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MRRTLMVLLLALVATMPGAAHSATALIVGGAGKYAVLTEEQMAAALGGRFKDYTRVNVPFPGLPDDLRYS LDVGTENLHAAVYATPGPKTIGGVSEGAPVVDEVLRRLMNDPNPPPAGELNAVMLGTMSPIWYLFTGVDY RAVADTRYDVMVVKAEYDGIADWPDNWINVLAVANAVLGALQLHVSSAFYDISLVPPEYVARKTNSEGGT TTTVLIPTPLLPLLKPLADAGASQETIDCLDGVIRPIIDSGYWRFWFKDRSSGWPLPPPEPAGTAPMDIA VPEPGSPGDVERDLGAGLPPVVDPESDQSGTAAADDATAQPTDDATVQPTDDATVQPTDVPAPSDEAVGN REQEDDRNAATGNGEVAPAGDDAAAAEPEENESVAPAPDEAMADDGADSAGPSSSTSDDAPDAIGK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4723 | - | - | 100% (416) | hypothetical protein Mvan_4723 |
| M. vanbaalenii PYR-1 | Mvan_1838 | - | 6e-38 | 30.05% (436) | hypothetical protein Mvan_1838 |
| M. vanbaalenii PYR-1 | Mvan_2535 | - | 9e-34 | 31.57% (434) | hypothetical protein Mvan_2535 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3852 | - | 6e-28 | 32.57% (304) | hypothetical protein Mb3852 |
| M. gilvum PYR-GCK | Mflv_3371 | - | 6e-33 | 31.35% (437) | hypothetical protein Mflv_3371 |
| M. tuberculosis H37Rv | Rv3822 | - | 4e-28 | 33.79% (290) | hypothetical protein Rv3822 |
| M. leprae Br4923 | MLBr_01232 | - | 5e-24 | 32.38% (210) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_0936c | - | 6e-27 | 34.02% (241) | hypothetical protein MAB_0936c |
| M. marinum M | MMAR_4939 | - | 1e-19 | 33.99% (203) | PE-PGRS family protein |
| M. avium 104 | MAV_1760 | - | 4e-29 | 32.94% (252) | hypothetical protein MAV_1760 |
| M. smegmatis MC2 155 | MSMEG_0412 | - | 2e-33 | 35.13% (279) | hypothetical protein MSMEG_0412 |
| M. thermoresistible (build 8) | TH_3724 | - | 3e-21 | 28.41% (345) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_0967 | - | 1e-09 | 26.69% (266) | PE family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3852|M.bovis_AF2122/97 --------------------------------------MKCPGVSDCVAT
Rv3822|M.tuberculosis_H37Rv --------------------------------------MKCPGVSDCVAT
MAV_1760|M.avium_104 -------------------------------------MKQLLAGVTALLS
MSMEG_0412|M.smegmatis_MC2_155 ------------------------------------MRRRLLAFGTAFTT
MAB_0936c|M.abscessus_ATCC_199 -------------------------------------MRNLLAGTAVLVV
MLBr_01232|M.leprae_Br4923 -------------------------------------MKRLLATTLAALT
MMAR_4939|M.marinum_M --MSYVVAAPDFLSTAAEDLAAMGSAVSTATAAAARSTTLLLAAGADEVS
Mvan_4723|M.vanbaalenii_PYR-1 ------------------------------------MRRTLMVLLLALVA
Mflv_3371|M.gilvum_PYR-GCK -------------------------------------MRRSIRKRAGLAC
TH_3724|M.thermoresistible__bu ---------------------------------------VVAVGALTWGG
MUL_0967|M.ulcerans_Agy99 MAVIDLLASPQAMTATATEVAEIGLAINQADLAVAGPTTGLAAAAAAEVS
Mb3852|M.bovis_AF2122/97 VRHDNVFA-----------------------------------IAAGLRW
Rv3822|M.tuberculosis_H37Rv VRHDNVFA-----------------------------------IAAGLRW
MAV_1760|M.avium_104 VSTAGYFG-----------------------------------IGTAAAD
MSMEG_0412|M.smegmatis_MC2_155 IGTAGFLG-----------------------------------FGVAAAD
MAB_0936c|M.abscessus_ATCC_199 ACVTGCFG-----------------------------------IPSAVAD
