For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. avium 104 MAV_4114 (-)

annotation: response regulator receiver domain-containing protein
coordinates: 4235322 - 4235987
length: 221

MTDDATPTTVMVVDDHPIWRDAVARDLAESGFAVVATADGVATAQRRAGVVRPDVVVMDMQLPDGDGAQA
TAAVLAVSPSSRVLVLSASDERDDVLQAVKAGAAGYLVKSASKAELAQAVTDTAAGRAVFTPSLAGLVLG
EYRRIAQSKDDGPTRPRLTDRETEVLRYVAKGLSAKQIAEKLSLSHRTVENHVQATFRKLQVANRVELAR
YAIEHGLDEEP

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. avium 104 MAV_4114 - - 100% (221) response regulator receiver domain-containing protein
M. avium 104 MAV_0872 - 7e-29 39.67% (184) DNA-binding response regulator, LuxR family protein
M. avium 104 MAV_5280 - 7e-28 35.32% (218) two-component system response regulator

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0867c narL 7e-34 41.63% (209) nitrate/nitrite response transcriptional regulatory protein
M. gilvum PYR-GCK Mflv_3579 - 8e-94 83.02% (212) two component LuxR family transcriptional regulator
M. tuberculosis H37Rv Rv0844c narL 6e-34 41.63% (209) nitrate/nitrite response transcriptional regulatory protein
M. leprae Br4923 MLBr_02123 - 5e-13 33.33% (171) two-component response regulator
M. abscessus ATCC 19977 MAB_4519c - 7e-82 72.35% (217) two-component LuxR family response regulator
M. marinum M MMAR_3959 - 2e-97 83.11% (219) two-component transcriptional regulatory protein
M. smegmatis MC2 155 MSMEG_3240 - 9e-95 83.87% (217) DNA-binding response regulator, LuxR family protein
M. thermoresistible (build 8) TH_3563 - 1e-93 82.46% (211) PUTATIVE DNA-binding response regulator, LuxR family protein
M. ulcerans Agy99 MUL_3814 - 3e-96 81.74% (219) two component transcriptional regulatory protein
M. vanbaalenii PYR-1 Mvan_2836 - 4e-90 81.43% (210) two component LuxR family transcriptional regulator

CLUSTAL 2.0.9 multiple sequence alignment


Mb0867c|M.bovis_AF2122/97           MS-NPQPEKVRVVVGDDHPLFREGVVRALSLSGSVNVVGEADDGAAALEL
Rv0844c|M.tuberculosis_H37Rv        MS-NPQPEKVRVVVGDDHPLFREGVVRALSLSGSVNVVGEADDGAAALEL
MMAR_3959|M.marinum_M               MS--EHESP-TVMVVDDHPIWRDAVARDLSDDG-FAVVATADGVATAQRR
MUL_3814|M.ulcerans_Agy99           MS--EHESP-TVMVVDDHPIWRDAVARDLSDDG-FAVVATADGVATAQRR
MAV_4114|M.avium_104                MT--DDATPTTVMVVDDHPIWRDAVARDLAESG-FAVVATADGVATAQRR
Mflv_3579|M.gilvum_PYR-GCK          -M--GIDRT-SVMVVDDHPIWRDAVARDLADDG-FDVVATADGVASAKRR
Mvan_2836|M.vanbaalenii_PYR-1       -----------MMVVDDHPIWRDAVARDLADDG-FDVVATADGVASAKRR
MSMEG_3240|M.smegmatis_MC2_155      MM--TDAAP-TVMVVDDHPIWRDAVARDLADDG-FDVVATADGVASASRR
TH_3563|M.thermoresistible__bu      MG--EPQQP-TVMVVDDHPIWREAVARDLAEAG-LSVVATADGVAAARRR
MAB_4519c|M.abscessus_ATCC_199      MTGNTDSEQISVMVVDDHPMWRDGVSRDLQAAG-LRVVATADGVASSGRI
MLBr_02123|M.leprae_Br4923          MD--TGVSSPRVLVVDDDSDVLASLERGLRLSG--FEVSTAIDGAEALRN
                                               ::* **..    .: * *   *    *. * . * : . 

Mb0867c|M.bovis_AF2122/97           IKAHLPDVALLDYRMPGMDGAQVPAAVRSYELPTRVLLISAHDEPAIVYQ
Rv0844c|M.tuberculosis_H37Rv        IKAHLPDVALLDYRMPGMDGAQVAAAVRSYELPTRVLLISAHDEPAIVYQ
MMAR_3959|M.marinum_M               AAIVKPDVVVMDMRLADGDGVQATTEVLKVSPATRVLVLSASDEREDVLE
MUL_3814|M.ulcerans_Agy99           AAIVKPDVVVMDMRLADGDGVQATTEVLKVSPATRVLVLSTSDEREDVLE
MAV_4114|M.avium_104                AGVVRPDVVVMDMQLPDGDGAQATAAVLAVSPSSRVLVLSASDERDDVLQ
Mflv_3579|M.gilvum_PYR-GCK          AAVVRPDVVVMDMRLGDGDGAQATTEVLAVSPSSRILVLSASDERDDVLE
Mvan_2836|M.vanbaalenii_PYR-1       AAVVQPAVVLMDMRLADGDGAQATAEVLAVSPSSRVLVLSASDERDDVLE
MSMEG_3240|M.smegmatis_MC2_155      AAVVRPDVVLMDMRLGDGSGAQATAEVLAVSPRSRVLVLSASDERDDVLQ
TH_3563|M.thermoresistible__bu      AAAVRPDVVLMDMRLPDGDGARATAEVRAVSPDSRVLVLSASEERDDVLE
MAB_4519c|M.abscessus_ATCC_199      AATVKPDVVLMDMQLTDGDGAQATAAVLSASPHSHILVLSASAEREDVLE
MLBr_02123|M.leprae_Br4923          ATETRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDRVA
                                         * . ::* .:   .*. . : :   .    : ::*:  .      

