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MQVAIITGASSGIGFGCATKLAEAGMAVLGVGRDKERLAELAQTIDAPDRVATLALDLTDDDAPQRIVDA AVTRWGKVDFLINNAGVGSPKPLHETDDESLDYFLGLMLRAPFRLARDVIPHMGPGSAIINVTSTFAVVG GLRGGAYSAAKGGLTALTTHIACQYGAQGIRCNAVAPGVTLTPMVATRLEDDRFRKINTEMTPHQRLGRV EDVASTVAFLCSEGGSFINGQTIVVDGGWSSTKYLSDHALNSDWVPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5632 | - | - | 100% (257) | oxidoreductase, short chain dehydrogenase/reductase family protein |
| M. smegmatis MC2 155 | MSMEG_4117 | - | 5e-32 | 33.47% (242) | 2-deoxy-D-gluconate 3-dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5584 | - | 2e-30 | 35.12% (242) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0950c | - | 7e-28 | 33.88% (242) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1783 | - | 1e-127 | 85.55% (256) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0927c | - | 8e-28 | 33.88% (242) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_02565 | fabG | 8e-22 | 34.30% (242) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_4632 | - | 2e-32 | 33.89% (239) | short chain dehydrogenase |
| M. marinum M | MMAR_0302 | - | 1e-116 | 78.91% (256) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_5213 | - | 1e-124 | 83.14% (255) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_4328 | - | 1e-127 | 85.44% (261) | PUTATIVE oxidoreductase, short chain dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_4820 | - | 1e-101 | 74.79% (238) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_4967 | - | 1e-125 | 85.60% (257) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1783|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4967|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4328|M.thermoresistible__bu --------------------------------------------------
MSMEG_5632|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5213|M.avium_104 --------------------------------------------------
MMAR_0302|M.marinum_M --------------------------------------------------
MUL_4820|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mb0950c|M.bovis_AF2122/97 --------------------------------------------------
Rv0927c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1783|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4967|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4328|M.thermoresistible__bu --------------------------------------------------
MSMEG_5632|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5213|M.avium_104 --------------------------------------------------
MMAR_0302|M.marinum_M --------------------------------------------------
MUL_4820|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
Mb0950c|M.bovis_AF2122/97 --------------------------------------------------
Rv0927c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1783|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4967|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4328|M.thermoresistible__bu --------------------------------------------------
MSMEG_5632|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5213|M.avium_104 --------------------------------------------------
