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QTAQVAIVTGASSGIGFGCATALADRGMVVLGTGRDAGRLAELEKAAPEPGRIATLAVDLTDDDAPQRIV SAALDRWGRIDFLVNNAGIGSPKPLHETDDETLDHFLGVMLRAPFRLARDVIVHMQPGSAIINVTSTFAV VGGLRGGAYSAAKGGLTALTSHIACQYGAQGIRCNAVAPGVTLTPMVATRLEDERFRKINTEMTPHQRLG RVEDIASTVAFLCSDGGEFINGQTIVVDGGWSSTKYLSDFALNSEWVARQGTS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1783 | - | - | 100% (264) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_4508 | - | 1e-29 | 33.20% (247) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_3483 | - | 4e-29 | 34.13% (252) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2788c | fabG | 7e-27 | 34.96% (246) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. tuberculosis H37Rv | Rv2766c | fabG | 7e-27 | 34.96% (246) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 7e-23 | 31.36% (236) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4632 | - | 1e-30 | 34.31% (239) | short chain dehydrogenase |
| M. marinum M | MMAR_0302 | - | 1e-112 | 75.00% (260) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_5213 | - | 1e-121 | 82.35% (255) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_5632 | - | 1e-127 | 85.55% (256) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_4328 | - | 1e-126 | 85.77% (260) | PUTATIVE oxidoreductase, short chain dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_4820 | - | 3e-97 | 72.15% (237) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_4967 | - | 1e-131 | 89.84% (256) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2788c|M.bovis_AF2122/97 -------------MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAHVVL
Rv2766c|M.tuberculosis_H37Rv -------------MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAHVVL
Mflv_1783|M.gilvum_PYR-GCK -----------------MQTAQVAIVTGASSGIGFGCATALADRGMVVLG
Mvan_4967|M.vanbaalenii_PYR-1 --------------------MQVAIVTGASSGIGFGCATTLAEQGMAVLG
TH_4328|M.thermoresistible__bu ------------------VNMQVAIVTGASSGIGFGCATKLAEQGMAVLG
MSMEG_5632|M.smegmatis_MC2_155 --------------------MQVAIITGASSGIGFGCATKLAEAGMAVLG
MAV_5213|M.avium_104 --------------------MQVAIVTGASSGIGLGCATRLAGTGMAVLG
MMAR_0302|M.marinum_M --------------------MQVAIITGATGGIGFGCAAKLAEMGMAVLG
MUL_4820|M.ulcerans_Agy99 --------------------MQVAIITAATGGIGFGCAAKFAEMSMAVVG
MAB_4632|M.abscessus_ATCC_1997 -----------MILDRFKLDGNVAVVTGAGRGLGAAIAEAFAQAGADVLI
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
. ::*.. *:* . * :. . *
Mb2788c|M.bovis_AF2122/97 TARRQEAADEAA------AQVGDRALGVGAHAVDEDAARRCVDLTLERFG
Rv2766c|M.tuberculosis_H37Rv TARRQEAADEAA------AQVGDRALGVGAHAVDEDAARRCVDLTLERFG
Mflv_1783|M.gilvum_PYR-GCK TGRDAGRLAELE----KAAPEPGRIATLAVDLTDDDAPQRIVSAALDRWG
Mvan_4967|M.vanbaalenii_PYR-1 TGRDPGRLAALE----KSS---DRIATLAVDLTDDDAPQRIVSAALERWG
TH_4328|M.thermoresistible__bu TGRDSGRLAGLEKTLRKAGVPADRIATLAVDLTADEAPQRIVDAAVSRWG
MSMEG_5632|M.smegmatis_MC2_155 VGRDKERLAELA----QTIDAPDRVATLALDLTDDDAPQRIVDAAVTRWG
MAV_5213|M.avium_104 TGRDPKRLAELE----TAIGDPDRVATVAVDLTDDDAPRRIVDRALQRWG
MMAR_0302|M.marinum_M TGRDERRLAELT----QLPGGPDRIATHPVDLTDDDAPGQLTRAALERWG
MUL_4820|M.ulcerans_Agy99 TARDERRLAELT----QLPGGPDRIATHPVDPTDDDAPGQLTRAALDRWG
MAB_4632|M.abscessus_ATCC_1997 ASRTESQLREVAA---KVQAAGRQAEVVVADLSDTEASAALAQKAVDRFG
MLBr_01807|M.leprae_Br4923 THRAS--------------VVPDWFFGVECDVTDNDAIGAAFKAVEEHQG
. * . :* . : *
Mb2788c|M.bovis_AF2122/97 SVDILINNAGTNPAYGPLLEQDHARFAKIFDVNLWAPLMWTSLVVTAWMG
Rv2766c|M.tuberculosis_H37Rv SVDILINNAGTNPAYGPLLEQDHARFAKIFDVNLWAPLMWTSLVVTAWMG
Mflv_1783|M.gilvum_PYR-GCK RIDFLVNNAGIGSPK-PLHETDDETLDHFLGVMLRAPFRLARDVIVHMQP
Mvan_4967|M.vanbaalenii_PYR-1 RIDFLVNNAGIGSPK-PLHETDDETLDRFLDIMLRAPFRLARDVIVHMQP
TH_4328|M.thermoresistible__bu HIDFLINNAGVGSPK-PLGETDDDTLDHFLGLMLRAPFRLARDVLPHMRP
MSMEG_5632|M.smegmatis_MC2_155 KVDFLINNAGVGSPK-PLHETDDESLDYFLGLMLRAPFRLARDVIPHMGP
MAV_5213|M.avium_104 HIDFLINNAGVGSPK-PLHETDDETLDYFLNLMLRAPFRLAREVLPHLPP
MMAR_0302|M.marinum_M RIDFLINAAGVGSPK-PVHETDDESLDYVLSLMLRAPFRLTREVLPHLRP
MUL_4820|M.ulcerans_Agy99 RIDFLINAAGEGSPK-SVHETDDESLDYVLSLMLRAPFRLTREVLPHLRP
MAB_4632|M.abscessus_ATCC_1997 RLDVVVNNVGGTMPK-PFLDTTNDDLAEAFSFNVLSGHALLRAAVPHLLK
MLBr_01807|M.leprae_Br4923 PVEVLVANAGITSDM-LIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIK
::.:: .* . . : :.. : . .
