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RDVLVVDDDFMVAEIHRRFVDRIDGFRVVGVARTGAEALEATRQLRPQLILLDVYLPDMTGLEVLQQLRS GGDRVDVIVITAARELDTVRGALDGGAADYLIKPFEFSQLETKLTAYAARADALQSARGADQDLIDALFG GPSVAPAKTMPKGLGAETGELVLDAVRTAGEVSAAECADLVGISRVSARRYLEHYLGTGTLELRLQYGVG RPERRYRIAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3002 | - | - | 100% (221) | response regulator receiver/unknown domain-containing protein |
| M. gilvum PYR-GCK | Mflv_1887 | - | 6e-17 | 41.53% (118) | two component transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0893 | - | 6e-17 | 35.71% (168) | two component transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1007 | mprA | 4e-17 | 40.00% (135) | two component response transcriptional regulatory protein |
| M. tuberculosis H37Rv | Rv0981 | mprA | 1e-16 | 39.26% (135) | two component response transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_00174 | - | 6e-18 | 40.00% (135) | putative two-component response regulator |
| M. abscessus ATCC 19977 | MAB_1076 | - | 7e-17 | 39.06% (128) | two component response transcriptional regulatory protein MprA |
| M. marinum M | MMAR_4529 | mprA | 3e-17 | 42.37% (118) | two component response transcriptional regulatory protein |
| M. avium 104 | MAV_1094 | - | 8e-17 | 41.53% (118) | two component response transcriptional regulatory protein MprA |
| M. smegmatis MC2 155 | MSMEG_4212 | - | 9e-95 | 79.00% (219) | transcriptional regulatory protein CitT |
| M. thermoresistible (build 8) | TH_1732 | phoP | 2e-17 | 40.74% (135) | DNA-binding response regulator PhoP |
| M. ulcerans Agy99 | MUL_4701 | mprA | 2e-17 | 41.09% (129) | two component response transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_3504 | - | 1e-105 | 85.97% (221) | response regulator receiver/unknown domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1007|M.bovis_AF2122/97 MSVRILVVDDDRAVRESLRRSLS-FNGY-SVELAHDGVEALDMIASDRPD
Rv0981|M.tuberculosis_H37Rv MSVRILVVDDDRAVRESLRRSLS-FNGY-SVELAHDGVEALDMIASDRPD
MAV_1094|M.avium_104 --MRILVVDDDRAVRESLRRSLS-FNGY-SVELAHDGVEALDMIASDRPD
MMAR_4529|M.marinum_M MSVRILVVDDDRAVRESLRRSLS-FNGY-TVELAHDGVEALEMIASDRPD
MUL_4701|M.ulcerans_Agy99 MSVRILVVDDDRAVRESLRRSLS-FNGY-TVELAHDGVEALEMIASDRPD
MLBr_00174|M.leprae_Br4923 --MRILAVDDDRAVRESLRRSLS-FNGY-SVELANDGVEALEMVARDRPD
TH_1732|M.thermoresistible__bu VAVRILVVDDDRAVRESLRRSLS-FNGY-SVELAEDGVEALDLIANDRPD
MAB_1076|M.abscessus_ATCC_1997 MPVRILVVDDDRAVRESLRRSLS-FNGY-SVDLAEDGVDALNVIANDRPD
Mflv_3002|M.gilvum_PYR-GCK -MRDVLVVDDDFMVAEIHRRFVDRIDGFRVVGVARTGAEALEATRQLRPQ
Mvan_3504|M.vanbaalenii_PYR-1 -MRDVLVVDDDFMVADIHRRFVDRVDGFRAVGVARTGEEALTATKELRPQ
MSMEG_4212|M.smegmatis_MC2_155 -MRDVLVVDDDFMVAEIHRRFVDRVDGFRAVGVARTGAEAMASADALRPD
:*.**** * : ** :. .:*: * :*. * :*: **:
Mb1007|M.bovis_AF2122/97 ALVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGAD
Rv0981|M.tuberculosis_H37Rv ALVLDVMMPRLDGLEVCRQLRGTGDDLPILVLTARDSVSERVAGLDAGAD
MAV_1094|M.avium_104 ALVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGAD
MMAR_4529|M.marinum_M ALVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGAD
MUL_4701|M.ulcerans_Agy99 ALVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGAD
