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VNLFALLDQTAARHGDRGAVYHGERLVHTWSSLRERALRLASSLREFGPGARIAVASENRPEIVELMFAI WAAECVFVPLNYKLHVREMEQILSDAGAARVFTSPKIGAELAPVASTGIEIIGAAEYESRCAAMPSPAPR DTDPASPAWLFYTSGTTGRSKGAMLSHRNLMAMTVSHLADFDCPDENSSLIHGAPMSHGSGLYVPPYVSR GARQVVPASGTFDPDEFLDLCESHPGCSAFLAPTMVARLVQTGRACPANLRTIVYGGGPMYVDSLKKAMA AFGPVFVQLYGQGEAPMTITGLRRRDHLDAPDAVLGSVGYARSGVDVAVLGPDGAPVAVGEIGEIVCRGD VVMSGYWQNPEATEAALQHGWLRTGDMGSFDAHGFLTLRDRSKDVVISGGSNIYPREVEEVLLEHPGVVE AGVVGAPDEEWGEVVVAFIVGAASAADLDAHLLERIARFKRPKRYEFVDELPKNSYGKVLKRELRARLG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4968 | - | - | 100% (489) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_0943 | - | 1e-69 | 36.61% (489) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_0131 | - | 2e-65 | 35.71% (490) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0172 | fadD5 | 8e-65 | 35.99% (489) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_1782 | - | 0.0 | 84.35% (492) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv0166 | fadD5 | 8e-65 | 36.20% (489) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_01051 | xclC | 5e-43 | 32.23% (453) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4559 | - | 1e-67 | 34.63% (488) | putative long-chain-fatty-acid CoA ligase |
| M. marinum M | MMAR_0409 | fadD5 | 4e-68 | 36.08% (485) | fatty-acid-CoA ligase FadD5 |
| M. avium 104 | MAV_3523 | - | 2e-71 | 36.51% (504) | acyl-CoA synthase |
| M. smegmatis MC2 155 | MSMEG_5633 | - | 0.0 | 76.78% (491) | feruloyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_3645 | - | 0.0 | 79.15% (494) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_0650 | fadD8 | 2e-64 | 33.14% (516) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4968|M.vanbaalenii_PYR-1 -------------------------MNLFALLDQTAARHGDRGAVYHGER
Mflv_1782|M.gilvum_PYR-GCK -------------------------MNLFALLEQAAARHGERGAVYHGVQ
TH_3645|M.thermoresistible__bu ---------------------MGAAVNLFALLDQTATRFGDRGAVFHGER
MSMEG_5633|M.smegmatis_MC2_155 -------------------------MNLFGLLDQTAARHGDRGAVFCGER
MUL_0650|M.ulcerans_Agy99 ----------------MSDDLLRNPTHNGHLLVGALERHKNRPVLFLGDT
Mb0172|M.bovis_AF2122/97 MTAQLASHLTRALTLAQQQPYLARRQNWVNQLERHAMMQPDAPALRFVGN
Rv0166|M.tuberculosis_H37Rv MTAQLASHLTRALTLAQQQPYLARRQNWVNQLERHAMMQPDAPALRFVGN
MMAR_0409|M.marinum_M MTAELASHLPQAA-HALEQPYLARRQNWVNQLERHAMMQPRATAIRYLGH
MAB_4559|M.abscessus_ATCC_1997 --MQFTQWLHRAL-----QQYPDR------------LITIDQ------GR
MAV_3523|M.avium_104 ------------------MPAAETRETLAGIVERHAQRRPDAIAIRYGER
MLBr_01051|M.leprae_Br4923 ------------------------------MLLASLNPSVVTATDIADAV
Mvan_4968|M.vanbaalenii_PYR-1 LVHTWSSLRERALRLASSLR-EFGPGARIAVASENRPEIVELMFAIWAAE
Mflv_1782|M.gilvum_PYR-GCK QIHSWASLRERALRLAGSLR-DLGPGARIAVASENRPEIVELMFAIWAAE
TH_3645|M.thermoresistible__bu QVTTWSGLRDRALRLAGSIRREVDAGARIAIASENRPEIVELMFAVWAAE
MSMEG_5633|M.smegmatis_MC2_155 ELYTWTQLRDRAARLGSTLT---EPGTRVAVASENRPEIIEIMFGVWAAE
MUL_0650|M.ulcerans_Agy99 TLTGGQLAERISQYIQAFEALGAGTGVTVGLLSLNRPEVLMILGASQARG
Mb0172|M.bovis_AF2122/97 TMTWADLRRRVAALAGALSGRGVGFGDRVMILMLNRTEFVESVLAANMIG
Rv0166|M.tuberculosis_H37Rv TMTWADLRRRVAALAGALSGRGVGFGDRVMILMLNRTEFVESVLAANMIG
MMAR_0409|M.marinum_M TVTWADLRYRVAALAGSLSRRGVGFGDRVMILMLNRTEFVESVLAANMLG
MAB_4559|M.abscessus_ATCC_1997 EHTVEQFADRVARLSAGLRANGVRPGDRVGMLSLNSDRYIEYLTAVPWLG
MAV_3523|M.avium_104 QWSWAEWSSRIRRAAGALRGDGIERGQCVAFLDKNHPACLEVLIGGASVG
MLBr_01051|M.leprae_Br4923 CVDGVVLSRSGLVGAATSVAERVGGARLVAVLATPTASTVLAITGCLIAG
. : . : : .
