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VAAQRTRVRLLVAAGVPLLAVVNAMALWGDEVARRGEAILQVSTSLAAAACGVVVARRVGGAARWWRLLY VAALVSWVSGQILWWTGADEAAPALARAAYLSLPVFALGAVVLLVRSSGGVTAPRDSPLRHPLVTNVLDG VVAGIAFLILVAMGGFGTHSTASLPRSGVPVVDVVFAVAELLLVAWAVVMAMLYEPGRPYRKNYLLLAGG LVMMAASDRVVAYFRSVGLEGGDLWGGIGLIIGPMVIAFAMLETSESDDSGAGRGIDWAQLVLPYLGFLG IAVMFGFHVLIGRQLNPFVVSLTVAMVALVTVRQILATRAQSLLTQRLYWAQRGLAYQVHHDALTGLPNR ILFARRLDEAMAHGRFVLIFVDLDDFKEVNDRFGHAAGDELLRAVGERLKRCVTAADTLARIGGDEFAVL IVAEAEQLEVVAERLRIALRDPFPVHGSSVRVKASMGLVRPEGDGMPQTSDDLLRQADISMYAGKRMGKD TAVVYQPASGVIVDFPTMLRTADGGAPPGFRLVYQPVVRLPEGTPVAVEALARWTAPNGIDISPETFVAV TEAAGMGADFDALVLDLACREVQGRGLNLDIHVNIGAARLGNPGFEQQVSQVLARHRIPRNRLVLEITET EPIVDLDRAAAQIRRLGQLGVRVALDDFGAGFNSLTYLHCLPVHIVKLDRSLAVGGEPARDLSLYRSVIR LCDDLGLDVIAEGIELPAQSEMVHSAGGRLAQGHLFGRPVPIAELGDAVIGDREWGLSPAALPDLTQAD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1918 | - | - | 100% (769) | diguanylate cyclase/phosphodiesterase |
| M. vanbaalenii PYR-1 | Mvan_4640 | - | 2e-65 | 29.19% (764) | diguanylate cyclase/phosphodiesterase |
| M. vanbaalenii PYR-1 | Mvan_1967 | - | 5e-58 | 32.63% (429) | diguanylate cyclase/phosphodiesterase with GAF sensor |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 1e-60 | 33.33% (447) | hypothetical protein Mb1389c |
| M. gilvum PYR-GCK | Mflv_4444 | - | 0.0 | 58.70% (741) | diguanylate cyclase/phosphodiesterase |
| M. tuberculosis H37Rv | Rv1354c | - | 2e-60 | 33.33% (447) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_01750 | - | 4e-53 | 32.31% (424) | hypothetical protein MLBr_01750 |
| M. abscessus ATCC 19977 | MAB_1839 | - | 8e-15 | 36.75% (166) | diguanylate cyclase/phosphodiesterase |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_1132 | - | 7e-54 | 32.11% (436) | cyclic diguanylate phosphodiesterase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 4e-55 | 32.03% (434) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_0811 | - | 9e-55 | 31.58% (437) | sensory box/response regulator |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1918|M.vanbaalenii_PYR-1 MAAQRTRVRLLVAAGVPLLAVVNAMALWGDEVARRGEAILQVSTSLAAAA
Mflv_4444|M.gilvum_PYR-GCK MTGYRIRASVVLAA--TLLVLVNGFAPWGQAAALRVDAILQVCTAAVAVV
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MLBr_01750|M.leprae_Br4923 --------------------------------------------------
MAV_1132|M.avium_104 --------------------------------------------------
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1918|M.vanbaalenii_PYR-1 CGVVVARRVGGAARWWRLLYVAALVSWVSGQILWWTGADEAAPALARAAY
Mflv_4444|M.gilvum_PYR-GCK YGLWVARRVHGVSRTWRLLAVGAVAGLLVGELVWWERAG-LLPLVGVIPY
Mb1389c|M.bovis_AF2122/97 -----------------------------------------MCNDTATPQ
Rv1354c|M.tuberculosis_H37Rv -----------------------------------------MCNDTATPQ
MSMEG_2196|M.smegmatis_MC2_155 ----------------------------------------------MSES
TH_0811|M.thermoresistible__bu ----------------------------------------------VSTE
MLBr_01750|M.leprae_Br4923 ----------------------------------------------MTRS
MAV_1132|M.avium_104 ----------------------------------------------MPRS
