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MTDPALLARFQAARPRLGALAYRMLGSLADAEDVVQEAWLRLNATTDRPEGAQELVNLDAWLTTVVARLC LNLLRDRRGRGREELVGQLPDPIVDGVAAFDPEHHAMLADAVGLALFVVLDTLAPAERLAFVLHDVFAVP FDQIAPILERTPEATRKLASRARRRIERAEPFPDRDLCAQREVVDAFFAAGRSGNFERLVSVLHPDVVLR GDFGPNTPRFRAQGAATVAKLARSYAGPERTVLNTLVNGAAGAVISISEQASAVMRFLVRNGRIAAIDVL ADPQRIATLDISGLSGPGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3630 | - | - | 100% (299) | alternative RNA polymerase sigma factor SigJ- like |
| M. ulcerans Agy99 | MUL_1076 | sigG | 8e-14 | 28.18% (220) | RNA polymerase factor sigma-70 |
| M. ulcerans Agy99 | MUL_4519 | sigE | 3e-09 | 30.92% (152) | RNA polymerase sigma factor SigE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3361c | sigJ | 1e-39 | 39.07% (302) | RNA polymerase sigma factor SigJ |
| M. gilvum PYR-GCK | Mflv_4852 | - | 9e-44 | 40.73% (302) | RNA polymerase sigma factor SigJ |
| M. tuberculosis H37Rv | Rv3328c | sigJ | 1e-39 | 39.00% (300) | RNA polymerase sigma factor SigJ |
| M. leprae Br4923 | MLBr_01076 | sigE | 5e-09 | 31.06% (161) | RNA polymerase sigma factor SigE |
| M. abscessus ATCC 19977 | MAB_3678c | - | 2e-45 | 42.86% (294) | RNA polymerase sigma factor SigJ |
| M. marinum M | MMAR_3687 | - | 1e-165 | 99.00% (299) | alternative RNA polymerase sigma factor SigJ-like protein |
| M. avium 104 | MAV_2018 | - | 1e-113 | 72.73% (297) | RNA polymerase ECF-subfamily protein sigma factor |
| M. smegmatis MC2 155 | MSMEG_1666 | - | 1e-40 | 38.74% (302) | RNA polymerase sigma factor SigJ |
| M. thermoresistible (build 8) | TH_1144 | - | 2e-29 | 30.00% (290) | RNA polymerase sigma factor, sigma-70 family protein |
| M. vanbaalenii PYR-1 | Mvan_1575 | - | 1e-44 | 40.73% (302) | RNA polymerase sigma factor SigJ |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3630|M.ulcerans_Agy99 ----------MTDP---ALLARFQAARPRLGALAYRMLGSLADAEDVVQE
MMAR_3687|M.marinum_M ----------MTDP---ALLARFQAARPRLGALAYRMLGSLADAEDVVQE
MAV_2018|M.avium_104 ----------MTSPDAADLTARFEAARPRLGALAYRMLGSIDDAQDAVQE
Mflv_4852|M.gilvum_PYR-GCK MPHGGIYTRRMTAS---ARVAEFEQMRPHLLSVAYRLTGTVADAEDIVQD
Mvan_1575|M.vanbaalenii_PYR-1 ----------MTTS---ARVGEFEQLRPHLLSVAYRLTGTLADAEDIVQD
MSMEG_1666|M.smegmatis_MC2_155 ----------MTTA---ARTDQFEALRPHLLAVAYRLTGTYADAEDIVQE
Mb3361c|M.bovis_AF2122/97 -----------------MEVSEFEALRQHLMSVAYRLTGTVADAEDIVQE
Rv3328c|M.tuberculosis_H37Rv -----------------MEVSEFEALRQHLMSVAYRLTGTVADAEDIVQE
MAB_3678c|M.abscessus_ATCC_199 --------MVVRAG---DRTDEFEALRPRLQAVAYRLTGSVADAEDIVQD
TH_1144|M.thermoresistible__bu -----VTVGSAAGAADGEHAERFTLLRPLLFTIAYEILGSATEADDVLQD
MLBr_01076|M.leprae_Br4923 ------------------MGDGIGMER------EGRWTGNTQCPLRVVPG
