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VSEHADRFTHLRPLLFTIAYEILGSATESDDVLQESYLRWAEVDLAAVTDTKAYLARLVTRQALNALRAQ SRRREDYVGPWLPEPLLTEADPSADVVLAESVSMAMLVVLETLSPDERAVFVLREVFGFGHDEIAATLGK STEAVRQTAHRARAHVQSRRKRFEPVDPKVSTEITTRFFTAAATGDLDGLMAMLAPDVVWTADSDGKVSA ARRPVAGADRVARLIMGFVRQAGADGRVEPAVYNSAPALVLYLGDNLEGVVTFEVVDGRITNFYAMRNPE KLAGVKVPRQISR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4806 | - | - | 100% (293) | ECF subfamily RNA polymerase sigma-24 factor |
| M. vanbaalenii PYR-1 | Mvan_5347 | - | e-112 | 70.17% (295) | ECF subfamily RNA polymerase sigma-24 factor |
| M. vanbaalenii PYR-1 | Mvan_4999 | - | 3e-49 | 41.70% (247) | ECF subfamily RNA polymerase sigma-24 factor |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3361c | sigJ | 1e-45 | 36.33% (289) | RNA polymerase sigma factor SigJ |
| M. gilvum PYR-GCK | Mflv_1927 | - | 1e-145 | 90.38% (291) | ECF subfamily RNA polymerase sigma-24 factor |
| M. tuberculosis H37Rv | Rv3328c | sigJ | 1e-45 | 36.33% (289) | RNA polymerase sigma factor SigJ |
| M. leprae Br4923 | MLBr_01076 | sigE | 1e-09 | 27.39% (157) | RNA polymerase sigma factor SigE |
| M. abscessus ATCC 19977 | MAB_4200 | - | 1e-107 | 65.75% (292) | putative sigma factor |
| M. marinum M | MMAR_4487 | - | 1e-113 | 69.52% (292) | alternative RNA polymerase sigma factor |
| M. avium 104 | MAV_1129 | - | 1e-109 | 67.89% (299) | sigma factor |
| M. smegmatis MC2 155 | MSMEG_5444 | - | 1e-131 | 79.79% (292) | RNA polymerase sigma-70 factor protein |
| M. thermoresistible (build 8) | TH_1142 | - | 1e-124 | 76.53% (294) | RNA polymerase sigma factor, sigma-70 family protein |
| M. ulcerans Agy99 | MUL_3630 | - | 1e-34 | 34.24% (295) | alternative RNA polymerase sigma factor SigJ- like |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3361c|M.bovis_AF2122/97 ------------MEVSEFEALRQHLMSVAYRLTGTVADAEDIVQEAWLRW
Rv3328c|M.tuberculosis_H37Rv ------------MEVSEFEALRQHLMSVAYRLTGTVADAEDIVQEAWLRW
Mvan_4806|M.vanbaalenii_PYR-1 ----------MSEHADRFTHLRPLLFTIAYEILGSATESDDVLQESYLRW
Mflv_1927|M.gilvum_PYR-GCK -----MTAAPGDEHAERFTQLRPLLFTIAYEILGSATESDDVLQESYLRW
MSMEG_5444|M.smegmatis_MC2_155 --MNNPSAGNSTEHAERFTALRPLLFTIAYEILGTATESDDVLQESYLRW
TH_1142|M.thermoresistible__bu MTGSGAPSARGDEHAERFTHLRPLLFTIAYEILGSATEADDVLQESYLRW
MMAR_4487|M.marinum_M ----MTPPSHSDEHAERFTLLRPLLFTIAYEILGSATESDDVLQESYLRW
MAV_1129|M.avium_104 ---MMTQAPTGSEHADRFTLLRPLLFTIAYEMLGSATEADDVLQDSYLRW
MAB_4200|M.abscessus_ATCC_1997 -------MINSDEHAERFTLLRPLLFTIVYEILGSATESDDVLQDSYLRW
MUL_3630|M.ulcerans_Agy99 --------MTDPALLARFQAARPRLGALAYRMLGSLADAEDVVQEAWLRL
MLBr_01076|M.leprae_Br4923 -----------------------MGDGIGMEREGRWTGN----TQCPLRV
