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MIDVLIVEDEHLIADAHQAYLQRLQGFSVAAVAHTARDAMRAAAEAAAAGSPIDLVLLDLGLPDASGIAL ASALSGLSPAPDIIAITSERDLEMVRAAVGHGALAYLLKPFTFAAFRDRLERYRRYREALPAGTDAASQA EVDRALAELRVGPDRTAAPKGASPGTNDEIARAVRDSADGATADQVAKQVGVSRVTAWRYLERLADEGTV RRHTDYGRAGRPKTRYQWR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4698 | - | - | 100% (229) | response regulator receiver/unknown domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_3504 | - | 4e-31 | 34.80% (227) | response regulator receiver/unknown domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0831 | - | 4e-10 | 36.76% (136) | two component transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1055c | kdpE | 2e-10 | 39.32% (117) | transcriptional regulatory protein KdpE |
| M. gilvum PYR-GCK | Mflv_3002 | - | 6e-32 | 36.12% (227) | response regulator receiver/unknown domain-containing protein |
| M. tuberculosis H37Rv | Rv1027c | kdpE | 2e-10 | 39.32% (117) | transcriptional regulatory protein KdpE |
| M. leprae Br4923 | MLBr_01286 | - | 2e-09 | 36.04% (111) | putative two-component response regulatory protein |
| M. abscessus ATCC 19977 | MAB_4519c | - | 2e-10 | 26.87% (201) | two-component LuxR family response regulator |
| M. marinum M | MMAR_3959 | - | 3e-10 | 27.09% (203) | two-component transcriptional regulatory protein |
| M. avium 104 | MAV_4114 | - | 3e-10 | 27.94% (204) | response regulator receiver domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_5306 | - | 1e-103 | 82.02% (228) | two-component system response regulator |
| M. thermoresistible (build 8) | TH_3563 | - | 1e-11 | 27.14% (199) | PUTATIVE DNA-binding response regulator, LuxR family protein |
| M. ulcerans Agy99 | MUL_3814 | - | 2e-10 | 27.09% (203) | two component transcriptional regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3959|M.marinum_M ----MS--EHESP-TVMVVDDHPIWRDAVARDLS-DDGFAVVATADGVAT
MUL_3814|M.ulcerans_Agy99 ----MS--EHESP-TVMVVDDHPIWRDAVARDLS-DDGFAVVATADGVAT
MAV_4114|M.avium_104 ----MT--DDATPTTVMVVDDHPIWRDAVARDLA-ESGFAVVATADGVAT
TH_3563|M.thermoresistible__bu ----MG--EPQQP-TVMVVDDHPIWREAVARDLA-EAGLSVVATADGVAA
MAB_4519c|M.abscessus_ATCC_199 ----MTGNTDSEQISVMVVDDHPMWRDGVSRDLQ-AAGLRVVATADGVAS
Mvan_4698|M.vanbaalenii_PYR-1 ------------MIDVLIVEDEHLIADAHQAYLQRLQGFSVAAVAHTARD
MSMEG_5306|M.smegmatis_MC2_155 -----------MTITVLVVEDEPLIAEAHQTYLGRLEGFSITAVVHTARD
Mflv_3002|M.gilvum_PYR-GCK ------------MRDVLVVDDDFMVAEIHRRFVDRIDGFRVVGVARTGAE
Mb1055c|M.bovis_AF2122/97 ------------MTLVLVIDDEPQILRALRINLT-VRGYQVITAS-TGAG
Rv1027c|M.tuberculosis_H37Rv ------------MTLVLVIDDEPQILRALRINLT-VRGYQVITAS-TGAG
MLBr_01286|M.leprae_Br4923 MTGPTTDADAATPHRVLIAEDEALIRLDLAEMLR-DEGYDIVGEAADGQE
*:: :*. : * :
MMAR_3959|M.marinum_M AQRRAAIVKP-----DVVVMDMRLADGDGVQATTEVLKVSPATRVLVLSA
MUL_3814|M.ulcerans_Agy99 AQRRAAIVKP-----DVVVMDMRLADGDGVQATTEVLKVSPATRVLVLST
MAV_4114|M.avium_104 AQRRAGVVRP-----DVVVMDMQLPDGDGAQATAAVLAVSPSSRVLVLSA
TH_3563|M.thermoresistible__bu ARRRAAAVRP-----DVVLMDMRLPDGDGARATAEVRAVSPDSRVLVLSA
MAB_4519c|M.abscessus_ATCC_199 SGRIAATVKP-----DVVLMDMQLTDGDGAQATAAVLSASPHSHILVLSA
