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SGGRPRLLGSCIAVPVGLTVALAVVLAVGGDGAWVPVLDDVIIVALSSCATVCAVLAAKSAEGRQRRAWA TMAAAMGAWAVADLIWLVCEYVLRVEPFPSPADFFYLAFSVLVVPAVLGMAQFDAWSRRQATLRIALDGV TVALCSFLLAWIFALDRVYEAYRDDKLALGLAFFYPVADMVILAVAVAVLARVDAAHRAVPALLVFGFAV MTLTDSAFAYGVAVDSYRTGSFIDLGWAVALVAICAAAQLSRENPQFRMPIVLVPSNTALWAPYVPLLLA GTIGPPLVMSGLEQLVVPVIVVAVCLRQVVAAWENRQLLRAAAEQALRDPLTELANQRLFYDRLAHALTL SSREGHSVAVVSLDLDDFKLVNDSVGHPEADSLLVRVGQRIADCVRAGDTVARIQGDEFALLLEGEHDDS KLIAERVVDAFDEPFVLHGEHILLRPSVGVAAASPGEAEVAPETMVMRAETAMNVAKRSRSSRVHVFDAT LESAAPDVVAPERGSPQNWPDGAAKVRLLGELRRAIDNGEFHMVYQPIVDLRSGFIVGVEALLRWPHPRL GMLSPDAFLPLVRQHGLMRPVTEVVLDNVLDDAARWMADGVPMPVAVNLFAPFLRDAQLPSALCQALERR GLPTDLLTVEITEDLVLHDFDVVTGVLGQLREQGIRVAIDDFGSGFSALSYLRELRIDEIKLDRHFIATV ASDPRAAAVVRAVIDLTHDLGSVVVAEGVEEPATAAWLRDRGCDMAQGYYFGKPIEAADVPGLVRMAKDP A*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4640 | - | - | 100% (772) | diguanylate cyclase/phosphodiesterase |
| M. vanbaalenii PYR-1 | Mvan_1918 | - | 2e-65 | 29.19% (764) | diguanylate cyclase/phosphodiesterase |
| M. vanbaalenii PYR-1 | Mvan_1967 | - | 7e-54 | 31.92% (473) | diguanylate cyclase/phosphodiesterase with GAF sensor |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 1e-58 | 32.36% (445) | hypothetical protein Mb1389c |
| M. gilvum PYR-GCK | Mflv_3478 | - | 0.0 | 63.30% (782) | diguanylate cyclase/phosphodiesterase |
| M. tuberculosis H37Rv | Rv1354c | - | 1e-58 | 32.36% (445) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_01750 | - | 6e-51 | 29.40% (466) | hypothetical protein MLBr_01750 |
| M. abscessus ATCC 19977 | MAB_0124 | - | 3e-11 | 33.85% (130) | hypothetical protein MAB_0124 |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_1410 | - | 6e-77 | 30.10% (721) | cyclic diguanylate phosphodiesterase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 2e-55 | 32.14% (473) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_0811 | - | 3e-53 | 30.46% (476) | sensory box/response regulator |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4640|M.vanbaalenii_PYR-1 ----------MSGGRPRLLG-SCIAVPVGLTVALAVVLAVGGDGAWVPVL
Mflv_3478|M.gilvum_PYR-GCK ----------MGSGRWRLVTRLPIALPAAACIGLAVLLAVDRGGSAVPLI
MAV_1410|M.avium_104 MKRWAVNPWRRSGVPARVGWLLAGGYGTAALLVLLSSVRGWRGPYGTRPV
MSMEG_2196|M.smegmatis_MC2_155 ---------------------------------------------MSESL
TH_0811|M.thermoresistible__bu ---------------------------------------------VSTEL
MLBr_01750|M.leprae_Br4923 ---------------------------------------------MTRSL
Mb1389c|M.bovis_AF2122/97 ----------------------------------------MCNDTATPQL
Rv1354c|M.tuberculosis_H37Rv ----------------------------------------MCNDTATPQL
MAB_0124|M.abscessus_ATCC_1997 ------------------------------------------MGAGEMTF
.
