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LHRIALLAIAAPRRVLVVALLIMVGCGIFGAPVAKHLSAGGFQDPTSESARATQLLVDKFDQGDMELLIS ITDDNSADGANSPAARAVGTDLADRLAASPHVGAVTSAWTAPPSAAPALVSEDGRTGLIIAGITGGESEA QKHAKTLTDELVRDRDGVTVRAGGVAMTYVQINTQSEKDLLMMESIAIPLSFVVLVWVFGGLLAAALPLA VGAFAILGSMAVLRAVTLVTDVSIFALNLSIAMGLALAIDYTLLIISRYRDELAEGHDRDSALVRTMMTA GRTVLFSALTVALSMVAMVLFPMYFLKSFAYAGIAVVGFAAVAAIVVAPAAIVLAGARLDSMDVRRLVRR VLGRPEPVAKPVEQMFWYRSTKFVMRRSIPIGVVVVTLLLLLGAPFLGANWGFPDDRVLPQSASARQVGD ELRTDFAVDSSANVVVVLPDAEGLGPDALDGYAAELSRVQDVSSVSAPGGTFVDGAKAGPPSAATGIAEG SAFLTIGSTAPLFTDASETQLDRLHDVAPPEGRDVLLTGLAQINRDSADAITSRLPTVLAVIAAITFVLL FLLTGSVVLPLKALVLNVLSLTAAFGALVWIFQDGHLGALGTTPTGTLVANMPVLLFCIAFGLSMDYEVF LVSRIREYWLASGGAGADSSTAHQRSDDLAPHVRSDESVALGLARTGRVVTAAALLMSISFAALIAAKVA FMRMFGVGLTLAILADATLVRMLLVPAFMHVLGRWNWWAPKPLARLHERIGFSETLDDSSDSPPRSRQHV ATGNEHG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_4573 | - | - | 100% (778) | MMPL domain-containing protein |
M. vanbaalenii PYR-1 | Mvan_1197 | - | 0.0 | 66.89% (746) | hypothetical protein Mvan_1197 |
M. vanbaalenii PYR-1 | Mvan_1577 | - | 0.0 | 63.71% (755) | polyprenyl synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1177 | mmpL13 | 0.0 | 68.96% (770) | transmembrane transport protein MmpL13 |
M. gilvum PYR-GCK | Mflv_2131 | - | 0.0 | 81.90% (757) | MMPL domain-containing protein |
M. tuberculosis H37Rv | Rv1146 | mmpL13b | 0.0 | 71.05% (456) | transmembrane transport protein MmpL13B |
M. leprae Br4923 | MLBr_02620 | - | 2e-91 | 30.07% (765) | hypothetical protein MLBr_02620 |
M. abscessus ATCC 19977 | MAB_1287 | - | 0.0 | 62.12% (755) | MmpL family membrane protein |
M. marinum M | MMAR_4305 | mmpL13 | 0.0 | 69.70% (759) | transmembrane transport protein MmpL13 |
M. avium 104 | MAV_1287 | - | 0.0 | 67.83% (771) | mmpL protein |
M. smegmatis MC2 155 | MSMEG_5178 | - | 0.0 | 75.79% (756) | integral membrane protein |
M. thermoresistible (build 8) | TH_1538 | - | 0.0 | 61.86% (776) | PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL13B |
M. ulcerans Agy99 | MUL_0989 | mmpL13 | 0.0 | 69.57% (759) | transmembrane transport protein MmpL13 |