MLBr_01232|M.leprae_Br4923 VGTVSGFG-----------------------------------STVASSE
MMAR_4939|M.marinum_M THIAALFSTHGLQYQLASAQAAEFHERFVLTLAADANTYLTTEIANAQRC
Mvan_4723|M.vanbaalenii_PYR-1 TMPGAAHS------------------------------------------
Mflv_3371|M.gilvum_PYR-GCK GAVFASAA------------------------------------------
TH_3724|M.thermoresistible__bu XGVASPAG------------------------------------------
MUL_0967|M.ulcerans_Agy99 EAIATLFDNYAQG-----------------------YQAVSRQTAAFHDA
Mb3852|M.bovis_AF2122/97 SAAVPPLHKGDAVTKLLVGAIAGGMLAYAAILG-DGIAS---ADTALIVP
Rv3822|M.tuberculosis_H37Rv SAAVPPLHKGDAVTKLLVGAIAGGMLACAAILG-DGIAS---ADTALIVP
MAV_1760|M.avium_104 ---------GGPIGGPPTPGAPGD--QTAYALGGAHVLG---IPYDQYIR
MSMEG_0412|M.smegmatis_MC2_155 DTKPVDPAPGGAHAEAPSMGTPG----RGYALGGAHVLG---IPYDEYIM
MAB_0936c|M.abscessus_ATCC_199 DPQVPGPPIPGIAPDGTVKAAPSAPDRTAYALGGAHVLG---IPYDEYIR
MLBr_01232|M.leprae_Br4923 -------PGEPWLPPSPVPVRENSPAKIVYALGGARPPT---FDWDYYTI
MMAR_4939|M.marinum_M LAGAINAPATALLGHPLLGADPTASASTAATPAGGASMAPAAAGTRITVP
Mvan_4723|M.vanbaalenii_PYR-1 --------------------------ATALIVGGAGKYA---VLTEEQMA
Mflv_3371|M.gilvum_PYR-GCK --------------MAVSTATGASAVTTAVAIGGLGTPDMHEIVINPLLG
TH_3724|M.thermoresistible__bu --------QPERAAALRLTATADAIIMPGTKIGYIPSQD-EFTAYATAVI
MUL_0967|M.ulcerans_Agy99 FAQTLFAASDSYVRAEAAAVKALAGLTEPVANLFAPVLSGPESVAASATA
Mb3852|M.bovis_AF2122/97 GTAPSPYGPLRSLYHFNPAMQPQIGANYYTPTATRHVVSYPGSF------
Rv3822|M.tuberculosis_H37Rv GTAPSPYGPLRSLYHFNPAMQPQIGANYYNPTATRHVVSYPGSF------
MAV_1760|M.avium_104 MEGADWFPGQQRQIVRYPAGQVQG---HVLERLFPGIGKLDESF------
MSMEG_0412|M.smegmatis_MC2_155 RTGADWFPGLDRQIVDYPAGQVQG---HTLERLFPGIGALGERF------
MAB_0936c|M.abscessus_ATCC_199 MTGKDWFPNMKRENVWYPAGQVQG---HTLERFFPGIGPIGEKI------
MLBr_01232|M.leprae_Br4923 RAGDEFFPDVNRKLIDYPARAPFR---YVPTFLVPGP-------------
MMAR_4939|M.marinum_M GAGPLYYPRFLTELPYLGQALLLGIPGPSSASILQGYDLINHAIGENWFP
Mvan_4723|M.vanbaalenii_PYR-1 AALGGRFKDYTRVNVPFPG-------------------------------
Mflv_3371|M.gilvum_PYR-GCK GKLARENDILDGVEWPAEAKRP----------------------------
TH_3724|M.thermoresistible__bu GATAGAPGAVDYLGVPGEFWPATG--------------------------
MUL_0967|M.ulcerans_Agy99 LLSGAPLKPVEAALILSESGVPTPSASYISDVYTKYVEPNFPSATAPQGV
Mb3852|M.bovis_AF2122/97 --------------WPVTGLNSPTVGSSVSAGTNNLDAAIR------STD
Rv3822|M.tuberculosis_H37Rv --------------WPVTGLNSPTVGSSVSAGTNNLDAAIR------STD
MAV_1760|M.avium_104 ---------------PGLGMDGPSVGESVAEGIDNLDAAIR------TTG
MSMEG_0412|M.smegmatis_MC2_155 --------------MPGLGLDGPSYGESIDVGAPNLINAIR------QGG
MAB_0936c|M.abscessus_ATCC_199 --------------LPGLGLDGPSIGESIDIGEPNLENAIR------SGG
MLBr_01232|M.leprae_Br4923 -------------------RDEVTIGEAIAVATKNLNQAIH------RGT
MMAR_4939|M.marinum_M DTIASVINYPASIGILSGSLAAPDTNTAVAIGARMLHEQIMSAVT-NGSG
Mvan_4723|M.vanbaalenii_PYR-1 --------------------LPDDLRYSLDVGTENLHAAVY------ATP
Mflv_3371|M.gilvum_PYR-GCK -------------------GTGQTLGQSITVGITNLGTHFDAAFARLEAG
TH_3724|M.thermoresistible__bu -------------------LDSLTFDASVAXGQAMLTPMVDG---AIESD
MUL_0967|M.ulcerans_Agy99 STPNG--------LYPFTGIKDLSLDISLARGATILNDAILQQLAALPAG
:: . * .
