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MMLERLARSVIAAPRLVLGMALLIAIAAALFGVPVTKHLAAGGQQDPNSESAYVTKALRDKFDISDQSLV FMLTSEQGVKSPQMRAVAADLERQLKDSGVVINLTSAWTAPPQVAEELLGADGKAGLIVAGLTGGENDAQ KHAAKLIKSLAVDRDGVAVKAGGVATLYNQIVTQSEKDLLVMESIAIPISFVVLVWIFGGLYAALLPLVV GVFSIVGAMSILRGLTYVTDVSVFALNLAVAMGLALAIDYSLLIISRYREEVNAGKPRDEALVLTMTTAG RTVLFSALTVALALVALILFPMYFLKSFGYAGVAVVFVGAIAALVIVPAVVTLLGDRIDALDVRRLIRRV LGRPEPVAKDVTQSFWYRTTKRVMARAVPIAIIIVSALVVLGLPFLDGKFGFPDDRVLPASASAHQVGNE MRRNFNNNSSTNLSVIAEGVGSVPPREIDEYAADLSNIEDVKEVAAPTGAFIRGMKVGPSASATGIKNDT ALFTVQTAAKPYTEAAERQLDAIHALPGPADVLVRIGGGAQLDRDAVDGIVHKLPLVLAIIAVVTFVLLF LLTGSVVLPIKALVLNVLSLTATFGALIWIFQEGHLGGFGTEVTGTIVATMPMLLFCIAFGLSMDYEVFL ISRIREYWMASGRTRADNDEAVALGVARTGRVVTAAALIMAIAFAALMAAQVSFMRMFGTGLTIAILVDA TIIRMLLVPSFMRLLGRFNWWAPKPLVTLHERIGFSD
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_1287 | - | - | 100% (737) | MmpL family membrane protein |
M. abscessus ATCC 19977 | MAB_2275 | - | e-172 | 44.22% (735) | MmpL family protein |
M. abscessus ATCC 19977 | MAB_4508 | - | 1e-96 | 30.45% (739) | putative membrane protein, MmpL |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1177 | mmpL13 | 0.0 | 57.91% (746) | transmembrane transport protein MmpL13 |
M. gilvum PYR-GCK | Mflv_2131 | - | 0.0 | 62.50% (736) | MMPL domain-containing protein |
M. tuberculosis H37Rv | Rv1146 | mmpL13b | 1e-144 | 58.16% (435) | transmembrane transport protein MmpL13B |
M. leprae Br4923 | MLBr_02620 | - | 1e-92 | 29.91% (759) | hypothetical protein MLBr_02620 |
M. marinum M | MMAR_4305 | mmpL13 | 0.0 | 57.94% (749) | transmembrane transport protein MmpL13 |
M. avium 104 | MAV_1287 | - | 0.0 | 56.97% (746) | mmpL protein |
M. smegmatis MC2 155 | MSMEG_5178 | - | 0.0 | 61.03% (739) | integral membrane protein |
M. thermoresistible (build 8) | TH_1538 | - | 0.0 | 53.51% (740) | PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL13B |
M. ulcerans Agy99 | MUL_0989 | mmpL13 | 0.0 | 57.68% (749) | transmembrane transport protein MmpL13 |
M. vanbaalenii PYR-1 | Mvan_4573 | - | 0.0 | 62.12% (755) | MMPL domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment Mb1177|M.bovis_AF2122/97 -MLQRIARLAIAAPRRIIGFAVFVFIAAAVFGVPVADSLSPGGFQDPRSE Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 -MLQKIARVAIAAPRRIIALGVLVFLAAAVFGIPVAKSLSPGGFQDPDSE MMAR_4305|M.marinum_M -MLQGIARLAIAAPRRIIGVALLVFIAAAVFGIPVANSLSPGGFQDPNAE