Mvan_4968|M.vanbaalenii_PYR-1 CVFVPLNYKLHVREMEQILSDAGAARVFTSP------------------K
Mflv_1782|M.gilvum_PYR-GCK CVFVPLNFKLHPREMEQILDDSGAARVFASP------------------K
TH_3645|M.thermoresistible__bu CVVVPINFKLHPREMAQILDDAEASRVFTSA------------------S
MSMEG_5633|M.smegmatis_MC2_155 CVYVPINYKLHPREMADILADSGAALVFASP------------------K
MUL_0650|M.ulcerans_Agy99 YRRTALHPLGSLDDHAYVLYDAGASALIIDPNPMFVERALGLLEKVDSLE
Mb0172|M.bovis_AF2122/97 AIAVPLNFRLTPTEIAVLVEDCAAHVMLTEAALAPVAIG-----VRNIQP
Rv0166|M.tuberculosis_H37Rv AIAVPLNFRLTPTEIAVLVEDCVAHVMLTEAALAPVAIG-----VRNIQP
MMAR_0409|M.marinum_M AIAVPLNFRLTPSEIAFLVEDCAPRLVITEEVLAQVAVG-----VREIAP
MAB_4559|M.abscessus_ATCC_1997 AALNAVNIRWSLAEIGYSLRESGTRVLLVDDTFKAAAAP-----LRAACA
MAV_3523|M.avium_104 AVTTVVNWRVIGDELVHVLADSGARVLVVGAELRP-------------AA
MLBr_01051|M.leprae_Br4923 VPVVPVPADIGVVERRHMLTDSGAQAWLGPG-------------------
: : : :. . .
Mvan_4968|M.vanbaalenii_PYR-1 IGAELAPVASTGIEIIGAAEYESRCAAMPSPAPRDTDPASPAWLFYTSGT
Mflv_1782|M.gilvum_PYR-GCK IAAQLTPVTSAPVEVTGSAEYRSRCAADPLSVPRYTEAASLAWLFYTSGT
TH_3645|M.thermoresistible__bu IGAALAPATEVPVETVVGDEYARRLTADPAPVPTGTDPAALAWLFYTSGT
MSMEG_5633|M.smegmatis_MC2_155 IAPGLFEVTDVPVEVVGTDAYTQRFESEPVPAP-LTDPAELAWLFYTSGT
MUL_0650|M.ulcerans_Agy99 QVLTIGPVPEALEDRAVDLSAEAAKYQPKPLVVADLPPNHIGGLTYTGGT
Mb0172|M.bovis_AF2122/97 LLSVIVVAG-GSSQDSVFGYEDLLNEAGDVHEPVDIPNDSPALIMYTAGT
Rv0166|M.tuberculosis_H37Rv LLSVIVVAG-GSSQDSVFGYEDLLNEAGDVHEPVDIPNDSPALIMYTSGT
MMAR_0409|M.marinum_M ALSTIVVAG-GASDPTVVGYDELISETGDPPEPVDIPNDSPALIMYTSGT
MAB_4559|M.abscessus_ATCC_1997 CLETVIYCGAGPAPQDMIGYEDLLASH-EPIDDTRTGGDSLLGVFYTGGT
MAV_3523|M.avium_104 EAAARRVPSLERIIEVGDEYESLLAAAEPAPSDAGVDTDETALVIYSSGT
MLBr_01051|M.leprae_Br4923 --------PSADSAPDGLPHIPVQLDARSWNRYPEPSPDATAMVIYTSGT
: *:.**
Mvan_4968|M.vanbaalenii_PYR-1 TGRSKGAMLSHRNLMAMTVSHLADFDCPDENSSLIHGAPMSHGSGL-YVP
Mflv_1782|M.gilvum_PYR-GCK TGRSKGAMLSHRNLMAMTVSHLADFDSPDENSSLIHGAPMSHGSGL-YVP
TH_3645|M.thermoresistible__bu TGRSKGAMLSHRNLMAMTVAHLADFDDPDQNCSLIHGAPMSHGSGL-YIP
MSMEG_5633|M.smegmatis_MC2_155 TGKSKGAMLSHRNLMAMTVAHLADFDAPDEFCSLVHGAPMSHGSGL-YIP
MUL_0650|M.ulcerans_Agy99 TGKPKGVIGTAGNITAMTSIQLAEWEWP-EHPRFLMCTPLSHAGAA-FFT
Mb0172|M.bovis_AF2122/97 TGRPKGAVLTHANLTGQAMTALYTSGANINSDVGFVGVPLFHIAGIGNML