Mb3852|M.bovis_AF2122/97 GPIFVAGLSQGTLVLDREQARLAND-PTAPPPGQLTFIKAGDP-------
Rv3822|M.tuberculosis_H37Rv GPIFVAGLSQGTLVLDREQARLAND-PTAPPPGQLTFIKAGDP-------
MAV_1760|M.avium_104 RPGTAIGLSEGAFVVDGEQARLAND-PTAPPPNTLNFATFGDPIGRHAFG
MSMEG_0412|M.smegmatis_MC2_155 -PGTVIGLSEGASVLDEVQARLAYD-PAAPPPDSLSFATYGNPVGKHAFG
MAB_0936c|M.abscessus_ATCC_199 -PGTAMGLSEGALVLNAVKNALATD-PTAPEPESLTFATFGDPIAKSPFS
MLBr_01232|M.leprae_Br4923 EPAAVVGLSQGSLALDTEQEQLATD-PTAPPPDQLTFNTFGDPSGYHGFG
MMAR_4939|M.marinum_M LPVHVATLSQGTIVANRELAYLATD-PNAPPAHALEFALFGSP------E
Mvan_4723|M.vanbaalenii_PYR-1 GPKTIGGVSEGAPVVDEVLRRLMND-PNPPPAGELNAVMLGTMS------
Mflv_3371|M.gilvum_PYR-GCK EQFTVVGFSAGSLVVNDFMRELAND-PDAPTKDQVKFILVADS-------
TH_3724|M.thermoresistible__bu TPIVVFGHSQSAVIATKEKQRLLAEYPDPDTAPDVTFVMVANPN-----R
MUL_0967|M.ulcerans_Agy99 SSVAVLGYSQSAVLSSRVMPKLLAE---GVTSSQVNFVLLGNPMN-----
* .: * : : .
Mb3852|M.bovis_AF2122/97 NNLLWRAFRPGTHVPIIDYTV----PAPVESQYDTINIVGQYDIFSDPPN
Rv3822|M.tuberculosis_H37Rv NNLLWRAFRPGTHVPIIDYTV----PAPAESQYDTINIVGQYDIFSDPPN
MAV_1760|M.avium_104 QSFLTAMFGVGSVVPALDYTM----PPPYESQYDTNRFVAAYDSIADFPD
MSMEG_0412|M.smegmatis_MC2_155 ESFLTQMFPVGSVVPSLDYRI----PAPVESQYDTYQFVSAYDSIADWPD
MAB_0936c|M.abscessus_ATCC_199 ESFLTQNFAPGSVVPFMDYPV----PARVDSQYHTDQFISAYDSIADWPD
MLBr_01232|M.leprae_Br4923 KSVLASIFRPGDYIPLIDYTM----PQRMDSQYDSNRVVAAYDGLSEFPD
MMAR_4939|M.marinum_M LGLAHIYLPDGLTVPLINYTV----HGLSNTQYDVSVVNGQYDFWGNPPD
Mvan_4723|M.vanbaalenii_PYR-1 --------PIWYLFTGVDY------RAVADTRYDVMVVKAEYDGIADWPD
Mflv_3371|M.gilvum_PYR-GCK -SRQKLLNETSKYNPQYDYTY----RPAPQTMYDIDVVTGEYDGAADLPD
TH_3724|M.thermoresistible__bu PNGGLLARFPGLYIPILGVTFNGATPAPADGPFDSYDVAREFDGWADFPR
MUL_0967|M.ulcerans_Agy99 PNGGVLARFPDLTLPSLGFTFYG---ATPDNAFPTVSYTLEYDGFADFPR
. . : : :* .: *
Mb3852|M.bovis_AF2122/97 RPGNLLADLNAIAAGGYYGHSATAFSDPARVAPRD-ITTTTNSLGATTTT
Rv3822|M.tuberculosis_H37Rv RPGNLLADLNAIAAGGYYGHSATAFSDPARVAPRD-ITTTTNSLGATTTT
MAV_1760|M.avium_104 RPDNMFALANTLMG-LATGHTAVAFTNPSMVPPQN-IRTTINSRGAKDTT
MSMEG_0412|M.smegmatis_MC2_155 RPDNWISVANAIVG-LATGHTAVAFTNPSMVPPQN-IRTTVNSRGAKDTT