: * . *. . :
MUL_3630|M.ulcerans_Agy99 AWLRLNATTDRPEGAQELVNLDAWLTTVVARLCLNLLRDRRGRGREELVG
MMAR_3687|M.marinum_M AWLRLNATTDRPQGAQELVNLDAWLTTVVARLCLNLLRDRRGRGREELVG
MAV_2018|M.avium_104 AWLRLDRS-----GGADIANLDAWLTTVVARICLNMLRDRRTRDGAEPAA
Mflv_4852|M.gilvum_PYR-GCK AWLRWSTH-----RGAAVEDLKAWLTTVVSRLALDKLRSAAHRRETYVGE
Mvan_1575|M.vanbaalenii_PYR-1 AWLRWEAN-----SATVIEDLKAWLTTVVSRLALDRLRSAAHRRETYVGE
MSMEG_1666|M.smegmatis_MC2_155 AWIRWAG------QEAPIENLQAWLTTVVSRLGLDRLRSAAHRRESYYGE
Mb3361c|M.bovis_AF2122/97 AWLRWDS------QDTVIADPRAWLTTVVSRLGLDKLRSAAHRRETYTGT
Rv3328c|M.tuberculosis_H37Rv AWLRWDS------PDTVIADPRAWLTTVVSRLGLDKLRSAAHRRETYTGT
MAB_3678c|M.abscessus_ATCC_199 AWLRLYS------TTAEIEDLAAWLTTVVSRLGLDRLRSAVYRRETYVGE
TH_1144|M.thermoresistible__bu GYLRWSQV-----DLGTVRDTKAFLAQLITREALKVLRTRSRRREDYVGP
MLBr_01076|M.leprae_Br4923 D------------ESPTLDGRASPEDLIITNLLSPTIMSHPPPSRD----
: . : :::. :
MUL_3630|M.ulcerans_Agy99 QLPDPIVDGVAAFDPEHHAMLADAVGLALFVVLDTLAPAERLAFVLHDVF
MMAR_3687|M.marinum_M QLPDPIVDGVAAFDPEHHAMLADAVGLALFVVLDTLAPAERLAFVLHDVF
MAV_2018|M.avium_104 HLPDPIVEPAGEFDPEHRAMLADAVGMALFVVLDTLPPAERLAFVLHDVF
Mflv_4852|M.gilvum_PYR-GCK WLPEPVVTGLDGRDPLSALVADEDARFAAMVVLENLTPDQRVAFVLHDGF
Mvan_1575|M.vanbaalenii_PYR-1 WLPEPVVTGFDGVDPLASVVAGEDARFAAMVVLENLTPDQRVAFVLHDGF
MSMEG_1666|M.smegmatis_MC2_155 WLPEPVVTGIDGNDPLNAVVAGEDARFAAMVVLEQLSPDQRVAFVLYDGF
Mb3361c|M.bovis_AF2122/97 WLPEPVVTGLDATDPLAAVVAAEDARFAAMVVLERLRPDQRVAFVLHDGF
Rv3328c|M.tuberculosis_H37Rv WLPEPVVTGLDATDPLAAVVAAEDARFAAMVVLERLRPDQRVAFVLHDGF
MAB_3678c|M.abscessus_ATCC_199 WLPEPVVTGLDGDDPLAALVASEDARFAAMVVLDRLAPDQRVAFVLHDGF
TH_1144|M.thermoresistible__bu WLPEPLL--LEDHDPESDVVLAESVSMAMLVLLETLSPDERAVFVLREVF
MLBr_01076|M.leprae_Br4923 ---DDWVEPFDALQG--TAVFDATGDKATMPSWEELVR-QHAARVYWLAY
: : : : * : : * :: . * :
MUL_3630|M.ulcerans_Agy99 AVPFDQIAPILERTPEATRKLASRARRRIERAEPFPDRD-LCAQREVVDA
MMAR_3687|M.marinum_M AVPFDQIAPILERTPEATRKLASRARRRIERAEPFPDRD-LCAQREVVDA
MAV_2018|M.avium_104 AVPFAQIAAIVDGTPESARKLASRARRRIERADPVPDGD-LAAQREVVDA
Mflv_4852|M.gilvum_PYR-GCK AVPFSAIAEVLGTSTQAARQLASRARRAVSSAPPPAAD-----HAEVVGK
Mvan_1575|M.vanbaalenii_PYR-1 AVPFAEIAEVLGSSPESARQLASRARRAASAAPPPADE-----HAEVVGK
MSMEG_1666|M.smegmatis_MC2_155 GVPFPDIADVLGVSAASARQLASRARRAVADAPPPVDDN---THNEIAGA
Mb3361c|M.bovis_AF2122/97 AVPFAEVAEVLGTSEAAARQLASRARKAVTAQPALISGDPDPAHNEVVGR
Rv3328c|M.tuberculosis_H37Rv AVPFAEVAEVLGTSEAAARQLASRARKAVTAQPALISGDPDPAHNEVVGR
MAB_3678c|M.abscessus_ATCC_199 SVPFKQIADILGISDAAARQLASRARRMVTATPEPVADA---EHNEVVGE
TH_1144|M.thermoresistible__bu DFDYDEIAGAVGKSVPAVRQVAHRSREHVRARRKRFDPVPAAQTTELAEE
MLBr_01076|M.leprae_Br4923 -----RLSGNQHDAEDLTQETFIRVFRSVQNYQPGTFEG--WLHRITTNL
:: : .:: * . .
