For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_3645 | - | - | 100% (500) | AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_2854 | - | 5e-81 | 38.23% (497) | PUTATIVE putative AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_2878 | - | 2e-73 | 37.40% (500) | PUTATIVE AMP-binding enzyme, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0566c | fadD8 | 2e-65 | 33.82% (479) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_1782 | - | 0.0 | 75.71% (494) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv0166 | fadD5 | 1e-65 | 35.92% (490) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 3e-41 | 29.35% (511) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4559 | - | 2e-66 | 34.65% (482) | putative long-chain-fatty-acid CoA ligase |
| M. marinum M | MMAR_0409 | fadD5 | 2e-68 | 36.12% (490) | fatty-acid-CoA ligase FadD5 |
| M. avium 104 | MAV_1867 | - | 3e-70 | 37.48% (515) | AMP-dependent synthetase and ligase |
| M. smegmatis MC2 155 | MSMEG_5633 | - | 0.0 | 76.10% (498) | feruloyl-CoA synthetase |
| M. ulcerans Agy99 | MUL_0650 | fadD8 | 5e-67 | 34.79% (480) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_4968 | - | 0.0 | 79.15% (494) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0166|M.tuberculosis_H37Rv ----------------------MTAQLASHLTRALTLAQQQPYLARRQNW
MMAR_0409|M.marinum_M ----------------------MTAELASHLPQAA-HALEQPYLARRQNW
MAB_4559|M.abscessus_ATCC_1997 -----------------------------------------------MQF
Mb0566c|M.bovis_AF2122/97 MSTAGDDAVGVPPACGGRSDAVGVPQLARESGAMRDQDCSGELLRSPTHN
MUL_0650|M.ulcerans_Agy99 --------------------------------------MSDDLLRNPTHN
Mflv_1782|M.gilvum_PYR-GCK -----------------------------------------------MNL
Mvan_4968|M.vanbaalenii_PYR-1 -----------------------------------------------MNL
TH_3645|M.thermoresistible__bu -------------------------------------------MGAAVNL
MSMEG_5633|M.smegmatis_MC2_155 -----------------------------------------------MNL
MAV_1867|M.avium_104 ----------------------------------------MCADDLDLTL
MLBr_02546|M.leprae_Br4923 ---MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGD
Rv0166|M.tuberculosis_H37Rv VNQLERHAMMQPDAPALRFVGN-TMTWADLRRRVAALAGALSGRGVGFGD
MMAR_0409|M.marinum_M VNQLERHAMMQPRATAIRYLGH-TVTWADLRYRVAALAGSLSRRGVGFGD
MAB_4559|M.abscessus_ATCC_1997 TQWLHRALQQYPDRLITIDQGR-EHTVEQFADRVARLSAGLRANGVRPGD
Mb0566c|M.bovis_AF2122/97 GHLLVGALKRHQNKPVLFLGDTRLTGG-QLADRISQYIQAFEALGAGTGV
MUL_0650|M.ulcerans_Agy99 GHLLVGALERHKNRPVLFLGDTTLTGG-QLAERISQYIQAFEALGAGTGV