: . * : :. **
Mb3361c|M.bovis_AF2122/97 DSQD------TVIADPRAWLTTVVSRLGLD---KLRSAAHRRETYTGTWL
Rv3328c|M.tuberculosis_H37Rv DSPD------TVIADPRAWLTTVVSRLGLD---KLRSAAHRRETYTGTWL
Mvan_4806|M.vanbaalenii_PYR-1 AEVDL-----AAVTDTKAYLARLVTRQALN---ALRAQSRRREDYVGPWL
Mflv_1927|M.gilvum_PYR-GCK AEVDL-----ATVTDTKAYLARLVTRQALN---TLRAQSRRREDYVGPWL
MSMEG_5444|M.smegmatis_MC2_155 AEVDL-----ATVTDTKAYLAKLVTRQSLN---ALRARSRLREEYVGPWL
TH_1142|M.thermoresistible__bu AEVDL-----AAVRDTKSYLAKLVSRQALN---ALRAGARRREDYVGPWL
MMAR_4487|M.marinum_M AAVDL-----SAVRDTKSYLAQLVTRQSLN---ALRAGARRREEYVGPWL
MAV_1129|M.avium_104 STVDL-----ATVRDTKSYLAQLVTRQALN---ALRAGARRREEYVGPWL
MAB_4200|M.abscessus_ATCC_1997 AQVDL-----ATVRDTKSYLAQLVTRQALK---ALRTSVRRREDYIGPWL
MUL_3630|M.ulcerans_Agy99 NATTDRPEGAQELVNLDAWLTTVVARLCLN---LLRDRRGRGREELVGQL
MLBr_01076|M.leprae_Br4923 VPGDE-----SPTLDGRASPEDLIITNLLSPTIMSHPPPSRDDDWVEPFD
: : :: *. :
Mb3361c|M.bovis_AF2122/97 PEPVVTGLDATDPLAAVVAAEDARFAAMVVLERLRPDQRVAFVLHDGFAV
Rv3328c|M.tuberculosis_H37Rv PEPVVTGLDATDPLAAVVAAEDARFAAMVVLERLRPDQRVAFVLHDGFAV
Mvan_4806|M.vanbaalenii_PYR-1 PEPLL--TEA-DPSADVVLAESVSMAMLVVLETLSPDERAVFVLREVFGF
Mflv_1927|M.gilvum_PYR-GCK PEPLL--TEA-DPSADVVLAESVSMAMLVVLETLSPDERAVFVLREVFGF
MSMEG_5444|M.smegmatis_MC2_155 PEPLL--VAE-DASSDVVLAESVSMAMLVVLETLTPDERAVFVLHDVFGF
TH_1142|M.thermoresistible__bu PEPLL--LEERDASADVVLAESVSMAMMVVLESLTPDERAVFVLREVFGF
MMAR_4487|M.marinum_M PEPLL--LDESDPSADLVLAESVSMAMLVLLETLTPDERAVFVLREVFGF
MAV_1129|M.avium_104 PEPLL--LDEQDPSTDVVLAESISMAMLVLLETLSPDERAVFVLREVFGF
MAB_4200|M.abscessus_ATCC_1997 PEPLL--LDEHDGSADVLLAESVSMAMLILLETLTPDERAVFVLREVFGF
MUL_3630|M.ulcerans_Agy99 PDPIVDGVAAFDPEHHAMLADAVGLALFVVLDTLAPAERLAFVLHDVFAV
MLBr_01076|M.leprae_Br4923 -----------ALQGTAVFDATGDKATMPSWEELVR-QHAARVYWLAYRL
: * : : * :: . * : .
Mb3361c|M.bovis_AF2122/97 PFAEVAEVLGTSEAAARQLASRARKAVTAQPALIS----GDPDPAHNEVV
Rv3328c|M.tuberculosis_H37Rv PFAEVAEVLGTSEAAARQLASRARKAVTAQPALIS----GDPDPAHNEVV
Mvan_4806|M.vanbaalenii_PYR-1 GHDEIAATLGKSTEAVRQTAHRARAHVQSRRKRFE----PVDPKVSTEIT
Mflv_1927|M.gilvum_PYR-GCK GHDEIAATLGKSTAAVRQIAHRAREHVQSRRKRFE----PVDPKTSGEIT
MSMEG_5444|M.smegmatis_MC2_155 SHDEIASTIGKSAAAVRQMAHRARNHVQARRKRFE----PVDPQVSMEIT
TH_1142|M.thermoresistible__bu EYGEIATTVGKSVTAVRQIAHRARSHVHARRKRFE----PVDPEVSMEIT
MMAR_4487|M.marinum_M DYDEIADAVGKPAPTVRQVAHRARAHIQARRKKYG----DVDPQRNAQLT
MAV_1129|M.avium_104 DYDEIAEAVGKPAPTVRQVARRAREHVRARRKRHPGAGQAIDPKRNAELT
MAB_4200|M.abscessus_ATCC_1997 GYDEIAGAVSKSATAVRQIAHRAREHVHARRKRFD----PLDAKESTRIA
MUL_3630|M.ulcerans_Agy99 PFDQIAPILERTPEATRKLASRARRRIERAEPFPD-----RDLCAQREVV
MLBr_01076|M.leprae_Br4923 SGNQHDAEDLTQETFIRVFRSVQNYQPGTFEGWLH------------RIT
: * . .:.