MUL_0989|M.ulcerans_Agy99 -MLQGIARLAIAAPRRIIGVALLVFIAAAVFGIPVANSLSRGGFQDPNAE Mflv_2131|M.gilvum_PYR-GCK -MLHRIARLAIAAPRRVLMAALLVAIACGVFGIPVVTHLSAGGFQDPTSE Mvan_4573|M.vanbaalenii_PYR-1 -MLHRIALLAIAAPRRVLVVALLIMVGCGIFGAPVAKHLSAGGFQDPTSE MSMEG_5178|M.smegmatis_MC2_155 -MLQRIATTAIAAPRRILVVAALVMIAAGIFGIPVANKLSAGGFQDPTAE TH_1538|M.thermoresistible__bu -MLETLARRIVAAPRRVLALVVLVIVGAAMFGLPVAGSLSAGGFRDPHSE MAB_1287|M.abscessus_ATCC_1997 MMLERLARSVIAAPRLVLGMALLIAIAAALFGVPVTKHLAAGGQQDPNSE MLBr_02620|M.leprae_Br4923 -MFAWWGRTVYRYRFIVIGITVALCLCGGVFGLSLGKHVTQSGFYDDSSQ Mb1177|M.bovis_AF2122/97 SARAIEVLTDKFGQSGQKMLIVVTAA---AGADSPPAREVGTDIVEVLR- Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 SARAIGVLTDKFGQSGQQMLILVTAP---GGSNSDPARRVGTELVEQLQ- MMAR_4305|M.marinum_M SARAIKVLADKFGQSGQQMLILVTAP---GGVGTERARAVGTDIVAELN- MUL_0989|M.ulcerans_Agy99 SARAIKVLADKFGQSGQQMLILVTAP---GGVGTERARAVGTDIVAELN- Mflv_2131|M.gilvum_PYR-GCK SARATQMLVDTFGQGDMELILAVTSD---DGAQSPAARDVGVELVERLS- Mvan_4573|M.vanbaalenii_PYR-1 SARATQLLVDKFDQGDMELLISITDDNSADGANSPAARAVGTDLADRLA- MSMEG_5178|M.smegmatis_MC2_155 SARATQLLADKFHRGDMQLVIAVTAEAPGGRADGGRAREVGTEIVSELK- TH_1538|M.thermoresistible__bu SAQASALLAERFDQTDMQLLVTVSSS---AGVYGEAARRVGTEIVAALE- MAB_1287|M.abscessus_ATCC_1997 SAYVTKALRDKFDISDQSLVFMLTSE---QGVKSPQMRAVAADLERQLK- MLBr_02620|M.leprae_Br4923 SVKASILGDQVYGRDRSGHIVAIFHAPDGKTVNDPAWAKKITDELNQFQR Mb1177|M.bovis_AF2122/97 -RSPLVYNVTSPWTVP---PTAAADLLSTDGKSGLIVVNVKGGENDAQNH Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 -RSPLVYNVSSPWTAP---PQASADLVSRDGKSGLIVVNLKGGENFVQNN MMAR_4305|M.marinum_M -HSPLVFNVSSPWTGPSADPKSAPDLVSKDGKSGLIVVNIKGGESNAQKN MUL_0989|M.ulcerans_Agy99 -HSPLVFNVSSPWTGPSADPKSAPDLVSKDGKSGLIVVNIKGGESNAQKN Mflv_2131|M.gilvum_PYR-GCK -DSPHVAAITSAWTSP---PSAAPALISEDGRTGLIVAGITGGESGAQKL Mvan_4573|M.vanbaalenii_PYR-1 -ASPHVGAVTSAWTAP---PSAAPALVSEDGRTGLIIAGITGGESEAQKH MSMEG_5178|M.smegmatis_MC2_155 -ASPYVTEVTSAWTAP---PSAAAALVSKDARTGLIVAGLNGGENGAQQH TH_1538|M.thermoresistible__bu -ASPQVAGVQSPWTVP---PGAGDRLVSEDATAGLIVAPIRGNETESSDI MAB_1287|M.abscessus_ATCC_1997 -DSGVVINLTSAWTAP---PQVAEELLGADGKAGLIVAGLTGGENDAQKH MLBr_02620|M.leprae_Br4923 NNSNKVTGWAGYLRASDTTNTVVQGMATPDKKYTFVSIPLKGDDDDTILN Mb1177|M.bovis_AF2122/97 AQTLSDEVAHDRDGVTVRAGGSAMEYAQINRQNKDDLLVMELIAIPLSFL Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 AQTLADQFVHDRDGVTVRAGGAAMQYAQINTQNQADLLVMEMIALPLSFL