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MNEAHRDAHAASTAPVSRLQRRKMRTRMALIHAAQGFIAEGKLAVPVLEITQAADVGMGSFYNHFDSKDE LFEAAVTEALDGFGALLDSYTAAVADPAEAFATSFRLSGRLFRIRPQEAKLLLANGSSLILSEHGLSPRA LRDITAAIDKGRFKITDPELGLAIAAGALYGLGTLLTQRPDRDGASATDEVTASVLRMFGMTSQQARGLC RHPLPDLSSLQDTRAARPTPIPPAGVT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4909 | - | - | 100% (237) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5283 | - | 6e-06 | 32.59% (135) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_3496 | - | 1e-05 | 26.92% (104) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0068c | - | 4e-06 | 39.06% (64) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1483 | - | 2e-06 | 34.21% (76) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0067c | - | 4e-06 | 39.06% (64) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00316 | - | 2e-05 | 32.99% (97) | putative TetR/AcrR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2577 | - | 3e-72 | 62.91% (213) | TetR family transcriptional regulator |
| M. marinum M | MMAR_2984 | - | 8e-75 | 67.16% (204) | TetR family transcriptional regulator |
| M. avium 104 | MAV_1801 | - | 9e-72 | 63.38% (213) | TetR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_0532 | - | 6e-10 | 31.79% (151) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2855 | - | 1e-06 | 26.37% (182) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_4947 | - | 2e-07 | 28.28% (145) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0068c|M.bovis_AF2122/97 ---------------------------MAPTDRRVRADAARNRARVLEVA
Rv0067c|M.tuberculosis_H37Rv ---------------------------MAPTDRRVRADAARNRARVLEVA
MLBr_00316|M.leprae_Br4923 ----------------MSVPRSGLSVQMAQPARPLRADAARNRARILGVA
MAB_2577|M.abscessus_ATCC_1997 --------------------MSASQ---DEPANRLERRKQRTRAALIQAA
MMAR_2984|M.marinum_M --------------------MTTSDRGAPAQANRSERRKRRTRTALLRAA
MAV_1801|M.avium_104 ---------------------MAADLADGVTPNRLERRKQRTRTALIRAA
Mvan_4909|M.vanbaalenii_PYR-1 ----------------MNEAHRDAHAASTAPVSRLQRRKMRTRMALIHAA
MSMEG_0532|M.smegmatis_MC2_155 -------------------------------MS-AARDRLMAAALKLFAA
MUL_4947|M.ulcerans_Agy99 -------------------------------MSTSGRDRLLSAALKLFAV
TH_2855|M.thermoresistible__bu LSQSPDNATSSSRAGSGAGSGAGSGAEPIGRDTPRRRPRIRPEEIVSAAA
Mflv_1483|M.gilvum_PYR-GCK ---------------------------------MDRALPSRRDELLQLAA
..
Mb0068c|M.bovis_AF2122/97 YQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRII
Rv0067c|M.tuberculosis_H37Rv YQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRII
MLBr_00316|M.leprae_Br4923 YEAFATEGLSVPIDEIARRAGVGAGTVYRHFPTKEALCAAVIGDRMPHLV
MAB_2577|M.abscessus_ATCC_1997 QALIAEGKLNVPVLEITQAADVGMGSFYNHFDSKEALFDAAVADVLDNHG
MMAR_2984|M.marinum_M QRLIAEGKLNVPVLEITQAADVGMGSFYNHFDSKEQLFEAAVADVLDAHG
MAV_1801|M.avium_104 QAFIASGKLNAPILEITQAADVGMGSFYNHFESKEELFEAAVAEVLDAHG
Mvan_4909|M.vanbaalenii_PYR-1 QGFIAEGKLAVPVLEITQAADVGMGSFYNHFDSKDELFEAAVTEALDGFG
MSMEG_0532|M.smegmatis_MC2_155 KGYAAT---SVAEIQQQAGLAPGSGALYKHFGSKRELLEAAITHRIDNIV
MUL_4947|M.ulcerans_Agy99 KGYAAT---SVADIQRCSGLAPGSGALYKHFGSKHELLEAAVEHRIDSIV
TH_2855|M.thermoresistible__bu EFFAREGYANVGMRDVAEAVGIRGASLYHHFGSKEEILYAICLTVTKEPN
Mflv_1483|M.gilvum_PYR-GCK TMFADRGLRATTVRDIADSAGILSGSLYHHFKSKEQMVEEVLKDFLDWLF