MAB_0936c|M.abscessus_ATCC_199 RPDNLFALANAIAG-LATGHTAVAFTNPKMVPARN-IVTETNSRGGTTTT
MLBr_01232|M.leprae_Br4923 RADNLLAQLNCFAG-GAISHTPSGFFNPEDVPPQN-IRTTVNSRGAKTTT
MMAR_4939|M.marinum_M RPWNLPAWVNSLFG-AAYYHNTSSFASLS--DAVE-VSSVTTSLGGTITT
Mvan_4723|M.vanbaalenii_PYR-1 NWINVLAVANAVLG-ALQLHVSSAFYDISLVPPEY-VARKTNSEGGTTTT
Mflv_3371|M.gilvum_PYR-GCK RWWNFLALANAIAG-GLFVHVPMMFSDYEAVTPEENITRVTNTLGGTTTT
TH_3724|M.thermoresistible__bu YPLNLVATANAILG-IYYLHGGYYELLTENPDILDDPERTIVQQYGDTTY
MUL_0967|M.ulcerans_Agy99 YPINLLADINAVMG---IPFVHADYQDLTQAQLDS-AVQLPTEGPTQSTY
* : * . . . *
Mb3852|M.bovis_AF2122/97 YFIRTDQLPLVRALVDMAGLPPQAAGTVDAALRPIIDRAYQPGPAPAVNP
Rv3822|M.tuberculosis_H37Rv YFIRTDQLPLVRALVDMAGLPPQAAGTVDAALRPIIDRAYQPGPAPAVNP
MAV_1760|M.avium_104 IMIPEKHLPLVMPLKYIG-IDENTLNKLDAILTPRVNAGYSRNDDPATAP
MSMEG_0412|M.smegmatis_MC2_155 IMIPEEHLPLVLPFKYLG-VDKDTLNKLDGVLKPYVDAGYSRNDDPLTAP
MAB_0936c|M.abscessus_ATCC_199 YFIPEQHLPLVMGFKYLG-VPEETLNRLDAILQPRVDAGYSRNDDPATAP
MLBr_01232|M.leprae_Br4923 YLIPVNHLPLTLPLRYLG-WSDALVDQIDAVLQPKIDAAYAYNDNPLNKP
MMAR_4939|M.marinum_M YLIPSPTLPMLLPLEQIG-VPAPIVAGLNSVLAPIVNDGYS-----SLTP
Mvan_4723|M.vanbaalenii_PYR-1 VLIPTPLLPLLKPLADAG-ASQETIDCLDGVIRPIIDSGYWRFWFKDRSS
Mflv_3371|M.gilvum_PYR-GCK YLVPTKTLPLVQLLPFLK--------SQEASLKAKIDAGYSRNDDRLAAA
TH_3724|M.thermoresistible__bu YLIRTEQLPLLRPLRDLG-VPEEFVDALEPYVRRIVDLGYDRNTPYGEPA
MUL_0967|M.ulcerans_Agy99 YMIPTEHLPLLAPLRFIPYVGDPLAELLEPNLRVLVNFGYGDPAYGYDTG
:: **: : : : :: .*
Mb3852|M.bovis_AF2122/97 RDLV-------QGIRGIPAIAPAIAIPIGSTTGASAATSTAAATAAATNA
Rv3822|M.tuberculosis_H37Rv RDLV-------QGIRGIPAIAPAIAIPIGSTTGASAATSTAAATAAATNA
MAV_1760|M.avium_104 -----------VQVDPVHGFDPAEVTAPANQATFGGGADPLSQIMAGAMS
MSMEG_0412|M.smegmatis_MC2_155 -----------ITVDPVNGYDPAAVTAPATQAAFGGGTDPVSQLLAGLQY
MAB_0936c|M.abscessus_ATCC_199 -----------IAVDPRRGFDPAEVTAPASQATFGGGSDPISQITSGALA
MLBr_01232|M.leprae_Br4923 -----------ISVDPVNGMDPIAGIDAELR-------DSILNVFAQLRS
MMAR_4939|M.marinum_M ------------NAGPYFSQGALVGLPSAADVLGSWPWPALGSVTAHIC-
Mvan_4723|M.vanbaalenii_PYR-1 GWPLPPPE--PAGTAPMDIAVPEPGSPGDVERDLGAGLPPVVDPESDQSG