Rv0166|M.tuberculosis_H37Rv TGRPKGAVLTHANLTGQAMTALYTSGANINSDVGFVGVPLFHIAGIGNML
MMAR_0409|M.marinum_M TGRPKGAVLTHTNLTGQVMTALYTGGANINSDVGFIGVPFFHIAGIGNML
MAB_4559|M.abscessus_ATCC_1997 TGNPKGVMLSHNNVLASAMGSLSTGNFLTRGGRLLHSAPMFHMADFSAVL
MAV_3523|M.avium_104 TGRPKGVLLSQRALVNHAAN-LAPAFPFGDGDANLVAMPLFHVGGIGYAL
MLBr_01051|M.leprae_Br4923 TGPPKGVLLSRR-AIAVDLDALAQAWQWTADDVLVHGLPLFHVHGLVLGL
** .**.: : * . *: *
Mvan_4968|M.vanbaalenii_PYR-1 PYVSRGARQVVPASGTFDPDEFLDLCESHPGCSAFLAPTMVARLVQTGRA
Mflv_1782|M.gilvum_PYR-GCK PYVSRGARQVVPASGAFDPDEFLDLCGQHPRCSAFLAPTMVARLVQTGRP
TH_3645|M.thermoresistible__bu PYVARGARQVIPASGVFDPGEFLDLCEHHPGCSAFLAPTMVQRLIDTGRS
MSMEG_5633|M.smegmatis_MC2_155 PYVLRGARQVIPESGAFEPDEFLDLCDHHPGCSAFLAPTMVQRLIQTGRP
MUL_0650|M.ulcerans_Agy99 PTLVKGGEMIVLAK--FDPGEVLRVIEEQRITATMLVPSMLYALMDHPDP
Mb0172|M.bovis_AF2122/97 TGLLLGLPTVIYPLGAFDPGQLLDVLEAEKVTGIFLVPAQWQAVCTEQQA
Rv0166|M.tuberculosis_H37Rv TGLLLGLPTVIYPLGAFDPGQLLDVLEAEKVTGIFLVPAQWQAVCTEQQA
MMAR_0409|M.marinum_M SGMLLGVPTVIYPLGAFNPGQLLDVLEAERVSGIFLVPAQWQAVCAEQQA
MAB_4559|M.abscessus_ATCC_1997 AGNLSGSTHVIVPS--FSPQGVLDAIVAHDVQDMLLVPTMIQMLVDHPGA
MAV_3523|M.avium_104 FGIRAGAPTIMTREP--DAAALIGAVRAG-ATHAFFVPPVIARFLDAGEA
MLBr_01051|M.leprae_Br4923 LGSLR-IGNRFVHTGKPTPTAYAQACSEAGGSLYFGVPTVWSRLVADEAV
. . : .*. .
Mvan_4968|M.vanbaalenii_PYR-1 CP---ANLRTIVYGGGPMYVDSLKKAMAAFG-PVFVQLYGQGEAPMTITG
Mflv_1782|M.gilvum_PYR-GCK SP---AHLDTVVYGGGPMYVDSLKKAMAAFG-PIFVQLYGQGEAPMTITG
TH_3645|M.thermoresistible__bu AP---ANLRTIVYGGGPMYVESLKKALAAFG-PVFVQLYGQGEAPMTITG
MSMEG_5633|M.smegmatis_MC2_155 RP---ANLRTVVYGGGPMYVDSLKKALAAYG-QIFVQLYGQGEAPMTITG
MUL_0650|M.ulcerans_Agy99 HTRDLSSLETVYYGASAINPVRLAEAIDRFG-PIFAQYYGQSEAPMVITY
Mb0172|M.bovis_AF2122/97 RPRDLR-LRVLSWGAAPAPDALLRQMSATFPETQILAAFGQTEMSPVTCM
Rv0166|M.tuberculosis_H37Rv RPRDLR-LRVLSWGAAPAPDALLRQMSATFPETQILAAFGQTEMSPVTCM
MMAR_0409|M.marinum_M RPRELS-LRVMSWGAAPAPDALLRQMSEVFPGTQIMAAFGQTEMSPVTCM
MAB_4559|M.abscessus_ATCC_1997 AQLDLSGIRSITYGASVISEAVLQRATRVFPNARFTQAYGMTEVSPVATL
MAV_3523|M.avium_104 ARASIAGLRYIVYGAAPMPLPLLHRALSTWPGTKFVQVYGQTELCGAVTA
MLBr_01051|M.leprae_Br4923 AR-ALRPARLLVSGSASLPVPVFDRLAHLTG-HRPIERYGSTESLITLST
: *.. : . :* * .