MAB_1839|M.abscessus_ATCC_1997 -----------------------MVTTYPGRNGFGSESNRCSTGAQVYGA
Mvan_1918|M.vanbaalenii_PYR-1 LSLPVFALGAVVLLVRSSGGVTAPRDSPLRHPLVTNVLDGVVAGIAFLIL
Mflv_4444|M.gilvum_PYR-GCK LLFLILGLASMLVLVGAGRGISVPADGSLRYTAVITVLDGLVAAAAFAIL
Mb1389c|M.bovis_AF2122/97 LEELVTTVANQLMTVDAATSAEVSQR------VLAYLVEQLGVDVSFLRH
Rv1354c|M.tuberculosis_H37Rv LEELVTTVANQLMTVDAATSAEVSQR------VLAYLVEQLGVDVSFLRH
MSMEG_2196|M.smegmatis_MC2_155 LDVLVTSVATQLMAVEAATSVSVSQQ------VLAELVSFFDVDVSFLRH
TH_0811|M.thermoresistible__bu LDLLVTGVATKLMAADAATARDVSRR------VLADLVRAFELDFSFLRH
MLBr_01750|M.leprae_Br4923 LDELVTRVASKLMAATAATAVTISEG------VLAILVEHFGVDVSFLRH
MAV_1132|M.avium_104 LDLVVTSVATALMEATASTARSVSET------VLAQLVEQFDVDASFLHH
MAB_1839|M.abscessus_ATCC_1997 NNDILERVGLRRPVSRANAVFITAVG------AAAILLAATGMSTIPLLC
: :. : . ::
Mvan_1918|M.vanbaalenii_PYR-1 VAMGGFGTHSTASLPRSGVPVVDVVFAVAELLLVAWAVVMAMLYEPGRPY
Mflv_4444|M.gilvum_PYR-GCK VFLVRYGAYSSSSWPHSSSPPIEIGYAVFQLVVVVVAAVVGMMYAADRPF
Mb1389c|M.bovis_AF2122/97 NDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVFALCEHAKEPLVF
Rv1354c|M.tuberculosis_H37Rv NDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVFALCEHAKEPLVF
MSMEG_2196|M.smegmatis_MC2_155 NDHRAHATRLVAEWPPRPVDAATDPIAVVHFADADPVFAMAEHLKEPAVF
TH_0811|M.thermoresistible__bu NDHEIRASKLIAEWPVRENVPDPDPIGVVHFEGADPVFALAEHAKEIHIF
MLBr_01750|M.leprae_Br4923 NNHDIHETKLIVEWPPRDYVPDPDPIGVVYFADADPVFAMAEYLKEPAVL
MAV_1132|M.avium_104 --HDAAGPVPVAEWPRRTDAAG--PMAALRSEDVESVLAQCERQRRPVVS
MAB_1839|M.abscessus_ATCC_1997 ISLSIPAFLWGIRYARARAVTYGESVAYVLYCDVAILIGICVVTTTGVAF
. .
Mvan_1918|M.vanbaalenii_PYR-1 RKNYLLLAGGLVMMAASDRVVAYFRSVGLEGGDLWGGIGLIIGPMVIAFA
Mflv_4444|M.gilvum_PYR-GCK RSNFLQLACGVVMAISSDRVIAYFDSIGNEGAQIWAGVGLVLGPLLIAFS
Mb1389c|M.bovis_AF2122/97 RPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGL------------
Rv1354c|M.tuberculosis_H37Rv RPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGL------------
MSMEG_2196|M.smegmatis_MC2_155 RPEPLYDDYQRTIEAGRHIPATSMACVPLLSGDVTTGV------------
TH_0811|M.thermoresistible__bu RPEPATDEFQRLIEESSGVPASTVAAVPLVSGEITTGV------------
MLBr_01750|M.leprae_Br4923 RPEPANADYQRRIEEGASVPAVSLACVPLLSGEITTGV------------
MAV_1132|M.avium_104 SPDQADGWLRRWLQRDKAAGAPSVAAAPLVSGDATTGV------------
MAB_1839|M.abscessus_ATCC_1997 VKLAWLLAVSAYVSLVHGRVAVAMQSLVTTAGTVLAVVG-----------
: . .. :
Mvan_1918|M.vanbaalenii_PYR-1 MLETSESDDSGAG--RGIDWAQLVLPYLGFLGIAVMFGFHVLIGRQLNPF
Mflv_4444|M.gilvum_PYR-GCK FRERTDATREPAETMRPMDWAQMTLPYAGFIGITILQAYHLLTGHTIGRG
Mb1389c|M.bovis_AF2122/97 ------------------------------------LGFIKFGDRKWHEA
Rv1354c|M.tuberculosis_H37Rv ------------------------------------LGFIKFGDRKWHEA
MSMEG_2196|M.smegmatis_MC2_155 ------------------------------------LGFVKFGDREWLPA
TH_0811|M.thermoresistible__bu ------------------------------------LGFVKYGDRQWHPD
MLBr_01750|M.leprae_Br4923 ------------------------------------LGFVKYGDREWHDD
MAV_1132|M.avium_104 ------------------------------------LGFVKFGARRWKPE
MAB_1839|M.abscessus_ATCC_1997 -------------------------------------AVSRDEYSAAALA
.
