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MTQAPTGSEHADRFTLLRPLLFTIAYEMLGSATEADDVLQDSYLRWSTVDLATVRDTKSYLAQLVTRQAL NALRAGARRREEYVGPWLPEPLLLDEQDPSTDVVLAESISMAMLVLLETLSPDERAVFVLREVFGFDYDE IAEAVGKPAPTVRQVARRAREHVRARRKRHPGAGQAIDPKRNAELTAQFLATAASGDVEALMAMLAPDAT WTADSGGVVSAARRPVVGAEKVARAITGLFRKAAEYATLRVDTVTCNGAPAVLLYLGDRLEGVITVEIAA DKITNFYVMRNPHKLAALATARDVSRG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1129 | - | - | 100% (308) | sigma factor |
| M. avium 104 | MAV_4301 | - | 8e-42 | 38.02% (242) | RNA polymerase sigma factor SigJ |
| M. avium 104 | MAV_2475 | - | 2e-31 | 31.21% (298) | RNA polymerase sigma factor |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3361c | sigJ | 5e-42 | 39.39% (231) | RNA polymerase sigma factor SigJ |
| M. gilvum PYR-GCK | Mflv_1927 | - | 1e-111 | 68.63% (306) | ECF subfamily RNA polymerase sigma-24 factor |
| M. tuberculosis H37Rv | Rv3328c | sigJ | 5e-42 | 39.39% (231) | RNA polymerase sigma factor SigJ |
| M. leprae Br4923 | MLBr_01076 | sigE | 6e-08 | 25.62% (160) | RNA polymerase sigma factor SigE |
| M. abscessus ATCC 19977 | MAB_4200 | - | 1e-107 | 68.12% (298) | putative sigma factor |
| M. marinum M | MMAR_4487 | - | 1e-134 | 79.15% (307) | alternative RNA polymerase sigma factor |
| M. smegmatis MC2 155 | MSMEG_5444 | - | 1e-104 | 64.36% (303) | RNA polymerase sigma-70 factor protein |
| M. thermoresistible (build 8) | TH_1142 | - | 1e-113 | 67.33% (300) | RNA polymerase sigma factor, sigma-70 family protein |
| M. ulcerans Agy99 | MUL_3630 | - | 7e-28 | 31.29% (294) | alternative RNA polymerase sigma factor SigJ- like |
| M. vanbaalenii PYR-1 | Mvan_5347 | - | 1e-110 | 66.44% (298) | ECF subfamily RNA polymerase sigma-24 factor |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3361c|M.bovis_AF2122/97 ---------------MEVSEFEALRQHLMSVAYRLTGTVADAEDIVQEAW
Rv3328c|M.tuberculosis_H37Rv ---------------MEVSEFEALRQHLMSVAYRLTGTVADAEDIVQEAW
MUL_3630|M.ulcerans_Agy99 -----------MTDPALLARFQAARPRLGALAYRMLGSLADAEDVVQEAW
MAV_1129|M.avium_104 --MMTQAPT----GSEHADRFTLLRPLLFTIAYEMLGSATEADDVLQDSY
MMAR_4487|M.marinum_M ---MTPPSH----SDEHAERFTLLRPLLFTIAYEILGSATESDDVLQESY
MAB_4200|M.abscessus_ATCC_1997 ------MIN----SDEHAERFTLLRPLLFTIVYEILGSATESDDVLQDSY
TH_1142|M.thermoresistible__bu ---MTGSGAPSARGDEHAERFTHLRPLLFTIAYEILGSATEADDVLQESY
Mvan_5347|M.vanbaalenii_PYR-1 ---MTAS------TDEHGERFTVLRPLLFTIAYEILGSATESEDVLQDSY
Mflv_1927|M.gilvum_PYR-GCK ---MTAAP-----GDEHAERFTQLRPLLFTIAYEILGSATESDDVLQESY
MSMEG_5444|M.smegmatis_MC2_155 MNNPSAGN-----STEHAERFTALRPLLFTIAYEILGTATESDDVLQESY
MLBr_01076|M.leprae_Br4923 ----------------MGDGIGMEREGRWTGNTQCPLRVVPGD---ESPT
: * : . . .: :..