Mflv_3371|M.gilvum_PYR-GCK AA---------ATSTARSLAAPTVTNEATDEVADDEAVATVQKISTDSDA
TH_3724|M.thermoresistible__bu PVRVLPPL--TPAPGPATQHNAGQGITVASATSTPDKRTPVVEAPVEEPP
MUL_0967|M.ulcerans_Agy99 PANVPTPFGLFPPVSPLTVAEHLAAGTQQGIVNSGAALQAQGPPSIPLSD
.
Mb3852|M.bovis_AF2122/97 LRGANVGPGANKALSMVRGLLPKGKKH-----------------------
Rv3822|M.tuberculosis_H37Rv LRGANVGPGANKALSMVRGLLPKGKKH-----------------------
MAV_1760|M.avium_104 VLSHGAGEADH---------------------------------------
MSMEG_0412|M.smegmatis_MC2_155 VVNNQPAPKP----------------------------------------
MAB_0936c|M.abscessus_ATCC_199 VLGNGTRPTPPN--------------------------------------
MLBr_01232|M.leprae_Br4923 ILPPPPG-------------------------------------------
MMAR_4939|M.marinum_M --------------------------------------------------
Mvan_4723|M.vanbaalenii_PYR-1 TAAADDATAQPTDDATVQPTDDATVQPTDVPAPSDEAVGNREQEDDRNAA
Mflv_3371|M.gilvum_PYR-GCK EQADVPAERTSSKPAVDDAADDDEAAANEDAEADAADAKVDAKEDAEAAV
TH_3724|M.thermoresistible__bu VQTGRSTLKREKPVSARHLVRNSLRAVPG-------------LRRGEPAA
MUL_0967|M.ulcerans_Agy99 IAHTLTANPPWAGTPALPPSTSPASSIEDFILAVQAANSSISRGFVKTLS
Mb3852|M.bovis_AF2122/97 --------------------------------------------------
Rv3822|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
MSMEG_0412|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MMAR_4939|M.marinum_M --------------------------------------------------
Mvan_4723|M.vanbaalenii_PYR-1 TGNGEVAP-AGDDAAAAEPEENESVAPAPDEAMADDGADSAGPSSSTSDD
Mflv_3371|M.gilvum_PYR-GCK KDDADASAGTNDDGEEGADSGSNDSAAAAGDTDSSDGSSSEGPGSSDSGS
TH_3724|M.thermoresistible__bu TPTPDVTPDVTPDAPAGQPEPAEPNESAAPPAAAEADDASE---------
MUL_0967|M.ulcerans_Agy99 TAYATLLPTTDIASELVFTLPSYNLNLFLDGVIQAINGQPIGD-------
Mb3852|M.bovis_AF2122/97 -------
Rv3822|M.tuberculosis_H37Rv -------
MAV_1760|M.avium_104 -------
MSMEG_0412|M.smegmatis_MC2_155 -------
MAB_0936c|M.abscessus_ATCC_199 -------
MLBr_01232|M.leprae_Br4923 -------
MMAR_4939|M.marinum_M -------
Mvan_4723|M.vanbaalenii_PYR-1 APDAIGK
Mflv_3371|M.gilvum_PYR-GCK SE-----
TH_3724|M.thermoresistible__bu -------
MUL_0967|M.ulcerans_Agy99 -------