MMAR_4305|M.marinum_M AQTLADEIVHDRDGVTVRAGGSAMEYAQINKQNQDDLLVMELIAIPLSFL MUL_0989|M.ulcerans_Agy99 AQTLADEIVHDRDGVTVRAGGSAMEYAQINKQNQDDLLVMELIAIPLSFL Mflv_2131|M.gilvum_PYR-GCK AKALTDELVYDRDGVTVRAGGAAMTYVQINTQTEKDLLLMESIAIPLSFV Mvan_4573|M.vanbaalenii_PYR-1 AKTLTDELVRDRDGVTVRAGGVAMTYVQINTQSEKDLLMMESIAIPLSFV MSMEG_5178|M.smegmatis_MC2_155 AKELTDQFVRDHDGVRVRAGGEAMIYVQINGQSEKDLLMMESIAIPLSFV TH_1538|M.thermoresistible__bu ARQLAAAVGSDRDRVNVRAGGPALVNAQIDTQTEHDLLVMEAIAIPLSFV MAB_1287|M.abscessus_ATCC_1997 AAKLIKSLAVDRDGVAVKAGGVATLYNQIVTQSEKDLLVMESIAIPISFV MLBr_02620|M.leprae_Br4923 NYKAIAPDLQKLDGGTVQLAGLDPIANALTSTIATDQRRMEVLALPLVAV Mb1177|M.bovis_AF2122/97 VLIWVFGGLLAAGLPMAQAVLAVVGSMAVLRLVTFATEVSTFALNLSTAL Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 VLIWVFGGLLAAALPMALGALAVVGSMSVLRLITFTTEVSIFALNLSTAL MMAR_4305|M.marinum_M VLVWVFGGLLAAALPMALGALAVVGSMSVLRLVTFTTDVSIFALNLSTAL MUL_0989|M.ulcerans_Agy99 VLVWVFGGLLAAALPMALGALAVVGSMSVLRLVTFTTDVSIFALNLSTAL Mflv_2131|M.gilvum_PYR-GCK VLVWVFGGLLAAALPLAVGVFAILGSMAVLRGFTLVTDVSIFALNLSIAM Mvan_4573|M.vanbaalenii_PYR-1 VLVWVFGGLLAAALPLAVGAFAILGSMAVLRAVTLVTDVSIFALNLSIAM MSMEG_5178|M.smegmatis_MC2_155 VLVWVFGGLLAAALPLAVGGFAILGSLAVLRLFTMVTDVSIFALNLTVAM TH_1538|M.thermoresistible__bu VLVWVFGGLLAAALPLAVGVLAIVGSMAVLRTFTMFTEVSVFALNLSIAM MAB_1287|M.abscessus_ATCC_1997 VLVWIFGGLYAALLPLVVGVFSIVGAMSILRGLTYVTDVSVFALNLAVAM MLBr_02620|M.leprae_Br4923 VLFLVFGGVIAACLPVMVGGLSIAGALGILRFIALFGPVHFFAQPVVSLI Mb1177|M.bovis_AF2122/97 GLALAIDYTLLIVSRYRDELAEGSDRDEALIRTMATSGRTVLFSAVTVAL Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 GLALAIDYTLLIVSRYRDELAEGHDRDQALIRTMATSGRTVLFSAVTVAL MMAR_4305|M.marinum_M GLALAIDYTLLIISRYRDELAEGSSREEALVRTMATSGRTVLFSAVTVAL MUL_0989|M.ulcerans_Agy99 GLALAIDYTLLIISRYRDELAEGSSREEALVRTMATSGRTVLFSAVTVAL Mflv_2131|M.gilvum_PYR-GCK GLALAIDYTLLIISRYRDELADGHDRDTALLRTMTTAGRTVVFSATTVAL Mvan_4573|M.vanbaalenii_PYR-1 GLALAIDYTLLIISRYRDELAEGHDRDSALVRTMMTAGRTVLFSALTVAL MSMEG_5178|M.smegmatis_MC2_155 GLALAIDYTLLIISRFRDELAEGADRETALVRTMMTAGRTVLFSAMTVAL TH_1538|M.thermoresistible__bu GLALAIDYTLLLLNRYRDELAEGCSREQAVIRTMTSAGRTVIFSAVIVAT MAB_1287|M.abscessus_ATCC_1997 GLALAIDYSLLIISRYREEVNAGKPRDEALVLTMTTAGRTVLFSALTVAL MLBr_02620|M.leprae_Br4923 GLGIAVDYGLFVVSRFREEIAEGYDTEAAVRRTVMTAGRTVTFSAVLIAA Mb1177|M.bovis_AF2122/97 SMSATALFPMYFLKSFAYAGVATVAFVATASIVITPAAIVLLGPRLDALD Rv1146|M.tuberculosis_H37Rv --------------------MATVAFVATASIVITPAAIVLLGPRLDALD