. : .:.*.** :* :
Mb0068c|M.bovis_AF2122/97 DKGHALLKS---------KHPGDALFAFLRS-MVLQWG-----------A
Rv0067c|M.tuberculosis_H37Rv DKGHALLKS---------KHPGDALFAFLRS-MVLQWG-----------A
MLBr_00316|M.leprae_Br4923 DDGYVLLKS---------AGPGEALFTYLRS-LVLHWG-----------A
MAB_2577|M.abscessus_ATCC_1997 ALLDRLTES--------IDDPAETFACSFRL-TGRLFRRRPQES-QILLV
MMAR_2984|M.marinum_M ALLDRCTAS--------IEDPAETFAASFRL-TGRLFRRRPQES-EILLA
MAV_1801|M.avium_104 ALLDQLVAD--------LDDPAEKFACSFRL-TGRFFRRRPEES-KVLLA
Mvan_4909|M.vanbaalenii_PYR-1 ALLDSYTAA--------VADPAEAFATSFRL-SGRLFRIRPQEA-KLLLA
MSMEG_0532|M.smegmatis_MC2_155 AAREQYDAEKPRTVEDAVRSAGQLIWTNLTQ-SEELLRVMLREPDELGDL
MUL_4947|M.ulcerans_Agy99 AAREQYDAGEPGGVEQAVRTAGHLIWTNLKQ-SEDLLKVMLREPGALGDL
TH_2855|M.thermoresistible__bu ELNLPLLDA--------AGTPAERLSALIRAHLEHLIRRRVEHLVALHDI
Mflv_1483|M.gilvum_PYR-GCK TRYDEIVAA--------TTDPLERVSGLFMVSFEAIEHRHAQVVIYQDEA
. . . :
Mb0068c|M.bovis_AF2122/97 TDRG------LVEALAGVG-IEISSAAPE-AEADFLD-LLTDLLRAAQRA
Rv0067c|M.tuberculosis_H37Rv TDRG------LVEALAGVG-IEISSAAPE-AEADFLD-LLTDLLRAAQRA
MLBr_00316|M.leprae_Br4923 TDRG------LVDALAGAGGIDILGVAPD-AEDAFLT-ILSDLLYAAQYA
MAB_2577|M.abscessus_ATCC_1997 NGLS------LIGSDRGLGPRALRDITAG-VAAGRFT-VDDSKLALAVAA
MMAR_2984|M.marinum_M NGAA------LLSSDRGLAPRALRDIKAA-SDAGRFR-VEDPELALAMAG
MAV_1801|M.avium_104 NGLS------LMSSDRGLAPRALRDIKDA-IEAGRFR-VDDPRLALAVAG
Mvan_4909|M.vanbaalenii_PYR-1 NGSS------LILSEHGLSPRALRDITAA-IDKGRFK-ITDPELGLAIAA
MSMEG_0532|M.smegmatis_MC2_155 DEKT------WQVITDNAYQRFADELAAS-NRAGRTE-IPDPEATAAVAI
MUL_4947|M.ulcerans_Agy99 DEKT------WQIITDNAYQRFADELAAS-NRSGRTR-IPDPEAAASVAI
TH_2855|M.thermoresistible__bu NSLTPEHRA-IIDDLRRYYQRRVRDVIVAGVRSGEFD-VPDPKLAALLIL
Mflv_1483|M.gilvum_PYR-GCK KRLNSLPQFGFLDDRNRQQRRMWVEVLKQGIAEGSFRPDIDVDLVYRFIR
Mb0068c|M.bovis_AF2122/97 GTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLRANRK----
Rv0067c|M.tuberculosis_H37Rv GTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLRANRK----
MLBr_00316|M.leprae_Br4923 GTARTDVGVREVKSILVGCQAMEAYNSALAERVTDVVVDGLRAAR-----
MAB_2577|M.abscessus_ATCC_1997 GALLGLGKLLQQEPERDDATAADRVTEDVLRLLGLPAEEARQICKRPLPS
MMAR_2984|M.marinum_M GALLGLGTLLRADPQRDGCAAADAVTEDLLRLFGLDAEQARAICRRPLPD
MAV_1801|M.avium_104 GALMGLGQLLHDEPSRDDELATDQVTASVLRLFGLRANEADKICRRPLPE
Mvan_4909|M.vanbaalenii_PYR-1 GALYGLGTLLTQRPDRDGASATDEVTASVLRMFGMTSQQARGLCRHPLPD
MSMEG_0532|M.smegmatis_MC2_155 ASLSYVATLHALNGRTPGNVDHDRFFEAWVAQTVAAIEQHRTDN-----Q
MUL_4947|M.ulcerans_Agy99 ASLSYALTLQALTGRSPGNIDDSRYFEAWVNQTVSMLSQYTNPAPSRKPQ
TH_2855|M.thermoresistible__bu DALNGVSGWFHPDRGHSLPDVIAAYTEMIVERVLRARIS-----------
Mflv_1483|M.gilvum_PYR-GCK DTTWVSVRWYQPGGPLTAEQVGRQYLAIVLGGITEGSK------------
:
Mb0068c|M.bovis_AF2122/97 ---------------------
Rv0067c|M.tuberculosis_H37Rv ---------------------
MLBr_00316|M.leprae_Br4923 ---------------------
MAB_2577|M.abscessus_ATCC_1997 LDGASEHD-------------
MMAR_2984|M.marinum_M LDGWDQPDSAA----------
MAV_1801|M.avium_104 IDGLTRPDSAA----------
Mvan_4909|M.vanbaalenii_PYR-1 LSSLQDTRAARPTPIPPAGVT
MSMEG_0532|M.smegmatis_MC2_155 TDNR-----------------
MUL_4947|M.ulcerans_Agy99 ADNKFQE--------------
TH_2855|M.thermoresistible__bu ---------------------
Mflv_1483|M.gilvum_PYR-GCK ---------------------