CLUSTAL 2.0.9 multiple sequence alignment Mvan_4573|M.vanbaalenii_PYR-1 -MLHRIALLAIAAPRRVLVVALLIMVGCGIFGAPVAKHLSAGGFQDPTSE Mflv_2131|M.gilvum_PYR-GCK -MLHRIARLAIAAPRRVLMAALLVAIACGVFGIPVVTHLSAGGFQDPTSE MSMEG_5178|M.smegmatis_MC2_155 -MLQRIATTAIAAPRRILVVAALVMIAAGIFGIPVANKLSAGGFQDPTAE Mb1177|M.bovis_AF2122/97 -MLQRIARLAIAAPRRIIGFAVFVFIAAAVFGVPVADSLSPGGFQDPRSE Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 -MLQKIARVAIAAPRRIIALGVLVFLAAAVFGIPVAKSLSPGGFQDPDSE MMAR_4305|M.marinum_M -MLQGIARLAIAAPRRIIGVALLVFIAAAVFGIPVANSLSPGGFQDPNAE MUL_0989|M.ulcerans_Agy99 -MLQGIARLAIAAPRRIIGVALLVFIAAAVFGIPVANSLSRGGFQDPNAE TH_1538|M.thermoresistible__bu -MLETLARRIVAAPRRVLALVVLVIVGAAMFGLPVAGSLSAGGFRDPHSE MAB_1287|M.abscessus_ATCC_1997 MMLERLARSVIAAPRLVLGMALLIAIAAALFGVPVTKHLAAGGQQDPNSE MLBr_02620|M.leprae_Br4923 -MFAWWGRTVYRYRFIVIGITVALCLCGGVFGLSLGKHVTQSGFYDDSSQ Mvan_4573|M.vanbaalenii_PYR-1 SARATQLLVDKFDQGDMELLISITDDNSADGANSPAARAVGTDLADRLA- Mflv_2131|M.gilvum_PYR-GCK SARATQMLVDTFGQGDMELILAVTSD---DGAQSPAARDVGVELVERLS- MSMEG_5178|M.smegmatis_MC2_155 SARATQLLADKFHRGDMQLVIAVTAEAPGGRADGGRAREVGTEIVSELK- Mb1177|M.bovis_AF2122/97 SARAIEVLTDKFGQSGQKMLIVVTAA---AGADSPPAREVGTDIVEVLR- Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 SARAIGVLTDKFGQSGQQMLILVTAP---GGSNSDPARRVGTELVEQLQ- MMAR_4305|M.marinum_M SARAIKVLADKFGQSGQQMLILVTAP---GGVGTERARAVGTDIVAELN- MUL_0989|M.ulcerans_Agy99 SARAIKVLADKFGQSGQQMLILVTAP---GGVGTERARAVGTDIVAELN- TH_1538|M.thermoresistible__bu SAQASALLAERFDQTDMQLLVTVSSS---AGVYGEAARRVGTEIVAALE- MAB_1287|M.abscessus_ATCC_1997 SAYVTKALRDKFDISDQSLVFMLTSE---QGVKSPQMRAVAADLERQLK- MLBr_02620|M.leprae_Br4923 SVKASILGDQVYGRDRSGHIVAIFHAPDGKTVNDPAWAKKITDELNQFQR Mvan_4573|M.vanbaalenii_PYR-1 -ASPHVGAVTSAWTAP---PSAAPALVSEDGRTGLIIAGITGGESEAQKH Mflv_2131|M.gilvum_PYR-GCK -DSPHVAAITSAWTSP---PSAAPALISEDGRTGLIVAGITGGESGAQKL MSMEG_5178|M.smegmatis_MC2_155 -ASPYVTEVTSAWTAP---PSAAAALVSKDARTGLIVAGLNGGENGAQQH Mb1177|M.bovis_AF2122/97 -RSPLVYNVTSPWTVP---PTAAADLLSTDGKSGLIVVNVKGGENDAQNH Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 -RSPLVYNVSSPWTAP---PQASADLVSRDGKSGLIVVNLKGGENFVQNN MMAR_4305|M.marinum_M -HSPLVFNVSSPWTGPSADPKSAPDLVSKDGKSGLIVVNIKGGESNAQKN MUL_0989|M.ulcerans_Agy99 -HSPLVFNVSSPWTGPSADPKSAPDLVSKDGKSGLIVVNIKGGESNAQKN TH_1538|M.thermoresistible__bu -ASPQVAGVQSPWTVP---PGAGDRLVSEDATAGLIVAPIRGNETESSDI MAB_1287|M.abscessus_ATCC_1997 -DSGVVINLTSAWTAP---PQVAEELLGADGKAGLIVAGLTGGENDAQKH MLBr_02620|M.leprae_Br4923 NNSNKVTGWAGYLRASDTTNTVVQGMATPDKKYTFVSIPLKGDDDDTILN Mvan_4573|M.vanbaalenii_PYR-1 AKTLTDELVRDRDGVTVRAGGVAMTYVQINTQSEKDLLMMESIAIPLSFV Mflv_2131|M.gilvum_PYR-GCK AKALTDELVYDRDGVTVRAGGAAMTYVQINTQTEKDLLLMESIAIPLSFV