Mb3361c|M.bovis_AF2122/97 LRWDSQD------TVIADPRAWLTTVVSRLGLDKLRSAAHRRETYTGTWL
Rv3328c|M.tuberculosis_H37Rv LRWDSPD------TVIADPRAWLTTVVSRLGLDKLRSAAHRRETYTGTWL
MUL_3630|M.ulcerans_Agy99 LRLNATTDRPEGAQELVNLDAWLTTVVARLCLNLLRDRRGRGREELVGQL
MAV_1129|M.avium_104 LRWSTVD-----LATVRDTKSYLAQLVTRQALNALRAGARRREEYVGPWL
MMAR_4487|M.marinum_M LRWAAVD-----LSAVRDTKSYLAQLVTRQSLNALRAGARRREEYVGPWL
MAB_4200|M.abscessus_ATCC_1997 LRWAQVD-----LATVRDTKSYLAQLVTRQALKALRTSVRRREDYIGPWL
TH_1142|M.thermoresistible__bu LRWAEVD-----LAAVRDTKSYLAKLVSRQALNALRAGARRREDYVGPWL
Mvan_5347|M.vanbaalenii_PYR-1 LRWADVD-----LATVRDTKSYLAQLVTREALNALRARSRRREEYVGPWL
Mflv_1927|M.gilvum_PYR-GCK LRWAEVD-----LATVTDTKAYLARLVTRQALNTLRAQSRRREDYVGPWL
MSMEG_5444|M.smegmatis_MC2_155 LRWAEVD-----LATVTDTKAYLAKLVTRQSLNALRARSRLREEYVGPWL
MLBr_01076|M.leprae_Br4923 LDGRASP-----------EDLIITNLLSPTIMSHPPPS--RDDDWVEPFD
* :: ::: :.
Mb3361c|M.bovis_AF2122/97 PEPVVTGLDATDPLAAVVAAEDARFAAMVVLERLR--PDQRVAFVLHDGF
Rv3328c|M.tuberculosis_H37Rv PEPVVTGLDATDPLAAVVAAEDARFAAMVVLERLR--PDQRVAFVLHDGF
MUL_3630|M.ulcerans_Agy99 PDPIVDGVAAFDPEHHAMLADAVGLALFVVLDTLA--PAERLAFVLHDVF
MAV_1129|M.avium_104 PEPLL--LDEQDPSTDVVLAESISMAMLVLLETLS--PDERAVFVLREVF
MMAR_4487|M.marinum_M PEPLL--LDESDPSADLVLAESVSMAMLVLLETLT--PDERAVFVLREVF
MAB_4200|M.abscessus_ATCC_1997 PEPLL--LDEHDGSADVLLAESVSMAMLILLETLT--PDERAVFVLREVF
TH_1142|M.thermoresistible__bu PEPLL--LEERDASADVVLAESVSMAMMVVLESLT--PDERAVFVLREVF
Mvan_5347|M.vanbaalenii_PYR-1 PEPLL--LDERDASADIVLAESVSMAMLVLLETLT--PDERAVFVLREVF
Mflv_1927|M.gilvum_PYR-GCK PEPLL--TEA-DPSADVVLAESVSMAMLVVLETLS--PDERAVFVLREVF
MSMEG_5444|M.smegmatis_MC2_155 PEPLL--VAE-DASSDVVLAESVSMAMLVVLETLT--PDERAVFVLHDVF
MLBr_01076|M.leprae_Br4923 -----------ALQGTAVFDATGDKATMPSWEELVRQHAARVYWLAYRLS
: * : : * * ::
Mb3361c|M.bovis_AF2122/97 AVPFAEVAEVLGTSEAAARQLASRARKAVTAQPALISGDP----DPAHNE
Rv3328c|M.tuberculosis_H37Rv AVPFAEVAEVLGTSEAAARQLASRARKAVTAQPALISGDP----DPAHNE
MUL_3630|M.ulcerans_Agy99 AVPFDQIAPILERTPEATRKLASRARRRIERAEPFPDRD-----LCAQRE
MAV_1129|M.avium_104 GFDYDEIAEAVGKPAPTVRQVARRAREHVRARRKRHPGAGQAIDPKRNAE
MMAR_4487|M.marinum_M GFDYDEIADAVGKPAPTVRQVAHRARAHIQARRKKYG----DVDPQRNAQ
MAB_4200|M.abscessus_ATCC_1997 GFGYDEIAGAVSKSATAVRQIAHRAREHVHARRKRFD----PLDAKESTR
TH_1142|M.thermoresistible__bu GFEYGEIATTVGKSVTAVRQIAHRARSHVHARRKRFE----PVDPEVSME
Mvan_5347|M.vanbaalenii_PYR-1 GFDYDEIAGAVGRSTQAVRQIAHRAKEHVHARRKRFG----PVDSRRTTQ
Mflv_1927|M.gilvum_PYR-GCK GFGHDEIAATLGKSTAAVRQIAHRAREHVQSRRKRFE----PVDPKTSGE
MSMEG_5444|M.smegmatis_MC2_155 GFSHDEIASTIGKSAAAVRQMAHRARNHVQARRKRFE----PVDPQVSME
MLBr_01076|M.leprae_Br4923 GNQHDAEDLTQETFIRVFRSVQNYQPGTFEG---------------WLHR
. . . *.: . .