MMAR_0302|M.marinum_M --------------------------------------------------
MUL_4820|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
Mb0950c|M.bovis_AF2122/97 --------------------------------------------------
Rv0927c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1783|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4967|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4328|M.thermoresistible__bu --------------------------------------------------
MSMEG_5632|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5213|M.avium_104 --------------------------------------------------
MMAR_0302|M.marinum_M --------------------------------------------------
MUL_4820|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
Mb0950c|M.bovis_AF2122/97 --------------------------------------------------
Rv0927c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1783|M.gilvum_PYR-GCK ---------MQTAQVAIVTGASSGIGFGCATALADRGMVVLGTGRDAGRL
Mvan_4967|M.vanbaalenii_PYR-1 ------------MQVAIVTGASSGIGFGCATTLAEQGMAVLGTGRDPGRL
TH_4328|M.thermoresistible__bu ----------VNMQVAIVTGASSGIGFGCATKLAEQGMAVLGTGRDSGRL
MSMEG_5632|M.smegmatis_MC2_155 ------------MQVAIITGASSGIGFGCATKLAEAGMAVLGVGRDKERL
MAV_5213|M.avium_104 ------------MQVAIVTGASSGIGLGCATRLAGTGMAVLGTGRDPKRL
MMAR_0302|M.marinum_M ------------MQVAIITGATGGIGFGCAAKLAEMGMAVLGTGRDERRL
MUL_4820|M.ulcerans_Agy99 ------------MQVAIITAATGGIGFGCAAKFAEMSMAVVGTARDERRL
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
Mb0950c|M.bovis_AF2122/97 ---MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSEL
Rv0927c|M.tuberculosis_H37Rv ---MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSEL
MAB_4632|M.abscessus_ATCC_1997 ---MILDRFKLDGNVAVVTGAGRGLGAAIAEAFAQAGADVLIASRTESQL
:**::*.. *:* . * .* . *:
Mflv_1783|M.gilvum_PYR-GCK AELE----KAAPEPGRIATLAVDLTDDDAPQRIVSAALDRWG-RIDFLVN
Mvan_4967|M.vanbaalenii_PYR-1 AALE----KSS---DRIATLAVDLTDDDAPQRIVSAALERWG-RIDFLVN
TH_4328|M.thermoresistible__bu AGLEKTLRKAGVPADRIATLAVDLTADEAPQRIVDAAVSRWG-HIDFLIN
MSMEG_5632|M.smegmatis_MC2_155 AELA----QTIDAPDRVATLALDLTDDDAPQRIVDAAVTRWG-KVDFLIN
MAV_5213|M.avium_104 AELE----TAIGDPDRVATVAVDLTDDDAPRRIVDRALQRWG-HIDFLIN
MMAR_0302|M.marinum_M AELT----QLPGGPDRIATHPVDLTDDDAPGQLTRAALERWG-RIDFLIN
MUL_4820|M.ulcerans_Agy99 AELT----QLPGGPDRIATHPVDPTDDDAPGQLTRAALDRWG-RIDFLIN
MLBr_02565|M.leprae_Br4923 ALDET------ANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVN
Mb0950c|M.bovis_AF2122/97 DAVAE---QIRAAGRRAHTVAADLAHPEVTAQLAGQAVGAFG-KLDIVVN
Rv0927c|M.tuberculosis_H37Rv DAVAE---QIRAAGRRAHTVAADLAHPEVTAQLAGQAVGAFG-KLDIVVN
MAB_4632|M.abscessus_ATCC_1997 REVAA---KVQAAGRQAEVVVADLSDTEASAALAQKAVDRFG-RLDVVVN
. * : :. :. * : *.::*
Mflv_1783|M.gilvum_PYR-GCK NAGIGSPKPLHETDDETLDHFLGVMLRAPFRLARDVIVH--MQPGSA-II
Mvan_4967|M.vanbaalenii_PYR-1 NAGIGSPKPLHETDDETLDRFLDIMLRAPFRLARDVIVH--MQPGSA-II
TH_4328|M.thermoresistible__bu NAGVGSPKPLGETDDDTLDHFLGLMLRAPFRLARDVLPH--MRPGSA-II
MSMEG_5632|M.smegmatis_MC2_155 NAGVGSPKPLHETDDESLDYFLGLMLRAPFRLARDVIPH--MGPGSA-II
MAV_5213|M.avium_104 NAGVGSPKPLHETDDETLDYFLNLMLRAPFRLAREVLPH--LPPGSA-II