MSMEG_5178|M.smegmatis_MC2_155 AKELTDQFVRDHDGVRVRAGGEAMIYVQINGQSEKDLLMMESIAIPLSFV Mb1177|M.bovis_AF2122/97 AQTLSDEVAHDRDGVTVRAGGSAMEYAQINRQNKDDLLVMELIAIPLSFL Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 AQTLADQFVHDRDGVTVRAGGAAMQYAQINTQNQADLLVMEMIALPLSFL MMAR_4305|M.marinum_M AQTLADEIVHDRDGVTVRAGGSAMEYAQINKQNQDDLLVMELIAIPLSFL MUL_0989|M.ulcerans_Agy99 AQTLADEIVHDRDGVTVRAGGSAMEYAQINKQNQDDLLVMELIAIPLSFL TH_1538|M.thermoresistible__bu ARQLAAAVGSDRDRVNVRAGGPALVNAQIDTQTEHDLLVMEAIAIPLSFV MAB_1287|M.abscessus_ATCC_1997 AAKLIKSLAVDRDGVAVKAGGVATLYNQIVTQSEKDLLVMESIAIPISFV MLBr_02620|M.leprae_Br4923 NYKAIAPDLQKLDGGTVQLAGLDPIANALTSTIATDQRRMEVLALPLVAV Mvan_4573|M.vanbaalenii_PYR-1 VLVWVFGGLLAAALPLAVGAFAILGSMAVLRAVTLVTDVSIFALNLSIAM Mflv_2131|M.gilvum_PYR-GCK VLVWVFGGLLAAALPLAVGVFAILGSMAVLRGFTLVTDVSIFALNLSIAM MSMEG_5178|M.smegmatis_MC2_155 VLVWVFGGLLAAALPLAVGGFAILGSLAVLRLFTMVTDVSIFALNLTVAM Mb1177|M.bovis_AF2122/97 VLIWVFGGLLAAGLPMAQAVLAVVGSMAVLRLVTFATEVSTFALNLSTAL Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 VLIWVFGGLLAAALPMALGALAVVGSMSVLRLITFTTEVSIFALNLSTAL MMAR_4305|M.marinum_M VLVWVFGGLLAAALPMALGALAVVGSMSVLRLVTFTTDVSIFALNLSTAL MUL_0989|M.ulcerans_Agy99 VLVWVFGGLLAAALPMALGALAVVGSMSVLRLVTFTTDVSIFALNLSTAL TH_1538|M.thermoresistible__bu VLVWVFGGLLAAALPLAVGVLAIVGSMAVLRTFTMFTEVSVFALNLSIAM MAB_1287|M.abscessus_ATCC_1997 VLVWIFGGLYAALLPLVVGVFSIVGAMSILRGLTYVTDVSVFALNLAVAM MLBr_02620|M.leprae_Br4923 VLFLVFGGVIAACLPVMVGGLSIAGALGILRFIALFGPVHFFAQPVVSLI Mvan_4573|M.vanbaalenii_PYR-1 GLALAIDYTLLIISRYRDELAEGHDRDSALVRTMMTAGRTVLFSALTVAL Mflv_2131|M.gilvum_PYR-GCK GLALAIDYTLLIISRYRDELADGHDRDTALLRTMTTAGRTVVFSATTVAL MSMEG_5178|M.smegmatis_MC2_155 GLALAIDYTLLIISRFRDELAEGADRETALVRTMMTAGRTVLFSAMTVAL Mb1177|M.bovis_AF2122/97 GLALAIDYTLLIVSRYRDELAEGSDRDEALIRTMATSGRTVLFSAVTVAL Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 GLALAIDYTLLIVSRYRDELAEGHDRDQALIRTMATSGRTVLFSAVTVAL MMAR_4305|M.marinum_M GLALAIDYTLLIISRYRDELAEGSSREEALVRTMATSGRTVLFSAVTVAL MUL_0989|M.ulcerans_Agy99 GLALAIDYTLLIISRYRDELAEGSSREEALVRTMATSGRTVLFSAVTVAL TH_1538|M.thermoresistible__bu GLALAIDYTLLLLNRYRDELAEGCSREQAVIRTMTSAGRTVIFSAVIVAT MAB_1287|M.abscessus_ATCC_1997 GLALAIDYSLLIISRYREEVNAGKPRDEALVLTMTTAGRTVLFSALTVAL MLBr_02620|M.leprae_Br4923 GLGIAVDYGLFVVSRFREEIAEGYDTEAAVRRTVMTAGRTVTFSAVLIAA Mvan_4573|M.vanbaalenii_PYR-1 SMVAMVLFPMYFLKSFAYAGIAVVGFAAVAAIVVAPAAIVLAGARLDSMD Mflv_2131|M.gilvum_PYR-GCK