Mb3361c|M.bovis_AF2122/97 VVGRLMAAMAAGDLDTVVSLLHPDVTFTGDSNGKAPTAVRAVRGSDKVVR
Rv3328c|M.tuberculosis_H37Rv VVGRLMAAMAAGDLDTVVSLLHPDVTFTGDSNGKAPTAVRAVRGSDKVVR
MUL_3630|M.ulcerans_Agy99 VVDAFFAAGRSGNFERLVSVLHPDVVLRGDFGPNTPRFR--AQGAATVAK
MAV_1129|M.avium_104 LTAQFLATAASGDVEALMAMLAPDATWTADSGGVVSAARRPVVGAEKVAR
MMAR_4487|M.marinum_M LTAQFLQTAASGDVEALMAMLAPDATWLADSGGKVSAARKPVVGAERVAR
MAB_4200|M.abscessus_ATCC_1997 IAEQFLLATETGDVEGLMALLAPDATWIADGNGRAGAARRPLTGAGKLAR
TH_1142|M.thermoresistible__bu ITERFLTAASTGDMDGLLAMLAPDATWTADGGGKATAARRPIVGAEKVAA
Mvan_5347|M.vanbaalenii_PYR-1 ITEQFLTAAATGDMEELVSMLAPGATWTADHGGKATAVRRPVVGARKVAA
Mflv_1927|M.gilvum_PYR-GCK ITMTFFAAAATGDLDALMAMLAPDVVWTADSDGKVSAARRPVEGADKVAR
MSMEG_5444|M.smegmatis_MC2_155 ITQRFFTAASTGDIDALMELLAPDVVWTADSAGKRSAARRPVSGADAVAR
MLBr_01076|M.leprae_Br4923 ITTNLFLDMVRRRARIRMDALPDDYDRVPADEPNPEQIYHDSRLGPDLQA
:. :: : * . . :
Mb3361c|M.bovis_AF2122/97 FILGLVQRYGPGLFGANQLALVNGELGAYTAGLPGVDGYRAMAPRITAIT
Rv3328c|M.tuberculosis_H37Rv FILGLVQRYGPGLFGANQLALVNGELGAYTAGLPGVDGYRAMAPRITAIT
MUL_3630|M.ulcerans_Agy99 LARSYAGPERTVLN-----TLVNGAAGAVIS-------ISEQASAVMRFL
MAV_1129|M.avium_104 AITGLFRKAAEYATLRVDTVTCNGAPAVLLYL-------GDRLEGVITVE
MMAR_4487|M.marinum_M AITGLIRKAAT--ELQVELVTCNSAPAVLFYL-------GGQLEGVITLE
MAB_4200|M.abscessus_ATCC_1997 IFAGPFRKGMA--DRRTEIVIANAAPAVAVYA-------GDALEVVITME
TH_1142|M.thermoresistible__bu VILGIFRAGQRLPDVRIETAIYNCAPAVVVYS-------RDNLEGVFTVE
Mvan_5347|M.vanbaalenii_PYR-1 IMARVFQAVRKTPQMRLETAVYNSAPAVVVYT-------EDHLEGVLLFE
Mflv_1927|M.gilvum_PYR-GCK LILGFVRLAGG--EARVEPAFYNSAPALVLYT-------GDVLEGVVTFE
MSMEG_5444|M.smegmatis_MC2_155 LVSGLVRLGGE--GARVEPAMYNNAPALKLYL-------GDSFEGVITIE
MLBr_01076|M.leprae_Br4923 ALDSLPPEFRAAVVLCDIEGLSYEEIGATLGV--------KLGTVRSRIH
. .
Mb3361c|M.bovis_AF2122/97 VRDGKVCALWDIANPDKFTGSPLKERRAQPTGRGRHHRN
Rv3328c|M.tuberculosis_H37Rv VRDGKVCALWDIANPDKFTGSPLKERRAQPTGRGRHHRN
MUL_3630|M.ulcerans_Agy99 VRNGRIAAIDVLADPQRIATLDISG-LSGPGG-------
MAV_1129|M.avium_104 IAADKITNFYVMRNPHKLAALATARDVSRG---------
MMAR_4487|M.marinum_M IVGDKITNFYVMRNPDKLTAVARAHEISRG---------
MAB_4200|M.abscessus_ATCC_1997 IADGKITRLYAVANPDKLVAAATTRMVSR----------
TH_1142|M.thermoresistible__bu VVDGRITHFYAVRNPEKLAAVDTPRQISR----------
Mvan_5347|M.vanbaalenii_PYR-1 VVDDKITNLYAMRNPDKLTGITIPRKITR----------
Mflv_1927|M.gilvum_PYR-GCK VADGRITNFYAMRNPEKLTGVMVARTISR----------
MSMEG_5444|M.smegmatis_MC2_155 IVDGRITHFYAMRNPDKLAGVDIPRVISR----------
MLBr_01076|M.leprae_Br4923 RGRQALRDYLLTAHPRDGATTDATHVKSA----------
: .* . :