Mvan_1918|M.vanbaalenii_PYR-1 VVSLTVAMVALVTVRQILATRAQSLLTQRLYWAQRGLAYQVHHDALTGLP
Mflv_4444|M.gilvum_PYR-GCK VVATTLVMVVLVAARQTVAMGTQRQLTRKLYEAQRGLAHQVHHDALTGLP
Mb1389c|M.bovis_AF2122/97 ELNALMTIATLFAQVQARVA------------AEARLRYLADHDDLTGLH
Rv1354c|M.tuberculosis_H37Rv ELNALMTIATLFAQVQARVA------------AEARLRYLADHDDLTGLH
MSMEG_2196|M.smegmatis_MC2_155 ELNALKAIASLFAQVQARIE------------AEERLRYLADHDHLTGLY
TH_0811|M.thermoresistible__bu ELNALKAIASLFAQVQARVE------------AEERLRYLAEHDDLTGLH
MLBr_01750|M.leprae_Br4923 ELRALQAIATLFAQLQARIV------------AEEQLRYLAEHDDLTGLL
MAV_1132|M.avium_104 EINTLEAVAALFAQLQARIA------------AEERLRYLAEHDDLTGVY
MAB_1839|M.abscessus_ATCC_1997 AAVVTMLLANLFAGLVIYVG------KAQFSEHADGRDRLARHDVLTGLL
:. *.: . ** ***:
Mvan_1918|M.vanbaalenii_PYR-1 NRILFARRLDEAMAHG---RFVLIFVDLDDFKEVNDRFGHAAGDELLRAV
Mflv_4444|M.gilvum_PYR-GCK NRLMFAQRLEAAVQHG---DFVLIFVDLDDFKEVNDRFGHAAGDELLCAV
Mb1389c|M.bovis_AF2122/97 NRRALLQHLDQRLAPGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVF
Rv1354c|M.tuberculosis_H37Rv NRRALLQHLDQRLAPGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVF
MSMEG_2196|M.smegmatis_MC2_155 NRRALMAHLEARLAPGQPGPVAVMFFDLDRLKAINDYLGHTAGDAFISIL
TH_0811|M.thermoresistible__bu NRRALLAHLDARLAAGQPGPVSALYFDLDRLKAVNDYLGHTVGDWFIRVL
MLBr_01750|M.leprae_Br4923 NRRALIAHLDERLADGQRGPVTLLFLGLDRLKAVNDYLGHNAGDRLIEVF
MAV_1132|M.avium_104 NRRALVAHLTERLAAGNPGPVAVFYLDLDRLKPINDYLGHTAGDWFIRVF
MAB_1839|M.abscessus_ATCC_1997 NRRGLQEAYEATVGVPG-MHVTVVVVDLNLFKQINDTFGHHVGDQVLQRT
** : : . . ..*: :* :** :** .** .:
Mvan_1918|M.vanbaalenii_PYR-1 GERLKRCVTAADTLARIGGDEFAVLIVA--EAEQLEVVAERLRIALRDPF
Mflv_4444|M.gilvum_PYR-GCK GERLRRHVRSEDTLARIGGDEFAILIDG--VRDIPELIADRLRVALRDPF
Mb1389c|M.bovis_AF2122/97 AQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHV
Rv1354c|M.tuberculosis_H37Rv AQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHV
MSMEG_2196|M.smegmatis_MC2_155 AQRLQRGDDAPKLIARLGGDEFVVVPDDPMSLDEATALAYRLQSVLRERV
TH_0811|M.thermoresistible__bu AERLREGAGPDDLIARLGGDEFVVVPSGPVDADAALELANRLRSRLQQQV
MLBr_01750|M.leprae_Br4923 ADRLREAAESLTVIARFGGDEFVVVPAESVSVDVAESFAHRLQTRLQKQV
MAV_1132|M.avium_104 AQRIEECAGEQSMIARLGGDEFVVIPHQPMASEAAEAFARRLSTLLCDRL
MAB_1839|M.abscessus_ATCC_1997 AHRLRSVVGPDALLARLGGDEFGIVVVG------DAPPHIDYQRAVEEAL
..*: :**:***** :: : . .