SMVAMVLFPMYFLKSFAYAGIAVVSFAALAAIVVTPAAIALAGDRLDALD MSMEG_5178|M.smegmatis_MC2_155 SMVAMVLFPMYFLKSFAYAGIAVVALAATAAIVLTPAAIVLLGDRLDAYD Mb1177|M.bovis_AF2122/97 SMSATALFPMYFLKSFAYAGVATVAFVATASIVITPAAIVLLGPRLDALD Rv1146|M.tuberculosis_H37Rv --------------------MATVAFVATASIVITPAAIVLLGPRLDALD MAV_1287|M.avium_104 SMSATVAFPMYFLKSFAYAGVATVAFVATASIVITPAAIVLLGDRLDALD MMAR_4305|M.marinum_M SMSATVAFPMYFLKSFAYAGVATVAFVATASIVVTPAAIVLLGPRLDALN MUL_0989|M.ulcerans_Agy99 SMSATVAFPMYFLKSFAYAGVATVAFVATASIVVTPAAIVLLGPRLDALN TH_1538|M.thermoresistible__bu SMVPLALFPMYFLRSFAYAGVGVVAFALCAALVITPAAITVLGARLDSWD MAB_1287|M.abscessus_ATCC_1997 ALVALILFPMYFLKSFGYAGVAVVFVGAIAALVIVPAVVTLLGDRIDALD MLBr_02620|M.leprae_Br4923 SGASLLLLPQGFVKSLTYALIAAVTLAALLSITLLPACLAILAKHVDALG :..* . ::.: ** :.: . ::*: . Mvan_4573|M.vanbaalenii_PYR-1 VRRLVRRVLGRP-----------------EPVAKPVEQMFWYRSTKFVMR Mflv_2131|M.gilvum_PYR-GCK VRRLVRRILGRP-----------------DPVAKPVEQNFWYRSTTFVMR MSMEG_5178|M.smegmatis_MC2_155 VRRFFRRVFGRP-----------------EPEPKPVEQGFWYRTAKAAMR Mb1177|M.bovis_AF2122/97 VRRLVRRLLGRP-----------------DPVHKPVKQLFWYRSSKFVMR Rv1146|M.tuberculosis_H37Rv VRRLVRRLLGRP-----------------DPVHKPVKQLFWYRSSKFVMR MAV_1287|M.avium_104 VRRLLRRALRRA-----------------QPVRKPVEQLFWYRSSKFVMR MMAR_4305|M.marinum_M VRRLARRMLGRP-----------------EPQHKPVDQLFWYRSTKFVMR MUL_0989|M.ulcerans_Agy99 VRRLARRMLGRP-----------------KPQHKPVDQLFWYRSTKFVMR TH_1538|M.thermoresistible__bu IRRLIRRLMRRTP-------------AAAEPAPRAVCGSKWYRWAKAVMR MAB_1287|M.abscessus_ATCC_1997 VRRLIRRVLGRP-----------------EPVAKDVTQSFWYRTTKRVMA MLBr_02620|M.leprae_Br4923 VRTLFRVPLLRNWRMSHACLNWLADRLQKTKTREEVEAGFWGKLVNFVMK :* : * : * . * * : . .* Mvan_4573|M.vanbaalenii_PYR-1 RSIPIGVVVVTLLLLLGAPFLGANWGFPDDRVLPQSASARQVGDELRTDF Mflv_2131|M.gilvum_PYR-GCK RSIPIGGVVVVLLVLLGAPFLGATWGFPDDRVLPETASARQIGDELRQDF MSMEG_5178|M.smegmatis_MC2_155 RAVPIGVGIIALLVLLGVPFTGIKWGFPDDRVLPQSASARQIGDEMRTNF Mb1177|M.bovis_AF2122/97 RWLPVGTAVVALLVLLGLPFLSVKWGFPDDRVLPRSASARQVGDILRDDF Rv1146|M.tuberculosis_H37Rv RWLPVGTAVVALLVLLGLPFLSVKWGFPDDRVLPRSASARQVGDILRDDF MAV_1287|M.avium_104 RWAPVGLIVVGLLLLLGLPFFSVKWGFPDDRVLPRSASAHQVGDRLRSGF MMAR_4305|M.marinum_M RALPVGLAVVAVLVILGLPFFSVKWGFPDDRVLPATASSHQVGDELRTNF MUL_0989|M.ulcerans_Agy99 RALPVGLAVVAVLVILGLPFFSVKWGFPDDRVLPATASSHQVGDELRTNF TH_1538|M.thermoresistible__bu HWLVAGLAVTVVLLLLGAPFLGVRWGFPDERVLPRSASAHQVGHELRTNF