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SPARNTESCLTVGVSEARTGDADGDLADAVAAFTAVRPRIFGVAYRMLGSVAEAEDVLQEVWLRWQKCDR RAVRDPAAFLITATTRLSINERQSARARRETYIGPWLPDPVDTGADPTLGAERAEALEFATLMLMERLTP AERAAYVLREAFDYPYGLIAETIETSQANARQLVSRARRHLAEARRHDVDPAEQRQLLTAFVAAAQNGDM ATLESLFAEDIVSYTDGNGIRNAARHPVVGRETVARFVCAFRRRVFADAVLTWVTVNSAPAVVISHGGGP FHDGGVFETFVALTPSERGITQLLWHRLEGKVSHLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4999 | - | - | 100% (317) | ECF subfamily RNA polymerase sigma-24 factor |
| M. vanbaalenii PYR-1 | Mvan_4806 | - | 3e-49 | 41.70% (247) | ECF subfamily RNA polymerase sigma-24 factor |
| M. vanbaalenii PYR-1 | Mvan_5347 | - | 1e-41 | 41.02% (256) | ECF subfamily RNA polymerase sigma-24 factor |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3361c | sigJ | 9e-42 | 40.69% (231) | RNA polymerase sigma factor SigJ |
| M. gilvum PYR-GCK | Mflv_1927 | - | 5e-49 | 39.48% (271) | ECF subfamily RNA polymerase sigma-24 factor |
| M. tuberculosis H37Rv | Rv3328c | sigJ | 9e-42 | 40.69% (231) | RNA polymerase sigma factor SigJ |
| M. leprae Br4923 | MLBr_01076 | sigE | 4e-05 | 27.01% (174) | RNA polymerase sigma factor SigE |
| M. abscessus ATCC 19977 | MAB_1126c | - | 1e-46 | 36.95% (295) | putative sigma factor |
| M. marinum M | MMAR_4487 | - | 1e-49 | 42.17% (249) | alternative RNA polymerase sigma factor |
| M. avium 104 | MAV_1129 | - | 8e-48 | 39.19% (273) | sigma factor |
| M. smegmatis MC2 155 | MSMEG_1692 | - | 9e-92 | 60.85% (281) | ECF-family protein RNA polymerase sigma factor |
| M. thermoresistible (build 8) | TH_1142 | - | 1e-45 | 40.64% (251) | RNA polymerase sigma factor, sigma-70 family protein |
| M. ulcerans Agy99 | MUL_3630 | - | 3e-30 | 36.72% (256) | alternative RNA polymerase sigma factor SigJ- like |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4999|M.vanbaalenii_PYR-1 MSPARNTESCLTVGVSEARTGDADGDLADAVAAFTAVRPRIFGVAYRMLG
MSMEG_1692|M.smegmatis_MC2_155 MDPAPSSAS------DPAWT-----ELSEAEAVFTRVRPRLFGVAYRMTG
Mflv_1927|M.gilvum_PYR-GCK ----------------MT-----AAPGDEHAERFTQLRPLLFTIAYEILG
TH_1142|M.thermoresistible__bu ----------------MTGSGAPSARGDEHAERFTHLRPLLFTIAYEILG
MMAR_4487|M.marinum_M ----------------MT----PPSHSDEHAERFTLLRPLLFTIAYEILG
MAV_1129|M.avium_104 ---------------MMT----QAPTGSEHADRFTLLRPLLFTIAYEMLG
MAB_1126c|M.abscessus_ATCC_199 -------------MS-----------GTDHAELFTHLRPLLFTIAYEMLG
Mb3361c|M.bovis_AF2122/97 ----------------------------MEVSEFEALRQHLMSVAYRLTG
Rv3328c|M.tuberculosis_H37Rv ----------------------------MEVSEFEALRQHLMSVAYRLTG
MUL_3630|M.ulcerans_Agy99 ------------------------MTDPALLARFQAARPRLGALAYRMLG
MLBr_01076|M.leprae_Br4923 ---------------------------------------MGDGIGMEREG
:. . *
Mvan_4999|M.vanbaalenii_PYR-1 SVAEAEDVLQEVWLRWQKCD-----RRAVRDPAAFLITATTRLSINERQS
