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MAVQLDLTGRRVLITGAGQGVGRGLALAFASAGAAVVVNDLRAERAEAVADEIRAEGGTATAAAFDVTDF DAVTAAVTAAGHVDILVNNAGNAGAEGFASRAPFAETAPEDWEPFLRVNLYGVLHCTRAVLPSMIDHTWG RVLTIVSDAGRTGDANGATYAAAKAGAAGLTRSLALETGRYGITANNIALGTMRTPLTEPLWAEQADSPQ AKAILAGYAVRRPGLPEDVTHLAVLLASDHGSWITGQTIPVNGGYSFAL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0655 | - | - | 100% (259) | glucose 1-dehydrogenase, putative |
| M. smegmatis MC2 155 | MSMEG_4835 | - | 4e-39 | 39.38% (259) | 3-oxoacyl- |
| M. smegmatis MC2 155 | MSMEG_0527 | - | 3e-37 | 39.04% (251) | 2-hydroxycyclohexnecarboxyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0792 | - | 4e-32 | 38.46% (247) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1586 | - | 1e-109 | 74.70% (253) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0769 | - | 1e-32 | 38.87% (247) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 4e-25 | 32.93% (249) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0608 | - | 7e-33 | 37.97% (266) | short chain dehydrogenase |
| M. marinum M | MMAR_2592 | - | 6e-34 | 35.91% (259) | short chain dehydrogenase |
| M. avium 104 | MAV_1395 | - | 1e-39 | 39.02% (246) | 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_2435 | - | 2e-34 | 36.73% (245) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_4110 | - | 2e-31 | 37.31% (268) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5171 | - | 1e-110 | 76.19% (252) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1586|M.gilvum_PYR-GCK ---------MTS-RRVLITGAGQGVGR---GLASAFADSGAE---VLVND
Mvan_5171|M.vanbaalenii_PYR-1 ---------MTSGRRVLITGAGQGVGR---GLALAFGAAGAE---VLVND
MSMEG_0655|M.smegmatis_MC2_155 ---MAVQLDLTG-RRVLITGAGQGVGR---GLALAFASAGAA---VVVND
MAB_0608|M.abscessus_ATCC_1997 ------MPGLLDGRVVIITGAGRGIGR---AHALAFAAEGAR---VVVND
MUL_4110|M.ulcerans_Agy99 -------MGLLDGRVVIVTGAGGGIGR---AHALAFAVEGAR---VVVND
Mb0792|M.bovis_AF2122/97 ---------MFDSKVAIVTGAAQGIGQ---AYAQALAREGAS---VVVAD
Rv0769|M.tuberculosis_H37Rv ---------MFDSKVAIVTGAAQGIGQ---AYAQALAREGAS---VVVAD
MMAR_2592|M.marinum_M MDEATPARQLLTDRVAVVTGGAGGIGA---ATSRLFAQHGAQ---VVIAD
MAV_1395|M.avium_104 --------------MAVVTGGGSGIGR-AIVER--LAHDGHR---VAVLD
TH_2435|M.thermoresistible__bu -----------------VTGGASGLGR-AIAAR--LGDDGHR---VAVLD
MLBr_01807|M.leprae_Br4923 -----------MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVAR
.... * * : * : :
Mflv_1586|M.gilvum_PYR-GCK LHL----------ERCQQVADEIRAAGGTAVPTPFDVCDYES----VVAA
