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GQSDRLDVFFEELAELAGQRNAIDGRIAQIAAEIDDAGLWGFTGVRSMEGLIAWKLGTSFRNAETIVAVA RRLEEFPRCSRDLCEGRLSLDQVGVIAERAGAGSDDHYAELAAHSTVAQLRTAVKQEPRPEPEPDRDPGR DCDPEAESEAECGSESESGADCDPESESEAKPRRDPVPRASITKTSDEQYTYWRIALPHEEAATFDTALN CHLEGLVAQWKRDHNITDHTDDHNHDINSDPGRGDGHDTVDRGYDTDDGGGGGGGGEGVGRAPLPDTVAA FWALVKAGWDVEVARRPHGAHTTVVMHVDVKDRIAALHLGPALSAAERRYLSCDATCEVWFERHGQVIGS GRTTRAISRRLRRALEHRDRTCVVPGCGATRGLHAHHIRHWEDGGLTELDNLVLVCPHHHRLHHRGVITI TGPADQLTVTDSVGRHLEPGSLARPPTTPPPAVAPYQGPPGERAQWKWYTPFQPPPPTTN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4621 | - | - | 100% (481) | hypothetical protein Mvan_4621 |
| M. vanbaalenii PYR-1 | Mvan_4558 | - | 0.0 | 88.98% (490) | hypothetical protein Mvan_4558 |
| M. vanbaalenii PYR-1 | Mvan_0273 | - | 0.0 | 88.57% (481) | hypothetical protein Mvan_0273 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1794c | - | 1e-162 | 60.37% (482) | hypothetical protein Mb1794c |
| M. gilvum PYR-GCK | Mflv_1988 | - | 1e-164 | 59.79% (475) | hypothetical protein Mflv_1988 |
| M. tuberculosis H37Rv | Rv2015c | - | 1e-162 | 60.37% (482) | hypothetical protein Rv2015c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0990c | - | 3e-10 | 41.25% (80) | hypothetical protein MAB_0990c |
| M. marinum M | MMAR_0868 | - | 3e-08 | 37.21% (86) | hypothetical protein MMAR_0868 |
| M. avium 104 | MAV_4292 | - | 1e-152 | 57.93% (473) | hypothetical protein MAV_4292 |
| M. smegmatis MC2 155 | MSMEG_3404 | - | 1e-142 | 54.81% (478) | HNH endonuclease domain-containing protein |
| M. thermoresistible (build 8) | TH_1926 | - | 2e-43 | 73.08% (104) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_2371 | - | 2e-05 | 33.77% (77) | hypothetical protein MUL_2371 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1794c|M.bovis_AF2122/97 ------------------MSSTATSGAAVVSPAERVEVLFEELAELAGQR
Rv2015c|M.tuberculosis_H37Rv ------------------MSSTATSGAAVVSPAERVEVLFEELAELAGQR
MAV_4292|M.avium_104 -------------------------------------MLFEELAELTGQR
Mvan_4621|M.vanbaalenii_PYR-1 -----------------------------MGQSDRLDVFFEELAELAGQR
Mflv_1988|M.gilvum_PYR-GCK -----------------MRPGSAPSFIPSPPREARLEALFDELSELAGQR
MSMEG_3404|M.smegmatis_MC2_155 ------------------MTSAATSPAAQPTPVERLEALFDALAELTGQR
TH_1926|M.thermoresistible__bu --------------------------------------------------
MAB_0990c|M.abscessus_ATCC_199 ------------MSSIGVVEAAVDAFCAESIEDLTAGEALAMLARLKVVQ
MUL_2371|M.ulcerans_Agy99 MHSNGCSDRESVVATLDRLDRAVDALVEVSFEALTTPERLRVLERLEVVA
MMAR_0868|M.marinum_M --------MRSIAGLLDALDAAVAAIGEAHLEGLQPVERLRMLARLETAR