MAB_1287|M.abscessus_ATCC_1997 RAVPIAIIIVSALVVLGLPFLDGKFGFPDDRVLPASASAHQVGNEMRRNF MLBr_02620|M.leprae_Br4923 RPLVFAIPIVIGMILLVIPLGNLSFGGMSEKYLPPNNAVRQSQEHFDQLF : . : :::* *: . :* .:: ** . : :* . : * Mvan_4573|M.vanbaalenii_PYR-1 AVDSSANVVVVLPDAEGLGPDALDGYAAELSRVQDVSSVSAPGGTFVDGA Mflv_2131|M.gilvum_PYR-GCK AVDSSTNVVVVLPDADGISREDFDAYAIALSGVADVSSVSAPSGTFIGGA MSMEG_5178|M.smegmatis_MC2_155 AVDSATSVTVVLPDATTVAPAEIDRYAARLSQVADVSSVSAPGGTDVQGR Mb1177|M.bovis_AF2122/97 GHDPATQIPIVVPDARGLGPVELDSYAAELSRVPDVSAVAAPTGTFVDGS Rv1146|M.tuberculosis_H37Rv GHDPATQIPIVVPDARGLGPVELDSYAAELSRVPDVSAVAAPTGTFVDGS MAV_1287|M.avium_104 AHDSATSVPVVIPDAAGLSPADLDDYAAALSRVPDVSAVSAPGGTFTGGT MMAR_4305|M.marinum_M AHDLAMAVPVVVPDVRGLVPADLDGYAADLSRVPDVASVTAPSGTFVNGS MUL_0989|M.ulcerans_Agy99 AHDLAMAVPVVVPDVHGLVPADLDGYAADLSRVPDVASVTAPSGTFVNGS TH_1538|M.thermoresistible__bu ATDSASDVTVVLPDAPGLTADELAGYAARLSEVTDVAWVSAPAGTFVRGR MAB_1287|M.abscessus_ATCC_1997 NNNSSTNLSVIAEGVGSVPPREIDEYAADLSNIEDVKEVAAPTGAFIRGM MLBr_02620|M.leprae_Br4923 PGYRTNPLTLVIQTSN-HQPVTDQEIADIRSKAMAISGFIEPDNNYVN-- : : :: * * : . * . Mvan_4573|M.vanbaalenii_PYR-1 KAGPPSAATGIAEGSAFLTIGSTAPLFTDASETQLDRLHDVAPPEGRDVL Mflv_2131|M.gilvum_PYR-GCK RAGPPSAATGSADGSAFLTIGSRAPLFTDASEVQLDRLHAIAPPGDRQVL MSMEG_5178|M.smegmatis_MC2_155 HVGPPSAATGIGDGSAFLTVGSDAPLFSDASEAQLDALHAVAAH--AEVQ Mb1177|M.bovis_AF2122/97 WVGTPRGATGLAEGSAFLTVSSTAPLFSRASDIQLKRLHQVAGPAGRSVV Rv1146|M.tuberculosis_H37Rv WVGTPRGATGLAEGSAFLTVSSTAPLFSRASDIQLKRLHQVAGPAGRSVV MAV_1287|M.avium_104 RVGPPAGATGLGDGSAFLTVSSTAPLFSTANDVQLKRLHEVPGPAGRSVE MMAR_4305|M.marinum_M RVGPPAGATGFSDGSAFLTVDSTAPLFSHASDIQLKRLHQVTGPAGRTVE MUL_0989|M.ulcerans_Agy99 RVGPPAGATGFSDGSAFLTVDSTAPLFSHASDIQLKRLHQVTGPAGRTVE TH_1538|M.thermoresistible__bu SVGPPSAPTGIADGSAFVTVGSVAPLFSDDSLEQLNDIRAVPAPGGTAVQ MAB_1287|M.abscessus_ATCC_1997 KVGPSASATGIKNDTALFTVQTAAKPYTEAAERQLDAIHALPGPADVLVR MLBr_02620|M.leprae_Br4923 -MWQERTVAPGASKDPSVRVLQNGLINPNDASKKINELRSITPPKGLTVS : . . . : . . ::. :: :. * Mvan_4573|M.vanbaalenii_PYR-1 LTGLAQINRDSADAITSRLPTVLAVIAAITFVLLFLLTGSVVLPLKALVL Mflv_2131|M.gilvum_PYR-GCK LTGLAQINRDSADAITSRLPLVLAVIAAITFVLLFVLTGSVVLPLKALVL MSMEG_5178|M.smegmatis_MC2_155 FTGVAQVNRDSSQAITSRLPLVLGIIAGITFVLLFLLTGSVVLPLKALVL Mb1177|M.bovis_AF2122/97 MAGVAQVNRDSVDAVTDRLPMVLGLIAAITYVLLFLLTGSVVLPAKALVC Rv1146|M.tuberculosis_H37Rv MAGVAQVNRDSVDAVTDRLPMVLGLIAAITYVLLFLLTGSVVLPAKALVC MAV_1287|M.avium_104 