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RQSDRLEVCFEELAELAGQRNAIDGRIAQIAAEIDGAGLWAITGVKSMEGLIAWKLGTSFRNAETIVAVA RRLEQFPRCSRDLREGRLSLDQVGVIAERAGAGSDDHYADLAAHSTVAQLRIAVKQEPRPEPEPDRDPGR DCDPEAESGAECGSESESGADCDPESESEAKPRRDPVPRASITKTSDEQYTYWRIALPHEEAATFDTALR SHHEALVAQWKRDHDITDHTDGHDITDRTDGHDTDGHDDNVGDHTDTDGRDITNPGPYYDGDGGEGVGRA PLPDTVAAFWALVKAGWDVEVARRPHGQHTTVVMHVDVKERIAALHLGPALSAAERRYLSCDATCEVWFE RHGQVIGSGRTTRAISRRLRRALEHRDRTCVVPGCGATRGLHAHHIRHWEDGGLTELDNLVLVCPHHHRL HHRGVITITGPAERLTVTDSVGRHLEPGSLARPPTQSPPAVAPYQGPPGERAQWKWYTPFQPPPPTTN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4558 | - | - | 100% (489) | hypothetical protein Mvan_4558 |
| M. vanbaalenii PYR-1 | Mvan_4621 | - | 0.0 | 88.98% (490) | hypothetical protein Mvan_4621 |
| M. vanbaalenii PYR-1 | Mvan_0273 | - | 0.0 | 89.16% (489) | hypothetical protein Mvan_0273 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1794c | - | 1e-161 | 59.59% (490) | hypothetical protein Mb1794c |
| M. gilvum PYR-GCK | Mflv_1988 | - | 1e-164 | 59.01% (483) | hypothetical protein Mflv_1988 |
| M. tuberculosis H37Rv | Rv2015c | - | 1e-161 | 59.59% (490) | hypothetical protein Rv2015c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0990c | - | 2e-10 | 35.11% (131) | hypothetical protein MAB_0990c |
| M. marinum M | MMAR_0868 | - | 2e-08 | 37.08% (89) | hypothetical protein MMAR_0868 |
| M. avium 104 | MAV_0036 | - | 1e-151 | 55.51% (490) | hypothetical protein MAV_0036 |
| M. smegmatis MC2 155 | MSMEG_3404 | - | 1e-139 | 52.67% (486) | HNH endonuclease domain-containing protein |
| M. thermoresistible (build 8) | TH_1926 | - | 2e-42 | 71.15% (104) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_2371 | - | 2e-05 | 33.77% (77) | hypothetical protein MUL_2371 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1794c|M.bovis_AF2122/97 ------------------MSSTATSGAAVVSPAERVEVLFEELAELAGQR
Rv2015c|M.tuberculosis_H37Rv ------------------MSSTATSGAAVVSPAERVEVLFEELAELAGQR
MAV_0036|M.avium_104 ------------------MSSSVLAAEVEVRPYDRLAVLFDELAELTGQR
Mvan_4558|M.vanbaalenii_PYR-1 -----------------------------MRQSDRLEVCFEELAELAGQR
Mflv_1988|M.gilvum_PYR-GCK -----------------MRPGSAPSFIPSPPREARLEALFDELSELAGQR
MSMEG_3404|M.smegmatis_MC2_155 ------------------MTSAATSPAAQPTPVERLEALFDALAELTGQR
TH_1926|M.thermoresistible__bu --------------------------------------------------
MAB_0990c|M.abscessus_ATCC_199 ------------MSSIGVVEAAVDAFCAESIEDLTAGEALAMLARLKVVQ
MUL_2371|M.ulcerans_Agy99 MHSNGCSDRESVVATLDRLDRAVDALVEVSFEALTTPERLRVLERLEVVA
MMAR_0868|M.marinum_M --------MRSIAGLLDALDAAVAAIGEAHLEGLQPVERLRMLARLETAR
