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TSRRVLITGAGQGVGRGLASAFADSGAEVLVNDLHLERCQQVADEIRAAGGTAVPTPFDVCDYESVVAAV TEHGPVDVLVNNAGNAGADGFGNRAKFADTAPADWEPFLRVNLYGVLHCTRAVLPAMITNTWGRILTIVS DAGRTGDPGGAVYGASKAAAAGLTRSVALENGRFNITANNISLGTMRTPMTEPLWADPANSPQTKEILRN YAIRRPGVPEDITELALLLAGEHGSWITGQTICVNGGYSFGL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1586 | - | - | 100% (253) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_2469 | - | 2e-37 | 38.34% (253) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_1258 | - | 2e-32 | 32.54% (252) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0792 | - | 1e-30 | 36.25% (251) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv0769 | - | 4e-31 | 36.65% (251) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 2e-21 | 31.50% (254) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0833 | - | 1e-29 | 32.14% (252) | Short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4927 | - | 2e-32 | 36.44% (247) | dehydrogenase/reductase |
| M. avium 104 | MAV_1395 | - | 9e-36 | 36.59% (246) | 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0655 | - | 1e-109 | 74.70% (253) | glucose 1-dehydrogenase, putative |
| M. thermoresistible (build 8) | TH_2435 | - | 1e-31 | 34.29% (245) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0478 | - | 6e-31 | 36.03% (247) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5171 | - | 1e-123 | 83.46% (254) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1586|M.gilvum_PYR-GCK -----------------MTS-RRVLITGAGQGVGRGLASAFADSGAEVLV
Mvan_5171|M.vanbaalenii_PYR-1 -----------------MTSGRRVLITGAGQGVGRGLALAFGAAGAEVLV
MSMEG_0655|M.smegmatis_MC2_155 -----------MAVQLDLTG-RRVLITGAGQGVGRGLALAFASAGAAVVV
Mb0792|M.bovis_AF2122/97 -----------------MFDSKVAIVTGAAQGIGQAYAQALAREGASVVV
Rv0769|M.tuberculosis_H37Rv -----------------MFDSKVAIVTGAAQGIGQAYAQALAREGASVVV
MMAR_4927|M.marinum_M ---------------MGQFENKVAIVTGAAQGIGQAYADALAREGARVVV
MUL_0478|M.ulcerans_Agy99 ---------------MGQFENKVAIVTGAAQGIGQAYADALAREGARVVV
MAB_0833|M.abscessus_ATCC_1997 -------MNRETFSRLFDLTGRTAIVTGGTRGIGRALAEGYACAGANVVV
MAV_1395|M.avium_104 ----------------------MAVVTGGGSGIGRAIVERLAHDGHRVAV
TH_2435|M.thermoresistible__bu -------------------------VTGGASGLGRAIAARLGDDGHRVAV
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
:**. *:* . . * * *
Mflv_1586|M.gilvum_PYR-GCK NDLHLERCQQVADEIRAAGGTAVPTPFDVCD----YESVVAAVTEHGPVD
Mvan_5171|M.vanbaalenii_PYR-1 NDLHRERSENVVDEIRAAGGSATPAPFDVCD----YASVVTAVAATGPVD
MSMEG_0655|M.smegmatis_MC2_155 NDLRAERAEAVADEIRAEGGTATAAAFDVTD----FDAVTAAVTAAGHVD
Mb0792|M.bovis_AF2122/97 ADINADGAAAVAKQIVADGGTVIHVPVDVSDEDSAKAMVDRAVGAFGGID
Rv0769|M.tuberculosis_H37Rv ADINADGAAAVAKQIVADGGTAIHVPVDVSDEDSAKAMVDRAVGAFGGID
MMAR_4927|M.marinum_M ADINAEAAEKTAKQIVADGGTAIHVPVDVSDEESARAMADRTVSEFGGID
MUL_0478|M.ulcerans_Agy99 ADINAEAAEKTAKQIVADGGTAIHVPVDVSDEESARAMADRTVSEFGGID
MAB_0833|M.abscessus_ATCC_1997 ASRKPEACTEAVERLRSLGARALGVPTHTGDIHSLEELVRATAEEFGGID
MAV_1395|M.avium_104 LDVNEEAAEKVAARVAADGAHAIAVPTDVAESASVAAAFESVRRALGSVQ
TH_2435|M.thermoresistible__bu LDIDHAAAEQTAAELRAHGGDAVAVGADVADQDAVHDAFAAIRGSLGPVH
MLBr_01807|M.leprae_Br4923 T-----------HRASVVPDWFFGVECDVTDNDAIGAAFKAVEEHQGPVE
. . .. : * :.