MUL_3630|M.ulcerans_Agy99 FFAAGRSGNFERLVSVLHPDVVLRGDFG--PNTPRFRAQGAATVAKLAR-
MMAR_3687|M.marinum_M FFAAGRSGNFERLVSVLHPDVVLRGDFG--PNTPRFRAQGAATVAKLAR-
MAV_2018|M.avium_104 FFAAGRSGDFDRLVSVLHPDVVLRGDFG--PATATVRVQGAAAVAKLAR-
Mflv_4852|M.gilvum_PYR-GCK LLAAMASGDLTAVVSLLHPDVTFTGDSNRRAPTAARVIRGSDKVARFLLG
Mvan_1575|M.vanbaalenii_PYR-1 LLAAMASGDLTEVVAVLHPDVTFTGDSNRRAPTAARVIHGSDKVARFLLG
MSMEG_1666|M.smegmatis_MC2_155 LMAALAAGDMDGVVRLLHPDVTFTGDSNRKAPTAPRVIHGPEKVARFLFG
Mb3361c|M.bovis_AF2122/97 LMAAMAAGDLDTVVSLLHPDVTFTGDSNGKAPTAVRAVRGSDKVVRFILG
Rv3328c|M.tuberculosis_H37Rv LMAAMAAGDLDTVVSLLHPDVTFTGDSNGKAPTAVRAVRGSDKVVRFILG
MAB_3678c|M.abscessus_ATCC_199 LLEALMSGSVEAVVRLLHPDVTMTGDSDGKAPTAVRVIHGPDKVARFLLG
TH_1144|M.thermoresistible__bu FIHAATTGDLDRLLSLLAPGATFTTDHGGKAPAVARPVEGAKKVANLVMG
MLBr_01076|M.leprae_Br4923 FLDMVRRRARIRMDALPDDYDRVPADEPNPEQIYHDSRLGPDLQAALDSL
:: : : . * *. . :
MUL_3630|M.ulcerans_Agy99 --SYAGPE---RTVLNTLVNGAAGAVIS-------ISEQASAVMRFLVRN
MMAR_3687|M.marinum_M --SYAGPE---RTVLNALVNGAAGAVIS-------ISEQASAVMGFLVRN
MAV_2018|M.avium_104 --SYAGPE---REACAATVNGAAGAVIF-------VAGRAASVMGFVVRG
Mflv_4852|M.gilvum_PYR-GCK LGAKYGPERLLAGSELGLVNGELGVYSPGADATPDAPRIMPRIQALAVRD
Mvan_1575|M.vanbaalenii_PYR-1 LARRYGEQRFFGSGVLGMVNGELGVYTMGAPATEDAPAIAPRIQALTVHR
MSMEG_1666|M.smegmatis_MC2_155 LARRYGPN-WLAGAQLALINGELGTYTPGAPAGDGYPELLPRITAMTVRD
Mb3361c|M.bovis_AF2122/97 LVQRYGPG-LFGANQLALVNGELGAYTAGLPGVDGYRAMAPRITAITVRD
Rv3328c|M.tuberculosis_H37Rv LVQRYGPG-LFGANQLALVNGELGAYTAGLPGVDGYRAMAPRITAITVRD
MAB_3678c|M.abscessus_ATCC_199 LMERYGPQ-MTQAINPALVNGQFGMYLTETDTDPNFRPVLPRVSAFTVRD
TH_1144|M.thermoresistible__bu FFRNRHRVPDLRLEATNCNHAPAVLVYTG--------DHLEAVVLLEIVD
MLBr_01076|M.leprae_Br4923 PPEFRAAV--VLCDIEGLSYEEIGATLG--------VKLGTVRSRIHRGR
:
MUL_3630|M.ulcerans_Agy99 GRIAAIDVLADPQRIATLDISGLSGPGG--------
MMAR_3687|M.marinum_M GRIAAIDVLADPQRIATLDISGLSGPGG--------
MAV_2018|M.avium_104 GRIRAIDVLADPDRIAKLELGALRADH---------
Mflv_4852|M.gilvum_PYR-GCK GLVVAIYDVANPDKFTASPLAR--------------
Mvan_1575|M.vanbaalenii_PYR-1 GQVVAIYDIANPDKFTASPLR---------------
MSMEG_1666|M.smegmatis_MC2_155 GKVCAVWDVANPDKFTGSPLGTAVRRP---------
Mb3361c|M.bovis_AF2122/97 GKVCALWDIANPDKFTGSPLKERRAQPTGRGRHHRN
Rv3328c|M.tuberculosis_H37Rv GKVCALWDIANPDKFTGSPLKERRAQPTGRGRHHRN
MAB_3678c|M.abscessus_ATCC_199 GRVLAVWDVSNPDKFSGTPLREA-------------
TH_1144|M.thermoresistible__bu GAITNLYATRNPDKLAAVAAPRTITR----------
MLBr_01076|M.leprae_Br4923 QALRDYLLTAHPRDGATTDATHVKSA----------
: .* :