MSMEG_1692|M.smegmatis_MC2_155 TVAEAEDAVQEAWLRWQDTD-----RAAVTDPVPFLMTVVTRICLNVLQS
Mflv_1927|M.gilvum_PYR-GCK SATESDDVLQESYLRWAEVD-----LATVTDTKAYLARLVTRQALNTLRA
TH_1142|M.thermoresistible__bu SATEADDVLQESYLRWAEVD-----LAAVRDTKSYLAKLVSRQALNALRA
MMAR_4487|M.marinum_M SATESDDVLQESYLRWAAVD-----LSAVRDTKSYLAQLVTRQSLNALRA
MAV_1129|M.avium_104 SATEADDVLQDSYLRWSTVD-----LATVRDTKSYLAQLVTRQALNALRA
MAB_1126c|M.abscessus_ATCC_199 SATEADDVLQESYLRWAQVD-----LDTVTDTKAYLAQIVSRQALNTLRT
Mb3361c|M.bovis_AF2122/97 TVADAEDIVQEAWLRWDSQD------TVIADPRAWLTTVVSRLGLDKLRS
Rv3328c|M.tuberculosis_H37Rv TVADAEDIVQEAWLRWDSPD------TVIADPRAWLTTVVSRLGLDKLRS
MUL_3630|M.ulcerans_Agy99 SLADAEDVVQEAWLRLNATTDRPEGAQELVNLDAWLTTVVARLCLNLLRD
MLBr_01076|M.leprae_Br4923 RWTGNTQCPLRVVPGDESPT-----LDGRASPEDLIITNLLSPTIMS-HP
: : . : : :
Mvan_4999|M.vanbaalenii_PYR-1 ARARRETYIGPWLPDPVDTG-----ADPTLGAERAEALEFATLMLMERLT
MSMEG_1692|M.smegmatis_MC2_155 ARARHETYIGPWLPEPVDTT-----ADPALGAERGAALELATLMLLERLA
Mflv_1927|M.gilvum_PYR-GCK QSRRREDYVGPWLPEPLLT-----EADPSADVVLAESVSMAMLVVLETLS
TH_1142|M.thermoresistible__bu GARRREDYVGPWLPEPLLLE----ERDASADVVLAESVSMAMMVVLESLT
MMAR_4487|M.marinum_M GARRREEYVGPWLPEPLLLD----ESDPSADLVLAESVSMAMLVLLETLT
MAV_1129|M.avium_104 GARRREEYVGPWLPEPLLLD----EQDPSTDVVLAESISMAMLVLLETLS
MAB_1126c|M.abscessus_ATCC_199 NSRRREEYVGPWLPEPVRVAYDDSDKDASTDVVLAESVSMAMLVVLETLA
Mb3361c|M.bovis_AF2122/97 AAHRRETYTGTWLPEPVVTG--LDATDPLAAVVAAEDARFAAMVVLERLR
Rv3328c|M.tuberculosis_H37Rv AAHRRETYTGTWLPEPVVTG--LDATDPLAAVVAAEDARFAAMVVLERLR
MUL_3630|M.ulcerans_Agy99 RRGRGREELVGQLPDPIVDG--VAAFDPEHHAMLADAVGLALFVVLDTLA
MLBr_01076|M.leprae_Br4923 PPSRDDDWVEPFD-------------ALQGTAVFDATGDKATMPSWEELV
* * : : *
Mvan_4999|M.vanbaalenii_PYR-1 PAERAAYVLREAFDYPYGLIAETIETSQANARQLVSRARRHLAEARRHDV
MSMEG_1692|M.smegmatis_MC2_155 PPERAAYILREAFDYPYEQIAETVGVSVPNARQLVSRARRRVTTRRAAPV
Mflv_1927|M.gilvum_PYR-GCK PDERAVFVLREVFGFGHDEIAATLGKSTAAVRQIAHRAREHVQSRRKRFE
TH_1142|M.thermoresistible__bu PDERAVFVLREVFGFEYGEIATTVGKSVTAVRQIAHRARSHVHARRKRFE
MMAR_4487|M.marinum_M PDERAVFVLREVFGFDYDEIADAVGKPAPTVRQVAHRARAHIQARRKKYG
MAV_1129|M.avium_104 PDERAVFVLREVFGFDYDEIAEAVGKPAPTVRQVARRAREHVRARRKRHP
MAB_1126c|M.abscessus_ATCC_199 PDERAVFVMREVFGFDYSEIASTVGKSEVAVRQMAHRARAHVQSRRRRFT
Mb3361c|M.bovis_AF2122/97 PDQRVAFVLHDGFAVPFAEVAEVLGTSEAAARQLASRARKAVTAQPALIS
Rv3328c|M.tuberculosis_H37Rv PDQRVAFVLHDGFAVPFAEVAEVLGTSEAAARQLASRARKAVTAQPALIS
MUL_3630|M.ulcerans_Agy99 PAERLAFVLHDVFAVPFDQIAPILERTPEATRKLASRARRRIERAEPFPD
MLBr_01076|M.leprae_Br4923 RQHAAR-----VYWLAYRLSGNQHDAEDLTQETFIRVFRSVQNYQPGTFE
. : . . . . *
Mvan_4999|M.vanbaalenii_PYR-1 D------PAEQRQLLTAFVAAAQNGDMATLESLFAEDIVSYTDGNGIRNA
MSMEG_1692|M.smegmatis_MC2_155 A------TAEQDRLLRAFVTAARSGDLDALEEILAEDVVSHTDGNGARNA