MGGVAQVNRDSVDAVTDRLPLVLGLMAAITFVLLFLLTGSVLLPAKALAC MMAR_4305|M.marinum_M MAGVAQVNRDSVDAVTERLPLVLGLMAAITFVLLFLLTGSVVLPAKALIC MUL_0989|M.ulcerans_Agy99 MAGVAQVNRDSVDAVTERLPLVLGLMAAITFVLLFLLTGSVVLPAKALIC TH_1538|M.thermoresistible__bu LTGTAQINHDIVVAVTSRLTVVLTVIALTTLVWLFLLTGSIVLPIKALVL MAB_1287|M.abscessus_ATCC_1997 IGGGAQLDRDAVDGIVHKLPLVLAIIAVVTFVLLFLLTGSVVLPIKALVL MLBr_02620|M.leprae_Br4923 VGGTPALEQDSIHSLVAQAPLMVIMLITTTMLLMFLAFGSFVLPIKAAVM . * . :::* .:. : . :: :: * : :*: **.:** ** Mvan_4573|M.vanbaalenii_PYR-1 NVLSLTAAFGALVWIFQDGHLGALGTTPTGTLVANMPVLLFCIAFGLSMD Mflv_2131|M.gilvum_PYR-GCK NVLSLTAAFGALVWIFQEGHLGALGTTPTGTLVATMPVLLFCIAFGLSMD MSMEG_5178|M.smegmatis_MC2_155 NVLSLSAAFGALVWIFQDGHLGALGTTPTGTLVANLPVLLFCIAFGLSMD Mb1177|M.bovis_AF2122/97 NVLSLTAAFGALVWIFQEGHFGALGTTPSGTLVANMPVLLFCIAFGLSMD Rv1146|M.tuberculosis_H37Rv NVLSLTAAFGALVWIFQEGHFGALGTTPSGTLVANMPVLLFCIAFGLSMD MAV_1287|M.avium_104 NFLSLTAAFGALVWIFQDGHLGALGTTPSGTLVANMPVLLFCIAFGLSMD MMAR_4305|M.marinum_M NVLSLTAAFGALVWIFQDGHLGALGTTPSGTLVANMPVLLFCIAFGLSMD MUL_0989|M.ulcerans_Agy99 NVLSLTAAFGALVWIFQDGHLGALGTIPSGTLVANMPVLLFCIAFGLSMD TH_1538|M.thermoresistible__bu NALSLTAAFGALVWIFQDGHLGALGTTPSGTMAVTMPALLLCVAFGISMD MAB_1287|M.abscessus_ATCC_1997 NVLSLTATFGALIWIFQEGHLGGFGTEVTGTIVATMPMLLFCIAFGLSMD MLBr_02620|M.leprae_Br4923 SALTLGSTMGILTWIFVDGHLSKWLNFTPTPLMVVIIALVVAVGYGLATD . *:* :::* * *** :**:. . . .: . : *:..:.:*:: * Mvan_4573|M.vanbaalenii_PYR-1 YEVFLVSRIREYWLASGGAGADSSTAHQRSDDLAPHVRSDESVALGLART Mflv_2131|M.gilvum_PYR-GCK YEVFLVSRIREYWLETG--------------------ENGRSVALGLART MSMEG_5178|M.smegmatis_MC2_155 YEVFLVSRIREFWLQSDQS----------------RAANEESVALGLAHT Mb1177|M.bovis_AF2122/97 YEVFLVSRIREYWLESGAAR------PARRSVAEVHAANDESVALGVART Rv1146|M.tuberculosis_H37Rv YEVFLVSRIREYWLESGAAR------PARRSVAEVHAANDESVALGVART MAV_1287|M.avium_104 YEVFLLSRIREYWLASGAAR------PARPTPKRAHAANDESVALGVART MMAR_4305|M.marinum_M YEVFLVARIREYWLASGAAR------PATPSPAQAHAANDESVALGLART MUL_0989|M.ulcerans_Agy99 YEVFLVARIREYWLASGAAG------PATPSPAQAHAANDESVALGLART TH_1538|M.thermoresistible__bu YEVFLIARIREHWLASSRTA----------------AANDEAVALGVART MAB_1287|M.abscessus_ATCC_1997 YEVFLISRIREYWMASGRTR----------------ADNDEAVALGVART MLBr_02620|M.leprae_Br4923 YEVFLVSRMVEARAESMSTQ--------------------EAVRIGTAST *****::*: * : .:* :* * * Mvan_4573|M.vanbaalenii_PYR-1 GRVVTAAALLMSISFAALIAAKVAFMRMFGVGLTLAILADATLVRMLLVP Mflv_2131|M.gilvum_PYR-GCK