Mflv_1782|M.gilvum_PYR-GCK FALLEQAAARHGERGAVYHGVQQIHSWASLRERALRLAGSLR-D-LGPGA
Mvan_4968|M.vanbaalenii_PYR-1 FALLDQTAARHGDRGAVYHGERLVHTWSSLRERALRLASSLR-E-FGPGA
TH_3645|M.thermoresistible__bu FALLDQTATRFGDRGAVFHGERQVTTWSGLRDRALRLAGSIRRE-VDAGA
MSMEG_5633|M.smegmatis_MC2_155 FGLLDQTAARHGDRGAVFCGERELYTWTQLRDRAARLGSTLT----EPGT
MAV_1867|M.avium_104 GDIVTDNAVRFGDVPAYKLGSR-MVTHAQLHDRAVQLVSAMAAAGVRRQD
MLBr_02546|M.leprae_Br4923 LAMLPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGD
: : :
Rv0166|M.tuberculosis_H37Rv RVMILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCVAHVM
MMAR_0409|M.marinum_M RVMILMLNRTEFVESVLAANMLGAIAVPLNFRLTPSEIAFLVEDCAPRLV
MAB_4559|M.abscessus_ATCC_1997 RVGMLSLNSDRYIEYLTAVPWLGAALNAVNIRWSLAEIGYSLRESGTRVL
Mb0566c|M.bovis_AF2122/97 AVGLLSLNRPEVLMIIGAGQARGYRRTALHPLGSLADHAYVLNDAGISSL
MUL_0650|M.ulcerans_Agy99 TVGLLSLNRPEVLMILGASQARGYRRTALHPLGSLDDHAYVLYDAGASAL
Mflv_1782|M.gilvum_PYR-GCK RIAVASENRPEIVELMFAIWAAECVFVPLNFKLHPREMEQILDDSGAARV
Mvan_4968|M.vanbaalenii_PYR-1 RIAVASENRPEIVELMFAIWAAECVFVPLNYKLHVREMEQILSDAGAARV
TH_3645|M.thermoresistible__bu RIAIASENRPEIVELMFAVWAAECVVVPINFKLHPREMAQILDDAEASRV
MSMEG_5633|M.smegmatis_MC2_155 RVAVASENRPEIIEIMFGVWAAECVYVPINYKLHPREMADILADSGAALV
MAV_1867|M.avium_104 RVAVLSRNSVEFGEVMAATHLSGVIMATVNFRLSPDEVLDVLKRVSPSMV
MLBr_02546|M.leprae_Br4923 GIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVI
: : * . :: : :
Rv0166|M.tuberculosis_H37Rv LTEAALAPVAIGVRNIQPLLSVIVVAG-GSSQDSVFG-----YEDLLNEA
MMAR_0409|M.marinum_M ITEEVLAQVAVGVREIAPALSTIVVAG-GASDPTVVG-----YDELISET
MAB_4559|M.abscessus_ATCC_1997 LVDDTFKAAAAPLRAACACLETVIYCGAGPAPQDMIG-----YEDLLASH
Mb0566c|M.bovis_AF2122/97 IIDPNPMFVERALALLEQVDSLQQILTIGPVPDALKHVAVDLSAEAAKYQ
MUL_0650|M.ulcerans_Agy99 IIDPNPMFVERALGLLEKVDSLEQVLTIGPVPEALEDRAVDLSAEAAKYQ
Mflv_1782|M.gilvum_PYR-GCK FAS-----PKIAAQLTPVTSAPVEVTGSAEYRSR---------CAADPL-
Mvan_4968|M.vanbaalenii_PYR-1 FTS-----PKIGAELAPVASTGIEIIGAAEYESR---------CAAMPS-
TH_3645|M.thermoresistible__bu FTS-----ASIGAALAPATEVPVETVVGDEYARR---------LTADPA-
MSMEG_5633|M.smegmatis_MC2_155 FAS-----PKIAPGLFEVTDVPVEVVGTDAYTQR---------FESEPV-
MAV_1867|M.avium_104 FCSDE--FALVAAGLAPQLASPPLLVSIGGSGRTGMLDFEEFVGGGDGG-
MLBr_02546|M.leprae_Br4923 IYDDEY---TKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELIARS
: .
Rv0166|M.tuberculosis_H37Rv GDVHEPVDIPNDSPALIMYTSGTTGRPKGAVLTHANLTGQAMTALYTSGA
MMAR_0409|M.marinum_M GDPPEPVDIPNDSPALIMYTSGTTGRPKGAVLTHTNLTGQVMTALYTGGA