Mvan_4968|M.vanbaalenii_PYR-1 LRRRDHLDA-----PDAVLGSVGYARSGVDVAVLGPD-GAPVAVG--EIG
Mflv_1782|M.gilvum_PYR-GCK LRRGDHVTAD-GWAPDAVLGSVGYARSGVDVAVLGED-GEPAGVD--EIG
TH_3645|M.thermoresistible__bu LRRADHFDETGAVAEDAVLGSVGHPRSGVQVAVLRPD-GRPAAVG--EVG
MSMEG_5633|M.smegmatis_MC2_155 LRRDDHLDAD-----DATLGSVGYPRSGVQVAVLRSD-GTPADIG--EIG
MUL_0650|M.ulcerans_Agy99 LPKADHDEKR--------LTSCGRPTLFARVALLGED-GKPVPQG--EPG
Mb0172|M.bovis_AF2122/97 LLG--EDAIA-------KRGSVGRVIPTVAARVVDQN-MNDVPVG--EVG
Rv0166|M.tuberculosis_H37Rv LLG--EDAIA-------KRGSVGRVIPTVAARVVDQN-MNDVPVG--EVG
MMAR_0409|M.marinum_M LLG--EDAIR-------KRGSVGKVIPTVSARVVDDE-MNDVPIG--QVG
MAB_4559|M.abscessus_ATCC_1997 LLPDDHDDPA-------LLRSAGRAAPHCEVRIVDPD-DNEVPRG--EIG
MAV_3523|M.avium_104 LSDDDHRDAAR----PQLQLSAGKAVQGCEIRIVDPNNCAELPAG--RSG
MLBr_01051|M.leprae_Br4923 LADGERRAGW-----------VGLPLAGVQTRLVDES-GGPVPYDGETVG
* . * :: . . *
Mvan_4968|M.vanbaalenii_PYR-1 EIVCRGDVVMSGYWQNPEATEAALQHG-WLRTGDMGSFDAHGFLTLRDR-
Mflv_1782|M.gilvum_PYR-GCK EIVCRGDVVMSGYWNNLGATQATLKDG-WLRTGDMGSFDAHGFLTLRDR-
TH_3645|M.thermoresistible__bu EIVCRGDVVMSGYWRNPTATADTLRDG-WLYTGDMGSFDDRGHLTLRDR-
MSMEG_5633|M.smegmatis_MC2_155 EIVCRGDVVMSGYWNNPEATAATLKDG-WLHTGDMGSFDARGHLTLRDR-
MUL_0650|M.ulcerans_Agy99 EICVSGPLLAGGYWNKPDDTAQTFRDG-WLHTGDMAREDEDGFYFIVDR-
Mb0172|M.bovis_AF2122/97 EIVYRAPTLMSCYWNNPEATAEAFAGG-WFHSGDLVRMDSDGYVWVVDR-
Rv0166|M.tuberculosis_H37Rv EIVYRAPTLMSCYWNNPEATAEAFAGG-WFHSGDLVRMDSDGYVWVVDR-
MMAR_0409|M.marinum_M EIVYRAPTLMSGYWNNPDATAEAFAGG-WFHSGDLVRMDEDGYVWVVDR-
MAB_4559|M.abscessus_ATCC_1997 EVIVKGDNVMLGYWELPEESAAAIRDG-WMHTGDAGRMDDRGYVYIVDR-
MAV_3523|M.avium_104 EVWVRSNQNMSGYLNRAEATAETITADGWVRTGDVGRLDADGYVYIEDR-
MLBr_01051|M.leprae_Br4923 RLQVRSPTMFGGYLNRPEATAEAFDEDGWYRTGDVAVVDSGGMHRIVGRE
.: . * . : :: . * :** * * : .*
Mvan_4968|M.vanbaalenii_PYR-1 SKDVVISGGSNIYPREVEEVLLEHPGVVEAGVVGAPDEEWGEVVVAFIVG
Mflv_1782|M.gilvum_PYR-GCK SKDVVISGGSNIYPREVEEVLLEHPGVLEVGVVGAPDTDWGEVVVAFVVG
TH_3645|M.thermoresistible__bu SKDVVISGGSNIYPREVEEVLIEHPGVAEACVVGAPDPEWGEIVVAFIVG
MSMEG_5633|M.smegmatis_MC2_155 SKDVVISGGSNIYPREVEEVLLEHPDVVEAGVVGAPDAEWGEIVVAFVVT