GRVVTAAALVMSISFAALIAAQVSFMRMFGGGLTLAVLVDATLVRMLLVP MSMEG_5178|M.smegmatis_MC2_155 GRVITAAALLMSISFAALIAAQVAFMRMFGLGLTLAVLVDATLVRMLLVP Mb1177|M.bovis_AF2122/97 GRVITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAVAADATLVRMVVVP Rv1146|M.tuberculosis_H37Rv GRVITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAVAADATLVRMVVVP MAV_1287|M.avium_104 GRVITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAVFADATLVRMVVVP MMAR_4305|M.marinum_M GRVITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAVAADATLVRMVLVP MUL_0989|M.ulcerans_Agy99 GRVITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAMAADATLVRMVLVP TH_1538|M.thermoresistible__bu ARVITAAALIMSISFAALIGAQVSFMRMIGLGLMVAVLVDATLVRLILVP MAB_1287|M.abscessus_ATCC_1997 GRVVTAAALIMAIAFAALMAAQVSFMRMFGTGLTIAILVDATIIRMLLVP MLBr_02620|M.leprae_Br4923 GRLITAAALVLAVVAGSFVFSDLVMMKYLAFGLMAALLLDATVVRMFLVP .*::*****:::: .::: :.: :*: :. ** *: ***::*:.:** Mvan_4573|M.vanbaalenii_PYR-1 AFMHVLGRWNWWAPKPLARLHERIGFSETLDDSSDSPP----------RS Mflv_2131|M.gilvum_PYR-GCK AFMHLLGRWNWWAPPPLARLHARIGVSETVP------------------- MSMEG_5178|M.smegmatis_MC2_155 AFMRVMGRWNWWAPAPLARLHERIGFSESGLPPDPKP------------- Mb1177|M.bovis_AF2122/97 AFMHVTGRWNWWAPRPLAWLHERFGVSEAAEPVSRRRSHAGG--LGKIAG Rv1146|M.tuberculosis_H37Rv AFMHVTGRWNWWAPRPLAWLHERFGVSEAAEPVSRRRSHAGG--LGKIAG MAV_1287|M.avium_104 AFMHVMGRWNWWAPKPLAWLHDRFGISEAADEEPRLRACPRTRRIRRIAR MMAR_4305|M.marinum_M AFMHVMGRWNWWAPKPLVWLHQRFGISETGAVGDADAAATEA------AD MUL_0989|M.ulcerans_Agy99 AFMHVMGRWNWWAPKPLVWLHQRFGISETGAVGGADAAATEA------AD TH_1538|M.thermoresistible__bu AFMHVMGRANWWAPAPLARWHDRFGIREAADAPDRPRSDPAPTPXXXDAS MAB_1287|M.abscessus_ATCC_1997 SFMRLLGRFNWWAPKPLVTLHERIGFSD---------------------- MLBr_02620|M.leprae_Br4923 SVMKLLGDDCWWAPRWARLLQNRIGLGEIHLPDERRRPTVSGRPVRPPVT :.*:: * **** : *:*. : Mvan_4573|M.vanbaalenii_PYR-1 RQHVATG-----------------------NEHG---------------- Mflv_2131|M.gilvum_PYR-GCK -QRV---------------------------------------------- MSMEG_5178|M.smegmatis_MC2_155 -QPASVG-----------------------MTQSG--------------- Mb1177|M.bovis_AF2122/97 RSDGQT---------IPAS-----------LTRNG--------------- Rv1146|M.tuberculosis_H37Rv RSDGQT---------IPAS-----------LTRNG--------------- MAV_1287|M.avium_104 RRGRRTGAQHRLTAVRPTARRVWRSDPILRLIRGGRCTQA---------- MMAR_4305|M.marinum_M RRDRPT---------IPAA-----------LSGRG--------------- MUL_0989|M.ulcerans_Agy99 