MAV_1287|M.avium_104 SMSATVAFPMYFLKSFAYAGVATVAFVATASIVITPAAIVLLGDRLDALD MMAR_4305|M.marinum_M SMSATVAFPMYFLKSFAYAGVATVAFVATASIVVTPAAIVLLGPRLDALN MUL_0989|M.ulcerans_Agy99 SMSATVAFPMYFLKSFAYAGVATVAFVATASIVVTPAAIVLLGPRLDALN Mflv_2131|M.gilvum_PYR-GCK SMVAMVLFPMYFLKSFAYAGIAVVSFAALAAIVVTPAAIALAGDRLDALD Mvan_4573|M.vanbaalenii_PYR-1 SMVAMVLFPMYFLKSFAYAGIAVVGFAAVAAIVVAPAAIVLAGARLDSMD MSMEG_5178|M.smegmatis_MC2_155 SMVAMVLFPMYFLKSFAYAGIAVVALAATAAIVLTPAAIVLLGDRLDAYD TH_1538|M.thermoresistible__bu SMVPLALFPMYFLRSFAYAGVGVVAFALCAALVITPAAITVLGARLDSWD MAB_1287|M.abscessus_ATCC_1997 ALVALILFPMYFLKSFGYAGVAVVFVGAIAALVIVPAVVTLLGDRIDALD MLBr_02620|M.leprae_Br4923 SGASLLLLPQGFVKSLTYALIAAVTLAALLSITLLPACLAILAKHVDALG :..* . ::.: ** :.: . ::*: . Mb1177|M.bovis_AF2122/97 VRRLVRRLLGRP-----------------DPVHKPVKQLFWYRSSKFVMR Rv1146|M.tuberculosis_H37Rv VRRLVRRLLGRP-----------------DPVHKPVKQLFWYRSSKFVMR MAV_1287|M.avium_104 VRRLLRRALRRA-----------------QPVRKPVEQLFWYRSSKFVMR MMAR_4305|M.marinum_M VRRLARRMLGRP-----------------EPQHKPVDQLFWYRSTKFVMR MUL_0989|M.ulcerans_Agy99 VRRLARRMLGRP-----------------KPQHKPVDQLFWYRSTKFVMR Mflv_2131|M.gilvum_PYR-GCK VRRLVRRILGRP-----------------DPVAKPVEQNFWYRSTTFVMR Mvan_4573|M.vanbaalenii_PYR-1 VRRLVRRVLGRP-----------------EPVAKPVEQMFWYRSTKFVMR MSMEG_5178|M.smegmatis_MC2_155 VRRFFRRVFGRP-----------------EPEPKPVEQGFWYRTAKAAMR TH_1538|M.thermoresistible__bu IRRLIRRLMRRTP-------------AAAEPAPRAVCGSKWYRWAKAVMR MAB_1287|M.abscessus_ATCC_1997 VRRLIRRVLGRP-----------------EPVAKDVTQSFWYRTTKRVMA MLBr_02620|M.leprae_Br4923 VRTLFRVPLLRNWRMSHACLNWLADRLQKTKTREEVEAGFWGKLVNFVMK :* : * : * . * * : . .* Mb1177|M.bovis_AF2122/97 RWLPVGTAVVALLVLLGLPFLSVKWGFPDDRVLPRSASARQVGDILRDDF Rv1146|M.tuberculosis_H37Rv RWLPVGTAVVALLVLLGLPFLSVKWGFPDDRVLPRSASARQVGDILRDDF MAV_1287|M.avium_104 RWAPVGLIVVGLLLLLGLPFFSVKWGFPDDRVLPRSASAHQVGDRLRSGF MMAR_4305|M.marinum_M RALPVGLAVVAVLVILGLPFFSVKWGFPDDRVLPATASSHQVGDELRTNF MUL_0989|M.ulcerans_Agy99 RALPVGLAVVAVLVILGLPFFSVKWGFPDDRVLPATASSHQVGDELRTNF Mflv_2131|M.gilvum_PYR-GCK RSIPIGGVVVVLLVLLGAPFLGATWGFPDDRVLPETASARQIGDELRQDF Mvan_4573|M.vanbaalenii_PYR-1 RSIPIGVVVVTLLLLLGAPFLGANWGFPDDRVLPQSASARQVGDELRTDF MSMEG_5178|M.smegmatis_MC2_155 RAVPIGVGIIALLVLLGVPFTGIKWGFPDDRVLPQSASARQIGDEMRTNF TH_1538|M.thermoresistible__bu HWLVAGLAVTVVLLLLGAPFLGVRWGFPDERVLPRSASAHQVGHELRTNF MAB_1287|M.abscessus_ATCC_1997 