Mb1794c|M.bovis_AF2122/97 NAIDGRIVEIVAELDRDGLWGVTGARSVAGLVAWKMGCSSGNAHTIATVA
Rv2015c|M.tuberculosis_H37Rv NAIDGRIVEIVAELDRDGLWGVTGARSVAGLVAWKMGCSSGNAHTIATVA
MAV_0036|M.avium_104 NAIDGRIVEIVAQIEREQLWGATGARSLGALVAWKTGCSPGNAETIATVA
Mvan_4558|M.vanbaalenii_PYR-1 NAIDGRIAQIAAEIDGAGLWAITGVKSMEGLIAWKLGTSFRNAETIVAVA
Mflv_1988|M.gilvum_PYR-GCK NAIDGRIVDIVAEIDGDQLWGATGARSIAALVAWKLGTSAGNAERIVAIA
MSMEG_3404|M.smegmatis_MC2_155 NAIDAKIVQIVAEIDRDGLWGATGARSISALVAWKTGASERNAKAIAAVA
TH_1926|M.thermoresistible__bu --------------------------------------------------
MAB_0990c|M.abscessus_ATCC_199 RRLASRGLGLVSAVTGQASPMQLGGTSYAEVLSRRMHMGKRAARRRIADA
MUL_2371|M.ulcerans_Agy99 RRLPAAQYALVNQLDEQPGEAELGGR-LAAVVASRLRITRSEAGRRVAEA
MMAR_0868|M.marinum_M RLQAVISHDVIAGLYTED-PAAIGGP-VTKVVADWLRITPTDARRRLRDA
Mb1794c|M.bovis_AF2122/97 RRLP------------EFPRCARGMREGRLSLDQVGVIAGRAGEGSDAHY
Rv2015c|M.tuberculosis_H37Rv RRLP------------EFPRCARGMREGRLSLDQVGVIAGRAGEGSDAHY
MAV_0036|M.avium_104 RRLD------------SFPRCAAGLREGRFSLDQLGVIAQRAGEGSDEHY
Mvan_4558|M.vanbaalenii_PYR-1 RRLE------------QFPRCSRDLREGRLSLDQVGVIAERAGAGSDDHY
Mflv_1988|M.gilvum_PYR-GCK DRAA------------EFPRCTQALREGRLSVDQVGVIAEGAGQGSDDHY
MSMEG_3404|M.smegmatis_MC2_155 HRAE------------EFPRCVQGLGAGRLSLDQVGVIAEGAADGSDEHY
TH_1926|M.thermoresistible__bu --------------------------------------------------
MAB_0990c|M.abscessus_ATCC_199 ELLAPRRAITGEQLAPQLPHTAQALGRGDIGEEHLRIIRHFFDRLPVVVD
MUL_2371|M.ulcerans_Agy99 AEVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFFRQLPAGVD
MMAR_0868|M.marinum_M QQLSARTTLTGQVLPPELPATARAWRDGQLDGQHLRVIATFVRDLPQDTA
Mb1794c|M.bovis_AF2122/97 AQLAGVATVNQLRTALKLEPRPEPEPD-----------------------
Rv2015c|M.tuberculosis_H37Rv AQLAGVATVNQLRTALKLEPRPEPEPD-----------------------
MAV_0036|M.avium_104 AQLAGVATVNQLRTAVKLEPRPQPE-------------------------
Mvan_4558|M.vanbaalenii_PYR-1 ADLAAHSTVAQLRIAVKQEPRPEPEPDRDPGRDCDPEAESGAECGSESES
Mflv_1988|M.gilvum_PYR-GCK ARLAQNASVSQLRTAIKQEPRPEPEPSADDGDEPDHDLPDHDE-------
MSMEG_3404|M.smegmatis_MC2_155 AALASVATVSQLRKAISLEPKPEPEPKPD---------------------
TH_1926|M.thermoresistible__bu --------------------------------------------------
MAB_0990c|M.abscessus_ATCC_199 AATREAAEAQLAVMATQFRPEALRVGADRMMALLNPDGQFSDA-------
MUL_2371|M.ulcerans_Agy99 VGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDGRHSDE-------
MMAR_0868|M.marinum_M PQIVAGAEKLLAHQALQLRPDQLEKAAHRCALLINPDGRFSDA-------
Mb1794c|M.bovis_AF2122/97 ---------------FRPEPRPSITRSADEQFSCWRIKLPHVEAAKFDAA
Rv2015c|M.tuberculosis_H37Rv ---------------FRPEPRPSITRSADEQFSCWRIKLPHVEAAKFDAA
MAV_0036|M.avium_104 ---------------AKPAPQPGLTKTSDEELSCWRITLDRLDAATFDAA