MAB_4559|M.abscessus_ATCC_1997 -EPIDDTRTGGDSLLGVFYTGGTTGNPKGVMLSHNNVLASAMGSLSTGNF
Mb0566c|M.bovis_AF2122/97 PQPLVAADLPPDQVIGLTYTGGTTGKPKGVIGTAQSIATMTSIQLAEWEW
MUL_0650|M.ulcerans_Agy99 PKPLVVADLPPNHIGGLTYTGGTTGKPKGVIGTAGNITAMTSIQLAEWEW
Mflv_1782|M.gilvum_PYR-GCK ---SVPRYTEAASLAWLFYTSGTTGRSKGAMLSHRNLMAMTVSHLADFDS
Mvan_4968|M.vanbaalenii_PYR-1 ---PAPRDTDPASPAWLFYTSGTTGRSKGAMLSHRNLMAMTVSHLADFDC
TH_3645|M.thermoresistible__bu ---PVPTGTDPAALAWLFYTSGTTGRSKGAMLSHRNLMAMTVAHLADFDD
MSMEG_5633|M.smegmatis_MC2_155 ---PAP-LTDPAELAWLFYTSGTTGKSKGAMLSHRNLMAMTVAHLADFDA
MAV_1867|M.avium_104 ---RLPFAARPDDIACLLFTSGTTGASKCCILGQAELRRVAFTMNVEMRT
MLBr_02546|M.leprae_Br4923 --SSAPAPKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSKVPF
: *.**** .*
Rv0166|M.tuberculosis_H37Rv NINSDVGFVGVPLFHIAGIGNMLTGLLLGLPTVIYPLGAFDPGQLLDVLE
MMAR_0409|M.marinum_M NINSDVGFIGVPFFHIAGIGNMLSGMLLGVPTVIYPLGAFNPGQLLDVLE
MAB_4559|M.abscessus_ATCC_1997 LTRGGRLLHSAPMFHMADFSAVLAGNLSGSTHVIVPS--FSPQGVLDAIV
Mb0566c|M.bovis_AF2122/97 PA-NPR-FLMCTPLSHAGAAFFTPTVIKGGEMIVLAK--FDPAEVLRIIE
MUL_0650|M.ulcerans_Agy99 PE-HPR-FLMCTPLSHAGAAFFTPTLVKGGEMIVLAK--FDPGEVLRVIE
Mflv_1782|M.gilvum_PYR-GCK PD-ENSSLIHGAPMSHGSGLYVPPYVSRGARQVVPASGAFDPDEFLDLCG
Mvan_4968|M.vanbaalenii_PYR-1 PD-ENSSLIHGAPMSHGSGLYVPPYVSRGARQVVPASGTFDPDEFLDLCE
TH_3645|M.thermoresistible__bu PD-QNCSLIHGAPMSHGSGLYIPPYVARGARQVIPASGVFDPGEFLDLCE
MSMEG_5633|M.smegmatis_MC2_155 PD-EFCSLVHGAPMSHGSGLYIPPYVLRGARQVIPESGAFEPDEFLDLCD
MAV_1867|M.avium_104 GS-SDRGLINMPMFHVGAMAIVAGLHARGGSVVLQQQ--FDAGEAVQLIT
MLBr_02546|M.leprae_Br4923 RA-HEVTLLPAPMFHALGYLHATLAMFLGSTLVLRRR--FKPATVLEDIE
: . : * :: *.. :
Rv0166|M.tuberculosis_H37Rv AEKVTGIFLVPAQWQAVCTEQQ--ARPRDLR-LRVLSWGAAPAPDALLRQ
MMAR_0409|M.marinum_M AERVSGIFLVPAQWQAVCAEQQ--ARPRELS-LRVMSWGAAPAPDALLRQ
MAB_4559|M.abscessus_ATCC_1997 AHDVQDMLLVPTMIQMLVDHPG--AAQLDLSGIRSITYGASVISEAVLQR
Mb0566c|M.bovis_AF2122/97 EQRITATMLVPSMLYALLDHPD--SHTRDLSSLETVYYGASAINPVRLAE
MUL_0650|M.ulcerans_Agy99 EQRITATMLVPSMLYALMDHPD--PHTRDLSSLETVYYGASAINPVRLAE
Mflv_1782|M.gilvum_PYR-GCK QHPRCSAFLAPTMVARLVQTGR--PSP---AHLDTVVYGGGPMYVDSLKK
Mvan_4968|M.vanbaalenii_PYR-1 SHPGCSAFLAPTMVARLVQTGR--ACP---ANLRTIVYGGGPMYVDSLKK
TH_3645|M.thermoresistible__bu HHPGCSAFLAPTMVQRLIDTGR--SAP---ANLRTIVYGGGPMYVESLKK
MSMEG_5633|M.smegmatis_MC2_155 HHPGCSAFLAPTMVQRLIQTGR--PRP---ANLRTVVYGGGPMYVDSLKK
MAV_1867|M.avium_104 DERITLLHLAPVMLRALLDEIT--DPRG-LDCLRTVIYSAAPMTVHTLRR
MLBr_02546|M.leprae_Br4923 KHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATR
. :.* : : : ... .