MMAR_0302|M.marinum_M AAGVGSPKPVHETDDESLDYVLSLMLRAPFRLTREVLPH--LRPGSA-II
MUL_4820|M.ulcerans_Agy99 AAGEGSPKSVHETDDESLDYVLSLMLRAPFRLTREVLPH--LRPGSA-II
MLBr_02565|M.leprae_Br4923 NAGITRDKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGR-VI
Mb0950c|M.bovis_AF2122/97 NVGGTMPNTLLSTSTKDLADAFAFNVGTAHALTVAAVPLMLEHSGGGSVI
Rv0927c|M.tuberculosis_H37Rv NVGGTMPNTLLSTSTKDLADAFAFNVGTAHALTVAAVPLMLEHSGGGSVI
MAB_4632|M.abscessus_ATCC_1997 NVGGTMPKPFLDTTNDDLAEAFSFNVLSGHALLRAAVPHLLK-SDNASVI
.* : . . : . : : * : .. :*
Mflv_1783|M.gilvum_PYR-GCK NVTSTFAVVGGLRGGAYSAAKGGLTALTSHIACQYGAQGIRCNAVAPGVT
Mvan_4967|M.vanbaalenii_PYR-1 NITSTFAVVGGLRGGAYSAAKGGLTALTTHIACQYGAQGIRCNAVAPGVT
TH_4328|M.thermoresistible__bu NITSTFAVVGGLRGGAYSAAKGGLTALTTHIACQYGAQGIRCNAVAPGVT
MSMEG_5632|M.smegmatis_MC2_155 NVTSTFAVVGGLRGGAYSAAKGGLTALTTHIACQYGAQGIRCNAVAPGVT
MAV_5213|M.avium_104 NVTSTFAVVGGLRGGAYSAAKGGLTALTTHIACQYGASGIRCNAVAPGVT
MMAR_0302|M.marinum_M NITSTFAVVGGLRGGAYSAAKGGLTALTTHIACQYGAQGIRCNAVAPGVI
MUL_4820|M.ulcerans_Agy99 NITSTFAVVGGLRGGAYSAAKGGLAALTTHIACQYGAQGIRCNAVAPGVI
MLBr_02565|M.leprae_Br4923 VLSSMAGIAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGFI
Mb0950c|M.bovis_AF2122/97 NISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCPR-VRVNAIAPGSI
Rv0927c|M.tuberculosis_H37Rv NISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCPR-VRVNAIAPGSI
MAB_4632|M.abscessus_ATCC_1997 NITSTMGRLPGRAFLGYCTAKGALAHYTRTAAMDLSPR-IRVNGIAPGSI
::* . * :**..: * * : *.:***
Mflv_1783|M.gilvum_PYR-GCK LTPMVATRLEDERFRKINTEMTPHQRLGRVEDIASTVAFLCSDGGEFING
Mvan_4967|M.vanbaalenii_PYR-1 LTPMVASRLEDERFRKINTEMTPHQRLGRVEDVASTVAFLCSEGGSFING
TH_4328|M.thermoresistible__bu LTPMVATRLEDERFRKINTEMTPHQRLGRVEDIAATVAFLCSPGAEFING
MSMEG_5632|M.smegmatis_MC2_155 LTPMVATRLEDDRFRKINTEMTPHQRLGRVEDVASTVAFLCSEGGSFING
MAV_5213|M.avium_104 VTPMVENRLQDPRFRKINTEMTPHQRLGSVDDIAATVAFLCSPGGSFING
MMAR_0302|M.marinum_M QTAMTQHRLADERFRRINVEMTPHQRLGTVDDVANTVAFLCSEGGAFING
MUL_4820|M.ulcerans_Agy99 QTAMTQHRLADERFRRLNVEITPHQRLGTVDDVANTVAFLCSEGGAFING
MLBr_02565|M.leprae_Br4923 ETQMTAAIPLAT--REVGRRLNSLLQGGLPVDVAETIAYFAIPASNAVTG
Mb0950c|M.bovis_AF2122/97 LTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFLTG
Rv0927c|M.tuberculosis_H37Rv LTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFLTG
MAB_4632|M.abscessus_ATCC_1997 LTSALEVVAGNDEMRNTLEQNTPLHRLGDPADIAAAAVYLASPAGSFLTG
* * . .. : * *:* : .::. .. :.*
Mflv_1783|M.gilvum_PYR-GCK QTIVVDGGWSSTKYLSDFALNSEWVARQGTS-
Mvan_4967|M.vanbaalenii_PYR-1 QTIVVDGGWSTTKYLSDFALNAHWVER-----
TH_4328|M.thermoresistible__bu QTIVVDGGWSSTKYLSDHALTSEWVPR-----
MSMEG_5632|M.smegmatis_MC2_155 QTIVVDGGWSSTKYLSDHALNSDWVPR-----
MAV_5213|M.avium_104 QTIVVDGGWSSTKYLSEYALTSEWIAP-----
MMAR_0302|M.marinum_M QTIVVDGGWSSTKYLSDFALTAQWSPAQDDSK
MUL_4820|M.ulcerans_Agy99 QTIVVDGG------------------------
MLBr_02565|M.leprae_Br4923 NVIRVCGQAMLGA-------------------
Mb0950c|M.bovis_AF2122/97 KTLEVDGGLTFPNLDLPIPDL-----------
Rv0927c|M.tuberculosis_H37Rv KTLEVDGGLTFPNLDLPIPDL-----------
MAB_4632|M.abscessus_ATCC_1997 KVLEVDGGLIAPNLDIPLPDLA----------
:.: * *