RAVPIAIIIVSALVVLGLPFLDGKFGFPDDRVLPASASAHQVGNEMRRNF MLBr_02620|M.leprae_Br4923 RPLVFAIPIVIGMILLVIPLGNLSFGGMSEKYLPPNNAVRQSQEHFDQLF : . : :::* *: . :* .:: ** . : :* . : * Mb1177|M.bovis_AF2122/97 GHDPATQIPIVVPDARGLGPVELDSYAAELSRVPDVSAVAAPTGTFVDGS Rv1146|M.tuberculosis_H37Rv GHDPATQIPIVVPDARGLGPVELDSYAAELSRVPDVSAVAAPTGTFVDGS MAV_1287|M.avium_104 AHDSATSVPVVIPDAAGLSPADLDDYAAALSRVPDVSAVSAPGGTFTGGT MMAR_4305|M.marinum_M AHDLAMAVPVVVPDVRGLVPADLDGYAADLSRVPDVASVTAPSGTFVNGS MUL_0989|M.ulcerans_Agy99 AHDLAMAVPVVVPDVHGLVPADLDGYAADLSRVPDVASVTAPSGTFVNGS Mflv_2131|M.gilvum_PYR-GCK AVDSSTNVVVVLPDADGISREDFDAYAIALSGVADVSSVSAPSGTFIGGA Mvan_4573|M.vanbaalenii_PYR-1 AVDSSANVVVVLPDAEGLGPDALDGYAAELSRVQDVSSVSAPGGTFVDGA MSMEG_5178|M.smegmatis_MC2_155 AVDSATSVTVVLPDATTVAPAEIDRYAARLSQVADVSSVSAPGGTDVQGR TH_1538|M.thermoresistible__bu ATDSASDVTVVLPDAPGLTADELAGYAARLSEVTDVAWVSAPAGTFVRGR MAB_1287|M.abscessus_ATCC_1997 NNNSSTNLSVIAEGVGSVPPREIDEYAADLSNIEDVKEVAAPTGAFIRGM MLBr_02620|M.leprae_Br4923 PGYRTNPLTLVIQTSN-HQPVTDQEIADIRSKAMAISGFIEPDNNYVN-- : : :: * * : . * . Mb1177|M.bovis_AF2122/97 WVGTPRGATGLAEGSAFLTVSSTAPLFSRASDIQLKRLHQVAGPAGRSVV Rv1146|M.tuberculosis_H37Rv WVGTPRGATGLAEGSAFLTVSSTAPLFSRASDIQLKRLHQVAGPAGRSVV MAV_1287|M.avium_104 RVGPPAGATGLGDGSAFLTVSSTAPLFSTANDVQLKRLHEVPGPAGRSVE MMAR_4305|M.marinum_M RVGPPAGATGFSDGSAFLTVDSTAPLFSHASDIQLKRLHQVTGPAGRTVE MUL_0989|M.ulcerans_Agy99 RVGPPAGATGFSDGSAFLTVDSTAPLFSHASDIQLKRLHQVTGPAGRTVE Mflv_2131|M.gilvum_PYR-GCK RAGPPSAATGSADGSAFLTIGSRAPLFTDASEVQLDRLHAIAPPGDRQVL Mvan_4573|M.vanbaalenii_PYR-1 KAGPPSAATGIAEGSAFLTIGSTAPLFTDASETQLDRLHDVAPPEGRDVL MSMEG_5178|M.smegmatis_MC2_155 HVGPPSAATGIGDGSAFLTVGSDAPLFSDASEAQLDALHAVAAH--AEVQ TH_1538|M.thermoresistible__bu SVGPPSAPTGIADGSAFVTVGSVAPLFSDDSLEQLNDIRAVPAPGGTAVQ MAB_1287|M.abscessus_ATCC_1997 KVGPSASATGIKNDTALFTVQTAAKPYTEAAERQLDAIHALPGPADVLVR MLBr_02620|M.leprae_Br4923 -MWQERTVAPGASKDPSVRVLQNGLINPNDASKKINELRSITPPKGLTVS : . . . : . . ::. :: :. * Mb1177|M.bovis_AF2122/97 MAGVAQVNRDSVDAVTDRLPMVLGLIAAITYVLLFLLTGSVVLPAKALVC Rv1146|M.tuberculosis_H37Rv MAGVAQVNRDSVDAVTDRLPMVLGLIAAITYVLLFLLTGSVVLPAKALVC MAV_1287|M.avium_104 MGGVAQVNRDSVDAVTDRLPLVLGLMAAITFVLLFLLTGSVLLPAKALAC MMAR_4305|M.marinum_M MAGVAQVNRDSVDAVTERLPLVLGLMAAITFVLLFLLTGSVVLPAKALIC MUL_0989|M.ulcerans_Agy99 MAGVAQVNRDSVDAVTERLPLVLGLMAAITFVLLFLLTGSVVLPAKALIC Mflv_2131|M.gilvum_PYR-GCK LTGLAQINRDSADAITSRLPLVLAVIAAITFVLLFVLTGSVVLPLKALVL