Mflv_1927|M.gilvum_PYR-GCK P----VDPKTSGEITMTFFAAAATGDLDALMAMLAPDVVWTADSDGKVSA
TH_1142|M.thermoresistible__bu P----VDPEVSMEITERFLTAASTGDMDGLLAMLAPDATWTADGGGKATA
MMAR_4487|M.marinum_M ----DVDPQRNAQLTAQFLQTAASGDVEALMAMLAPDATWLADSGGKVSA
MAV_1129|M.avium_104 GAGQAIDPKRNAELTAQFLATAASGDVEALMAMLAPDATWTADSGGVVSA
MAB_1126c|M.abscessus_ATCC_199 P-----TDRQAEELTTKFLLAAAGGDVDALVEMLAPDAVWTSDGGGKVSA
Mb3361c|M.bovis_AF2122/97 GDP----DPAHNEVVGRLMAAMAAGDLDTVVSLLHPDVTFTGDSNGKAPT
Rv3328c|M.tuberculosis_H37Rv GDP----DPAHNEVVGRLMAAMAAGDLDTVVSLLHPDVTFTGDSNGKAPT
MUL_3630|M.ulcerans_Agy99 RD-----LCAQREVVDAFFAAGRSGNFERLVSVLHPDVVLRGDFGPNTPR
MLBr_01076|M.leprae_Br4923 G-------WLHRITTNLFLDMVRRRARIRMDALPDDYDRVPADEPNPEQI
:. : : *
Mvan_4999|M.vanbaalenii_PYR-1 ARHPVVGRETVARFVCAFRRRVFA--DAVLTWVTVNSAPAVVISHGGGPF
MSMEG_1692|M.smegmatis_MC2_155 AQIPVVGRTTVAKFVRAFRNRLWP--GASLRWITANGHSAVLVVHDDSP-
Mflv_1927|M.gilvum_PYR-GCK ARRPVEGADKVARLILGFVRLAG--GEARVEPAFYNSAPALVLYTGDVL-
TH_1142|M.thermoresistible__bu ARRPIVGAEKVAAVILGIFRAGQRLPDVRIETAIYNCAPAVVVYSRDNL-
MMAR_4487|M.marinum_M ARKPVVGAERVARAITGLIRKAAT--ELQVELVTCNSAPAVLFYLGGQL-
MAV_1129|M.avium_104 ARRPVVGAEKVARAITGLFRKAAEYATLRVDTVTCNGAPAVLLYLGDRL-
MAB_1126c|M.abscessus_ATCC_199 ARRPVYGADRVARVAIGLSRAAAEFPDVRMEFSTFNSTPALLIYTEGRL-
Mb3361c|M.bovis_AF2122/97 AVRAVRGSDKVVRFILGLVQRYGPGLFGANQLALVNGELGAYTAGLPGVD
Rv3328c|M.tuberculosis_H37Rv AVRAVRGSDKVVRFILGLVQRYGPGLFGANQLALVNGELGAYTAGLPGVD
MUL_3630|M.ulcerans_Agy99 FR--AQGAATVAKLARSYAGPERTVLN-----TLVNGAAGAVIS------
MLBr_01076|M.leprae_Br4923 YHDSRLGPDLQAALDSLPPEFRAAVVLCDIEGLSYEEIGATLGVKLGTVR
* . : .
Mvan_4999|M.vanbaalenii_PYR-1 HDGGVFETFVALTPSERGITQLLWHRLEGKVSHLG---------------
MSMEG_1692|M.smegmatis_MC2_155 ------AAFLTVAASADGIHRLLWVLAPEKLAGIAQAQGR----------
Mflv_1927|M.gilvum_PYR-GCK ------EGVVTFEVADGRITNFYAMRNPEKLTGVMVARTISR--------
TH_1142|M.thermoresistible__bu ------EGVFTVEVVDGRITHFYAVRNPEKLAAVDTPRQISR--------
MMAR_4487|M.marinum_M ------EGVITLEIVGDKITNFYVMRNPDKLTAVARAHEISRG-------
MAV_1129|M.avium_104 ------EGVITVEIAADKITNFYVMRNPHKLAALATARDVSRG-------
MAB_1126c|M.abscessus_ATCC_199 ------DVVLAVSIEDGKVEHIFAIRNPDKLATAEITRHISR--------
Mb3361c|M.bovis_AF2122/97 GYRAMAPRITAITVRDGKVCALWDIANPDKFTGSPLKERRAQPTGRGRHH
Rv3328c|M.tuberculosis_H37Rv GYRAMAPRITAITVRDGKVCALWDIANPDKFTGSPLKERRAQPTGRGRHH
MUL_3630|M.ulcerans_Agy99 -ISEQASAVMRFLVRNGRIAAIDVLADPQRIATLDISG-LSGPGG-----
MLBr_01076|M.leprae_Br4923 ---------SRIHRGRQALRDYLLTAHPRDGATTDATHVKSA--------
. : :
Mvan_4999|M.vanbaalenii_PYR-1 --
MSMEG_1692|M.smegmatis_MC2_155 --
Mflv_1927|M.gilvum_PYR-GCK --
TH_1142|M.thermoresistible__bu --
MMAR_4487|M.marinum_M --
MAV_1129|M.avium_104 --
MAB_1126c|M.abscessus_ATCC_199 --
Mb3361c|M.bovis_AF2122/97 RN
Rv3328c|M.tuberculosis_H37Rv RN
MUL_3630|M.ulcerans_Agy99 --
MLBr_01076|M.leprae_Br4923 --