MUL_0650|M.ulcerans_Agy99 VKDMIVTGGFNVFPREVEDVVAEHSAVAQVCVVGAPDEKWGEAVTAVVVL
Mb0172|M.bovis_AF2122/97 KKDMIISGGENIYCAELENVLASHPDIAEVAVIGRADEKWGE-VPIAVAA
Rv0166|M.tuberculosis_H37Rv KKDMIISGGENIYCAELENVLASHPDIAEVAVIGRADEKWGE-VPIAVAA
MMAR_0409|M.marinum_M KKDMIISGGENVYCAEVENVLASHPSIVEVAVIGRADEKWGE-VPIAVAA
MAB_4559|M.abscessus_ATCC_1997 IKDMVVTGGENVYSAEVENALAKHPAVAACAVIGIPDEQWGERVHAVVVK
MAV_3523|M.avium_104 LKDMIITGGENVYGPEVESVLIEHPAVVDAAVIGVPDDFWGESVKAIVVA
MLBr_01051|M.leprae_Br4923 SVDLIKLGGYRIGAGEIEMALLGHPDVREVAVVGLPDEDLGQRIVAFVVG
*:: ** .: *:* .: *. : *:* .* *: : :.
Mvan_4968|M.vanbaalenii_PYR-1 -----------AASAADLDAHLLERIARFKRPKRYEFVDELPKNSYGKVL
Mflv_1782|M.gilvum_PYR-GCK -----------DVGVAELDAHLLERIARFKRPKRYEFVDELPKNSYGKVL
TH_3645|M.thermoresistible__bu -----------SATAEELDAHLLDRIARFKRPKRYEFIDELPKSSYGKVL
MSMEG_5633|M.smegmatis_MC2_155 NG--------TPVDAAALDAHLLERIARFKRPKRYEFIDALPKNSYGKVL
MUL_0650|M.ulcerans_Agy99 RADAARDDAAIETMTAEIQAAVKQRKGSVQSPKQVVVVDSLPLTGLGKPD
Mb0172|M.bovis_AF2122/97 VTN-------DDLRIEDLGEFLTDRLARYKHPKALEIVDALPRNPAGKVL
Rv0166|M.tuberculosis_H37Rv VTN-------DDLRIEDLGEFLTDRLARYKHPKALEIVDALPRNPAGKVL
MMAR_0409|M.marinum_M VTK-------DHLRIEDLDEYLTERLARYKHPKALEIVDALPRNPSGKVL
MAB_4559|M.abscessus_ATCC_1997 QAQ-------SECCDGDLQEHCREHIANYKVPRSFEFVDELPLSGAGKIL
MAV_3523|M.avium_104 DG---------DVDAADVIEFCRRHLAGFKCPRTVDFVAELPRNASGKIL
MLBr_01051|M.leprae_Br4923 AEA---------LDADELINYVAQQLSIHKRPREVRFVDALPRNAMGKVL
: : . : *: .: ** . **
Mvan_4968|M.vanbaalenii_PYR-1 KRELRARLG------------------------
Mflv_1782|M.gilvum_PYR-GCK KRELRERLK------------------------
TH_3645|M.thermoresistible__bu KRELRARLS------------------------
MSMEG_5633|M.smegmatis_MC2_155 KRELRERVTG-----------------------
MUL_0650|M.ulcerans_Agy99 KKAVRARFWEGAGRAVG----------------
Mb0172|M.bovis_AF2122/97 KTELRLRYGACVNVERRSASAGFTERRENRQKL
Rv0166|M.tuberculosis_H37Rv KTELRLRYGACVNVERRSASAGFTERRENRQKL
MMAR_0409|M.marinum_M KTELRLRYGVGVYSESRSVSRSFEFREGS----
MAB_4559|M.abscessus_ATCC_1997 KRVLRQKY-----WESRDAGVS-----------
MAV_3523|M.avium_104 KTQLREPFWRDRDRRV-----------------
MLBr_01051|M.leprae_Br4923 KKQLLFEG-------------------------
* :