Mvan_4698|M.vanbaalenii_PYR-1 AMRAAAEAAAAGSPIDLVLLDLGLPDASGIALASALSGLSPAPDIIAITS
MSMEG_5306|M.smegmatis_MC2_155 AMRAASEAAASAHPIDLVLLDIGLPDANGIALASALSGLRPAPDIIAITS
Mflv_3002|M.gilvum_PYR-GCK ALEATRQLRP-----QLILLDVYLPDMTGLEVLQQLRSGGDRVDVIVITA
Mb1055c|M.bovis_AF2122/97 ALRAAAEHPP-----DVVILDLGLPDMSGIDVLGGLRGWLTAP-VIVLSA
Rv1027c|M.tuberculosis_H37Rv ALRAAAEHPP-----DVVILDLGLPDMSGIDVLGGLRGWLTAP-VIVLSA
MLBr_01286|M.leprae_Br4923 AVELAERHKP-----DLVIMDVKMPRRDGIDAASEIASKRIAP-IVVLTA
: . : . :::::*: :. * : ::.:::
MMAR_3959|M.marinum_M SDEREDVLEAVKAGATGYLVKSASKAELADAVRATAAG--------RAVF
MUL_3814|M.ulcerans_Agy99 SDEREDVLEAVKTGATGYLVKSASKAELADAVRATAAG--------RAVF
MAV_4114|M.avium_104 SDERDDVLQAVKAGAAGYLVKSASKAELAQAVTDTAAG--------RAVF
TH_3563|M.thermoresistible__bu SEERDDVLEAVKAGATGYLVKSASKTELVDAVHATAQG--------RAVF
MAB_4519c|M.abscessus_ATCC_199 SAEREDVLEAVKAGATGYLVKSASAAELIDAVRATAKG--------QAVF
Mvan_4698|M.vanbaalenii_PYR-1 ERDLEMVRAAVGHGALAYLLKPFTFAAFRDRLERYRRY-REALPAGTDAA
MSMEG_5306|M.smegmatis_MC2_155 ERDLEMVRAAVAHGALAYLLKPFTFAAFRDRLERYRRY-REALPAGTAAA
Mflv_3002|M.gilvum_PYR-GCK ARELDTVRGALDGGAADYLIKPFEFSQLETKLTAYAAR-ADALQS-ARGA
Mb1055c|M.bovis_AF2122/97 RTDSSDKVQALDAGADDYVTKPFGMDEFLARLRAAVRRNTAAAELEQPVI
Rv1027c|M.tuberculosis_H37Rv RTDSSDKVQALDAGADDYVTKPFGMDEFLARLRAAVRRNTAAAELEQPVI
MLBr_01286|M.leprae_Br4923 FSQRDLVERARDAGAMAYLVKPFTISDLIPAIALAMSR------------
: . * ** *: *. : :
MMAR_3959|M.marinum_M TPSLAGLVLGEYRRIAQTADSSQDR-PSLTERETEILRYVAKGLSAKQIA
MUL_3814|M.ulcerans_Agy99 TPSLAGLVLGEYRRIAQTADSSQDR-PSLTERETEILRYVAKGLSAKQIA
MAV_4114|M.avium_104 TPSLAGLVLGEYRRIAQSKDDGPTR-PRLTDRETEVLRYVAKGLSAKQIA
TH_3563|M.thermoresistible__bu TPGLAGLVLGEYRRISRQPGAGPDA-PRLTERETEILRYVAKGLTAKQIA
MAB_4519c|M.abscessus_ATCC_199 TPGLAGLVLGEFRRMSSAPAADADETPRLSDRETEVLRLVAKGLSAKQIA
Mvan_4698|M.vanbaalenii_PYR-1 SQAEVDRALAELRVGPDRTAAPKGASPGTNDEIARAVRDSADGATADQVA
MSMEG_5306|M.smegmatis_MC2_155 SQAEVDRALAELRVATDKSTSPKGAAPQTTDEIARAVRDEPEGLTADEVA
Mflv_3002|M.gilvum_PYR-GCK DQDLIDALFGGPSVAPAK-TMPKGLGAETGELVLDAVR-TAGEVSAAECA
Mb1055c|M.bovis_AF2122/97 ETDSFTVDLAGKKVIKDG--AEVHLTPTEWGMLEMLARNRGKLVGRGELL
Rv1027c|M.tuberculosis_H37Rv ETDSFTVDLAGKKVIKDG--AEVHLTPTEWGMLEMLARNRGKLVGRGELL
MLBr_01286|M.leprae_Br4923 ----FSELTALEREVATLADRLETRKLVERAKGLLQVKQGMTEPEAFKWI
. : :
MMAR_3959|M.marinum_M EKLS-LSHRTVENHVQATFRKLQVANRVELTRYAIEHGLDK-------
MUL_3814|M.ulcerans_Agy99 EKLS-LSHRTVENHVQATFRKLQLANRVELTRYAIEHGLDK-------
MAV_4114|M.avium_104 EKLS-LSHRTVENHVQATFRKLQVANRVELARYAIEHGLDEEP-----
TH_3563|M.thermoresistible__bu AQLS-LSHRTVENHVQATFRKLQVANRVELARYAIEHGLDE-------
MAB_4519c|M.abscessus_ATCC_199 TRLS-LSHRTVENHVQSTLRKLQLGNRVELTRYAIEHGLDE-------
Mvan_4698|M.vanbaalenii_PYR-1 KQVG-VSRVTAWRYLERLADEGTVRRHTDYGRAGRPKTR----YQWR-
MSMEG_5306|M.smegmatis_MC2_155 KRVG-VSRVTAWRYLERLADENAVARNTEYGKAGRPRTR----YQWR-
Mflv_3002|M.gilvum_PYR-GCK DLVG-ISRVSARRYLEHYLGTGTLELRLQYG-VGRPERR----YRIAG
Mb1055c|M.bovis_AF2122/97 KEVWGPAYATETHYLRVYLAQLRRKLEDDPSHPKHLLTESGMGYRFEA
Rv1027c|M.tuberculosis_H37Rv KEVWGPAYATETHYLRVYLAQLRRKLEDDPSHPKHLLTESGMGYRFEA
MLBr_01286|M.leprae_Br4923 QRAAMDRRTTMKRVAEVVLETLDTPKDT--------------------
: . .