Mvan_1918|M.vanbaalenii_PYR-1 PVHGSSVRVKASMGLVRPEGDGMPQTSDDLLRQADISMYAGKRMGKDTAV
Mflv_4444|M.gilvum_PYR-GCK PVHGSSLRVRASMGLVRSGGAGGLQTPDDLLRQADISMYAGKRLGKDTAV
Mb1389c|M.bovis_AF2122/97 AIGGEVLTRTVSIGVAS--GTPGQHTPSDLLRRADQAALAAKHAGGDSVA
Rv1354c|M.tuberculosis_H37Rv AIGGEVLTRTVSIGVAS--GTPGQHTPSDLLRRADQAALAAKHAGGDSVA
MSMEG_2196|M.smegmatis_MC2_155 TVDGEMLTRTVSIGIAQ--GIPGKDSTSDVLNRADHAVLTAKGSGGNRVA
TH_0811|M.thermoresistible__bu CVDGEMLTRTASIGVAQ--GTPGRDTTSDLLRRADQAVLTAKSAGGNQIT
MLBr_01750|M.leprae_Br4923 VIDGEILTRTVSIGVAT--GLPGRDTTSDLLRWADHAALSAK-SDGSKVV
MAV_1132|M.avium_104 TIGGHVISRTVSIGLAV--GTPGADNCTDLLRRADEAVLTAKRAGGNQTA
MAB_1839|M.abscessus_ATCC_1997 NSASEDVPVSASVGVAA-----------AILPESDRTTIHTLGPIVTHLL
. : .*:*:. :* :* :
Mvan_1918|M.vanbaalenii_PYR-1 VYQPASGVIVDFP--TMLRTADGGAPPGFRLVYQPVVRLPEGTPVAVEAL
Mflv_4444|M.gilvum_PYR-GCK VYQPSAGVRAEFP--AALREAQGGVPDGFTLAYQPVVHLPDQTPAALEAL
Mb1389c|M.bovis_AF2122/97 IFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRTGDIVGTEAL
Rv1354c|M.tuberculosis_H37Rv IFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRTGDIVGTEAL
MSMEG_2196|M.smegmatis_MC2_155 VFSDAMAMEIDFRNDIELHLQSVIEGGALVLHYLPEIDMRTGEVLAAEAL
TH_0811|M.thermoresistible__bu VFTDDMSLEAEFRNDIELHLQSVIQDEALLLHFLPEVDMRTGEILATEAL
MLBr_01750|M.leprae_Br4923 VLDHGISAQHTLRTEVELHLAGMID-TDLVLHYLPEVDMSTGKVLGTEAL
MAV_1132|M.avium_104 VSTDDMSLKRAFRNDIELHLQGDIESEGLLLHYLPEVDLWTGAVVGAEAL
MAB_1839|M.abscessus_ATCC_1997 VEADGAMYGAKKAG------------------------------------
:
Mvan_1918|M.vanbaalenii_PYR-1 ARWTAPNGIDISPETFVAVTEAAGMGADFDALVLDLACREVQ-----GRG
Mflv_4444|M.gilvum_PYR-GCK ARWTAPNGILIAPETFVAVAEASGLGATLDAMVLRLACREVK-----DAG
Mb1389c|M.bovis_AF2122/97 VRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLG
Rv1354c|M.tuberculosis_H37Rv VRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLG
MSMEG_2196|M.smegmatis_MC2_155 VRWEHPTRGLLSPDSFIGVAESINLAGELGRWVLRTACAEFSRWRANGVG
TH_0811|M.thermoresistible__bu VRWHHPTRGLLAPDTFIGVAESVNLAGELGRWVMRTACGEFAKWRAEGIG
MLBr_01750|M.leprae_Br4923 VRWQHPTRGLLFPDSFIPVAESINLAGKLGRMVMHSACAEFSRWRSAGVG
MAV_1132|M.avium_104 VRWRHPIWGLLLPDSFIGVAESTNLGAELGGWVMRSACADFSRWRANGVG
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1918|M.vanbaalenii_PYR-1 LNLDIHVNIGAARLGNPGFEQQVSQVLARHRIPRNRLVLEITETEPIVDL
Mflv_4444|M.gilvum_PYR-GCK LDVDIHVNVGAARLGNPTFEEQVHRTFDECGMEPSRLVLEITETVPIVDL
Mb1389c|M.bovis_AF2122/97 HDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDL
