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VTITVLVVEDEPLIAEAHQTYLGRLEGFSITAVVHTARDAMRAASEAAASAHPIDLVLLDIGLPDANGIA LASALSGLRPAPDIIAITSERDLEMVRAAVAHGALAYLLKPFTFAAFRDRLERYRRYREALPAGTAAASQ AEVDRALAELRVATDKSTSPKGAAPQTTDEIARAVRDEPEGLTADEVAKRVGVSRVTAWRYLERLADENA VARNTEYGKAGRPRTRYQWR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5306 | - | - | 100% (230) | two-component system response regulator |
| M. smegmatis MC2 155 | MSMEG_4212 | - | 2e-29 | 37.05% (224) | transcriptional regulatory protein CitT |
| M. smegmatis MC2 155 | MSMEG_3240 | - | 2e-12 | 25.46% (216) | DNA-binding response regulator, LuxR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1055c | kdpE | 6e-12 | 37.31% (134) | transcriptional regulatory protein KdpE |
| M. gilvum PYR-GCK | Mflv_3002 | - | 9e-30 | 36.61% (224) | response regulator receiver/unknown domain-containing protein |
| M. tuberculosis H37Rv | Rv1027c | kdpE | 7e-12 | 37.31% (134) | transcriptional regulatory protein KdpE |
| M. leprae Br4923 | MLBr_01286 | - | 1e-10 | 27.45% (204) | putative two-component response regulatory protein |
| M. abscessus ATCC 19977 | MAB_4519c | - | 5e-11 | 24.88% (201) | two-component LuxR family response regulator |
| M. marinum M | MMAR_2429 | - | 2e-10 | 27.54% (207) | two-component system transcriptional regulator |
| M. avium 104 | MAV_4114 | - | 2e-12 | 25.35% (217) | response regulator receiver domain-containing protein |
| M. thermoresistible (build 8) | TH_3563 | - | 3e-13 | 25.93% (216) | PUTATIVE DNA-binding response regulator, LuxR family protein |
| M. ulcerans Agy99 | MUL_1608 | - | 2e-10 | 27.54% (207) | two-component system transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4698 | - | 1e-103 | 82.02% (228) | response regulator receiver/unknown domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5306|M.smegmatis_MC2_155 --------------MTITVLVVEDEPLIAEAHQTYLGRLEGFSITAVVHT
Mvan_4698|M.vanbaalenii_PYR-1 ---------------MIDVLIVEDEHLIADAHQAYLQRLQGFSVAAVAHT
Mflv_3002|M.gilvum_PYR-GCK ---------------MRDVLVVDDDFMVAEIHRRFVDRIDGFRVVGVART
MAV_4114|M.avium_104 -------MT--DDATPTTVMVVDDHPIWRDAVARDLA-ESGFAVVATADG
TH_3563|M.thermoresistible__bu -------MG--EPQQP-TVMVVDDHPIWREAVARDLA-EAGLSVVATADG
MAB_4519c|M.abscessus_ATCC_199 -------MTGNTDSEQISVMVVDDHPMWRDGVSRDLQ-AAGLRVVATADG
MMAR_2429|M.marinum_M ---MTGPTTDADAAKTRRVLIAEDEALIRMDLAEMLR-EEGYDIVGEAGD
MUL_1608|M.ulcerans_Agy99 MSVMTGPTTDADAAKTRRVLIAEDEALIRMDLAEMLR-EEGYDIVGEAGD
MLBr_01286|M.leprae_Br4923 ---MTGPTTDADAATPHRVLIAEDEALIRLDLAEMLR-DEGYDIVGEAAD
Mb1055c|M.bovis_AF2122/97 ---------------MTLVLVIDDEPQILRALRINLT-VRGYQVITASTG
Rv1027c|M.tuberculosis_H37Rv ---------------MTLVLVIDDEPQILRALRINLT-VRGYQVITASTG
*:: :*. : * :
MSMEG_5306|M.smegmatis_MC2_155 ARDAMRAASEAAASAHPIDLVLLDIGLPDANGIALASALSGLRPAPDIIA
Mvan_4698|M.vanbaalenii_PYR-1 ARDAMRAAAEAAAAGSPIDLVLLDLGLPDASGIALASALSGLSPAPDIIA
Mflv_3002|M.gilvum_PYR-GCK GAEALEATRQLRP-----QLILLDVYLPDMTGLEVLQQLRSGGDRVDVIV
MAV_4114|M.avium_104 VATAQRRAGVVRP-----DVVVMDMQLPDGDGAQATAAVLAVSPSSRVLV
TH_3563|M.thermoresistible__bu VAAARRRAAAVRP-----DVVLMDMRLPDGDGARATAEVRAVSPDSRVLV
MAB_4519c|M.abscessus_ATCC_199 VASSGRIAATVKP-----DVVLMDMQLTDGDGAQATAAVLSASPHSHILV
MMAR_2429|M.marinum_M GQEAVELAELHKP-----DLVIMDVKMPRRDGIDAASEIATKRIAP-IVV
MUL_1608|M.ulcerans_Agy99 GQEAVELAELHKP-----DLVIMDVKMPRRDGIDAASEIATKRIAP-IVV
MLBr_01286|M.leprae_Br4923 GQEAVELAERHKP-----DLVIMDVKMPRRDGIDAASEIASKRIAP-IVV
Mb1055c|M.bovis_AF2122/97 -AGALRAAAEHPP-----DVVILDLGLPDMSGIDVLGGLRGWLTAP-VIV
Rv1027c|M.tuberculosis_H37Rv -AGALRAAAEHPP-----DVVILDLGLPDMSGIDVLGGLRGWLTAP-VIV
: . : . :::::*: :. * : ::.