Mvan_4558|M.vanbaalenii_PYR-1 GADCDPESESEAKPRRDPVPRASITKTSDEQYTYWRIALPHEEAATFDTA
Mflv_1988|M.gilvum_PYR-GCK -------------PEPPSLPTAEITTSCDADYTYWRIKLPHEQAATFQAA
MSMEG_3404|M.smegmatis_MC2_155 -------------------PRRSIRTNPGDGYTTYHITLPRLEAAKFDTA
TH_1926|M.thermoresistible__bu --------------------------------------------------
MAB_0990c|M.abscessus_ATCC_199 --------------DRARRRGITIGPQGFDGMSAISGLLDPETRAYLDAV
MUL_2371|M.ulcerans_Agy99 --------------DRARRRGLSLGRQGLDGMSRISGWLTPEARAGLEAV
MMAR_0868|M.marinum_M --------------DRARQRGFTWCAQRRDGMSIGKLIATPELRANLDAW
Mb1794c|M.bovis_AF2122/97 LQSHLDALIAEYKRDHDNSD------------------------------
Rv2015c|M.tuberculosis_H37Rv LQSHLDALIAEYKRDHDNSD------------------------------
MAV_0036|M.avium_104 LAAHREALIAEWKRDHNHRA------------------------------
Mvan_4558|M.vanbaalenii_PYR-1 LRSHHEALVAQWKRDHDITDHTDGHDITDRTDGHDTDGHDDNVGDHTDTD
Mflv_1988|M.gilvum_PYR-GCK LHSHKDALIAQWTREHADSD------------------------------
MSMEG_3404|M.smegmatis_MC2_155 LEASHEGLIARWEREQ---D------------------------------
TH_1926|M.thermoresistible__bu --------------------------------------------------
MAB_0990c|M.abscessus_ATCC_199 FAKLAAPGMCNPNDQSPLVDGQP---------------------------
MUL_2371|M.ulcerans_Agy99 WAKLAAPGMCNPEDEAAVVDGPV---------------------------
MMAR_0868|M.marinum_M LARFAAPGMCNPDNQTPCVTDEP---------------------------
Mb1794c|M.bovis_AF2122/97 ---------------GVSDQRPPLPGNVEAFLRLVEAGWDAEVARRPHGQ
Rv2015c|M.tuberculosis_H37Rv ---------------GVSDQRPPLPGNVEAFLRLVEAGWDAEVARRPHGQ
MAV_0036|M.avium_104 ---------------GES--VPPLPGTLEAFIRLIETGWDAEAHRRPHGH
Mvan_4558|M.vanbaalenii_PYR-1 GRDITNPGPYYDGDGGEGVGRAPLPDTVAAFWALVKAGWDVEVARRPHGQ
Mflv_1988|M.gilvum_PYR-GCK ----------------EGPHRPPLPNLAEAFLALVEASWDAEALRRPHGQ
MSMEG_3404|M.smegmatis_MC2_155 ----------------PGDPAVPMPDLVDAFMALVETGWDREATRRPHGQ
TH_1926|M.thermoresistible__bu --------------------------------------------------
MAB_0990c|M.abscessus_ATCC_199 -----------ADDAAERDTRTVAQRHHDALRAALRSTLVSTELGSHHGL
MUL_2371|M.ulcerans_Agy99 -----------SRDAADRDSRSVSQRQHDGFNAALRAVLASGELGQHNGL
MMAR_0868|M.marinum_M -----------TEDAAATDARRPAQRQHDALNALVRGQLGDPALGTHNGL
Mb1794c|M.bovis_AF2122/97 HTTVVMHLDVQERAAGLHLGP------LLSESERRYLLCDATFEAWFERD
Rv2015c|M.tuberculosis_H37Rv HTTVVMHLDVQERAAGLHLGP------LLSESERRYLLCDATFEAWFERD
MAV_0036|M.avium_104 HTTVVVHLDAAQRVAGLHLGP------LLSDAERRYLTCDATCEVWVERD
Mvan_4558|M.vanbaalenii_PYR-1 HTTVVMHVDVKERIAALHLGP------ALSAAERRYLSCDATCEVWFERH
Mflv_1988|M.gilvum_PYR-GCK HTTVVVHVDVESKLAALHLGP------LLTAEERRYLSCEATCEVWFERH
MSMEG_3404|M.smegmatis_MC2_155 HTAVAVHVDLKSKVAALHLGP------LLGDDERRLLTCDATCEVWFELR