RRDRPT---------IPAA-----------LSGRG--------------- TH_1538|M.thermoresistible__bu VRKGPAPSSISRDPAVPAYVPDRP------RTRSACRCSR---------- MAB_1287|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02620|M.leprae_Br4923 AASLAAPASRVPRGPTHPATLEPSQRARSGLASRPQIKRPQELPSGASTA Mvan_4573|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_2131|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_5178|M.smegmatis_MC2_155 -------------------------------------------------- Mb1177|M.bovis_AF2122/97 -------------------------------------------------- Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 -------------------------------------------------- MMAR_4305|M.marinum_M -------------------------------------------------- MUL_0989|M.ulcerans_Agy99 -------------------------------------------------- TH_1538|M.thermoresistible__bu -------------------------------------------------- MAB_1287|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02620|M.leprae_Br4923 RIQMRPSQSVEATTTRLSVPGNAPTTAAVSSSQGVQAVPLAATRHPLPTP Mvan_4573|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_2131|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_5178|M.smegmatis_MC2_155 -------------------------------------------------- Mb1177|M.bovis_AF2122/97 -------------------------------------------------- Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 -------------------------------------------------- MMAR_4305|M.marinum_M -------------------------------------------------- MUL_0989|M.ulcerans_Agy99 -------------------------------------------------- TH_1538|M.thermoresistible__bu -------------------------------------------------- MAB_1287|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02620|M.leprae_Br4923 SPASGQTRAMPVPANRSSDNASETAEPTTALPIMRPQDNDSEVATEKLNA Mvan_4573|M.vanbaalenii_PYR-1 ------------------------------ Mflv_2131|M.gilvum_PYR-GCK ------------------------------ MSMEG_5178|M.smegmatis_MC2_155 ------------------------------ Mb1177|M.bovis_AF2122/97 ------------------------------ Rv1146|M.tuberculosis_H37Rv ------------------------------ MAV_1287|M.avium_104 ------------------------------ MMAR_4305|M.marinum_M ------------------------------ MUL_0989|M.ulcerans_Agy99 ------------------------------ TH_1538|M.thermoresistible__bu ------------------------------ MAB_1287|M.abscessus_ATCC_1997 ------------------------------ MLBr_02620|M.leprae_Br4923 LGQGDNSRQHRRATGGGISAQDLLRREGRL