Mflv_1586|M.gilvum_PYR-GCK VLVNNAGNAGADGFGNRAKFADTAPADWEPFLRVNLYGVLHCTRAVLPAM
Mvan_5171|M.vanbaalenii_PYR-1 VLVNNAGNAGAEGFGGRARFADTEPVDWDSFLRVNLYGVLHCTRAVLPTM
MSMEG_0655|M.smegmatis_MC2_155 ILVNNAGNAGAEGFASRAPFAETAPEDWEPFLRVNLYGVLHCTRAVLPSM
Mb0792|M.bovis_AF2122/97 YLVN---NAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVLVCTRAVYKHM
Rv0769|M.tuberculosis_H37Rv YLVN---NAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVLVCTRAVYKHM
MMAR_4927|M.marinum_M YLVN---NAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVLVCTRAVYKHM
MUL_0478|M.ulcerans_Agy99 YLVN---NAAIYGGMKLDLQLTVPLDYYKKFMSVNHDGVLVCTRAVYKHM
MAB_0833|M.abscessus_ATCC_1997 IVVN---NAAN---ALTEPVGAFTVDGWDKSFGVNLRGPVFLVQAALPHL
MAV_1395|M.avium_104 VLVT------SAAITGFKPFAEITIEDWNRHLAVNLTGTFLCLQAALPDM
TH_2435|M.thermoresistible__bu ILVT------SAAIAGFTRFDEITLDEWNRYLAVNLTGTFLCVQAALTDM
MLBr_01807|M.leprae_Br4923 VLVAN------AGITSDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNM
:* :. : ** * . : . :
Mflv_1586|M.gilvum_PYR-GCK ITNTWGRILTIVSDAGRTGDPGGAVYGASKAAAAGLTRSVALENGRFNIT
Mvan_5171|M.vanbaalenii_PYR-1 IANTWGRILTVVSDAGRTGDPGGAVYGAAKAGAAGLMRSVALENGRFNVT
MSMEG_0655|M.smegmatis_MC2_155 IDHTWGRVLTIVSDAGRTGDANGATYAAAKAGAAGLTRSLALETGRYGIT
Mb0792|M.bovis_AF2122/97 AKRGGGAIVNQSSTAAWLYSN---FYGLAKVGVNGLTQQLARELGGMKIR
Rv0769|M.tuberculosis_H37Rv AKRGGGAIVNQSSTAAWLYSN---FYGLAKVGVNGLTQQLARELGGMKIR
MMAR_4927|M.marinum_M AKRGGGAIVNQSSTAAWLYSN---FYGLAKVGVNGLTQQLSRELGGMKIR
MUL_0478|M.ulcerans_Agy99 AKRGGGAIVNQSSTAAWLYSN---FYGLAKVGVNGLTQQLSRELGGMKIR
MAB_0833|M.abscessus_ATCC_1997 VASPHAAVLNVVSVGAFMFGQGVSMYSAAKAALVSYTRSAAAELASRGVR
MAV_1395|M.avium_104 VEAGWGRVVTISSTAAQTGSPRQGHYSASKGGVIALTRTIALEYAAHGIT
TH_2435|M.thermoresistible__bu VADGWGRIVTISSAAGQQGAHRQGHYAATKGGVIALTKTVALDYAAKGIT
MLBr_01807|M.leprae_Br4923 IKQRFGRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSRSIT
. : * . *. :* . . : : : . :
Mflv_1586|M.gilvum_PYR-GCK ANNISLGTMRTPMTEPLWADPANSPQTKEILRNYAIRRPGVPEDITELAL
Mvan_5171|M.vanbaalenii_PYR-1 ANNISLGTMRTPLTEPLWAEHGDSPQAKEILRNYAIRRPGVPDDVTELAL
MSMEG_0655|M.smegmatis_MC2_155 ANNIALGTMRTPLTEPLWAEQADSPQAKAILAGYAVRRPGLPEDVTHLAV
Mb0792|M.bovis_AF2122/97 INAIAPGPIDTEATR----TVTPAELVKNMVQTIPLSRMGTPEDLVGMCL
Rv0769|M.tuberculosis_H37Rv INAIAPGPIDTEATR----TVTPAELVKNMVQTIPLSRMGTPEDLVGMCL
MMAR_4927|M.marinum_M INAIAPGPIDTEATR----TVTPGEFVKDMVKQIPLSRMGTPEDLVGMCL
MUL_0478|M.ulcerans_Agy99 INAIAPGPIDTEATR----TVTPGEFVKDMVKQIPLSRMGTPEDLVGMCL
MAB_0833|M.abscessus_ATCC_1997 VNALAPGAIDTDMVR----KTPPAEVER-MANTNHLKRLGLPDEMVGTAL
MAV_1395|M.avium_104 ANTVPPFSVDTPMLRAA-QEAGNLPPVKYLAKASPVGRLGTGEDIAAACA
TH_2435|M.thermoresistible__bu ANTVPPFVIDSPMLREQ-QRRGTLPPAEYLTRAIPMGRLGVAEDVAAVCS
MLBr_01807|M.leprae_Br4923 ANVVAPGFIDTEMTR-----AMDSKYQEAALQAIPLGRIGAVEEIAGAVS
* :. : : . . : * * :::.
Mflv_1586|M.gilvum_PYR-GCK LLAGEHGSWITGQTICVNGGYSFGL
Mvan_5171|M.vanbaalenii_PYR-1 LLASDHGSWITGQTICVNGGYSFGL
MSMEG_0655|M.smegmatis_MC2_155 LLASDHGSWITGQTIPVNGGYSFAL
Mb0792|M.bovis_AF2122/97 FLLSDSASWITGQIFNVDGGQIIRS
Rv0769|M.tuberculosis_H37Rv FLLSDSASWITGQIFNVDGGQIIRS
MMAR_4927|M.marinum_M FLLGDQASWITGQIFNVDGGQIIRS
MUL_0478|M.ulcerans_Agy99 FLLGDQASRITGQIFNVDGGQIIRS
MAB_0833|M.abscessus_ATCC_1997 LLTSDAGSYITGQTIIADGGLVAR-
MAV_1395|M.avium_104 FLCSDEAGYITGQIIGVNGGEVI--
TH_2435|M.thermoresistible__bu FLCSDAAGYLTGQVIGVNGGAIR--
MLBr_01807|M.leprae_Br4923 FLASEDAGYISGAVIPVDGGLGMGH
:* .: .. ::* : .:**