Mb1794c|M.bovis_AF2122/97 NAIDGRIVEIVAELDRDGLWGVTGARSVAGLVAWKMGCSSGNAHTIATVA
Rv2015c|M.tuberculosis_H37Rv NAIDGRIVEIVAELDRDGLWGVTGARSVAGLVAWKMGCSSGNAHTIATVA
MAV_4292|M.avium_104 NAIDGRIVDIVAEIDRDELCGITGARSVPALVAWKTGCSPANAHTIATIA
Mvan_4621|M.vanbaalenii_PYR-1 NAIDGRIAQIAAEIDDAGLWGFTGVRSMEGLIAWKLGTSFRNAETIVAVA
Mflv_1988|M.gilvum_PYR-GCK NAIDGRIVDIVAEIDGDQLWGATGARSIAALVAWKLGTSAGNAERIVAIA
MSMEG_3404|M.smegmatis_MC2_155 NAIDAKIVQIVAEIDRDGLWGATGARSISALVAWKTGASERNAKAIAAVA
TH_1926|M.thermoresistible__bu --------------------------------------------------
MAB_0990c|M.abscessus_ATCC_199 RRLASRGLGLVSAVTGQASPMQLGGTSYAEVLSRRMHMGKRAARRRIADA
MUL_2371|M.ulcerans_Agy99 RRLPAAQYALVNQLDEQPGEAELGGR-LAAVVASRLRITRSEAGRRVAEA
MMAR_0868|M.marinum_M RLQAVISHDVIAGLYTED-PAAIGGP-VTKVVADWLRITPTDARRRLRDA
Mb1794c|M.bovis_AF2122/97 RRL------------PEFPRCARGMREGRLSLDQVGVIAGRAGEGSDAHY
Rv2015c|M.tuberculosis_H37Rv RRL------------PEFPRCARGMREGRLSLDQVGVIAGRAGEGSDAHY
MAV_4292|M.avium_104 ARL------------PEFPRCAQGMREGWLSLDQVGVIAARGGAGSDEHY
Mvan_4621|M.vanbaalenii_PYR-1 RRL------------EEFPRCSRDLCEGRLSLDQVGVIAERAGAGSDDHY
Mflv_1988|M.gilvum_PYR-GCK DRA------------AEFPRCTQALREGRLSVDQVGVIAEGAGQGSDDHY
MSMEG_3404|M.smegmatis_MC2_155 HRA------------EEFPRCVQGLGAGRLSLDQVGVIAEGAADGSDEHY
TH_1926|M.thermoresistible__bu --------------------------------------------------
MAB_0990c|M.abscessus_ATCC_199 ELLAPRRAITGEQLAPQLPHTAQALGRGDIGEEHLRIIRHFFDRLPVVVD
MUL_2371|M.ulcerans_Agy99 AEVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFFRQLPAGVD
MMAR_0868|M.marinum_M QQLSARTTLTGQVLPPELPATARAWRDGQLDGQHLRVIATFVRDLPQDTA
Mb1794c|M.bovis_AF2122/97 AQLAGVATVNQLRTALKLEPRPEPEPDF----------------------
Rv2015c|M.tuberculosis_H37Rv AQLAGVATVNQLRTALKLEPRPEPEPDF----------------------
MAV_4292|M.avium_104 VELARVATVSQLRTAVKLEPRPEPEP------------------------
Mvan_4621|M.vanbaalenii_PYR-1 AELAAHSTVAQLRTAVKQEPRPEPEPDRDPGRDCDPEAESEAECGSESES
Mflv_1988|M.gilvum_PYR-GCK ARLAQNASVSQLRTAIKQEPRPEPEPSADDGDEPDHDLPDHDE-------
MSMEG_3404|M.smegmatis_MC2_155 AALASVATVSQLRKAISLEPKPEPEPKPD---------------------
TH_1926|M.thermoresistible__bu --------------------------------------------------
MAB_0990c|M.abscessus_ATCC_199 AATREAAEAQLAVMATQFRPEALRVGADRMMALLNPDGQFSDA-------
MUL_2371|M.ulcerans_Agy99 VGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDGRHSDE-------
MMAR_0868|M.marinum_M PQIVAGAEKLLAHQALQLRPDQLEKAAHRCALLINPDGRFSDA-------
Mb1794c|M.bovis_AF2122/97 ----------------RPEPRPSITRSADEQFSCWRIKLPHVEAAKFDAA
Rv2015c|M.tuberculosis_H37Rv ----------------RPEPRPSITRSADEQFSCWRIKLPHVEAAKFDAA
MAV_4292|M.avium_104 ----------------QREPERAFTRTSTEQGSCYRITLAHDEAAKFDAA