Mvan_5171|M.vanbaalenii_PYR-1 LHR----------ERSENVVDEIRAAGGSATPAPFDVCDYAS----VVTA
MSMEG_0655|M.smegmatis_MC2_155 LRA----------ERAEAVADEIRAEGGTATAAAFDVTDFDA----VTAA
MAB_0608|M.abscessus_ATCC_1997 IGVGLDGS--AGISPAQEVVEEITAAGGEAVTNGDDVADWSGAKNLIDTA
MUL_4110|M.ulcerans_Agy99 IGVGLDGSPAGGGSAAHGVVDEITAAGGEAVANGSDVSNWQQAADLISTA
Mb0792|M.bovis_AF2122/97 INA----------DGAAAVAKQIVADGGTVIHVPVDVSDEDSAKAMVDRA
Rv0769|M.tuberculosis_H37Rv INA----------DGAAAVAKQIVADGGTAIHVPVDVSDEDSAKAMVDRA
MMAR_2592|M.marinum_M IDA----------ELAHRTVDEIG---GAAWVVGTDVRDADQVSALAQRV
MAV_1395|M.avium_104 VNEEA--------AEKVAARVAADGA--HAIAVPTDVAESASVAAAFESV
TH_2435|M.thermoresistible__bu IDHAA--------AEQTAAELRAHGG--DAVAVGADVADQDAVHDAFAAI
MLBr_01807|M.leprae_Br4923 RLVAD--------GHRVAVTHRASVVPDWFFGVECDVTDNDAIGAAFKAV
. ** :
Mflv_1586|M.gilvum_PYR-GCK VTEHGPVDVLVNNAGNAGADGFGNRAKFADTAPADWEPFLRVNLYGVLHC
Mvan_5171|M.vanbaalenii_PYR-1 VAATGPVDVLVNNAGNAGAEGFGGRARFADTEPVDWDSFLRVNLYGVLHC
MSMEG_0655|M.smegmatis_MC2_155 VTAAGHVDILVNNAGNAGAEGFASRAPFAETAPEDWEPFLRVNLYGVLHC
MAB_0608|M.abscessus_ATCC_1997 VNSFGRLDVLVNNAG------FLRDRMLANMSEEEWDAVIRVHLKGHFAP
MUL_4110|M.ulcerans_Agy99 VDTFGGLDVLVNNAG------IVRDRMMANTSEEEFDAVIAVHLKGHFAT
Mb0792|M.bovis_AF2122/97 VGAFGGIDYLVNNAAIYGG---MKLDLLLTVPLDYYKKFMSVNHDGVLVC
Rv0769|M.tuberculosis_H37Rv VGAFGGIDYLVNNAAIYGG---MKLDLLLTVPLDYYKKFMSVNHDGVLVC
MMAR_2592|M.marinum_M LDRYGRVDILVNNVGHWLR---HPGNFVDTDP-QLWDELYRVNLHHVLLA
MAV_1395|M.avium_104 RRALGSVQVLVTSAA------ITGFKPFAEITIEDWNRHLAVNLTGTFLC
TH_2435|M.thermoresistible__bu RGSLGPVHILVTSAA------IAGFTRFDEITLDEWNRYLAVNLTGTFLC
MLBr_01807|M.leprae_Br4923 EEHQGPVEVLVANAG------ITSDMLIMRMSEEQFQKVIDVNLTGVFRV
* :. ** ... . :. *: :
Mflv_1586|M.gilvum_PYR-GCK TRAVLPAMITNTWG------RILTIVSDAGRTGDPGGAVYGASKAAAAGL
Mvan_5171|M.vanbaalenii_PYR-1 TRAVLPTMIANTWG------RILTVVSDAGRTGDPGGAVYGAAKAGAAGL
MSMEG_0655|M.smegmatis_MC2_155 TRAVLPSMIDHTWG------RVLTIVSDAGRTGDANGATYAAAKAGAAGL
MAB_0608|M.abscessus_ATCC_1997 LRHAAAYWRDEFKAGNAVDARIINTSSAAGLQGSVGQGNYAAAKAGIATL
MUL_4110|M.ulcerans_Agy99 MRHAASYWRGLSKVGKAVDARIINTSSGAGLQGSVGQANYSAAKAGIAAL
Mb0792|M.bovis_AF2122/97 TRAVYKHMAKRGGG------AIVNQSSTA---AWLYSNFYGLAKVGVNGL
Rv0769|M.tuberculosis_H37Rv TRAVYKHMAKRGGG------AIVNQSSTA---AWLYSNFYGLAKVGVNGL
MMAR_2592|M.marinum_M THAFLPAMIEQHGG------AIVNVSSVEGLRGYPEDPVYAAFKAAVIHF
MAV_1395|M.avium_104 LQAALPDMVEAGWG------RVVTISSTAAQTGSPRQGHYSASKGGVIAL
TH_2435|M.thermoresistible__bu VQAALTDMVADGWG------RIVTISSAAGQQGAHRQGHYAATKGGVIAL