Mb0867c|M.bovis_AF2122/97           ALQQGAAGFLLKDSTRTEIVKAVLDCAKGRDVVAPSLVGGLAGEIRQRAA
Rv0844c|M.tuberculosis_H37Rv        ALQQGAAGFLLKDSTRTEIVKAVLDCAKGRDVVAPSLVGGLAGEIRQRAA
MMAR_3959|M.marinum_M               AVKAGATGYLVKSASKAELADAVRATAAGRAVFTPSLAGLVLGEYRRIAQ
MUL_3814|M.ulcerans_Agy99           AVKTGATGYLVKSASKAELADAVRATAAGRAVFTPSLAGLVLGEYRRIAQ
MAV_4114|M.avium_104                AVKAGAAGYLVKSASKAELAQAVTDTAAGRAVFTPSLAGLVLGEYRRIAQ
Mflv_3579|M.gilvum_PYR-GCK          AVKAGATGYLVKSASKQELGDAVRATAQGRAVFTPGLAGLVLGEFRRIEQ
Mvan_2836|M.vanbaalenii_PYR-1       AVKAGATGYLVKSASKQELGDAVRATAQGRAVFTPGLAGLVLGEFRRIER
MSMEG_3240|M.smegmatis_MC2_155      AVKAGATGYLVKSASRTELADAVRATAEGRAVFTPGLAGLVLGEYRRIAQ
TH_3563|M.thermoresistible__bu      AVKAGATGYLVKSASKTELVDAVHATAQGRAVFTPGLAGLVLGEYRRISR
MAB_4519c|M.abscessus_ATCC_199      AVKAGATGYLVKSASAAELIDAVRATAKGQAVFTPGLAGLVLGEFRRMSS
MLBr_02123|M.leprae_Br4923          GLEAGADDYLVKPFVLAELVARVKALLRRRGATATSSSETIAVGPLEVDI
                                    .:: ** .:*:*     *:   *      : . :..    :     .   

Mb0867c|M.bovis_AF2122/97           P--------VAPVLSAREREVLNRIACGQSIPAIAAELYVAPS-------
Rv0844c|M.tuberculosis_H37Rv        P--------VAPVLSAREREVLNRIACGQSIPAIAAELYVAPS-------
MMAR_3959|M.marinum_M               T---ADSSQDRPSLTERETEILRYVAKGLSAKQIAEKLSLSHR-------
MUL_3814|M.ulcerans_Agy99           T---ADSSQDRPSLTERETEILRYVAKGLSAKQIAEKLSLSHR-------
MAV_4114|M.avium_104                S---KDDGPTRPRLTDRETEVLRYVAKGLSAKQIAEKLSLSHR-------
Mflv_3579|M.gilvum_PYR-GCK          S---SPAGADGPTLTERETEILRYVAKGLTAKQIASRLSLSHR-------
Mvan_2836|M.vanbaalenii_PYR-1       D---SPAG---PTLTERETEILRHVAKGLTAKQIASRLSLSHR-------
MSMEG_3240|M.smegmatis_MC2_155      QP--AQEGPATPTLTERETEILRYVAKGLTAKQIAARLSLSHR-------
TH_3563|M.thermoresistible__bu      Q---PGAGPDAPRLTERETEILRYVAKGLTAKQIAAQLSLSHR-------
MAB_4519c|M.abscessus_ATCC_199      AP--AADADETPRLSDRETEVLRLVAKGLSAKQIATRLSLSHR-------
MLBr_02123|M.leprae_Br4923          PGRRARVNGVDVDLTKREFDLLAVLAEHKTTVLSRAQLLELVWGYDFAAD
                                                 *: ** ::*  :*   :      .*            

Mb0867c|M.bovis_AF2122/97           --TVKTHVQRLYEKLGVSDRAAAVAEAMRQRLLD---
Rv0844c|M.tuberculosis_H37Rv        --TVKTHVQRLYEKLGVSDRAAAVAEAMRQRLLD---
MMAR_3959|M.marinum_M               --TVENHVQATFRKLQVANRVELTRYAIEHGLDK---
MUL_3814|M.ulcerans_Agy99           --TVENHVQATFRKLQLANRVELTRYAIEHGLDK---
MAV_4114|M.avium_104                --TVENHVQATFRKLQVANRVELARYAIEHGLDEEP-
Mflv_3579|M.gilvum_PYR-GCK          --TVENHVQATFRKLQVGNRVELARYAIEHGLDE---
Mvan_2836|M.vanbaalenii_PYR-1       --TVENHVQATFRKLQIGNRVELARYAIEHGLDE---
MSMEG_3240|M.smegmatis_MC2_155      --TVENHVQATFRKLQVANRVELARYAIEHGLDE---
TH_3563|M.thermoresistible__bu      --TVENHVQATFRKLQVANRVELARYAIEHGLDE---
MAB_4519c|M.abscessus_ATCC_199      --TVENHVQSTLRKLQLGNRVELTRYAIEHGLDE---
MLBr_02123|M.leprae_Br4923          TNVVDVFIGYLRRKLEANSGPRLLHTVRGVGFVLRMQ
                                      .*. .:    .**   .       .    :

species	id	gene	e-value	identity (len)	annotation
M. avium 104	MAV_4114	-	-	100% (221)	response regulator receiver domain-containing protein
M. avium 104	MAV_0872	-	7e-29	39.67% (184)	DNA-binding response regulator, LuxR family protein
M. avium 104	MAV_5280	-	7e-28	35.32% (218)	two-component system response regulator