Mvan_4573|M.vanbaalenii_PYR-1 LTGLAQINRDSADAITSRLPTVLAVIAAITFVLLFLLTGSVVLPLKALVL MSMEG_5178|M.smegmatis_MC2_155 FTGVAQVNRDSSQAITSRLPLVLGIIAGITFVLLFLLTGSVVLPLKALVL TH_1538|M.thermoresistible__bu LTGTAQINHDIVVAVTSRLTVVLTVIALTTLVWLFLLTGSIVLPIKALVL MAB_1287|M.abscessus_ATCC_1997 IGGGAQLDRDAVDGIVHKLPLVLAIIAVVTFVLLFLLTGSVVLPIKALVL MLBr_02620|M.leprae_Br4923 VGGTPALEQDSIHSLVAQAPLMVIMLITTTMLLMFLAFGSFVLPIKAAVM . * . :::* .:. : . :: :: * : :*: **.:** ** Mb1177|M.bovis_AF2122/97 NVLSLTAAFGALVWIFQEGHFGALGTTPSGTLVANMPVLLFCIAFGLSMD Rv1146|M.tuberculosis_H37Rv NVLSLTAAFGALVWIFQEGHFGALGTTPSGTLVANMPVLLFCIAFGLSMD MAV_1287|M.avium_104 NFLSLTAAFGALVWIFQDGHLGALGTTPSGTLVANMPVLLFCIAFGLSMD MMAR_4305|M.marinum_M NVLSLTAAFGALVWIFQDGHLGALGTTPSGTLVANMPVLLFCIAFGLSMD MUL_0989|M.ulcerans_Agy99 NVLSLTAAFGALVWIFQDGHLGALGTIPSGTLVANMPVLLFCIAFGLSMD Mflv_2131|M.gilvum_PYR-GCK NVLSLTAAFGALVWIFQEGHLGALGTTPTGTLVATMPVLLFCIAFGLSMD Mvan_4573|M.vanbaalenii_PYR-1 NVLSLTAAFGALVWIFQDGHLGALGTTPTGTLVANMPVLLFCIAFGLSMD MSMEG_5178|M.smegmatis_MC2_155 NVLSLSAAFGALVWIFQDGHLGALGTTPTGTLVANLPVLLFCIAFGLSMD TH_1538|M.thermoresistible__bu NALSLTAAFGALVWIFQDGHLGALGTTPSGTMAVTMPALLLCVAFGISMD MAB_1287|M.abscessus_ATCC_1997 NVLSLTATFGALIWIFQEGHLGGFGTEVTGTIVATMPMLLFCIAFGLSMD MLBr_02620|M.leprae_Br4923 SALTLGSTMGILTWIFVDGHLSKWLNFTPTPLMVVIIALVVAVGYGLATD . *:* :::* * *** :**:. . . .: . : *:..:.:*:: * Mb1177|M.bovis_AF2122/97 YEVFLVSRIREYWLESGAAR------PARRSVAEVHAANDESVALGVART Rv1146|M.tuberculosis_H37Rv YEVFLVSRIREYWLESGAAR------PARRSVAEVHAANDESVALGVART MAV_1287|M.avium_104 YEVFLLSRIREYWLASGAAR------PARPTPKRAHAANDESVALGVART MMAR_4305|M.marinum_M YEVFLVARIREYWLASGAAR------PATPSPAQAHAANDESVALGLART MUL_0989|M.ulcerans_Agy99 YEVFLVARIREYWLASGAAG------PATPSPAQAHAANDESVALGLART Mflv_2131|M.gilvum_PYR-GCK YEVFLVSRIREYWLETG--------------------ENGRSVALGLART Mvan_4573|M.vanbaalenii_PYR-1 YEVFLVSRIREYWLASGGAGADSSTAHQRSDDLAPHVRSDESVALGLART MSMEG_5178|M.smegmatis_MC2_155 YEVFLVSRIREFWLQSDQS----------------RAANEESVALGLAHT TH_1538|M.thermoresistible__bu YEVFLIARIREHWLASSRTA----------------AANDEAVALGVART MAB_1287|M.abscessus_ATCC_1997 YEVFLISRIREYWMASGRTR----------------ADNDEAVALGVART MLBr_02620|M.leprae_Br4923 YEVFLVSRMVEARAESMSTQ--------------------EAVRIGTAST *****::*: * : .:* :* * * Mb1177|M.bovis_AF2122/97 GRVITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAVAADATLVRMVVVP Rv1146|M.tuberculosis_H37Rv GRVITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAVAADATLVRMVVVP MAV_1287|M.avium_104 GRVITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAVFADATLVRMVVVP MMAR_4305|M.marinum_M GRVITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAVAADATLVRMVLVP MUL_0989|M.ulcerans_Agy99 GRVITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAMAADATLVRMVLVP Mflv_2131|M.gilvum_PYR-GCK GRVVTAAALVMSISFAALIAAQVSFMRMFGGGLTLAVLVDATLVRMLLVP Mvan_4573|M.vanbaalenii_PYR-1 GRVVTAAALLMSISFAALIAAKVAFMRMFGVGLTLAILADATLVRMLLVP MSMEG_5178|M.smegmatis_MC2_155 GRVITAAALLMSISFAALIAAQVAFMRMFGLGLTLAVLVDATLVRMLLVP TH_1538|M.thermoresistible__bu ARVITAAALIMSISFAALIGAQVSFMRMIGLGLMVAVLVDATLVRLILVP MAB_1287|M.abscessus_ATCC_1997 GRVVTAAALIMAIAFAALMAAQVSFMRMFGTGLTIAILVDATIIRMLLVP MLBr_02620|M.leprae_Br4923 GRLITAAALVLAVVAGSFVFSDLVMMKYLAFGLMAALLLDATVVRMFLVP .*::*****:::: .::: :.: :*: :. ** *: ***::*:.:** Mb1177|M.bovis_AF2122/97 AFMHVTGRWNWWAPRPLAWLHERFGVSEAAEPVSRRRSHAGG--LGKIAG Rv1146|M.tuberculosis_H37Rv AFMHVTGRWNWWAPRPLAWLHERFGVSEAAEPVSRRRSHAGG--LGKIAG MAV_1287|M.avium_104 AFMHVMGRWNWWAPKPLAWLHDRFGISEAADEEPRLRACPRTRRIRRIAR MMAR_4305|M.marinum_M AFMHVMGRWNWWAPKPLVWLHQRFGISETGAVGDADAAATEA------AD MUL_0989|M.ulcerans_Agy99 AFMHVMGRWNWWAPKPLVWLHQRFGISETGAVGGADAAATEA------AD Mflv_2131|M.gilvum_PYR-GCK AFMHLLGRWNWWAPPPLARLHARIGVSETVP------------------- Mvan_4573|M.vanbaalenii_PYR-1 AFMHVLGRWNWWAPKPLARLHERIGFSETLDDSSDSPP----------RS MSMEG_5178|M.smegmatis_MC2_155 AFMRVMGRWNWWAPAPLARLHERIGFSESGLPPDPKP------------- TH_1538|M.thermoresistible__bu AFMHVMGRANWWAPAPLARWHDRFGIREAADAPDRPRSDPAPTPXXXDAS MAB_1287|M.abscessus_ATCC_1997 SFMRLLGRFNWWAPKPLVTLHERIGFSD---------------------- MLBr_02620|M.leprae_Br4923 SVMKLLGDDCWWAPRWARLLQNRIGLGEIHLPDERRRPTVSGRPVRPPVT :.*:: * **** : *:*. : Mb1177|M.bovis_AF2122/97 RSDGQT---------IPAS-----------LTRNG--------------- Rv1146|M.tuberculosis_H37Rv RSDGQT---------IPAS-----------LTRNG--------------- MAV_1287|M.avium_104 RRGRRTGAQHRLTAVRPTARRVWRSDPILRLIRGGRCTQA---------- MMAR_4305|M.marinum_M RRDRPT---------IPAA-----------LSGRG--------------- MUL_0989|M.ulcerans_Agy99 RRDRPT---------IPAA-----------LSGRG--------------- Mflv_2131|M.gilvum_PYR-GCK -QRV---------------------------------------------- Mvan_4573|M.vanbaalenii_PYR-1 RQHVATG-----------------------NEHG---------------- MSMEG_5178|M.smegmatis_MC2_155 -QPASVG-----------------------MTQSG--------------- TH_1538|M.thermoresistible__bu