Mvan_4621|M.vanbaalenii_PYR-1 GADCDPESESEAKPRRDPVPRASITKTSDEQYTYWRIALPHEEAATFDTA
Mflv_1988|M.gilvum_PYR-GCK -------------PEPPSLPTAEITTSCDADYTYWRIKLPHEQAATFQAA
MSMEG_3404|M.smegmatis_MC2_155 -------------------PRRSIRTNPGDGYTTYHITLPRLEAAKFDTA
TH_1926|M.thermoresistible__bu --------------------------------------------------
MAB_0990c|M.abscessus_ATCC_199 --------------DRARRRGITIGPQGFDGMSAISGLLDPETRAYLDAV
MUL_2371|M.ulcerans_Agy99 --------------DRARRRGLSLGRQGLDGMSRISGWLTPEARAGLEAV
MMAR_0868|M.marinum_M --------------DRARQRGFTWCAQRRDGMSIGKLIATPELRANLDAW
Mb1794c|M.bovis_AF2122/97 LQSHLDALIAEYKRDHDNSDGVSDQ-------------------------
Rv2015c|M.tuberculosis_H37Rv LQSHLDALIAEYKRDHDNSDGVSDQ-------------------------
MAV_4292|M.avium_104 LQSHLDALIAEWEHDRDNTERVFDQ-------------------------
Mvan_4621|M.vanbaalenii_PYR-1 LNCHLEGLVAQWKRDHNITDHTDDHNHDINSDPGRGDGHDTVDRGYDTDD
Mflv_1988|M.gilvum_PYR-GCK LHSHKDALIAQWTREHADSDEGPHR-------------------------
MSMEG_3404|M.smegmatis_MC2_155 LEASHEGLIARWEREQ---DPGDPA-------------------------
TH_1926|M.thermoresistible__bu --------------------------------------------------
MAB_0990c|M.abscessus_ATCC_199 FAKLAAPGMCNPNDQSPLVDGQPADDAAERDT------------------
MUL_2371|M.ulcerans_Agy99 WAKLAAPGMCNPEDEAAVVDGPVSRDAADRDS------------------
MMAR_0868|M.marinum_M LARFAAPGMCNPDNQTPCVTDEPTEDAAATDA------------------
Mb1794c|M.bovis_AF2122/97 ------------RPPLPGNVEAFLRLVEAGWDAEVARRPHGQHTTVVMHL
Rv2015c|M.tuberculosis_H37Rv ------------RPPLPGNVEAFLRLVEAGWDAEVARRPHGQHTTVVMHL
MAV_4292|M.avium_104 ------------RPPLPDSLDAFMRLVETGWDAEAARRPHGQHTTVVMHL
Mvan_4621|M.vanbaalenii_PYR-1 GGGGGGGGEGVGRAPLPDTVAAFWALVKAGWDVEVARRPHGAHTTVVMHV
Mflv_1988|M.gilvum_PYR-GCK -------------PPLPNLAEAFLALVEASWDAEALRRPHGQHTTVVVHV
MSMEG_3404|M.smegmatis_MC2_155 -------------VPMPDLVDAFMALVETGWDREATRRPHGQHTAVAVHV
TH_1926|M.thermoresistible__bu --------------------------------------------------
MAB_0990c|M.abscessus_ATCC_199 ------------RTVAQRHHDALRAALRSTLVSTELGSHHGLPVTVVVTT
MUL_2371|M.ulcerans_Agy99 ------------RSVSQRQHDGFNAALRAVLASGELGQHNGLPASIIVST
MMAR_0868|M.marinum_M ------------RRPAQRQHDALNALVRGQLGDPALGTHNGLPVTVIVST
Mb1794c|M.bovis_AF2122/97 DVQERAAGLHLGP------LLSESERRYLLCDATFEAWFERDG-QVIGCG
Rv2015c|M.tuberculosis_H37Rv DVQERAAGLHLGP------LLSESERRYLLCDATFEAWFERDG-QVIGCG
MAV_4292|M.avium_104 DIAQRLAALNLGP------LLTDAERQYLTCDATCEVWFERDG-QPIGAG
Mvan_4621|M.vanbaalenii_PYR-1 DVKDRIAALHLGP------ALSAAERRYLSCDATCEVWFERHG-QVIGSG
Mflv_1988|M.gilvum_PYR-GCK DVESKLAALHLGP------LLTAEERRYLSCEATCEVWFERHG-RPIGAG
MSMEG_3404|M.smegmatis_MC2_155 DLKSKVAALHLGP------LLGDDERRLLTCDATCEVWFELRG-RVIGTG