Mb2788c|M.bovis_AF2122/97 EHGGAVVNTASIGGMHQSPAMGMYNATKAALIHVTKQLALELSPR-IRVN
Rv2766c|M.tuberculosis_H37Rv EHGGAVVNTASIGGMHQSPAMGMYNATKAALIHVTKQLALELSPR-IRVN
Mflv_1783|M.gilvum_PYR-GCK G--SAIINVTSTFAVVGGLRGGAYSAAKGGLTALTSHIACQYGAQGIRCN
Mvan_4967|M.vanbaalenii_PYR-1 G--SAIINITSTFAVVGGLRGGAYSAAKGGLTALTTHIACQYGAQGIRCN
TH_4328|M.thermoresistible__bu G--SAIINITSTFAVVGGLRGGAYSAAKGGLTALTTHIACQYGAQGIRCN
MSMEG_5632|M.smegmatis_MC2_155 G--SAIINVTSTFAVVGGLRGGAYSAAKGGLTALTTHIACQYGAQGIRCN
MAV_5213|M.avium_104 G--SAIINVTSTFAVVGGLRGGAYSAAKGGLTALTTHIACQYGASGIRCN
MMAR_0302|M.marinum_M G--SAIINITSTFAVVGGLRGGAYSAAKGGLTALTTHIACQYGAQGIRCN
MUL_4820|M.ulcerans_Agy99 G--SAIINITSTFAVVGGLRGGAYSAAKGGLAALTTHIACQYGAQGIRCN
MAB_4632|M.abscessus_ATCC_1997 SDNASVINITSTMGRLPGRAFLGYCTAKGALAHYTRTAAMDLSPR-IRVN
MLBr_01807|M.leprae_Br4923 QRFGRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSRSITAN
. : * . * ::*..* : * : .. * *
Mb2788c|M.bovis_AF2122/97 AICPGVVRTRLAEALWKDH--EDPLAATIALGRIGEPADIASAVAFLVSD
Rv2766c|M.tuberculosis_H37Rv AICPGVVRTRLAEALWKDH--EDPLAATIALGRIGEPADIASAVAFLVSD
Mflv_1783|M.gilvum_PYR-GCK AVAPGVTLTPMVATRLEDERFRKINTEMTPHQRLGRVEDIASTVAFLCSD
Mvan_4967|M.vanbaalenii_PYR-1 AVAPGVTLTPMVASRLEDERFRKINTEMTPHQRLGRVEDVASTVAFLCSE
TH_4328|M.thermoresistible__bu AVAPGVTLTPMVATRLEDERFRKINTEMTPHQRLGRVEDIAATVAFLCSP
MSMEG_5632|M.smegmatis_MC2_155 AVAPGVTLTPMVATRLEDDRFRKINTEMTPHQRLGRVEDVASTVAFLCSE
MAV_5213|M.avium_104 AVAPGVTVTPMVENRLQDPRFRKINTEMTPHQRLGSVDDIAATVAFLCSP
MMAR_0302|M.marinum_M AVAPGVIQTAMTQHRLADERFRRINVEMTPHQRLGTVDDVANTVAFLCSE
MUL_4820|M.ulcerans_Agy99 AVAPGVIQTAMTQHRLADERFRRLNVEITPHQRLGTVDDVANTVAFLCSE
MAB_4632|M.abscessus_ATCC_1997 GIAPGSILTSALEVVAGNDEMRNTLEQNTPLHRLGDPADIAAAAVYLASP
MLBr_01807|M.leprae_Br4923 VVAPGFIDTEMTR--AMDSKYQEAALQAIPLGRIGAVEEIAGAVSFLASE
:.** * : . . *:* ::* :. :* *
Mb2788c|M.bovis_AF2122/97 AASWITGETMIIDGGLLLGNALGFRAAPSTEH-------
Rv2766c|M.tuberculosis_H37Rv AASWITGETMIIDGGLLLGNALGFRAAPSTEH-------
Mflv_1783|M.gilvum_PYR-GCK GGEFINGQTIVVDGGWSSTKYLSDFALNSEWVARQGTS-
Mvan_4967|M.vanbaalenii_PYR-1 GGSFINGQTIVVDGGWSTTKYLSDFALNAHWVER-----
TH_4328|M.thermoresistible__bu GAEFINGQTIVVDGGWSSTKYLSDHALTSEWVPR-----
MSMEG_5632|M.smegmatis_MC2_155 GGSFINGQTIVVDGGWSSTKYLSDHALNSDWVPR-----
MAV_5213|M.avium_104 GGSFINGQTIVVDGGWSSTKYLSEYALTSEWIAP-----
MMAR_0302|M.marinum_M GGAFINGQTIVVDGGWSSTKYLSDFALTAQWSPAQDDSK
MUL_4820|M.ulcerans_Agy99 GGAFINGQTIVVDGG------------------------
MAB_4632|M.abscessus_ATCC_1997 AGSFLTGKVLEVDGGLIAPNLDIPLPDLA----------
MLBr_01807|M.leprae_Br4923 DAGYISGAVIPVDGGLGMGH-------------------
. ::.* .: :***