VRKGPAPSSISRDPAVPAYVPDRP------RTRSACRCSR---------- MAB_1287|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02620|M.leprae_Br4923 AASLAAPASRVPRGPTHPATLEPSQRARSGLASRPQIKRPQELPSGASTA Mb1177|M.bovis_AF2122/97 -------------------------------------------------- Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 -------------------------------------------------- MMAR_4305|M.marinum_M -------------------------------------------------- MUL_0989|M.ulcerans_Agy99 -------------------------------------------------- Mflv_2131|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_4573|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_5178|M.smegmatis_MC2_155 -------------------------------------------------- TH_1538|M.thermoresistible__bu -------------------------------------------------- MAB_1287|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02620|M.leprae_Br4923 RIQMRPSQSVEATTTRLSVPGNAPTTAAVSSSQGVQAVPLAATRHPLPTP Mb1177|M.bovis_AF2122/97 -------------------------------------------------- Rv1146|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1287|M.avium_104 -------------------------------------------------- MMAR_4305|M.marinum_M -------------------------------------------------- MUL_0989|M.ulcerans_Agy99 -------------------------------------------------- Mflv_2131|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_4573|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_5178|M.smegmatis_MC2_155 -------------------------------------------------- TH_1538|M.thermoresistible__bu -------------------------------------------------- MAB_1287|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02620|M.leprae_Br4923 SPASGQTRAMPVPANRSSDNASETAEPTTALPIMRPQDNDSEVATEKLNA Mb1177|M.bovis_AF2122/97 ------------------------------ Rv1146|M.tuberculosis_H37Rv ------------------------------ MAV_1287|M.avium_104 ------------------------------ MMAR_4305|M.marinum_M ------------------------------ MUL_0989|M.ulcerans_Agy99 ------------------------------ Mflv_2131|M.gilvum_PYR-GCK ------------------------------ Mvan_4573|M.vanbaalenii_PYR-1 ------------------------------ MSMEG_5178|M.smegmatis_MC2_155 ------------------------------ TH_1538|M.thermoresistible__bu ------------------------------ MAB_1287|M.abscessus_ATCC_1997 ------------------------------ MLBr_02620|M.leprae_Br4923 LGQGDNSRQHRRATGGGISAQDLLRREGRL