Mvan_4640|M.vanbaalenii_PYR-1 DDVIIVALSSCATVCAVLAAKSAEGRQRRAWATMAAAMGAWAVADLIWLV
Mflv_3478|M.gilvum_PYR-GCK DDITILGLSTYATVCAVLAALSAAGRMRTAWAIMAAALGSWAVADLIWLL
MAV_1410|M.avium_104 DDLVMFVCLAVAAMCAARAARAASGRRRYGWLALTTALLGWAVGEVIWAV
MSMEG_2196|M.smegmatis_MC2_155 DVLVTSVATQLMAVEAATSVSVSQQ-------------------------
TH_0811|M.thermoresistible__bu DLLVTGVATKLMAADAATARDVSRR-------------------------
MLBr_01750|M.leprae_Br4923 DELVTRVASKLMAATAATAVTISEG-------------------------
Mb1389c|M.bovis_AF2122/97 EELVTTVANQLMTVDAATSAEVSQR-------------------------
Rv1354c|M.tuberculosis_H37Rv EELVTTVANQLMTVDAATSAEVSQR-------------------------
MAB_0124|M.abscessus_ATCC_1997 GQEYRFATRALTVTRNLVPLKIAIG-------------------------
. . :
Mvan_4640|M.vanbaalenii_PYR-1 CEY--VLRVEPFPSPADFFYLAFSVLVVPAVLGMAQFDAWSRRQATLRIA
Mflv_3478|M.gilvum_PYR-GCK CDY--VLHIEPFPSPADLFYLAFSVLAVPGLLAMAPFDALARRQAKIRIT
MAV_1410|M.avium_104 YDVRPEFEHAAHPAAAEMVLLLFPVGAMTSLVLLSQLSRHSPR----RLL
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MLBr_01750|M.leprae_Br4923 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4640|M.vanbaalenii_PYR-1 LDGVTVALCSFLLAWIFALDRVYEAYRDDKLALGLAFFYPVADMVILAVA
Mflv_3478|M.gilvum_PYR-GCK LDGITVALCVFLLAWLLALNTVYETYRDDTLTLALALLYPAADIVILAVS
MAV_1410|M.avium_104 LDGLIVATSLFVISWVFVVEAQLREHTGTQVATLAEVFN---DIVLMTTA
MSMEG_2196|M.smegmatis_MC2_155 -------VLAELVSFFDVDVSFLRHNDHRAHATRLVAEWPPRPVDAATDP
TH_0811|M.thermoresistible__bu -------VLADLVRAFELDFSFLRHNDHEIRASKLIAEWPVRENVPDPDP
MLBr_01750|M.leprae_Br4923 -------VLAILVEHFGVDVSFLRHNNHDIHETKLIVEWPPRDYVPDPDP
Mb1389c|M.bovis_AF2122/97 -------VLAYLVEQLGVDVSFLRHNDRDRRATRLVAEWPPRLNIPDPDP
Rv1354c|M.tuberculosis_H37Rv -------VLAYLVEQLGVDVSFLRHNDRDRRATRLVAEWPPRLNIPDPDP
MAB_0124|M.abscessus_ATCC_1997 ----------LLCLSIVVLGTLIQFHPLGPHGLWPRLIHGVLVASALVVG
: . .
Mvan_4640|M.vanbaalenii_PYR-1 VAVLARVDAAHRAVPALLVFGFAVMTLTDSAFAYGVAVDSYRTGSFIDLG
Mflv_3478|M.gilvum_PYR-GCK VAVLARVDTRQRATLGLLVVAFAVMAVTDSTFAYGVAEDSYTTGSIIDVG
MAV_1410|M.avium_104 ILTLSRARPGDRPSRSLLACGIATISVTDIAMVFYTGIGSYHTDDIGDLA
MSMEG_2196|M.smegmatis_MC2_155 IAVVHFADADP---------VFAMAEHLKEPAVFRPEPLYDDYQRTIEAG
TH_0811|M.thermoresistible__bu IGVVHFEGADP---------VFALAEHAKEIHIFRPEPATDEFQRLIEES
MLBr_01750|M.leprae_Br4923 IGVVYFADADP---------VFAMAEYLKEPAVLRPEPANADYQRRIEEG
Mb1389c|M.bovis_AF2122/97 LRLIYFADADP---------VFALCEHAKEPLVFRPEPATEDYQRLIEEA
Rv1354c|M.tuberculosis_H37Rv LRLIYFADADP---------VFALCEHAKEPLVFRPEPATEDYQRLIEEA
MAB_0124|M.abscessus_ATCC_1997 MCWVVLPWPRRR-------VAIAFVWWADISMVVGACTLSAPASRLGALA
: : . :* . .