Rv0166|M.tuberculosis_H37Rv MSATFPETQILAAFGQTEMSPVTCMLLG--EDAIA-------KRGSVGRV
MMAR_0409|M.marinum_M MSEVFPGTQIMAAFGQTEMSPVTCMLLG--EDAIR-------KRGSVGKV
MAB_4559|M.abscessus_ATCC_1997 ATRVFPNARFTQAYGMTEVSPVATLLLPDDHDDPA-------LLRSAGRA
Mb0566c|M.bovis_AF2122/97 AIRRFG-PIFAQYYGQSEAPMVITYLAKGDHDEKR--------LTSCGRP
MUL_0650|M.ulcerans_Agy99 AIDRFG-PIFAQYYGQSEAPMVITYLPKADHDEKR--------LTSCGRP
Mflv_1782|M.gilvum_PYR-GCK AMAAFG-PIFVQLYGQGEAPMTITGLRRGDHVTAD-GWAPDAVLGSVGYA
Mvan_4968|M.vanbaalenii_PYR-1 AMAAFG-PVFVQLYGQGEAPMTITGLRRRDHLDA-----PDAVLGSVGYA
TH_3645|M.thermoresistible__bu ALAAFG-PVFVQLYGQGEAPMTITGLRRADHFDETGAVAEDAVLGSVGHP
MSMEG_5633|M.smegmatis_MC2_155 ALAAYG-QIFVQLYGQGEAPMTITGLRRDDHLDAD-----DATLGSVGYP
MAV_1867|M.avium_104 ALSVLPRTGFLNLYGQTEAIVSGLPRELHDADSPD----AADALRSVGFP
MLBr_02546|M.leprae_Br4923 ALEELG-PVIYNMYGSTEIAFATIAGPKDLQINSA----------TVGPV
: :* * : *
Rv0166|M.tuberculosis_H37Rv IPTVAARVVDQNMNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFAGGW
MMAR_0409|M.marinum_M IPTVSARVVDDEMNDVPIGQVGEIVYRAPTLMSGYWNNPDATAEAFAGGW
MAB_4559|M.abscessus_ATCC_1997 APHCEVRIVDPDDNEVPRGEIGEVIVKGDNVMLGYWELPEESAAAIRDGW
Mb0566c|M.bovis_AF2122/97 TLFARVALLDEHGKPVKQGEVGEICVSGPLLAGGYWNLPDETSRTFKDGW
MUL_0650|M.ulcerans_Agy99 TLFARVALLGEDGKPVPQGEPGEICVSGPLLAGGYWNKPDDTAQTFRDGW
Mflv_1782|M.gilvum_PYR-GCK RSGVDVAVLGEDGEPAGVDEIGEIVCRGDVVMSGYWNNLGATQATLKDGW
Mvan_4968|M.vanbaalenii_PYR-1 RSGVDVAVLGPDGAPVAVGEIGEIVCRGDVVMSGYWQNPEATEAALQHGW
TH_3645|M.thermoresistible__bu RSGVQVAVLRPDGRPAAVGEVGEIVCRGDVVMSGYWRNPTATADTLRDGW
MSMEG_5633|M.smegmatis_MC2_155 RSGVQVAVLRSDGTPADIGEIGEIVCRGDVVMSGYWNNPEATAATLKDGW
MAV_1867|M.avium_104 FPGVRVRIVGDDGRDVLPGEAGEIVVRSDSRFRGYWDDPVATLATLRDGW
MLBr_02546|M.leprae_Br4923 VKGVKVKILDDSGKEVPRGQVGRIFVGNAFPFEGYTG---GGGKQIIDGL
. :: . .: *.: * : *
Rv0166|M.tuberculosis_H37Rv FHSGDLVRMDSDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEV
MMAR_0409|M.marinum_M FHSGDLVRMDEDGYVWVVDRKKDMIISGGENVYCAEVENVLASHPSIVEV
MAB_4559|M.abscessus_ATCC_1997 MHTGDAGRMDDRGYVYIVDRIKDMVVTGGENVYSAEVENALAKHPAVAAC
Mb0566c|M.bovis_AF2122/97 LHTGDLAREDSDGFYYIVDRVKDMIVTGGFNVFPREVEDVVAEHPAVAQV
MUL_0650|M.ulcerans_Agy99 LHTGDMAREDEDGFYFIVDRVKDMIVTGGFNVFPREVEDVVAEHSAVAQV
Mflv_1782|M.gilvum_PYR-GCK LRTGDMGSFDAHGFLTLRDRSKDVVISGGSNIYPREVEEVLLEHPGVLEV
Mvan_4968|M.vanbaalenii_PYR-1 LRTGDMGSFDAHGFLTLRDRSKDVVISGGSNIYPREVEEVLLEHPGVVEA
TH_3645|M.thermoresistible__bu LYTGDMGSFDDRGHLTLRDRSKDVVISGGSNIYPREVEEVLIEHPGVAEA