MSMEG_5306|M.smegmatis_MC2_155 ITSERDLEMVRAAVAHGALAYLLKPFTFAAFRDRLERYRRYREALPAGTA
Mvan_4698|M.vanbaalenii_PYR-1 ITSERDLEMVRAAVGHGALAYLLKPFTFAAFRDRLERYRRYREALPAGTD
Mflv_3002|M.gilvum_PYR-GCK ITAARELDTVRGALDGGAADYLIKPFEFSQLETKLTAYAARADALQS-AR
MAV_4114|M.avium_104 LSASDERDDVLQAVKAGAAGYLVKSASKAELAQAVTDTAAGRAVFTP---
TH_3563|M.thermoresistible__bu LSASEERDDVLEAVKAGATGYLVKSASKTELVDAVHATAQGRAVFTP---
MAB_4519c|M.abscessus_ATCC_199 LSASAEREDVLEAVKAGATGYLVKSASAAELIDAVRATAKGQAVFTP---
MMAR_2429|M.marinum_M LTAFSQRDLVERARDAGAMAYLVKPFTVSDLVPAIELAVSRFSEISA---
MUL_1608|M.ulcerans_Agy99 LTAFSQRDLVERARDAGAMAYLVKPFTVSDLVPAIELAVSRFSEISA---
MLBr_01286|M.leprae_Br4923 LTAFSQRDLVERARDAGAMAYLVKPFTISDLIPAIALAMSRFSELTA---
Mb1055c|M.bovis_AF2122/97 LSARTDSSDKVQALDAGADDYVTKPFGMDEFLARLRAAVRRNTAAAELEQ
Rv1027c|M.tuberculosis_H37Rv LSARTDSSDKVQALDAGADDYVTKPFGMDEFLARLRAAVRRNTAAAELEQ
::: : . * ** *: *. : :
MSMEG_5306|M.smegmatis_MC2_155 AASQAEVDRALAELRVATDKSTSPKGAAPQTTDEIARAVRDEPEGLTADE
Mvan_4698|M.vanbaalenii_PYR-1 AASQAEVDRALAELRVGPDRTAAPKGASPGTNDEIARAVRDSADGATADQ
Mflv_3002|M.gilvum_PYR-GCK GADQDLIDALFGGPSVAPAK-TMPKGLGAETGELVLDAVR-TAGEVSAAE
MAV_4114|M.avium_104 ----SLAGLVLGEYRRIAQSKDDGPTR-PRLTDRETEVLRYVAKGLSAKQ
TH_3563|M.thermoresistible__bu ----GLAGLVLGEYRRISRQPGAGPDA-PRLTERETEILRYVAKGLTAKQ
MAB_4519c|M.abscessus_ATCC_199 ----GLAGLVLGEFRRMSSAPAADADETPRLSDRETEVLRLVAKGLSAKQ
MMAR_2429|M.marinum_M -----------LENEVATLSDRLETRKLVERAKGLLQAKQGMTEPEAFKW
MUL_1608|M.ulcerans_Agy99 -----------LENEVATLSDRLETRKLVERAKGLLQAKQGMTEPEAFKW
MLBr_01286|M.leprae_Br4923 -----------LEREVATLADRLETRKLVERAKGLLQVKQGMTEPEAFKW
Mb1055c|M.bovis_AF2122/97 PVIETDSFTVDLAGKKVIKDGAEVHLTPTEWGMLEMLARNRGKLVGRGEL
Rv1027c|M.tuberculosis_H37Rv PVIETDSFTVDLAGKKVIKDGAEVHLTPTEWGMLEMLARNRGKLVGRGEL
.
MSMEG_5306|M.smegmatis_MC2_155 VAKRVGVSRVTAWRYLERLADENAVARNTEYGKAGRPRTRYQWR-----
Mvan_4698|M.vanbaalenii_PYR-1 VAKQVGVSRVTAWRYLERLADEGTVRRHTDYGRAGRPKTRYQWR-----
Mflv_3002|M.gilvum_PYR-GCK CADLVGISRVSARRYLEHYLGTGTLELRLQYG-VGRPERRYRIAG----
MAV_4114|M.avium_104 IAEKLSLSHRTVENHVQATFRKLQVANRVELARYAIEHGLDEEP-----
TH_3563|M.thermoresistible__bu IAAQLSLSHRTVENHVQATFRKLQVANRVELARYAIEHGLDE-------
MAB_4519c|M.abscessus_ATCC_199 IATRLSLSHRTVENHVQSTLRKLQLGNRVELTRYAIEHGLDE-------
MMAR_2429|M.marinum_M IQRAAMDRRTTMKRVAEVVLETLDTPDEA--------------------
MUL_1608|M.ulcerans_Agy99 IQRAAMDRRTTMKRVAEVVLETLDTPDEA--------------------
MLBr_01286|M.leprae_Br4923 IQRAAMDRRTTMKRVAEVVLETLDTPKDT--------------------
Mb1055c|M.bovis_AF2122/97 LKEVWGPAYATETHYLRVYLAQLRRKLEDDPSHPKHLLTESGMGYRFEA
Rv1027c|M.tuberculosis_H37Rv LKEVWGPAYATETHYLRVYLAQLRRKLEDDPSHPKHLLTESGMGYRFEA
: . .