Rv1354c|M.tuberculosis_H37Rv HDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDL
MSMEG_2196|M.smegmatis_MC2_155 RNIVLRINVSPVQLVTDGFVESVAGIMKEFGLPRGSVCLEITESVVVQDI
TH_0811|M.thermoresistible__bu LDAVLRINVSPVQLVTDGFVASVADIIDEFGLDGSSVCLEITESVVVQDI
MLBr_01750|M.leprae_Br4923 LDALLRINVSPVQLVAEGFVDNVAGTLDEFGLDGSMVCLEITENVVVQNI
MAV_1132|M.avium_104 HGAMLRINVSPIQLISRGFVETVADTIGEFGIDAGSVCLEITERAVVHDT
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1918|M.vanbaalenii_PYR-1 DRAAAQIRRLGQLGVRVALDDFGAGFNSLTYLHCLPVHIVKLDRSLAVGG
Mflv_4444|M.gilvum_PYR-GCK ADAAAQIERFKALGIRIALDDFGAGYNSLTYLHALPVDIVKLDRSLAVGA
Mb1389c|M.bovis_AF2122/97 HTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQL
Rv1354c|M.tuberculosis_H37Rv HTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQL
MSMEG_2196|M.smegmatis_MC2_155 ETTRTTLTGLHNVGVQVAIDDFGTGYSVLSLLKSLPVDTLKIDRSFVAEL
TH_0811|M.thermoresistible__bu KTTRITLEGLNEVGVQVAIDDFGTGYSVLSHLKTLPVDTLKIDKGFVQDL
MLBr_01750|M.leprae_Br4923 DATRKTLAGLKEVGVHLAIDDFGTGYSVLTHLKSLPVDTIKIDKSFVAEL
MAV_1132|M.avium_104 ETTRKTLSELKEVGVQIAIDDFGTGYAVLSHLKSLPVDMLKIDAGFVREV
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1918|M.vanbaalenii_PYR-1 EP-ARDLSLYRSVIRLCDDLGLDVIAEGIELPAQSEMVHSAGGRLAQGHL
Mflv_4444|M.gilvum_PYR-GCK DP-ERDLALYRSVIGLCTDLGMDVVAEGIETQLQADTVHAAGCAFAQGHL
Mb1389c|M.bovis_AF2122/97 GTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGFL
Rv1354c|M.tuberculosis_H37Rv GTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGFL
MSMEG_2196|M.smegmatis_MC2_155 GSNPGDLPIVRAVIALAGAFGLQLVAEGVETERAALTLLRHGCYRAQGFL
TH_0811|M.thermoresistible__bu GNSPGDLAIVRAIIALAEAFGLQLVAEGVETEAAALTLLRHGCHRAQGFL
MLBr_01750|M.leprae_Br4923 GSNASDLAIVRAIMALAKEFELEVVAEGVETAVAAQVLLELGCNRAQGFL
MAV_1132|M.avium_104 GTDAGDLAIVRAIIGLAEAFGLEVVAEGVETPAAALTLMQHGCHRAQGFL
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1918|M.vanbaalenii_PYR-1 FGRPVPIAELGDAVIGDREWGLSPAALPDLTQAD-----
Mflv_4444|M.gilvum_PYR-GCK FGKPVAISEL---TRGWHERSGQIGGGRGVNQPS-----
Mb1389c|M.bovis_AF2122/97 FSRPVPGEAMRHMLSARRLPPTCIPATDPALS-------
Rv1354c|M.tuberculosis_H37Rv FSRPVPGEAMRHMLSARRLPPTCIPATDPALS-------
MSMEG_2196|M.smegmatis_MC2_155 LSKPILGSEMQTLLAKGRVPVHFSAAPRM----------
TH_0811|M.thermoresistible__bu LSRPIPSNEMRELLARGRIPMRFSATP------------
MLBr_01750|M.leprae_Br4923 LSRPVDGAAMESLLAKGVIPMALGTCQSPEPSEHQIHRS
MAV_1132|M.avium_104 LSRPIPGEAMEALLSARWMPMPFLADREASSMGSI----
MAB_1839|M.abscessus_ATCC_1997 ---------------------------------------