Mvan_4640|M.vanbaalenii_PYR-1 WAVALVAICAAAQLSRENPQFRMPIVLVPSNTALWAPYVPLLLAGTIGP-
Mflv_3478|M.gilvum_PYR-GCK WAVSSAMIGMAALVSRRTPPPRPATLSVPSGTALWAPYLPLLVAGIVVP-
MAV_1410|M.avium_104 RVAGVGTLALAGLASVYEQPAPGSPDEIEFRTRLWLPYLPLILAAAVGWG
MSMEG_2196|M.smegmatis_MC2_155 RHIPATSMACVPLLSG--DVTTGVLGFVKFGDREWL--------------
TH_0811|M.thermoresistible__bu SGVPASTVAAVPLVSG--EITTGVLGFVKYGDRQWH--------------
MLBr_01750|M.leprae_Br4923 ASVPAVSLACVPLLSG--EITTGVLGFVKYGDREWH--------------
Mb1389c|M.bovis_AF2122/97 RGVPVTSAAAVPLVSG--EITTGLLGFIKFGDRKWH--------------
Rv1354c|M.tuberculosis_H37Rv RGVPVTSAAAVPLVSG--EITTGLLGFIKFGDRKWH--------------
MAB_0124|M.abscessus_ATCC_1997 HMGLIGVFAAFLLGWRVLAVHCVFATVAIFGLMGWNVRLG----------
*
Mvan_4640|M.vanbaalenii_PYR-1 ---PLVMSGLEQLVVPVIVVAVCLRQVVAAWEN-RQLLRAAAEQALRDPL
Mflv_3478|M.gilvum_PYR-GCK ---PLVTTGLERYVAPAIVITVCLRQFFAAWEN-RQWLKAAAERSLRDPL
MAV_1410|M.avium_104 HAAGKAIHEPMLAALGILVAAVLARQFVVLVDN-QNLLSEVAREAFRDNL
MSMEG_2196|M.smegmatis_MC2_155 ----------PAELNALKAIASLFAQVQARIEA-EERLRYLADH---DHL
TH_0811|M.thermoresistible__bu ----------PDELNALKAIASLFAQVQARVEA-EERLRYLAEH---DDL
MLBr_01750|M.leprae_Br4923 ----------DDELRALQAIATLFAQLQARIVA-EEQLRYLAEH---DDL
Mb1389c|M.bovis_AF2122/97 ----------EAELNALMTIATLFAQVQARVAA-EARLRYLADH---DDL
Rv1354c|M.tuberculosis_H37Rv ----------EAELNALMTIATLFAQVQARVAA-EARLRYLADH---DDL
MAB_0124|M.abscessus_ATCC_1997 --EATWFDQYVYSAPALSSVVLLPIIIQVVVEGGRRSLKAISLAAHQDPL
. . . . * : * *
Mvan_4640|M.vanbaalenii_PYR-1 TELANQRLFYDRLAHALTLSSREGHSVAVVSLDLDDFKLVNDSVGHPEAD
Mflv_3478|M.gilvum_PYR-GCK TGLANGTLFHDRLRHAMMLHARGDRSVMVVSLDLDDFAFVNDNLGHPAAD
MAV_1410|M.avium_104 TGLANRALFVHRLEQAVARRHPDGTPIAVLCLDLDNFKAVNDALGHPAGD
MSMEG_2196|M.smegmatis_MC2_155 TGLYNRRALMAHLEARLAPGQPG--PVAVMFFDLDRLKAINDYLGHTAGD
TH_0811|M.thermoresistible__bu TGLHNRRALLAHLDARLAAGQPG--PVSALYFDLDRLKAVNDYLGHTVGD
MLBr_01750|M.leprae_Br4923 TGLLNRRALIAHLDERLADGQRG--PVTLLFLGLDRLKAVNDYLGHNAGD
Mb1389c|M.bovis_AF2122/97 TGLHNRRALLQHLDQRLAPGQPG--PVAALFLDLDRLKAINDYLGHAAGD
Rv1354c|M.tuberculosis_H37Rv TGLHNRRALLQHLDQRLAPGQPG--PVAALFLDLDRLKAINDYLGHAAGD
MAB_0124|M.abscessus_ATCC_1997 TGLLNRRGVQVALSSLLS-GQRATRIVAVVLVDVDELKELNDRLGHDAGD
* * * . * : : : ..:* : :** :** .*
Mvan_4640|M.vanbaalenii_PYR-1 SLLVRVGQRIADCVRAGDTVARIQGDEFALLLEG--EHDDSKLIAERVVD
Mflv_3478|M.gilvum_PYR-GCK RLLVHAGRRIAACVRPGDTVGRVAGDEFALLLEG--DVHDSQRVLQRVVA
MAV_1410|M.avium_104 ELLVRVAERLTAALGDSGTIARLGGDEFAAVIEA--SVDESQAAAHRILE
MSMEG_2196|M.smegmatis_MC2_155 AFISILAQRLQRGDDAPKLIARLGGDEFVVVPDDPMSLDEATALAYRLQS
TH_0811|M.thermoresistible__bu WFIRVLAERLREGAGPDDLIARLGGDEFVVVPSGPVDADAALELANRLRS
MLBr_01750|M.leprae_Br4923 RLIEVFADRLREAAESLTVIARFGGDEFVVVPAESVSVDVAESFAHRLQT
Mb1389c|M.bovis_AF2122/97 QFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPLAERLRD
Rv1354c|M.tuberculosis_H37Rv QFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPLAERLRD
MAB_0124|M.abscessus_ATCC_1997 ESIRAVAAMLATTTRASDLTARMGGDEFMVVGFFD-HADEATGLIERIG-
: . : .*. **** : . : *:
Mvan_4640|M.vanbaalenii_PYR-1 AFDEPFVLHGEHILLRPSVGVAAASPGEAEVAPETMVMRAETAMNVAKR-