MLBr_01807|M.leprae_Br4923 AKLASRNMIKQRFG------RYIFMGSVVGLSGVPGQANYAASKSGLIGM
: : * . *. * . :
Mflv_1586|M.gilvum_PYR-GCK TRSVALENGRFNITANNISLGTMRTPMT-EPLWADPANSPQTKEILRNYA
Mvan_5171|M.vanbaalenii_PYR-1 MRSVALENGRFNVTANNISLGTMRTPLT-EPLWAEHGDSPQAKEILRNYA
MSMEG_0655|M.smegmatis_MC2_155 TRSLALETGRYGITANNIALGTMRTPLT-EPLWAEQADSPQAKAILAGYA
MAB_0608|M.abscessus_ATCC_1997 TLQAAAEMGRYGITVNAIAP-AARTRMT-EAVFAETMAKP-------EDG
MUL_4110|M.ulcerans_Agy99 TLVGAAEMGRYGVTVNAIAP-AARTRMT-ETVFAEMMAKP-------DEG
Mb0792|M.bovis_AF2122/97 TQQLARELGGMKIRINAIAPGPIDTEATRTVTPAELVKNMVQT-----IP
Rv0769|M.tuberculosis_H37Rv TQQLARELGGMKIRINAIAPGPIDTEATRTVTPAELVKNMVQT-----IP
MMAR_2592|M.marinum_M TRSLAVQVGNHGVRINAIAP---DVTESLQVPYSQWLSDAEQTQWPGWVP
MAV_1395|M.avium_104 TRTIALEYAAHGITANTVPPFSVDTPMLRAAQEAGNLPPVKYLAK--ASP
TH_2435|M.thermoresistible__bu TKTVALDYAAKGITANTVPPFVIDSPMLREQQRRGTLPPAEYLTR--AIP
MLBr_01807|M.leprae_Br4923 ARSLARELGSRSITANVVAPGFIDTEMTRAMDSK----YQEAALQ--AIP
* : . : * :.
Mflv_1586|M.gilvum_PYR-GCK IRRPGVPEDITELALLLAGEHGSWITGQTICVNG-------GYSFGL---
Mvan_5171|M.vanbaalenii_PYR-1 IRRPGVPDDVTELALLLASDHGSWITGQTICVNG-------GYSFGL---
MSMEG_0655|M.smegmatis_MC2_155 VRRPGLPEDVTHLAVLLASDHGSWITGQTIPVNG-------GYSFAL---
MAB_0608|M.abscessus_ATCC_1997 AFDAMAPENVSPLVVWLGSPESREVTGKVFEVEAGIIRVAEGWAHGPQVD
MUL_4110|M.ulcerans_Agy99 -FDAMAPENVSPLVVWLASAEAGAVTGKVFEVEGGVIRVAEGWAHGPEVD
Mb0792|M.bovis_AF2122/97 LSRMGTPEDLVGMCLFLLSDSASWITGQIFNVDG-------GQIIRS---
Rv0769|M.tuberculosis_H37Rv LSRMGTPEDLVGMCLFLLSDSASWITGQIFNVDG-------GQIIRS---
MMAR_2592|M.marinum_M VGRMGVPEDQARVILFLACELSAFVTGHTIPTDG-------GTAAAGGWF
MAV_1395|M.avium_104 VGRLGTGEDIAAACAFLCSDEAGYITGQIIGVNG-------GEVI-----
TH_2435|M.thermoresistible__bu MGRLGVAEDVAAVCSFLCSDAAGYLTGQVIGVNG-------GAIR-----
MLBr_01807|M.leprae_Br4923 LGRIGAVEEIAGAVSFLASEDAGYISGAVIPVDG-------GLGMGH---
:: * . ::* : .:. *
Mflv_1586|M.gilvum_PYR-GCK --------------------------------
Mvan_5171|M.vanbaalenii_PYR-1 --------------------------------
MSMEG_0655|M.smegmatis_MC2_155 --------------------------------
MAB_0608|M.abscessus_ATCC_1997 KGARWDPSELGPVVTDLLDKARTPVPVYGSQG
MUL_4110|M.ulcerans_Agy99 KGAKWDPAELRLVVADLLAKSRPSVPVYGA--
Mb0792|M.bovis_AF2122/97 --------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------
MMAR_2592|M.marinum_M RSSRRPDREWTNRPIAP---------------
MAV_1395|M.avium_104 --------------------------------
TH_2435|M.thermoresistible__bu --------------------------------
MLBr_01807|M.leprae_Br4923 --------------------------------