Mb3361c|M.bovis_AF2122/97 GRLMAAMAAGDLDTVVSLLHPDVTFTGDSNGKAPTAVRAVRGSDKVVRFI
Rv3328c|M.tuberculosis_H37Rv GRLMAAMAAGDLDTVVSLLHPDVTFTGDSNGKAPTAVRAVRGSDKVVRFI
Mvan_4806|M.vanbaalenii_PYR-1 TRFFTAAATGDLDGLMAMLAPDVVWTADSDGKVSAARRPVAGADRVARLI
Mflv_1927|M.gilvum_PYR-GCK MTFFAAAATGDLDALMAMLAPDVVWTADSDGKVSAARRPVEGADKVARLI
MSMEG_5444|M.smegmatis_MC2_155 QRFFTAASTGDIDALMELLAPDVVWTADSAGKRSAARRPVSGADAVARLV
TH_1142|M.thermoresistible__bu ERFLTAASTGDMDGLLAMLAPDATWTADGGGKATAARRPIVGAEKVAAVI
MMAR_4487|M.marinum_M AQFLQTAASGDVEALMAMLAPDATWLADSGGKVSAARKPVVGAERVARAI
MAV_1129|M.avium_104 AQFLATAASGDVEALMAMLAPDATWTADSGGVVSAARRPVVGAEKVARAI
MAB_4200|M.abscessus_ATCC_1997 EQFLLATETGDVEGLMALLAPDATWIADGNGRAGAARRPLTGAGKLARIF
MUL_3630|M.ulcerans_Agy99 DAFFAAGRSGNFERLVSVLHPDVVLRGDFG--PNTPRFRAQGAATVAKLA
MLBr_01076|M.leprae_Br4923 TNLFLDMVRRRARIRMDALPDDYDRVPADEPNPEQIYHDSRLGPDLQAAL
:: : * * . :
Mb3361c|M.bovis_AF2122/97 LGLVQRYGPGLFGANQLALVNGELGAYTAGLPGVDGYRAMAPRITAITVR
Rv3328c|M.tuberculosis_H37Rv LGLVQRYGPGLFGANQLALVNGELGAYTAGLPGVDGYRAMAPRITAITVR
Mvan_4806|M.vanbaalenii_PYR-1 MGFVRQAG--ADGRVEPAVYNSAPALVLYLGDNLEG-------VVTFEVV
Mflv_1927|M.gilvum_PYR-GCK LGFVRLAG--GEARVEPAFYNSAPALVLYTGDVLEG-------VVTFEVA
MSMEG_5444|M.smegmatis_MC2_155 SGLVRLGG--EGARVEPAMYNNAPALKLYLGDSFEG-------VITIEIV
TH_1142|M.thermoresistible__bu LGIFRAGQRLPDVRIETAIYNCAPAVVVYSRDNLEG-------VFTVEVV
MMAR_4487|M.marinum_M TGLIRKAAT--ELQVELVTCNSAPAVLFYLGGQLEG-------VITLEIV
MAV_1129|M.avium_104 TGLFRKAAEYATLRVDTVTCNGAPAVLLYLGDRLEG-------VITVEIA
MAB_4200|M.abscessus_ATCC_1997 AGPFRKGMA--DRRTEIVIANAAPAVAVYAGDALEV-------VITMEIA
MUL_3630|M.ulcerans_Agy99 RSYAGPER-----TVLNTLVNGAAGAVISISEQASA-------VMRFLVR
MLBr_01076|M.leprae_Br4923 DSLPPEFRAAVVLCDIEGLSYEEIGATLGVKLGTVR--------SRIHRG
. . .
Mb3361c|M.bovis_AF2122/97 DGKVCALWDIANPDKFTGSPLKERRAQPTGRGRHHRN
Rv3328c|M.tuberculosis_H37Rv DGKVCALWDIANPDKFTGSPLKERRAQPTGRGRHHRN
Mvan_4806|M.vanbaalenii_PYR-1 DGRITNFYAMRNPEKLAGVKVPRQISR----------
Mflv_1927|M.gilvum_PYR-GCK DGRITNFYAMRNPEKLTGVMVARTISR----------
MSMEG_5444|M.smegmatis_MC2_155 DGRITHFYAMRNPDKLAGVDIPRVISR----------
TH_1142|M.thermoresistible__bu DGRITHFYAVRNPEKLAAVDTPRQISR----------
MMAR_4487|M.marinum_M GDKITNFYVMRNPDKLTAVARAHEISRG---------
MAV_1129|M.avium_104 ADKITNFYVMRNPHKLAALATARDVSRG---------
MAB_4200|M.abscessus_ATCC_1997 DGKITRLYAVANPDKLVAAATTRMVSR----------
MUL_3630|M.ulcerans_Agy99 NGRIAAIDVLADPQRIATLDISGLSGPGG--------
MLBr_01076|M.leprae_Br4923 RQALRDYLLTAHPRDGATTDATHVKSA----------
: .* . .