Mflv_3478|M.gilvum_PYR-GCK TFDEPFDVDGEPVTIRCSVGVAVAFADEPEVTPETMLRRADIAVRVAKR-
MAV_1410|M.avium_104 AFTGAILIDGIPITVRPSIGFTVCTG-ASTCTVDQLLRHADLAMYAAKRE
MSMEG_2196|M.smegmatis_MC2_155 VLRERVTVDGEMLTRTVSIGIAQGIP--GKDSTSDVLNRADHAVLTAKG-
TH_0811|M.thermoresistible__bu RLQQQVCVDGEMLTRTASIGVAQGTP--GRDTTSDLLRRADQAVLTAKS-
MLBr_01750|M.leprae_Br4923 RLQKQVVIDGEILTRTVSIGVATGLP--GRDTTSDLLRWADHAALSAK--
Mb1389c|M.bovis_AF2122/97 QLKDHVAIGGEVLTRTVSIGVASGTP--GQHTPSDLLRRADQAALAAKH-
Rv1354c|M.tuberculosis_H37Rv QLKDHVAIGGEVLTRTVSIGVASGTP--GQHTPSDLLRRADQAALAAKH-
MAB_0124|M.abscessus_ATCC_1997 --ARRFGIG--PHRASVSMGSAMRSTSVAGFDFESLRRAADEELRGAKIE
. : *:* : . : *: **
Mvan_4640|M.vanbaalenii_PYR-1 ---------SRSSRVHVFDATLESAAPDVVAP---------ERGSPQNWP
Mflv_3478|M.gilvum_PYR-GCK ---------SHFPRVRFFEDDIEDDFDDDMATTDSDAAQGGDRSTDRVAL
MAV_1410|M.avium_104 GGQCIRSFMPDLPLPYAFPPPPGSAAPTAVAAVAAGGNGAAPASPPQVAT
MSMEG_2196|M.smegmatis_MC2_155 ---------SGGNRVAVFSDAMA--------------------------M
TH_0811|M.thermoresistible__bu ---------AGGNQITVFTDDMS--------------------------L
MLBr_01750|M.leprae_Br4923 ---------SDGSKVVVLDHGIS--------------------------A
Mb1389c|M.bovis_AF2122/97 ---------AGGDSVAIFTADMS--------------------------V
Rv1354c|M.tuberculosis_H37Rv ---------AGGDSVAIFTADMS--------------------------V
MAB_0124|M.abscessus_ATCC_1997 -------------RRNGFHAVP----------------------------
:
Mvan_4640|M.vanbaalenii_PYR-1 DGAAKVRLLGELRR------------------------------------
Mflv_3478|M.gilvum_PYR-GCK TGAAKVRLLSELRR------------------------------------
MAV_1410|M.avium_104 AATSSPSPHDAARRPPRGIRAALGMLAIGVVAFSVSSVAHPDAGHGIFSA
MSMEG_2196|M.smegmatis_MC2_155 EIDFRNDIELHLQS------------------------------------
TH_0811|M.thermoresistible__bu EAEFRNDIELHLQS------------------------------------
MLBr_01750|M.leprae_Br4923 QHTLRTEVELHLAG------------------------------------
Mb1389c|M.bovis_AF2122/97 SGELRNDIELHLRR------------------------------------
Rv1354c|M.tuberculosis_H37Rv SGELRNDIELHLRR------------------------------------
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4640|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3478|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1410|M.avium_104 TALYSALNAVAAGLIALRACRIPADRWAWALIAAGMACSAVGDVVYAVWV
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MLBr_01750|M.leprae_Br4923 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4640|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3478|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1410|M.avium_104 PDGRSPSVADPEYLAYYPFVYAGLLLLMRARLKRLPIAVQLDSVVCALTL
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MLBr_01750|M.leprae_Br4923 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4640|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3478|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1410|M.avium_104 AAVAAALTAGPLHQAAVHAPKTVWVGLAYPWCDLMLLALAAGMLPILGWR