TH_1926|M.thermoresistible__bu --------------------------------------------------
MAB_0990c|M.abscessus_ATCC_199 PVTVVVTTTLKELEDAAGIAITGAGTRLPMRDLIRMATHAHHYLAIFDDH
MUL_2371|M.ulcerans_Agy99 PASIIVSTTLKELEAAAGRGLTGGGTLLPMSDVIRLARHAHHYLAVFD-R
MMAR_0868|M.marinum_M PVTVIVSTTLQEITAATGRAVTGGGTLLPMRDVIRMARHAYHYLAVFDEH
Mb1794c|M.bovis_AF2122/97 G-QVIGCGRTTRQINRRLRRALEHRDRTCVVPGCGAT-RGLHAHHIRHWQ
Rv2015c|M.tuberculosis_H37Rv G-QVIGCGRTTRQINRRLRRALEHRDRTCVVPGCGAT-RGLHAHHIRHWQ
MAV_0036|M.avium_104 G-QPIGAGRSTRVINRRLRRALEHRHRGCAIPGCGAT-RGLHAHHLRHWE
Mvan_4558|M.vanbaalenii_PYR-1 G-QVIGSGRTTRAISRRLRRALEHRDRTCVVPGCGAT-RGLHAHHIRHWE
Mflv_1988|M.gilvum_PYR-GCK G-RPIGAGRSTRTVNRRLRRALEHRDRSCVVPGCGAT-RGLHAHHIVHWE
MSMEG_3404|M.smegmatis_MC2_155 G-RVIGTGRATRTVNRRLRRALEHRDRCCVVPGCSAT-RGLHAHHLVHWE
TH_1926|M.thermoresistible__bu ------------------------------VPGCGAT-RGLHAHHIRHWE
MAB_0990c|M.abscessus_ATCC_199 G-RALYLGRSQRIASPDQRLVLHARDRGCTHPDCHVPGYLCQAHHITEWV
MUL_2371|M.ulcerans_Agy99 G-EAIGLYHAKRLATPGQRIVLYAKDRGCTRPGCDVAGYQCEVHHVAAWA
MMAR_0868|M.marinum_M SNRPLYLGRTRRIASPDQRVVLYAAERGCTHPGCDAPGYWCEVHHLADWA
*.* .. ..**: *
Mb1794c|M.bovis_AF2122/97 DGGATELANLVLVCPYHHRAHHRGLITITGPADNLTVADSAGRPLSAGSL
Rv2015c|M.tuberculosis_H37Rv DGGATELANLVLVCPYHHRAHHRGLITITGPADNLTVADSAGRPLSAGSL
MAV_0036|M.avium_104 DGGPTELSNLVLVCPYHHRAHHRGEITITGPADTLLVTDSSGRHLKPGSL
Mvan_4558|M.vanbaalenii_PYR-1 DGGLTELDNLVLVCPHHHRLHHRGVITITGPAERLTVTDSVGRHLEPGSL
Mflv_1988|M.gilvum_PYR-GCK DGGDTELDNLVLVCPYHHRAHHRGIIVITGPAHQLAVTDHTGRPLQSGTL
MSMEG_3404|M.smegmatis_MC2_155 DGGLTEMANLVLLCPYHHRAHHRGLITITGPADQLTVTDDRGRLLTNQSL
TH_1926|M.thermoresistible__bu HRGPTDLDNLVLVCRYHHRLHHRGLITISDTPDNLTVSDRDGDRLHPGSL
MAB_0990c|M.abscessus_ATCC_199 HDGPTDIDNLTFACAPHHRLLGHGWTTRK-------RKDGTTEWIPPPQL
MUL_2371|M.ulcerans_Agy99 ISGRTDINQLTLACGPDHKLLEQGWRTRK-------NAHGDTEWLPPPHL
MMAR_0868|M.marinum_M AGGPTDVDNLTFACTPHHRLAGKSWQTIK-------LPNSRTAWLPPPQL
* *:: :*.: * .*: :. . . . : *
Mb1794c|M.bovis_AF2122/97 ARASTKPPPAVAPWPGPTGERADWWWYEPFQPQPPPISN-----
Rv2015c|M.tuberculosis_H37Rv ARASTKPPPAVAPWPGPTGERADWWWYEPFQPQPPPISN-----
MAV_0036|M.avium_104 ARKPTRPPPAVPPCPGPLGQRADWWWYDPFQPQPPPTTN-----
Mvan_4558|M.vanbaalenii_PYR-1 ARPPTQSPPAVAPYQGPPGERAQWKWYTPFQP-PPPTTN-----
Mflv_1988|M.gilvum_PYR-GCK ARPPTQPPPAVPPYRGPSGERLYWKWYHPYQPPPTATAN-----
MSMEG_3404|M.smegmatis_MC2_155 ARTPTTPPPTVPPCPGPLGERAQWWWYQPFEPQPPPSAN-----
TH_1926|M.thermoresistible__bu ARPPDRPPPQVAPCTGPTGERADWWWYTPYQPPAPPPADETGPG
MAB_0990c|M.abscessus_ATCC_199 ALPG---------ETRHDDIVDQCPHGVGSR-------------
MUL_2371|M.ulcerans_Agy99 DHGQPRTNSYHHPEKLLRDSADDDDEGHGAA-------------
MMAR_0868|M.marinum_M RRGAR-TNDYHHPERLLDDRAAPD--------------------
.