRVTDHLRSEGVTAFAVGADVTDRAAVEEAFAKVRSELGAVG
MMAR_4715|M.marinum_M LDLKTPDGE-------------LAFSADVTNRSQVDAALTAIRQRLGPVT
MUL_0315|M.ulcerans_Agy99 LDLKTPDGG-------------LAFSADVTNRSQVDAALAAIRQRLGPVT
Mb1519|M.bovis_AF2122/97 THRGSGAPKG-----------LFGVECDVTDSDAVDRAFTAVEEHQGPVE
Rv1483|M.tuberculosis_H37Rv THRGSGAPKG-----------LFGVECDVTDSDAVDRAFTAVEEHQGPVE
MLBr_01807|M.leprae_Br4923 THRASVVPDW-----------FFGVECDVTDNDAIGAAFKAVEEHQGPVE
MAB_2723c|M.abscessus_ATCC_199 THRGSGAPEG-----------LLGVQCDITDNDQIDAAFKEVEEKQGPVE
Mvan_4185|M.vanbaalenii_PYR-1 ILVTSAGLVDFAPFLEISPDRWQRLIEVNLNGTFHCAQVAIPDMLAAGWG
Mflv_2469|M.gilvum_PYR-GCK ILVTSAGLVDFAPFLDISPQLWQRLIDVNLNGTFHCAQAAIPDMLAAGWG
TH_0026|M.thermoresistible__bu --------VDFAPFTEISRQAWQRLIDVNLTGTFHCCQVAIPDMVAAGWG
MAV_3962|M.avium_104 VLVTSAGMFGFSPFLDITAESWSRIIDVNLTGTFHCCQVALPDMVAANWG
MSMEG_0294|M.smegmatis_MC2_155 ILVTSAGMFGYASFADITEQSWAQMIDVNLSGTFRCCQVALPDMVDAGWG
MMAR_4715|M.marinum_M ILVNAAGLDGFKRFSNITFEDWQRVIDVNLNGVFHTIQAVLPDMVAAGWG
MUL_0315|M.ulcerans_Agy99 ILVNAAGLDGFKRFSNITFEDWQRVIDVNLNGVFHTIQAVLPDMVAAGWG
Mb1519|M.bovis_AF2122/97 VLVSNAGLSADAFLMRMTEEKFEKVINANLTGAFRVAQRASRSMQRNKFG
Rv1483|M.tuberculosis_H37Rv VLVSNAGLSADAFLMRMTEEKFEKVINANLTGAFRVAQRASRSMQRNKFG
MLBr_01807|M.leprae_Br4923 VLVANAGITSDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQRFG
MAB_2723c|M.abscessus_ATCC_199 VLVANAGITADMLIMRMSEEQFLKVIDANLIGTFRLAKRASRNMIKKRFG
: :: : : ::*:.** *.*: : . .* :*
Mvan_4185|M.vanbaalenii_PYR-1 RIVMISSSSAQRGSPGMAHYAASKGALISFTRSLAREYGPAGITVNNVPP
Mflv_2469|M.gilvum_PYR-GCK RIVMISSSSAQRGSPGMAHYAASKGALISLTRSLAREYGAAGITVNNIPP
TH_0026|M.thermoresistible__bu RIVMISSSSAQRGSPKMAHYAAAKGALISLTKSLAREYGPLGITVNNIPP
MAV_3962|M.avium_104 RIVMISSSSAQRGSPFAAHYAASKGAVITLTKSLAREYAPHGITVNNIPP
MSMEG_0294|M.smegmatis_MC2_155 RIVLISSSSAQRGTPFAAHYAASKGALLTLTKSLAREYAKHGITVNNIPP
MMAR_4715|M.marinum_M RIVNISSSSTHSGTPYMTHYVAAKSAVNGLTKALALEYGPSGITVNAVPP
MUL_0315|M.ulcerans_Agy99 RIVNISSSSTHSGTPYMTHYVAAKSAVNGLTKALALEYGPSGITVNAVPP
Mb1519|M.bovis_AF2122/97 RMIFIGSVSGSWGIGNQANYAASKAGVIGMARSIARELSKANVTANVVAP
Rv1483|M.tuberculosis_H37Rv RMIFIGSVSGSWGIGNQANYAASKAGVIGMARSIARELSKANVTANVVAP
MLBr_01807|M.leprae_Br4923 RYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSRSITANVVAP
MAB_2723c|M.abscessus_ATCC_199 RLIFMGSVAGQIGLPGQANYSASKAGLVGMARALTRELGSRSITANVVAP
* : :.* * ::* *:*..: :::::: * . .:*.* :.*
Mvan_4185|M.vanbaalenii_PYR-1 SGIETPMQHQSQAAGFLPPNEQMAASIPVGHLGTGDDIAAAVGFLCSEEA
Mflv_2469|M.gilvum_PYR-GCK SGIETPMQLQSQAAGFLPPNEQMAASIPVGHLGTGDDIAAAVGFLCSEQA
TH_0026|M.thermoresistible__bu SGIETPMQHRSQAAGHLPPNEQMAASIPVGHLGTGDDIAAAVGFLCSEAA
MAV_3962|M.avium_104 SGIETPMQHQGQAAGYLPSNEQIAANIPLGYLGTGADIAAAVGFLTSDEA
MSMEG_0294|M.smegmatis_MC2_155 SGIETPMQHASQAAGYLPPNETIAANIPLGRLGAPADIAAAVGFLCSEEA
MMAR_4715|M.marinum_M GFIDTPMLRNAAAQGHLGDIEQNIARTPVRRIGKPEDIAAACAFLVSEEA
MUL_0315|M.ulcerans_Agy99 GFIDTPMLRNAAAQGHLGDIEQNIARTPVRRIGKPEDIAAACAFLVSEEA
Mb1519|M.bovis_AF2122/97 GYIDTDMTRALDER----IQQGALQFIPAKRVGTPAEVAGVVSFLASEDA
Rv1483|M.tuberculosis_H37Rv GYIDTDMTRALDER----IQQGALQFIPAKRVGTPAEVAGVVSFLASEDA
MLBr_01807|M.leprae_Br4923 GFIDTEMTRAMDSK----YQEAALQAIPLGRIGAVEEIAGAVSFLASEDA
MAB_2723c|M.abscessus_ATCC_199 GFIDTDMTRELGEK----HVETALTAIPMGRIGEPSEVAGVVSWLASPDA
. *:* * : * :* ::*.. .:* * *
Mvan_4185|M.vanbaalenii_PYR-1 GFITGQTLGVNGGSVMA-----
Mflv_2469|M.gilvum_PYR-GCK GFITGQTLGVNGGSVMA-----
TH_0026|M.thermoresistible__bu GFITGQVLGVNGGSVL------
MAV_3962|M.avium_104 RYITGQVLGVNGGAVMLTVRIR
MSMEG_0294|M.smegmatis_MC2_155 GFITGQTLGVNGGSVM------
MMAR_4715|M.marinum_M GYITGQILGVNGGRNT------
MUL_0315|M.ulcerans_Agy99 GYITGQILGVNGGRNT------
Mb1519|M.bovis_AF2122/97 SYISGAVIPVDGGMGMGH----
Rv1483|M.tuberculosis_H37Rv SYISGAVIPVDGGMGMGH----
MLBr_01807|M.leprae_Br4923 GYISGAVIPVDGGLGMGH----
MAB_2723c|M.abscessus_ATCC_199 AYVSGAVIPVDGGLGMGH----
:::* : *:**