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MLBr_01750|M.leprae_Br4923 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4640|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3478|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1410|M.avium_104 NEIRWALLVAGLVLFAVADGAYLFQTAAGSYRVGSLLDVCWPASSVLIAM
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MLBr_01750|M.leprae_Br4923 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4640|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3478|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1410|M.avium_104 ASWAPPPATATQARRRFSPYVTPVASTIVALGVIVLAHHSRSAATLAALS
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MLBr_01750|M.leprae_Br4923 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4640|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3478|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1410|M.avium_104 LVVGAGRFSLTFRDVSLLHSHDRHAMTDELTALPNRRQLVTALQGLPASA
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MLBr_01750|M.leprae_Br4923 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4640|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3478|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1410|M.avium_104 SPGAGSMPSRANPRRALLLLSLSDFHEITESIGRQFGDELLCHIANRLAG
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MLBr_01750|M.leprae_Br4923 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4640|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3478|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1410|M.avium_104 SVRRDDLLARVGDDQFAVLLADGANLTAASAQAGRLLEALSEPIALDPIT
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MLBr_01750|M.leprae_Br4923 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4640|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3478|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1410|M.avium_104 VQVDGRIAIALCPDHCDHPRELLSRAETALAHAKSARSKIAVYDSAFEAH
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MLBr_01750|M.leprae_Br4923 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4640|M.vanbaalenii_PYR-1 --------------AIDNGEFHMVYQPIVDLRSGFIVGVEALLRWPHPRL
Mflv_3478|M.gilvum_PYR-GCK --------------AVDQGDLELAYQPKVDLVSGQVVGVEALLRWPHPEL
MAV_1410|M.avium_104 RDNDTNLIEELRTALFDTDELKLHYQPKIDGRDGSIHSVEAVLRWQHPTR
MSMEG_2196|M.smegmatis_MC2_155 --------------VIEGGALVLHYLPEIDMRTGEVLAAEALVRWEHPTR
TH_0811|M.thermoresistible__bu --------------VIQDEALLLHFLPEVDMRTGEILATEALVRWHHPTR
MLBr_01750|M.leprae_Br4923 --------------MID-TDLVLHYLPEVDMSTGKVLGTEALVRWQHPTR
Mb1389c|M.bovis_AF2122/97 --------------GIESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTR
Rv1354c|M.tuberculosis_H37Rv --------------GIESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTR
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4640|M.vanbaalenii_PYR-1 GMLSPDAFLPLVRQHGLMRPVTEVVLDNVLDDAARWMAD--GVPMPVAVN
Mflv_3478|M.gilvum_PYR-GCK GLLYPGTFMPLVREHKLIRPVTDLVIDKVLDDAARWVGT--GAPIPVAVN
MAV_1410|M.avium_104 GTLLPEEFLPVAERAGLMRKISNRTLSMALQQVRSWREE--GLRLTVAVN
MSMEG_2196|M.smegmatis_MC2_155 GLLSPDSFIGVAESINLAGELGRWVLRTACAEFSRWRANGVGRNIVLRIN