TH_1926|M.thermoresistible__bu --------------------------------------------------
MAB_0990c|M.abscessus_ATCC_199 TLKELEDAAGIAITGAGTRLPMRDLIRMATHAHHYLAIFDDHG-RALYLG
MUL_2371|M.ulcerans_Agy99 TLKELEAAAGRGLTGGGTLLPMSDVIRLARHAHHYLAVFD-RG-EAIGLY
MMAR_0868|M.marinum_M TLQEITAATGRAVTGGGTLLPMRDVIRMARHAYHYLAVFDEHSNRPLYLG
Mb1794c|M.bovis_AF2122/97 RTTRQINRRLRRALEHRDRTCVVPGCGAT-RGLHAHHIRHWQDGGATELA
Rv2015c|M.tuberculosis_H37Rv RTTRQINRRLRRALEHRDRTCVVPGCGAT-RGLHAHHIRHWQDGGATELA
MAV_4292|M.avium_104 RTTRVINRRLRRALEHRHPTCAVPGCGAT-RGLHAHHLRHWEDGGPTELA
Mvan_4621|M.vanbaalenii_PYR-1 RTTRAISRRLRRALEHRDRTCVVPGCGAT-RGLHAHHIRHWEDGGLTELD
Mflv_1988|M.gilvum_PYR-GCK RSTRTVNRRLRRALEHRDRSCVVPGCGAT-RGLHAHHIVHWEDGGDTELD
MSMEG_3404|M.smegmatis_MC2_155 RATRTVNRRLRRALEHRDRCCVVPGCSAT-RGLHAHHLVHWEDGGLTEMA
TH_1926|M.thermoresistible__bu ----------------------VPGCGAT-RGLHAHHIRHWEHRGPTDLD
MAB_0990c|M.abscessus_ATCC_199 RSQRIASPDQRLVLHARDRGCTHPDCHVPGYLCQAHHITEWVHDGPTDID
MUL_2371|M.ulcerans_Agy99 HAKRLATPGQRIVLYAKDRGCTRPGCDVAGYQCEVHHVAAWAISGRTDIN
MMAR_0868|M.marinum_M RTRRIASPDQRVVLYAAERGCTHPGCDAPGYWCEVHHLADWAAGGPTDVD
*.* .. ..**: * * *::
Mb1794c|M.bovis_AF2122/97 NLVLVCPYHHRAHHRGLITITGPADNLTVADSAGRPLSAGSLARASTKPP
Rv2015c|M.tuberculosis_H37Rv NLVLVCPYHHRAHHRGLITITGPADNLTVADSAGRPLSAGSLARASTKPP
MAV_4292|M.avium_104 NLVLVCPYHHRLHHRGIITITGPADALTVTDSDGRPLSPGSLARPPTQPP
Mvan_4621|M.vanbaalenii_PYR-1 NLVLVCPHHHRLHHRGVITITGPADQLTVTDSVGRHLEPGSLARPPTTPP
Mflv_1988|M.gilvum_PYR-GCK NLVLVCPYHHRAHHRGIIVITGPAHQLAVTDHTGRPLQSGTLARPPTQPP
MSMEG_3404|M.smegmatis_MC2_155 NLVLLCPYHHRAHHRGLITITGPADQLTVTDDRGRLLTNQSLARTPTTPP
TH_1926|M.thermoresistible__bu NLVLVCRYHHRLHHRGLITISDTPDNLTVSDRDGDRLHPGSLARPPDRPP
MAB_0990c|M.abscessus_ATCC_199 NLTFACAPHHRLLGHGWTTRK-------RKDGTTEWIPPPQLALPG----
MUL_2371|M.ulcerans_Agy99 QLTLACGPDHKLLEQGWRTRK-------NAHGDTEWLPPPHLDHGQPRTN
MMAR_0868|M.marinum_M NLTFACTPHHRLAGKSWQTIK-------LPNSRTAWLPPPQLRRGAR-TN
:*.: * .*: :. . . . : *
Mb1794c|M.bovis_AF2122/97 PAVAPWPGPTGERADWWWYEPFQPQPPPISN-----
Rv2015c|M.tuberculosis_H37Rv PAVAPWPGPTGERADWWWYEPFQPQPPPISN-----
MAV_4292|M.avium_104 PAVPPCPGPLGERADWWWYDPFQPQPPPTNN-----
Mvan_4621|M.vanbaalenii_PYR-1 PAVAPYQGPPGERAQWKWYTPFQP-PPPTTN-----
Mflv_1988|M.gilvum_PYR-GCK PAVPPYRGPSGERLYWKWYHPYQPPPTATAN-----
MSMEG_3404|M.smegmatis_MC2_155 PTVPPCPGPLGERAQWWWYQPFEPQPPPSAN-----
TH_1926|M.thermoresistible__bu PQVAPCTGPTGERADWWWYTPYQPPAPPPADETGPG
MAB_0990c|M.abscessus_ATCC_199 -----ETRHDDIVDQCPHGVGSR-------------
MUL_2371|M.ulcerans_Agy99 SYHHPEKLLRDSADDDDEGHGAA-------------
MMAR_0868|M.marinum_M DYHHPERLLDDRAAPD--------------------
.