MLBr_00174|M.leprae_Br4923 ALVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGAD
TH_1732|M.thermoresistible__bu AVVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGAD
MAB_1076|M.abscessus_ATCC_1997 ALVLDVMMPKLDGLEVCRRLRSTGDDLPILVLTARDSVSERVAGLDAGAD
Mflv_3002|M.gilvum_PYR-GCK LILLDVYLPDMTGLEVLQQLRSGGDRVDVIVITAARELDTVRGALDGGAA
Mvan_3504|M.vanbaalenii_PYR-1 LILLDVYLPDMTGLDVLQRLRAEGDRVDVIMITAARELDTVRGALDGGAA
MSMEG_4212|M.smegmatis_MC2_155 LILLDVYLPDMTGLEVLKRLRADGNLVGVIMITAARELDTVRGALDGGAA
::*** :* : **:* ::**. *: : ::::** .:. ..**.**
Mb1007|M.bovis_AF2122/97 DYLPKPFALEELLARMRALLRRTKPED--AAESMAMRFSDLTLDPVTREV
Rv0981|M.tuberculosis_H37Rv DYLPKPFALEELLARMRALLRRTKPED--AAESMAMRFSDLTLDPVTREV
MAV_1094|M.avium_104 DYLPKPFALEELLARMRALLRRTKPED--DAESVAMTFSDLTLDPVTREV
MMAR_4529|M.marinum_M DYLPKPFALEELLARMRALLRRTKPEDDEAADSVAMTFSDLSLDPVTREV
MUL_4701|M.ulcerans_Agy99 DYLPKPFALEELLARMRALLRRTKLEDDEAADSVAMTFSDLSLDPVTREV
MLBr_00174|M.leprae_Br4923 DYLPKPFALEELLARIRALLRRTKPDD--AAESVAMSFSDLTLDPVTREV
TH_1732|M.thermoresistible__bu DYLPKPFALEELLARLRALLRRTTPDD--AADSQKLTFADLTLDPVTREV
MAB_1076|M.abscessus_ATCC_1997 DYLPKPFALEELLARMRALLRRTTIDE--SADAATLSFGDLTLDPVTREV
Mflv_3002|M.gilvum_PYR-GCK DYLIKPFEFSQLETKLTAYAARADALQS-ARGADQDLIDALFGGPSVAPA
Mvan_3504|M.vanbaalenii_PYR-1 DYLIKPFEFAQLQAKLQAFAARADALQS-ASGVDQTLIDTLFGGPAVTPA
MSMEG_4212|M.smegmatis_MC2_155 DYLIKPFEFDQLRAKLVAFAARADALAA-DGGADQSMIDALFGGSAPTAT
*** *** : :* ::: * *: : * .. .
Mb1007|M.bovis_AF2122/97 NRGQRRISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALE
Rv0981|M.tuberculosis_H37Rv NRGQRRISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALE
MAV_1094|M.avium_104 TRGQRRISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALE
MMAR_4529|M.marinum_M TRGARRISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALE
MUL_4701|M.ulcerans_Agy99 TRGARRISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALE
MLBr_00174|M.leprae_Br4923 ARGQRWISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALE
TH_1732|M.thermoresistible__bu TRGNRQISLTRTEFALLELLIANPRRVLSRSRILEEVWGFDFPTSGNALE
MAB_1076|M.abscessus_ATCC_1997 HRGTRSISLTRTEFALLEMLMANPRRVLTRSRILEEVWGFDFPTSGNALE
Mflv_3002|M.gilvum_PYR-GCK KTMPKGLGAETGELVLDAVRTAG----EVSAAECADLVGISRVSARRYLE
Mvan_3504|M.vanbaalenii_PYR-1 KVLPKGLGAETGELVLAAVRGAG----EVSAAECADAVGISRVSARRYLE
MSMEG_4212|M.smegmatis_MC2_155 AALPKGLGAETGRLVMDAVRNAG----EVSAAQCAELVGISRVSARRYLE
: :. .:.: : *. : : *:. :: . **
Mb1007|M.bovis_AF2122/97 VYVGYLRRKTEADGEPRLIHTVRGVGYVLRETPP
Rv0981|M.tuberculosis_H37Rv VYVGYLRRKTEADGEPRLIHTVRGVGYVLRETPP
MAV_1094|M.avium_104 VYVGYLRRKTEADGEPRLIHTVRGVGYVLRETPP
MMAR_4529|M.marinum_M VYVGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP
MUL_4701|M.ulcerans_Agy99 VYVGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP
MLBr_00174|M.leprae_Br4923 VYVGYLRRKTEADGESRLIHTVRGVGYVLRETPP
TH_1732|M.thermoresistible__bu VYIGYLRRKTEAEGEPRLIHTVRGVGYVLRETPP
MAB_1076|M.abscessus_ATCC_1997 VYVGYLRRKTEAEGELRLIHTVRGVGYVLRETPP
Mflv_3002|M.gilvum_PYR-GCK HYLG------TGTLELRLQYGVGRPERRYRIAG-
Mvan_3504|M.vanbaalenii_PYR-1 HYLS------VGALELRLQYGVGRPERRYRIAG-
MSMEG_4212|M.smegmatis_MC2_155 HFLS------TGALELRLQYGTGRPERRYRIP--
::. . * ** : . * .