TH_0811|M.thermoresistible__bu GLLAPDTFIGVAESVNLAGELGRWVMRTACGEFAKWRAEGIGLDAVLRIN
MLBr_01750|M.leprae_Br4923 GLLFPDSFIPVAESINLAGKLGRMVMHSACAEFSRWRSAGVGLDALLRIN
Mb1389c|M.bovis_AF2122/97 GLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRIN
Rv1354c|M.tuberculosis_H37Rv GLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRIN
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4640|M.vanbaalenii_PYR-1 LFAPFLRDAQLPSALCQALERRGLPTDLLTVEITEDLVLHDFDVVTGVLG
Mflv_3478|M.gilvum_PYR-GCK LFAPSLIDARLPATLRAALERRGLPAELLTVEITEDLVINDLERVTAVLG
MAV_1410|M.avium_104 LSTTNLLDIELVGTVERLLANYDLPADALILEITESALVDSVRSRNTVT-
MSMEG_2196|M.smegmatis_MC2_155 VSPVQLVTDGFVESVAGIMKEFGLPRGSVCLEITESVVVQDIETTRTTLT
TH_0811|M.thermoresistible__bu VSPVQLVTDGFVASVADIIDEFGLDGSSVCLEITESVVVQDIKTTRITLE
MLBr_01750|M.leprae_Br4923 VSPVQLVAEGFVDNVAGTLDEFGLDGSMVCLEITENVVVQNIDATRKTLA
Mb1389c|M.bovis_AF2122/97 VSAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATLA
Rv1354c|M.tuberculosis_H37Rv VSAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATLA
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4640|M.vanbaalenii_PYR-1 QLREQGIRVAIDDFGSGFSALSYLRELRIDEIKLDRHFIATVASDPRAAA
Mflv_3478|M.gilvum_PYR-GCK QLRDHGIRVSIDDFGSGYSALSYLRDLLIDEIKLDRSFIAAVTTDPRAAV
MAV_1410|M.avium_104 ALQRLGIRISIDDYGTGWSSLARLQEVSVDELKLDRIFVARLAHDARSVA
MSMEG_2196|M.smegmatis_MC2_155 GLHNVGVQVAIDDFGTGYSVLSLLKSLPVDTLKIDRSFVAELGSNPGDLP
TH_0811|M.thermoresistible__bu GLNEVGVQVAIDDFGTGYSVLSHLKTLPVDTLKIDKGFVQDLGNSPGDLA
MLBr_01750|M.leprae_Br4923 GLKEVGVHLAIDDFGTGYSVLTHLKSLPVDTIKIDKSFVAELGSNASDLA
Mb1389c|M.bovis_AF2122/97 RLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLV
Rv1354c|M.tuberculosis_H37Rv RLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLV
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4640|M.vanbaalenii_PYR-1 VVRAVIDLTHDLGSVVVAEGVEEPATAAWLRDRGCDMAQGYYFGKPIEAA
Mflv_3478|M.gilvum_PYR-GCK VVRAIIELTHGLGMTVVAEGIEEAATANWLRDSGCDIGQGFYFGKPVDPA
MAV_1410|M.avium_104 IVRSTVALADNLGADLVAEGVENEDTLDALRRYGCNITQGFVHTPPLPPD
MSMEG_2196|M.smegmatis_MC2_155 IVRAVIALAGAFGLQLVAEGVETERAALTLLRHGCYRAQGFLLSKPILGS
TH_0811|M.thermoresistible__bu IVRAIIALAEAFGLQLVAEGVETEAAALTLLRHGCHRAQGFLLSRPIPSN
MLBr_01750|M.leprae_Br4923 IVRAIMALAKEFELEVVAEGVETAVAAQVLLELGCNRAQGFLLSRPVDGA
Mb1389c|M.bovis_AF2122/97 IVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPGE
Rv1354c|M.tuberculosis_H37Rv IVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPGE
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4640|M.vanbaalenii_PYR-1 DVPGLVR-MAKDPA-----------------
Mflv_3478|M.gilvum_PYR-GCK DVPSLGR-LAVGPS-----------------
MAV_1410|M.avium_104 ELRAWIASHAPDPSQSRG-------------
MSMEG_2196|M.smegmatis_MC2_155 EMQTLLAKGRVPVHFSAAPRM----------
TH_0811|M.thermoresistible__bu EMRELLARGRIPMRFSATP------------
MLBr_01750|M.leprae_Br4923 AMESLLAKGVIPMALGTCQSPEPSEHQIHRS
Mb1389c|M.bovis_AF2122/97 AMRHMLSARRLPPTCIPATDPALS-------
Rv1354c|M.tuberculosis_H37Rv AMRHMLSARRLPPTCIPATDPALS-------
MAB_0124|M.abscessus_ATCC_1997 -------------------------------