MSMEG_5633|M.smegmatis_MC2_155 LHTGDMGSFDARGHLTLRDRSKDVVISGGSNIYPREVEEVLLEHPDVVEA
MAV_1867|M.avium_104 CHTGDVGRFDHRGLLYLVDRKKDVIITGGENVYSPEVEEVLGGCEGVAAC
MLBr_02546|M.leprae_Br4923 LSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEA
:** * . : .* .:::::** *:: *:*: : :
Rv0166|M.tuberculosis_H37Rv AVIGRADEKWGE-VPIAVAAVTN-------DDLRIEDLGEFLTDRLARYK
MMAR_0409|M.marinum_M AVIGRADEKWGE-VPIAVAAVTK-------DHLRIEDLDEYLTERLARYK
MAB_4559|M.abscessus_ATCC_1997 AVIGIPDEQWGERVHAVVVKQAQ-------SECCDGDLQEHCREHIANYK
Mb0566c|M.bovis_AF2122/97 CVVGAPDEKWGEAVTAVVVLRSNAARDEPAIEAMTAEIQAAVKQRKGSVQ
MUL_0650|M.ulcerans_Agy99 CVVGAPDEKWGEAVTAVVVLRADAARDDAAIETMTAEIQAAVKQRKGSVQ
Mflv_1782|M.gilvum_PYR-GCK GVVGAPDTDWGEVVVAFVVG-----------DVGVAELDAHLLERIARFK
Mvan_4968|M.vanbaalenii_PYR-1 GVVGAPDEEWGEVVVAFIVG-----------AASAADLDAHLLERIARFK
TH_3645|M.thermoresistible__bu CVVGAPDPEWGEIVVAFIVG-----------SATAEELDAHLLDRIARFK
MSMEG_5633|M.smegmatis_MC2_155 GVVGAPDAEWGEIVVAFVVTNG--------TPVDAAALDAHLLERIARFK
MAV_1867|M.avium_104 AVVGAPDEKWGEAVCAVVVPTP-------GATPTLEAVQEFVRSSLAGYK
MLBr_02546|M.leprae_Br4923 TAIGVDDKEWGARLRAFVVKKQD-------ATIDEDAIKAYVRDHLARYK
.:* * .** : :. : . . :
Rv0166|M.tuberculosis_H37Rv HPKALEIVDALPRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENR
MMAR_0409|M.marinum_M HPKALEIVDALPRNPSGKVLKTELRLRYGVGVYSESRSVSRSFEFREGS-
MAB_4559|M.abscessus_ATCC_1997 VPRSFEFVDELPLSGAGKILKRVLRQKY-----WESRDAGVS--------
Mb0566c|M.bovis_AF2122/97 APKRVVVVDSLPLTGLGKPDKKAVRARFWEGAGRAVG-------------
MUL_0650|M.ulcerans_Agy99 SPKQVVVVDSLPLTGLGKPDKKAVRARFWEGAGRAVG-------------
Mflv_1782|M.gilvum_PYR-GCK RPKRYEFVDELPKNSYGKVLKRELRERLK---------------------
Mvan_4968|M.vanbaalenii_PYR-1 RPKRYEFVDELPKNSYGKVLKRELRARLG---------------------
TH_3645|M.thermoresistible__bu RPKRYEFIDELPKSSYGKVLKRELRARLS---------------------
MSMEG_5633|M.smegmatis_MC2_155 RPKRYEFIDALPKNSYGKVLKRELRERVTG--------------------
MAV_1867|M.avium_104 VPRRLVVVSDLPVLASGKVDKKRLRAEIAAAAAD----------------
MLBr_02546|M.leprae_Br4923 VPREVIFLEELPRNPTGKVLKRELRDFEVH--------------------
*: .:. ** ** * :*
Rv0166|M.tuberculosis_H37Rv QKL
MMAR_0409|M.marinum_M ---
MAB_4559|M.abscessus_ATCC_1997 ---
Mb0566c|M.bovis_AF2122/97 ---
MUL_0650|M.ulcerans_Agy99 ---
Mflv_1782|M.gilvum_PYR-GCK ---
Mvan_4968|M.vanbaalenii_PYR-1 ---
TH_3645|M.thermoresistible__bu ---
MSMEG_5633|M.smegmatis_MC2_155 ---
MAV_1867|M.avium_104 ---
MLBr_02546|M.leprae_Br4923 ---